# Tretinoin and palmitoyl pentapeptide-4

Page: https://lovi.care/skincare/es/ingredients/tretinoin-and-palmitoyl-pentapeptide-4

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Keep them apart

Use them at different times of day by applying [palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/palmitoyl-pentapeptide-4) in the morning and [tretinoin](https://lovi.care/skincare/es/ingredients/tretinoin) at night to prevent skin irritation. Both ingredients work hard to firm the skin, but combining them at the same time can cause redness and irritation. To safely get the benefits of both, you can simply use them in separate routines or apply a gentler peptide product.

- [All about tretinoin](https://lovi.care/skincare/es/ingredients/tretinoin)
- [All about palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/palmitoyl-pentapeptide-4)

### [Tretinoin](https://lovi.care/skincare/es/ingredients/tretinoin) products

- [Retin-A Cream](https://lovi.care/skincare/es/p/retin-a/cream/for/oily-skin) — High fit
- [Tri-Luma Cream](https://lovi.care/skincare/es/p/tri-luma/cream/for/dark-spots) — Average fit
- [Musely The Spot Cream](https://lovi.care/skincare/es/p/musely/the-spot-cream/for/mature-skin) — High fit
- [Obagi Tretinoin Cream 0.05%](https://lovi.care/skincare/es/p/obagi/tretinoin-cream-0-05/for/oily-skin) — High fit
- [Taro Tretinoin Cream](https://lovi.care/skincare/es/p/taro/tretinoin-cream/for/combination-skin) — High fit
- [Mylan Tretinoin](https://lovi.care/skincare/es/p/mylan/tretinoin/for/acne-prone-skin) — Average fit
- [Curology Formula](https://lovi.care/skincare/es/p/curology/formula/for/oily-skin) — High fit
- [Menarini A-Ret Gel](https://lovi.care/skincare/es/p/menarini/a-ret-gel/for/oily-skin) — High fit

### [Palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/palmitoyl-pentapeptide-4) products

- [Olay Eye Lifting Serum](https://lovi.care/skincare/es/p/olay/eye-lifting-serum/for/dry-skin) — High fit — [€28.99 at Amazon](https://www.amazon.de/dp/B00OUV2WYW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Can you use tretinoin and palmitoyl pentapeptide-4 together?

It is best to keep [tretinoin](https://lovi.care/skincare/es/ingredients/tretinoin) and [palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/palmitoyl-pentapeptide-4) apart in your routine because combined stimulation may increase skin irritation. Instead, alternate their usage by applying your retinoid in the evening and peptides in the morning.

### Which goes first, tretinoin or palmitoyl pentapeptide-4?

Keep tretinoin and palmitoyl pentapeptide-4 apart in your routine because combined use may increase irritation. Alternate them by applying tretinoin in the evening and palmitoyl pentapeptide-4 in the morning.

### Are tretinoin and palmitoyl pentapeptide-4 good for sensitive skin?

Keep tretinoin and palmitoyl pentapeptide-4 apart in your routine, as combined stimulation may increase irritation especially on sensitive skin. Alternate your usage by applying the retinoid in the evening and peptides in the morning.

## Research on tretinoin and palmitoyl pentapeptide-4

- [Restoration of collagen formation in photodamaged human skin by tretinoin (retinoic acid)](https://pubmed.ncbi.nlm.nih.gov/8336752/) Tretinoin · The New England Journal of Medicine, 1993
- [Topical palmitoyl pentapeptide provides improvement in photoaged human facial skin](https://pubmed.ncbi.nlm.nih.gov/18492182/) Palmitoyl pentapeptide-4 · International Journal of Cosmetic Science, 2005
- [Clinical Assessment of New Topical Cream Containing Two Essential Oils Combined with Tretinoin in the Treatment of Acne](https://pubmed.ncbi.nlm.nih.gov/32210603/) Tretinoin · Clinical, Cosmetic and Investigational Dermatology, 2020
- [Efficacy assessments of tretinoin-loaded nano lipid carriers in acne vulgaris: a double blind, split-face randomized clinical study](https://pubmed.ncbi.nlm.nih.gov/34146120/) Tretinoin · Archives of Dermatological Research, 2022
- [Topical tretinoin for treating photoaging: A systematic review of randomized controlled trials](https://pubmed.ncbi.nlm.nih.gov/35620028/) Tretinoin · International Journal of Women's Dermatology, 2022
- [Use of a Serum With the Infinite Glow® Device Improves Signs of Facial Aging: A Split-Face Case Report Using VISIA Analysis](https://pubmed.ncbi.nlm.nih.gov/42500768/) Palmitoyl pentapeptide-4 · Cureus, 2026

## Other combinations

- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and bio-placenta peptides](https://lovi.care/skincare/es/ingredients/tretinoin-and-bio-placenta-peptides)
- Keep them apart: [Tretinoin and collagen peptide](https://lovi.care/skincare/es/ingredients/tretinoin-and-collagen-peptide)
- Keep them apart: [Tretinoin and copper peptide](https://lovi.care/skincare/es/ingredients/tretinoin-and-copper-peptide)
- Keep them apart: [Tretinoin and hexapeptide](https://lovi.care/skincare/es/ingredients/tretinoin-and-hexapeptide)
- Keep them apart: [Tretinoin and hexapeptide-9](https://lovi.care/skincare/es/ingredients/tretinoin-and-hexapeptide-9)
- Keep them apart: [Adapalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/adapalene-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Granactive retinoid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/granactive-retinoid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Hydroxypinacolone retinoate and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/hydroxypinacolone-retinoate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Pro-retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/pro-retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinal and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/retinal-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Retinol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/retinol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Vitamin A and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/vitamin-a-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Tretinoin and palmitoyl tripeptide-1](https://lovi.care/skincare/es/ingredients/tretinoin-and-palmitoyl-tripeptide-1)
- Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/tretinoin-and-peptide-rich-plasma)
- Keep them apart: [Tretinoin and triple peptide blend](https://lovi.care/skincare/es/ingredients/tretinoin-and-triple-peptide-blend)
- Work well together: [Liposome and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/liposome-and-palmitoyl-pentapeptide-4)
- Work well together: [Microcapsule and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/microcapsule-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Vitamin C and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/vitamin-c-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/es/ingredients/niacinamide-and-tretinoin)
- Work well together: [Betaine and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/betaine-and-palmitoyl-pentapeptide-4)
- Work well together: [Glycerin and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/glycerin-and-palmitoyl-pentapeptide-4)
- Work well together: [Hyaluronic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/hyaluronic-acid-and-palmitoyl-pentapeptide-4)
- Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/niacinamide-and-palmitoyl-pentapeptide-4)
- Work well together: [Panthenol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/panthenol-and-palmitoyl-pentapeptide-4)
- Work well together: [Bakuchiol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/bakuchiol-and-palmitoyl-pentapeptide-4)
- Work well together: [Arginine and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/arginine-and-palmitoyl-pentapeptide-4)
- Work well together: [GABA and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/gaba-and-palmitoyl-pentapeptide-4)
- Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4)
- Work well together: [Taurine and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/taurine-and-palmitoyl-pentapeptide-4)
- Work well together: [Palmitoyl pentapeptide-4 and theanine](https://lovi.care/skincare/es/ingredients/palmitoyl-pentapeptide-4-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Citric acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/citric-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Glycolic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Mandelic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/mandelic-acid-and-palmitoyl-pentapeptide-4)
- Work well together: [Coenzyme Q10 and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/coenzyme-q10-and-palmitoyl-pentapeptide-4)
- Work well together: [Green tea and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/green-tea-and-palmitoyl-pentapeptide-4)
- Work well together: [Vitamin E and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/vitamin-e-and-palmitoyl-pentapeptide-4)
- Keep them apart: [AHA blend glycolic and citric acids and tretinoin](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-tretinoin)
- Keep them apart: [Tretinoin and citric acid](https://lovi.care/skincare/es/ingredients/tretinoin-and-citric-acid)
- Keep them apart: [Glycolic acid and tretinoin](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-tretinoin)
- Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/es/ingredients/tretinoin-and-lactic-acid)
- Keep them apart: [Tretinoin and mandelic acid](https://lovi.care/skincare/es/ingredients/tretinoin-and-mandelic-acid)
- Work well together: [Beta-sitosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/beta-sitosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Ceramide-building complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/ceramide-building-complex-and-palmitoyl-pentapeptide-4)
- Work well together: [Cholesterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/cholesterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosphingosine and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/phytosphingosine-and-palmitoyl-pentapeptide-4)
- Work well together: [Phytosterol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/phytosterol-and-palmitoyl-pentapeptide-4)
- Work well together: [Squalene and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/squalene-and-palmitoyl-pentapeptide-4)
- Work well together: [Tri-ceramide complex and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/tri-ceramide-complex-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Salicylic acid and tretinoin](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-tretinoin)
- Keep them apart: [Vitamin C and tretinoin](https://lovi.care/skincare/es/ingredients/vitamin-c-and-tretinoin)
- Keep them apart: [Baking soda and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/baking-soda-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Bleach and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/bleach-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Potassium hydroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/potassium-hydroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Behenyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/behenyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Isopropyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/isopropyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Polyvinyl alcohol and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/polyvinyl-alcohol-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Copper and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/copper-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Benzoyl peroxide and tretinoin](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-tretinoin)
- Keep them apart: [Benzoyl peroxide and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Magnesium and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/magnesium-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/zinc-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Zinc sulfate and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/zinc-sulfate-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Azelaic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/azelaic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Protease and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/protease-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Superoxide dismutase and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/superoxide-dismutase-and-palmitoyl-pentapeptide-4)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- United Kingdom: https://lovi.care/skincare/uk/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Ireland: https://lovi.care/skincare/ie/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Germany: https://lovi.care/skincare/de/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- France: https://lovi.care/skincare/fr/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Italy: https://lovi.care/skincare/it/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Netherlands: https://lovi.care/skincare/nl/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Spain: https://lovi.care/skincare/es/ingredients/tretinoin-and-palmitoyl-pentapeptide-4 (this page)
- Canada: https://lovi.care/skincare/ca/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Australia: https://lovi.care/skincare/au/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Singapore: https://lovi.care/skincare/sg/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/tretinoin-and-palmitoyl-pentapeptide-4
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/tretinoin-and-palmitoyl-pentapeptide-4