# Niacinamide and lipohydroxy acid Page: https://lovi.care/skincare/es/ingredients/niacinamide-and-lipohydroxy-acid The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain. Keep them apart Use them at different times of day, applying the hydroxy acid first and [niacinamide](https://lovi.care/skincare/es/ingredients/niacinamide) later, because combining them causes irritation. Using both at once overloads your skin with too much exfoliation and activity, leading to redness and dryness. To fix this, you can leave more time between applications or switch to a gentler product. - [All about niacinamide](https://lovi.care/skincare/es/ingredients/niacinamide) - [All about lipohydroxy acid](https://lovi.care/skincare/es/ingredients/lipohydroxy-acid) ### [Niacinamide](https://lovi.care/skincare/es/ingredients/niacinamide) products - [La Roche-Posay Toleriane Double Repair Face Moisturizer](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-double-repair-face-moisturizer/for/oily-acne-prone-skin) — High fit - [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [€20.50 at Amazon](https://www.amazon.de/dp/B01N1LL62W?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Cetaphil Gentle Skin Cleanser](https://lovi.care/skincare/es/p/cetaphil/gentle-skin-cleanser/for/dry-skin) — Superior fit — [€15.19 at Amazon](https://www.amazon.de/dp/B0GKQNQ5FK?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Roche-Posay Toleriane Hydrating Gentle Cleanser](https://lovi.care/skincare/es/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — [€19.75 at Amazon](https://www.amazon.de/dp/B0052EM8L8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Dr. Althea 345 Relief Cream](https://lovi.care/skincare/es/p/dr-althea/345-relief-cream/for/acne-prone-skin) — Superior fit — [€9.99 at Amazon](https://www.amazon.de/dp/B0G643D8ZG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Biodance Bio-Collagen Real Deep Mask](https://lovi.care/skincare/es/p/biodance/bio-collagen-real-deep-mask/for/mature-skin) — Superior fit — [€12.46 at Amazon](https://www.amazon.de/dp/B0B2RM68G2?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Olay Regenerist Micro-Sculpting Cream](https://lovi.care/skincare/es/p/olay/regenerist-micro-sculpting-cream/for/mature-skin) — Superior fit — [€22.99 at Amazon](https://www.amazon.de/dp/B0012J30LY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [CeraVe Resurfacing Retinol Serum](https://lovi.care/skincare/es/p/cerave/resurfacing-retinol-serum/for/dark-spots) — High fit — [€16.99 at Amazon](https://www.amazon.de/dp/B0B913JC2W?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [CeraVe PM Facial Moisturizing Lotion](https://lovi.care/skincare/es/p/cerave/pm-facial-moisturizing-lotion/for/acne-prone-skin) — Superior fit — [€6.00 at Notino](https://www.notino.es/cerave/moisturizers-leche-facial-y-corporal-hidratante-para-pieles-secas-y-muy-secas/p-16298665/) - [Medicube PDRN Pink Peptide Serum](https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-serum/for/mature-skin) — High fit — [€16.60 at Amazon](https://www.amazon.de/dp/B0DBF65JYY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [CeraVe Renewing SA Cleanser](https://lovi.care/skincare/es/p/cerave/renewing-sa-cleanser/for/oily-acne-prone-skin) — High fit — [€16.25 at Amazon](https://www.amazon.de/dp/B09MMJS8ZM?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Medicube Collagen Jelly Cream](https://lovi.care/skincare/es/p/medicube/collagen-jelly-cream/for/mature-skin) — Superior fit — [€14.48 at Amazon](https://www.amazon.de/dp/B0F4PNBXLZ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ### [Lipohydroxy acid](https://lovi.care/skincare/es/ingredients/lipohydroxy-acid) products - [La Roche-Posay Effaclar Medicated Gel Cleanser](https://lovi.care/skincare/es/p/la-roche-posay/effaclar-medicated-gel-cleanser/for/acne-prone-skin) — High fit — [€16.90 at Notino](https://www.notino.es/la-roche-posay/effaclar-gel-exfoliante-limpiador-para-pieles-grasas-y-problematicas/p-16024638/) - [SkinCeuticals LHA Cleanser Gel](https://lovi.care/skincare/es/p/skinceuticals/lha-cleanser-gel/for/oily-acne-prone-skin) — High fit - [SkinCeuticals Blemish + Age Defense](https://lovi.care/skincare/es/p/skinceuticals/blemish-age-defense/for/oily-skin) — Superior fit — [€95.10 at Amazon](https://www.amazon.de/dp/B07HCGKJ76?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [L'Oreal Paris Age Perfect Cell Renewal Midnight Cream](https://lovi.care/skincare/es/p/l-oreal-paris/age-perfect-cell-renewal-midnight-cream/for/dry-sensitive-skin) — High fit - [La Roche-Posay Effaclar Mat](https://lovi.care/skincare/es/p/la-roche-posay/effaclar-mat/for/combination-skin) — Average fit — [€14.99 at Amazon](https://www.amazon.de/dp/B00B4RJP72?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [MEDIHEAL Phyto-Enzyme Peeling Pad](https://lovi.care/skincare/es/p/mediheal/phyto-enzyme-peeling-pad/for/mature-skin) — High fit — [€26.99 at Amazon](https://www.amazon.de/dp/B0C6F2VL93?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [StriVectin Daily Reveal Exfoliating Pads](https://lovi.care/skincare/es/p/strivectin/daily-reveal-exfoliating-pads/for/oily-skin) — Average fit — [€38.90 at Amazon](https://www.amazon.de/dp/B089TPYFX3?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [La Roche-Posay Redermic R](https://lovi.care/skincare/es/p/la-roche-posay/redermic-r/for/mature-skin) — High fit — [€31.65 at Amazon](https://www.amazon.de/dp/B07N8HG4NV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Garnier Express Aclara](https://lovi.care/skincare/es/p/garnier/express-aclara/for/oily-acne-prone-skin) — Average fit - [Anua Heartleaf LHA Moisture Peeling Gel](https://lovi.care/skincare/es/p/anua/heartleaf-lha-moisture-peeling-gel/for/dark-spots) — High fit — [€19.00 at Notino](https://www.notino.es/anua/heartleaf-lha-moisture-peeling-gel-exfoliante-suave-en-gel-para-pieles-sensibles-con-tendencia-acneica/p-16246255/) - [La Roche-Posay Effaclar Micro-Peeling Purifying Gel](https://lovi.care/skincare/es/p/la-roche-posay/effaclar-micro-peeling-purifying-gel/for/oily-acne-prone-skin) — High fit — [€18.35 at Amazon](https://www.amazon.de/dp/B0866V21WT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) - [Kiehl's Vital Skin-Strengthening Super Serum](https://lovi.care/skincare/es/p/kiehl-s/vital-skin-strengthening-super-serum/for/mature-skin) — Average fit — [€52.80 at Amazon](https://www.amazon.de/dp/B092RBKPTC?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) ## Questions and answers ### Can you use niacinamide and lipohydroxy acid together? Keep [niacinamide](https://lovi.care/skincare/es/ingredients/niacinamide) and [lipohydroxy acid](https://lovi.care/skincare/es/ingredients/lipohydroxy-acid) apart by using one active per routine phase because combining them may overload the skin with redness and dryness. Products like La Roche-Posay Effaclar Clarifying Solution and La Roche-Posay Effaclar Ultra Concentrated [Serum](https://lovi.care/skincare/es/ingredients/serum) contain both ingredients. ### Which goes first, niacinamide or lipohydroxy acid? Keep niacinamide and lipohydroxy acid apart by using them in separate routine phases to avoid overloading your skin. Products like La Roche-Posay Effaclar Clarifying Solution and La Roche-Posay Effaclar Ultra Concentrated Serum contain both ingredients, so they should be applied at different times of day. ### Are niacinamide and lipohydroxy acid good for sensitive skin? Keep niacinamide and lipohydroxy acid apart by using one active per routine phase, as combining them may overload the skin with redness and dryness. ## Research on niacinamide and lipohydroxy acid - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021 - [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021 - [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024 - [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Lipohydroxy acid · Journal of Cosmetic Dermatology, 2021 - [Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin](https://pubmed.ncbi.nlm.nih.gov/19146601/) Lipohydroxy acid · Journal of Cosmetic Dermatology, 2008 - [A multicenter, double-blind study to evaluate the efficacy and safety of 2 treatments in participants with mild to moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/22838094/) Lipohydroxy acid · Cutis, 2012 - [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Lipohydroxy acid · Journal of Drugs in Dermatology, 2013 - [Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/36999489/) Lipohydroxy acid · Journal of Cosmetic Dermatology, 2023 ## Other combinations - Depends on the strength: [Retinol and niacinamide](https://lovi.care/skincare/es/ingredients/retinol-and-niacinamide) - Depends on the strength: [AHA blend glycolic and citric acids and niacinamide](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-niacinamide) - Depends on the strength: [Niacinamide and citric acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-citric-acid) - Depends on the strength: [Glycolic acid and niacinamide](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-niacinamide) - Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-lactic-acid) - Depends on the strength: [Niacinamide and mandelic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-mandelic-acid) - Depends on the strength: [Niacinamide and salicylic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-salicylic-acid) - Depends on the strength: [Niacinamide and gluconolactone](https://lovi.care/skincare/es/ingredients/niacinamide-and-gluconolactone) - Depends on the strength: [Niacinamide and lactobionic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-lactobionic-acid) - Work well together: [Niacinamide and cholesterol](https://lovi.care/skincare/es/ingredients/niacinamide-and-cholesterol) - Work well together: [Niacinamide and lauric acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-lauric-acid) - Work well together: [Niacinamide and linoleic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-linoleic-acid) - Work well together: [Niacinamide and tri-ceramide complex](https://lovi.care/skincare/es/ingredients/niacinamide-and-tri-ceramide-complex) - Depends on the strength: [Adapalene and niacinamide](https://lovi.care/skincare/es/ingredients/adapalene-and-niacinamide) - Depends on the strength: [Niacinamide and granactive retinoid](https://lovi.care/skincare/es/ingredients/niacinamide-and-granactive-retinoid) - Depends on the strength: [Niacinamide and hydroxypinacolone retinoate](https://lovi.care/skincare/es/ingredients/niacinamide-and-hydroxypinacolone-retinoate) - Depends on the strength: [Niacinamide and pro-retinol](https://lovi.care/skincare/es/ingredients/niacinamide-and-pro-retinol) - Depends on the strength: [Niacinamide and retinal](https://lovi.care/skincare/es/ingredients/niacinamide-and-retinal) - Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/es/ingredients/niacinamide-and-retinoid-blend) - Depends on the strength: [Niacinamide and tretinoin](https://lovi.care/skincare/es/ingredients/niacinamide-and-tretinoin) - Depends on the strength: [Niacinamide and vitamin A](https://lovi.care/skincare/es/ingredients/niacinamide-and-vitamin-a) - Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/niacinamide-and-acetyl-hexapeptide-3) - Depends on the strength: [Niacinamide and bio-placenta peptides](https://lovi.care/skincare/es/ingredients/niacinamide-and-bio-placenta-peptides) - Depends on the strength: [Niacinamide and collagen peptide](https://lovi.care/skincare/es/ingredients/niacinamide-and-collagen-peptide) - Depends on the strength: [Niacinamide and copper peptide](https://lovi.care/skincare/es/ingredients/niacinamide-and-copper-peptide) - Depends on the strength: [Niacinamide and hexapeptide](https://lovi.care/skincare/es/ingredients/niacinamide-and-hexapeptide) - Depends on the strength: [Niacinamide and hexapeptide-9](https://lovi.care/skincare/es/ingredients/niacinamide-and-hexapeptide-9) - Depends on the strength: [Niacinamide and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/niacinamide-and-palmitoyl-pentapeptide-4) - Depends on the strength: [Niacinamide and palmitoyl tripeptide-1](https://lovi.care/skincare/es/ingredients/niacinamide-and-palmitoyl-tripeptide-1) - Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/niacinamide-and-peptide-rich-plasma) - Depends on the strength: [Niacinamide and triple peptide blend](https://lovi.care/skincare/es/ingredients/niacinamide-and-triple-peptide-blend) - Work well together: [Niacinamide and hyaluronic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-hyaluronic-acid) - Work well together: [Niacinamide and bakuchiol](https://lovi.care/skincare/es/ingredients/niacinamide-and-bakuchiol) - Work well together: [Niacinamide and zinc](https://lovi.care/skincare/es/ingredients/niacinamide-and-zinc) - Work well together: [Niacinamide and zinc gluconate](https://lovi.care/skincare/es/ingredients/niacinamide-and-zinc-gluconate) - Work well together: [Niacinamide and zinc oxide](https://lovi.care/skincare/es/ingredients/niacinamide-and-zinc-oxide) - Work well together: [Niacinamide and zinc sulfate](https://lovi.care/skincare/es/ingredients/niacinamide-and-zinc-sulfate) - Work well together: [Benzoyl peroxide and niacinamide](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-niacinamide) - Work well together: [Ferulic acid and niacinamide](https://lovi.care/skincare/es/ingredients/ferulic-acid-and-niacinamide) - Work well together: [Green tea and niacinamide](https://lovi.care/skincare/es/ingredients/green-tea-and-niacinamide) - Work well together: [Niacinamide and vitamin E](https://lovi.care/skincare/es/ingredients/niacinamide-and-vitamin-e) - Keep them apart: [Niacinamide and isopropyl alcohol](https://lovi.care/skincare/es/ingredients/niacinamide-and-isopropyl-alcohol) - Work well together: [Niacinamide and ascorbyl glucoside](https://lovi.care/skincare/es/ingredients/niacinamide-and-ascorbyl-glucoside) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/ingredients/niacinamide-and-lipohydroxy-acid - United Kingdom: https://lovi.care/skincare/uk/ingredients/niacinamide-and-lipohydroxy-acid - Ireland: https://lovi.care/skincare/ie/ingredients/niacinamide-and-lipohydroxy-acid - Germany: https://lovi.care/skincare/de/ingredients/niacinamide-and-lipohydroxy-acid - France: https://lovi.care/skincare/fr/ingredients/niacinamide-and-lipohydroxy-acid - Italy: https://lovi.care/skincare/it/ingredients/niacinamide-and-lipohydroxy-acid - Netherlands: https://lovi.care/skincare/nl/ingredients/niacinamide-and-lipohydroxy-acid - Spain: https://lovi.care/skincare/es/ingredients/niacinamide-and-lipohydroxy-acid (this page) - Canada: https://lovi.care/skincare/ca/ingredients/niacinamide-and-lipohydroxy-acid - Australia: https://lovi.care/skincare/au/ingredients/niacinamide-and-lipohydroxy-acid - Singapore: https://lovi.care/skincare/sg/ingredients/niacinamide-and-lipohydroxy-acid - Saudi Arabia: https://lovi.care/skincare/sa/ingredients/niacinamide-and-lipohydroxy-acid - United Arab Emirates: https://lovi.care/skincare/ae/ingredients/niacinamide-and-lipohydroxy-acid