AMOREPACIFIC Time Response Eye Reserve Crème for mature skin

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Adenosine-loaded dissolving microneedle patches showed similar or better efficacy on skin wrinkles, dermal density, elasticity, and hydration compared to adenosine cream in 22 female subjects.

  International Journal of Cosmetic Science, 2018

• Horse oil-spread and adenosine-loaded dissolving microneedle patches significantly improved skin elasticity, hydration, dermal density, and wrinkles compared with adenosine-loaded dissolving microneedle patches in 20 women without causing adverse events.

  Journal of Cosmetic Dermatology, 2019

• Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants.

  International Journal of Molecular Sciences, 2026

• Sixty-day application of two retinyl palmitate-containing anti-aging creams improved skin surface parameters, reducing skin wrinkling by -6.68% and -8.27% in healthy male volunteers.

  Journal of Cosmetic Dermatology, 2018

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• A topical cosmetic slimming product containing tetrahydroxypropyl ethylenediamine, caffeine, carnitine, forskolin and retinol significantly reduced body circumferences and improved skin aspect compared with placebo in 78 women over 12 weeks.

  International Journal of Cosmetic Science, 2011

• Topical sunscreen formulations containing caffeine combined with UV filters increased in vivo anti-UVB protection by approximately 25% and showed higher SPF values compared to caffeine-free sunscreen, while being well tolerated by the skin of healthy subjects.

  Frontiers in Physiology, 2019

• Caffeine gel combined with choline geranate showed high skin permeation capacity and superior clinical results in cellulite treatment compared to caffeine gel without ionic liquid.

  AAPS PharmSciTech, 2021

• Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months.

  The Journal of Dermatology, 2008

• Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts.

  International Journal of Molecular Sciences, 2021

• Adenosine treatment of dermal papilla cells upregulates fibroblast growth factor-7 expression via the A2b adenosine receptor and intracellular cAMP signaling, and fibroblast growth factor-7 significantly stimulates hair fiber elongation in human scalp hair follicle organ cultures.

  The Journal of Investigative Dermatology, 2007

• Topical green tea extract significantly improved clinical symptoms, tear breakup times, and meibomian gland health compared to standard treatment in patients with dry eye and Meibomian Gland Dysfunction.

  Journal of Clinical and Diagnostic Research, 2017

• Topical low-dose green tea extract reduces UVB-induced p53 expression and apoptosis in human skin keratinocytes compared to placebo.

  Experimental Dermatology, 2009

• An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne.

  Clinical, Cosmetic and Investigational Dermatology, 2019

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

Ingredients

Camellia Sinensis Leaf Water, Butylene Glycol, Water, Glycerin, Hydrogenated Poly C6-14 Olefin, Butyrospermum Parkii Butter Shea Butter, Pentaerythrityl Tetraethylhexanoate, Hydrogenated Olive Lauryl Esters Oil, Jojoba Esters, Methyl Trimethicone, Caprylic Capric Triglyceride, Diisostearyl Malate, Cetyl Ethylhexanoate, Behenyl Alcohol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Propanediol, Hydrogenated Lecithin, Peg-40 Stearate, Camellia Sinensis Seed Oil, Arachidyl Alcohol, Betaine, Niacinamide, Polyglyceryl-10 Stearate, 1,2-Hexanediol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Glyceryl Stearate, Cetearyl Alcohol, Mica, Arachidyl Glucoside, Titanium Dioxide Ci 77891, Dipotassium Glycyrrhizate, Caffeine, Glyceryl Caprylate, Dipalmitoyl Hydroxyproline, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Disodium Edta, Ethylhexylglycerin, Adenosine, Beta-Glucan, Tromethamine, Sorbitan Isostearate, Polysorbate 60, Palmitic Acid, Natto Gum, Glycine Soja Seed Extract Soybean Seed Extract, Theobroma Cacao Extract, Dextrin, Camellia Sinensis Leaf Extract, Glucose, Tocopherol, Poloxamer 235, Ethoxydiglycol, Epigallocatechin Gallate, Tocophersolan, Poloxamer 338, Phenoxyethanol, Panax Ginseng Root Extract, Magnolia Obovata Bark Extract, Caprylyl Glycol

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.