# Anua Heartleaf 80 Moisture Soothing Ampoule for acne-prone skin

**Lovi Fit: Superior fit for acne-prone skin.**
Combination Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [Anua](https://lovi.care/skincare/es/brands/anua)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best moisturizers for acne-prone skin.

## Why this fit

- Excellent suitability for your combination skin is provided by Houttuynia Cordata Extract and Glycerin, which offer anti-inflammatory and humectant actions, respectively, providing optimal hydration and soothing benefits for your acne, blemishes, and breakouts.
- The high concentrations of glycerin and hyaluronic acid offer excellent moisturizing properties, hydrating and plumping your skin.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components like Houttuynia Cordata Extract, Allantoin, and Panthenol.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin): Superior (this page)
- [Skin with dark spots](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/oily-acne-prone-skin): Superior

## Key ingredients

Heartleaf Extract, Hyaluronic Acid, Glycerin, Allantoin, Panthenol

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))
- Topical gel containing chitosan, 0.2% chlorhexidine, allantoin and dexpanthenol did not improve postoperative comfort regarding swelling and pain, but improved the wound's aesthetic appearance following impacted lower third molar extraction compared to no gel. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2016](https://pubmed.ncbi.nlm.nih.gov/27475700/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- An overnight patch containing Allium cepa extract and allantoin safely promotes scar healing after dermatologic surgery, resulting in significantly greater reductions in observer- and patient-assessed POSAS scores compared to no treatment. ([Aesthetic Plastic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/29948103/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two. ([Auris, Nasus, Larynx, 2020](https://pubmed.ncbi.nlm.nih.gov/32067777/))

## What reviewers say

Based on a very large amount of data, this ampoule is widely praised by users with sensitive and acne-prone skin for its ability to rapidly soothe redness and provide deep hydration without clogging pores. While most users achieve a "glass skin" glow and reduced inflammation, a minority experience a tacky finish or find it ineffective for severe breakouts.

- Liked: Soothing redness (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Acne care (sometimes noted)
- Liked: Lightweight texture (sometimes noted)
- Disliked: Small quantity (sometimes noted)
- Disliked: Sticky finish (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Lack of results (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Anua Heartleaf 80 Moisture Soothing Ampoule one of the best fits for acne-prone skin?

This product is one of the best fits because heartleaf extract and glycerin calm breakouts and keep acne-prone skin well hydrated without irritation. Hyaluronic acid, allantoin, and panthenol also help soothe and soften your skin while supporting a healthy moisture barrier.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for acne-prone skin?

Heartleaf extract, glycerin, hyaluronic acid, allantoin, and panthenol make this serum a great fit by soothing breakouts, calming redness, and keeping acne-prone skin hydrated without irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Heartleaf Extract do for acne-prone skin?

Heartleaf Extract helps calm acne-prone skin by reducing redness, swelling, and breakouts. Studies show it helps lower inflammation and target acne-causing bacteria without irritating the skin.
Sources: [Bioscience, Biotechnology, and Biochemistry, 2016](https://pubmed.ncbi.nlm.nih.gov/27023331/), [The Journal of Dermatological Treatment, 2021](https://pubmed.ncbi.nlm.nih.gov/31424962/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing, which keeps the routine simple and safe. Using it then helps calm breakouts and hydrate your skin without any harsh risks of irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/)

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the serum first to help calm and hydrate your skin before putting on your retinol. Using a hydrating moisturizer like this is unlikely to cause irritation and may help your skin handle retinol better.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/), [The Journal of Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/24930436/)

### How often should I use this serum?

You can use this serum in your evening routine, and some people also use it in the morning or twice a day. Daily application helps improve skin moisture, smoothness, and overall barrier function.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause breakouts or clog pores on acne-prone skin. It has an excellent safety profile with soothing ingredients like heartleaf extract, allantoin, and panthenol that help calm blemishes and reduce irritation.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is well-suited for the thin skin around the eyes and body because its gentle formulation keeps irritation risks low while delivering deep hydration and soothing benefits. Hyaluronic acid and glycerin help draw moisture into dry areas, while ingredients like heartleaf extract, allantoin, and panthenol help calm sensitive or irritated skin.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/es/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — €39.50 at Notino
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/es/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — €20.00 at Notino

## Pairs well with

- Cleanser: [B.LAB Matcha Hydrating Foam Cleanser](https://lovi.care/skincare/es/p/b-lab/matcha-hydrating-foam-cleanser/for/acne-prone-skin) — Superior fit — €11.99 at Amazon
- Hydrating Toner: [Paula's Choice Resist Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/acne-prone-skin) — Superior fit — €34.00 at Amazon
- SPF: [SKIN1004 Madagascar Centella Air-Fit Suncream Plus](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-air-fit-suncream-plus/for/acne-prone-skin) — Superior fit — €12.94 at Amazon

## Where to buy

- Amazon.de: €17.98 (https://www.amazon.de/dp/B0DKSYXWZJ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €33.90 (https://www.notino.es/anua/heartleaf-80-moisture-ampoule-ampollas-de-renovacion-intensa-de-la-piel-con-efectos-calmantes/p-16242798/)
Prices checked 18 Oct – 6 Nov 2026.

## Ingredients

Water, Houttuynia Cordata Extract, Glycerin, Butylene Glycol, 1,2-Hexanediol, Hyaluronic Acid, Betaine, Allantoin, Panthenol, Ethylhexylglycerin, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- France: https://lovi.care/skincare/fr/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/anua/heartleaf-80-moisture-soothing-ampoule/for/acne-prone-skin