# A+ 345 Relief Cream for combination skin

**Lovi Fit: Low fit for combination skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/es/p/a/345-relief-cream/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Brand: [A+](https://lovi.care/skincare/es/brands/a)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/es/best/moisturizers)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A weak match for combination skin; the moisturizers alongside fit it better.

## Why this fit

- Suboptimal compatibility for your combination skin as niacinamide and hyaluronic acid offer moderate hydration and barrier repair, but do not specifically target oily shine. Glycerin provides basic moisturizing benefits, which are supportive but not ideal for managing excess oil.
- The formula is safe for your combination skin, with no harsh ingredients and the inclusion of soothing agents like panthenol and niacinamide to minimize irritation.
- While generally safe and providing some hydration, the product's functionality is limited in addressing your primary concern of oily shine.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/combination-skin): Low (this page)
- [Sensitive skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/es/p/a/345-relief-cream/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/es/p/a/345-relief-cream/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Hyaluronic Acid, Coptis Japonica Root Extract

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical steroid withdrawal is driven by excess mitochondrial NAD+ metabolism that can be successfully targeted using complex I-inhibiting interventions such as metformin and berberine. ([The Journal of Investigative Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40088241/))
- Topical steroid withdrawal presents as a distinct dermatopathology characterized by burning, flushing, thermodysregulation, and elevated mitochondrial NAD+ oxidation, which can be improved by targeting complex I with metformin or berberine. ([MedRxiv, 2024](https://pubmed.ncbi.nlm.nih.gov/38712043/))
- Hydroxypropyl methylcellulose hydrogel formulations of berberine chloride-loaded escinosomes increased skin residence time and transdermal permeability while maintaining high safety and biocompatibility without skin irritation. ([International Journal of Biological Macromolecules, 2020](https://pubmed.ncbi.nlm.nih.gov/32682035/))

## What reviewers say

Based on a very large amount of data, this lightweight, gel-like cream is widely celebrated by users with oily, combination, and sensitive skin for its ability to soothe redness and fade post-acne marks without clogging pores. However, those with dry skin often find it insufficiently moisturizing, and a subset of users report breakouts or fungal acne triggers despite its soothing claims.

- Liked: Lightweight & fast-absorbing (mostly mentioned)
- Liked: Ideal for oily/combo skin (often mentioned)
- Liked: Soothing & calming (often mentioned)
- Liked: Fades acne marks (sometimes noted)
- Disliked: Not moisturizing enough (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Fungal acne trigger (rarely noted)
- Disliked: Texture/pilling issues (rarely noted)

## How to apply

- Use this moisturizer in your AM and PM routine every day to control shine. Always pair with SPF in the morning.
- Apply this moisturizer after your cleanser and toner, right before your morning SPF.
- Gently press a small amount of the moisturizer into your skin and avoid harsh rubbing. Let it ⏳absorb for a minute.
- Apply the moisturizer on slightly damp skin to help it lock in moisture better. This keeps your combination skin balanced.
- Avoid the eye area when applying the moisturizer. Do a patch test before your first use.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### Why is A+ 345 Relief Cream a weak match for combination skin?

This cream is a weak match for combination skin because it provides basic hydration and barrier support from ingredients like glycerin and hyaluronic acid, but it does not target oily shine. A product of this type needs effective brightening and moisturizing ingredients that manage excess oil while keeping skin balanced and calm.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this cream a poor fit for combination skin?

This cream is a weak match for combination skin because niacinamide, hyaluronic acid, and glycerin provide moderate moisture and barrier support, but they do not specifically target or control oily shine. A better fit for this skin type requires ingredients that effectively reduce excess oil while still providing balanced hydration and brightness without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Hyaluronic Acid do for combination skin?

Hyaluronic acid is a great fit for combination skin because it quenches dry areas with a boost of hydration while keeping oily zones balanced. Regular use helps smooth out fine lines and makes your skin feel soft and plump without causing irritation.
Sources: [Dermatology and Therapy, 2021](https://pubmed.ncbi.nlm.nih.gov/34176098/), [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/)

### Where does this cream go in a skincare routine for combination skin?

This cream goes as a moisturizer step in the morning routine and after treatments in the evening routine. Because this is a weak match for combination skin, it provides basic moisture but needs ingredients that target oily shine and manage excess oil.

### Can I use it with retinol, and in what order?

You can use A+ 345 Relief Cream with retinol, applying it after your retinol treatment to help soothe your skin and keep it comfortable. A moisturizing treatment of this type needs barrier-supporting ingredients like ceramides and soothing agents to help calm dryness and irritation while you use retinol.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this cream?

You can use this moisturizing treatment twice a day as part of your daily routine. Because this cream is a weak match for combination skin, this type of product for your skin needs oil-controlling and balancing ingredients to manage excess shine while keeping skin hydrated.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can it clog pores, cause breakouts or purging for combination skin?

This product is unlikely to clog pores or cause breakouts for combination skin, as user complaints about breakouts are low and it contains gentle, soothing ingredients like panthenol and niacinamide. However, because it is a weak match for combination skin, a product of this type needs lightweight hydrators and oil-balancing ingredients like salicylic acid or niacinamide to keep oily shine under control.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/)

### Can I use this cream around the eyes or on my body?

This moisturizing treatment is safe to use on the body and around the eyes, where the skin is particularly thin. Regular application of a cream containing hyaluronic acid helps smooth fine lines in this delicate area while maintaining very good skin tolerance.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/), [Polymers, 2023](https://pubmed.ncbi.nlm.nih.gov/37896378/)

### Is this cream fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/es/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — €13.67 at Amazon
- [The Ordinary Natural Moisturizing Factors + HA](https://lovi.care/skincare/es/p/the-ordinary/natural-moisturizing-factors-ha/for/combination-skin) — High fit — €11.50 at Amazon
- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/es/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/combination-skin) — High fit — €92.00 at Amazon

## Routine for combination skin

### AM

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon

### PM

- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/es/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — €16.98 at Amazon
- Serum or Treatment: [SKIN1004 Madagascar Centella Spot Cream](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-spot-cream/for/combination-skin) — Superior fit — €18.49 at Amazon

### Weekly

- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — €97.52 at Amazon
- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.80 at Amazon
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/es/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — €48.55 at Amazon
- Cleansing Mask: [Origins Original Skin Retexturizing Mask with Rose Clay](https://lovi.care/skincare/es/p/origins/original-skin-retexturizing-mask-with-rose-clay/for/combination-skin) — Superior fit — €28.50 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Serum or Treatment: [SKIN1004 Madagascar Centella Spot Cream](https://lovi.care/skincare/es/p/skin1004/madagascar-centella-spot-cream/for/combination-skin) — Superior fit — €18.49 at Amazon

## Where to buy

No store in Spain has a checked price for this product, so the page shows none.

## Ingredients

Water, Propanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Niacinamide, Caprylic Capric Triglyceride, Polyglycerin-3, Panthenol, Polyglyceryl-10 Stearate, Hydrogenated Polydecene, Hydrogenated Poly C6-14 Olefin, Dicaprylyl Carbonate, Ammonium Acryloyldimethyltaurate Vp Copolymer, C14-22 Alcohols, Polymethylsilsesquioxane, C12-20 Alkyl Glucoside, Butylene Glycol, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Ethylhexylglycerin, Polyquaternium-51, Tromethamine, Hyaluronic Acid, Coptis Japonica Root Extract, Houttuynia Cordata Extract, Oenothera Biennis Flower Extract, Beta-Glucan, Resveratrol, Gardenia Florida Fruit Extract, Lavandula Angustifolia Flower Extract Lavender Flower Extract, Opuntia Ficus-Indica Stem Extract, Hydrolyzed Hyaluronic Acid, Centella Asiatica Leaf Extract, Phenoxyethanol, Hibiscus Sabdariffa Flower Extract, Tocopherol, Corallina Officinalis Extract, Ceramide Np
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/a/345-relief-cream/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/a/345-relief-cream/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/a/345-relief-cream/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/a/345-relief-cream/for/combination-skin
- France: https://lovi.care/skincare/fr/p/a/345-relief-cream/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/a/345-relief-cream/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/a/345-relief-cream/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/a/345-relief-cream/for/combination-skin (this page)
- Canada: https://lovi.care/skincare/ca/p/a/345-relief-cream/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/a/345-relief-cream/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/a/345-relief-cream/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/a/345-relief-cream/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/a/345-relief-cream/for/combination-skin