# Silk amino acids and acetyl hexapeptide-3 Page: https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain. Work well together Use them together, applying [silk amino acids](https://lovi.care/skincare/es/ingredients/silk-amino-acids) first and [acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3) right after, to boost hydration and repair. Silk amino acids help the peptides work better by supporting skin moisture and acting as building blocks. You can keep using them together as long as your skin feels comfortable, or apply them on alternate days if you want to ease in. - [All about silk amino acids](https://lovi.care/skincare/es/ingredients/silk-amino-acids) - [All about acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3) ### [Silk amino acids](https://lovi.care/skincare/es/ingredients/silk-amino-acids) products - [Dermalogica Active Moist](https://lovi.care/skincare/es/p/dermalogica/active-moist/for/oily-skin) — High fit — [€70.99 at Amazon](https://www.amazon.de/dp/B001AZVRII?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Allies of Skin Molecular Silk Amino Hydrating Cleanser](https://lovi.care/skincare/es/p/allies-of-skin/molecular-silk-amino-hydrating-cleanser/for/sensitive-skin) — High fit — [€43.70 at Lookfantastic](https://www.lookfantastic.es/p/allies-of-skin-molecular-silk-amino-hydrating-cleanser-100ml/14017898/) ### [Acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3) products - [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [€27.95 at Amazon](https://www.amazon.de/dp/B0C9DXGXZ3?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [€16.90 at Amazon](https://www.amazon.de/dp/B0BLHW7JZM?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Medik8 Liquid Peptides](https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€102.00 at Amazon](https://www.amazon.de/dp/B0DYV9VSDV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Mer The Treatment Lotion](https://lovi.care/skincare/es/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [€79.90 at Amazon](https://www.amazon.de/dp/B0B61KKT4K?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/es/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit - [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/es/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [€8.96 at Amazon](https://www.amazon.de/dp/B072JH13CD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Good Molecules Super Peptide Serum](https://lovi.care/skincare/es/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [€23.20 at Amazon](https://www.amazon.de/dp/B091MTKS35?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/es/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€71.30 at Lookfantastic](https://www.lookfantastic.es/p/clinique-smart-clinical-repair-wrinkle-correcting-serum-various-sizes/13279421/) - [La Mer The Renewal Oil](https://lovi.care/skincare/es/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [€189.00 at Amazon](https://www.amazon.de/dp/B0163GAMI4?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/es/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [€109.00 at Notino](https://www.notino.es/estee-lauder/micro-essence-treatment-lotion-locion-embellecedora-para-iluminar-la-piel/p-16118523/) - [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/es/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit - [La Mer The Eye Concentrate](https://lovi.care/skincare/es/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [€124.58 at Amazon](https://www.amazon.de/dp/B085614WX5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use silk amino acids and acetyl hexapeptide-3 together? Yes, you can use [silk amino acids](https://lovi.care/skincare/es/ingredients/silk-amino-acids) and [acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3) together because they support moisture balance and structural protein synthesis. Lovi rates the fit as High for all skin types. ### Which goes first, silk amino acids or acetyl hexapeptide-3? Silk amino acids and acetyl hexapeptide-3 work well together to support structural protein synthesis and moisture balance, so you can apply them in either order within your hydrating and reparative routine. ### Are silk amino acids and acetyl hexapeptide-3 good for sensitive skin? Yes, silk amino acids and acetyl hexapeptide-3 work well together to support structural protein synthesis and moisture balance for all skin types. Acetyl hexapeptide-3 helps reduce wrinkles and skin roughness, while amino acids improve cellular osmotic balance. [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/) [Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/) ## Research on silk amino acids and acetyl hexapeptide-3 - [The safety and efficacy of bacterial nanocellulose wound dressing incorporating sericin and polyhexamethylene biguanide: in vitro, in vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/26796543/) Silk amino acids · Archives of Dermatological Research, 2016 - [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013 - [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019 - [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017 - [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013 ## Other combinations - Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/adapalene-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid) - Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate) - Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/pro-retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/retinal-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and retinoid blend](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-retinoid-blend) - Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/retinol-and-acetyl-hexapeptide-3) - Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/tretinoin-and-acetyl-hexapeptide-3) - Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/vitamin-a-and-acetyl-hexapeptide-3) - Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/liposome-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-microcapsule) - Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/vitamin-c-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-betaine) - Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/glycerin-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/panthenol-and-acetyl-hexapeptide-3) - Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/bakuchiol-and-acetyl-hexapeptide-3) - Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/arginine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-gaba) - Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/taurine-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-theanine) - Work well together: [Bio-placenta peptides and silk amino acids](https://lovi.care/skincare/es/ingredients/bio-placenta-peptides-and-silk-amino-acids) - Work well together: [Silk amino acids and collagen peptide](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-collagen-peptide) - Work well together: [Silk amino acids and copper peptide](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-copper-peptide) - Work well together: [Hexapeptide and silk amino acids](https://lovi.care/skincare/es/ingredients/hexapeptide-and-silk-amino-acids) - Work well together: [Silk amino acids and hexapeptide-9](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-hexapeptide-9) - Work well together: [Silk amino acids and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-palmitoyl-pentapeptide-4) - Work well together: [Silk amino acids and palmitoyl tripeptide-1](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-palmitoyl-tripeptide-1) - Work well together: [Silk amino acids and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-peptide-rich-plasma) - Work well together: [Silk amino acids and triple peptide blend](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-triple-peptide-blend) - Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-citric-acid) - Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/lactic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-mandelic-acid) - Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3) - Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/green-tea-and-acetyl-hexapeptide-3) - Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/vitamin-e-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol) - Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3) - Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-cholesterol) - Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-phytosphingosine) - Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-phytosterol) - Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-squalene) - Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex) - Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-acetyl-hexapeptide-3) - Work well together: [AHA blend glycolic and citric acids and silk amino acids](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-silk-amino-acids) - Work well together: [Silk amino acids and citric acid](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-citric-acid) - Work well together: [Glycolic acid and silk amino acids](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-silk-amino-acids) - Work well together: [Silk amino acids and lactic acid](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-lactic-acid) - Work well together: [Silk amino acids and mandelic acid](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-mandelic-acid) - Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-baking-soda) - Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-bleach) - Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide) - Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol) - Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol) - Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/copper-and-acetyl-hexapeptide-3) - Work well together: [Silk amino acids and hyaluronic acid](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-hyaluronic-acid) - Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/magnesium-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-zinc) - Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate) - Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3) - Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/azelaic-acid-and-acetyl-hexapeptide-3) - Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-protease) - Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - United Kingdom: https://lovi.care/skincare/uk/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Ireland: https://lovi.care/skincare/ie/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Germany: https://lovi.care/skincare/de/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - France: https://lovi.care/skincare/fr/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Italy: https://lovi.care/skincare/it/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Netherlands: https://lovi.care/skincare/nl/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Spain: https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 (this page) - Canada: https://lovi.care/skincare/ca/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Australia: https://lovi.care/skincare/au/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Singapore: https://lovi.care/skincare/sg/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3 - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3