# Lactic acid and peptide-rich plasma

Page: https://lovi.care/skincare/es/ingredients/lactic-acid-and-peptide-rich-plasma

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Keep them apart

Use [lactic acid](https://lovi.care/skincare/es/ingredients/lactic-acid) in the morning and [peptide-rich plasma](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma) at night, because acid ruins the peptides. Acid breaks down the peptides so your skin misses out on their firming benefits. You can safely use both by applying them at different times of the day.

- [All about lactic acid](https://lovi.care/skincare/es/ingredients/lactic-acid)
- [All about peptide-rich plasma](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma)

### [Lactic acid](https://lovi.care/skincare/es/ingredients/lactic-acid) products

- [Medicube Zero Pore Pad](https://lovi.care/skincare/es/p/medicube/zero-pore-pad/for/oily-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [First Aid Beauty KP Bump Eraser Body Scrub](https://lovi.care/skincare/es/p/first-aid-beauty/kp-bump-eraser-body-scrub/for/dark-spots) — Average fit — [€25.02 at Amazon](https://www.amazon.de/dp/B08GNS58PQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [EltaMD UV Clear Broad-Spectrum SPF 46](https://lovi.care/skincare/es/p/eltamd/uv-clear-broad-spectrum-spf-46/for/oily-acne-prone-skin) — Superior fit — [€72.80 at Amazon](https://www.amazon.de/dp/B00ZPWR0N8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [First Aid Beauty Facial Radiance Pads](https://lovi.care/skincare/es/p/first-aid-beauty/facial-radiance-pads/for/sensitive-skin) — Superior fit — [€29.33 at Lookfantastic](https://www.lookfantastic.es/p/first-aid-beauty-brighten-glow-facial-radiance-pads-60-count/17659264/)
- [CeraVe SA Lotion for Rough & Bumpy Skin](https://lovi.care/skincare/es/p/cerave/sa-lotion-for-rough-and-bumpy-skin/for/oily-skin) — Average fit — [€21.16 at Lookfantastic](https://www.lookfantastic.es/p/cerave-sa-smoothing-cream-with-salicylic-acid-for-dry-rough-bumpy-skin-340g/12207664/)
- [CeraVe Renewing SA Cream](https://lovi.care/skincare/es/p/cerave/renewing-sa-cream/for/oily-acne-prone-skin) — High fit
- [The Ordinary Alpha Arbutin 2% + HA](https://lovi.care/skincare/es/p/the-ordinary/alpha-arbutin-2-ha/for/dark-spots) — Superior fit — [€12.39 at Amazon](https://www.amazon.de/dp/B06XCZFCFZ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Retinal 0.2% Emulsion](https://lovi.care/skincare/es/p/the-ordinary/retinal-0-2-emulsion/for/oily-acne-prone-skin) — High fit — [€17.50 at Amazon](https://www.amazon.de/dp/B0CZ5VG3L1?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Kate Somerville ExfoliKate Intensive Exfoliating Treatment](https://lovi.care/skincare/es/p/kate-somerville/exfolikate-intensive-exfoliating-treatment/for/mature-skin) — Superior fit
- [Dr. Dennis Gross Alpha Beta Universal Daily Peel](https://lovi.care/skincare/es/p/dr-dennis-gross/alpha-beta-universal-daily-peel/for/acne-prone-skin) — Superior fit — [€175.00 at Amazon](https://www.amazon.de/dp/B009QZ595Q?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Lactic Acid 5% + HA](https://lovi.care/skincare/es/p/the-ordinary/lactic-acid-5-ha/for/dry-skin) — Superior fit
- [Good Molecules Overnight Exfoliating Treatment](https://lovi.care/skincare/es/p/good-molecules/overnight-exfoliating-treatment/for/oily-skin) — Superior fit — [€20.99 at Amazon](https://www.amazon.de/dp/B08TMDRF1L?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

### [Peptide-rich plasma](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma) products

- [Eighth Day Regenerative Serum](https://lovi.care/skincare/es/p/eighth-day/regenerative-serum/for/dry-sensitive-skin) — High fit

## Questions and answers

### Can you use lactic acid and peptide-rich plasma together?

Keep [lactic acid](https://lovi.care/skincare/es/ingredients/lactic-acid) and [peptide-rich plasma](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma) apart because the low pH of the acid destabilizes the peptide bonds and reduces their bioactivity. Use them in separate steps or routines, such as AM and PM separation.

### Which goes first, lactic acid or peptide-rich plasma?

Keep lactic acid and peptide-rich plasma apart by using them in separate steps or routines, such as AM and PM, because the low pH of lactic acid can break down and weaken peptides. Lovi fit ratings for combining them are not available.

### Are lactic acid and peptide-rich plasma good for sensitive skin?

No, lactic acid and peptide-rich plasma should be kept apart in your routine because the low pH of the acid can break down the peptides and reduce their effectiveness. Sensitive skin should especially avoid combining them directly.

## Research on lactic acid and peptide-rich plasma

- [Lactate triggers KAT8-mediated LTBP1 lactylation at lysine 752 to promote skin rejuvenation by inducing collagen synthesis in fibroblasts](https://pubmed.ncbi.nlm.nih.gov/39102921/) Lactic acid · International Journal of Biological Macromolecules, 2024
- [Poly-L-Lactic acid increases collagen gene expression and synthesis in cultured dermal fibroblast (Hs68) through the TGF-β/Smad pathway](https://pubmed.ncbi.nlm.nih.gov/36575891/) Lactic acid · Journal of Cosmetic Dermatology, 2023
- [Do urea/ammonium lactate combinations achieve better skin protection and hydration than either component alone?](https://pubmed.ncbi.nlm.nih.gov/11803256/) Lactic acid · Skin Pharmacology and Applied Skin Physiology, 2002

## Other combinations

- Keep them apart: [Benzoyl peroxide and lactic acid](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-lactic-acid)
- Keep them apart: [Retinol and lactic acid](https://lovi.care/skincare/es/ingredients/retinol-and-lactic-acid)
- Depends on the strength: [Niacinamide and lactic acid](https://lovi.care/skincare/es/ingredients/niacinamide-and-lactic-acid)
- Work well together: [Lactic acid and sodium lactate](https://lovi.care/skincare/es/ingredients/lactic-acid-and-sodium-lactate)
- Work well together: [Lactic acid and tromethamine](https://lovi.care/skincare/es/ingredients/lactic-acid-and-tromethamine)
- Keep them apart: [Adapalene and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/adapalene-and-peptide-rich-plasma)
- Keep them apart: [Granactive retinoid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/granactive-retinoid-and-peptide-rich-plasma)
- Keep them apart: [Hydroxypinacolone retinoate and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/hydroxypinacolone-retinoate-and-peptide-rich-plasma)
- Keep them apart: [Pro-retinol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/pro-retinol-and-peptide-rich-plasma)
- Keep them apart: [Retinal and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/retinal-and-peptide-rich-plasma)
- Keep them apart: [Retinoid blend and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-peptide-rich-plasma)
- Depends on the strength: [Retinol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/retinol-and-peptide-rich-plasma)
- Keep them apart: [Tretinoin and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/tretinoin-and-peptide-rich-plasma)
- Keep them apart: [Vitamin A and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/vitamin-a-and-peptide-rich-plasma)
- Work well together: [Liposome and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/liposome-and-peptide-rich-plasma)
- Work well together: [Microcapsule and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/microcapsule-and-peptide-rich-plasma)
- Keep them apart: [Vitamin C and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/vitamin-c-and-peptide-rich-plasma)
- Work well together: [Betaine and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/betaine-and-peptide-rich-plasma)
- Work well together: [Glycerin and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/glycerin-and-peptide-rich-plasma)
- Work well together: [Hyaluronic acid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/hyaluronic-acid-and-peptide-rich-plasma)
- Work well together: [Lactic acid and betaine](https://lovi.care/skincare/es/ingredients/lactic-acid-and-betaine)
- Work well together: [Glycerin and lactic acid](https://lovi.care/skincare/es/ingredients/glycerin-and-lactic-acid)
- Depends on the strength: [Lactic acid and hyaluronic acid](https://lovi.care/skincare/es/ingredients/lactic-acid-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/niacinamide-and-peptide-rich-plasma)
- Work well together: [Panthenol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/panthenol-and-peptide-rich-plasma)
- Work well together: [Bakuchiol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/bakuchiol-and-peptide-rich-plasma)
- Work well together: [Arginine and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/arginine-and-peptide-rich-plasma)
- Work well together: [Peptide-rich plasma and GABA](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-gaba)
- Work well together: [Silk amino acids and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-peptide-rich-plasma)
- Work well together: [Taurine and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/taurine-and-peptide-rich-plasma)
- Work well together: [Peptide-rich plasma and theanine](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-peptide-rich-plasma)
- Keep them apart: [Citric acid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/citric-acid-and-peptide-rich-plasma)
- Keep them apart: [Glycolic acid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-peptide-rich-plasma)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and lactic acid](https://lovi.care/skincare/es/ingredients/bio-placenta-peptides-and-lactic-acid)
- Keep them apart: [Carnosine and lactic acid](https://lovi.care/skincare/es/ingredients/carnosine-and-lactic-acid)
- Keep them apart: [Lactic acid and collagen peptide](https://lovi.care/skincare/es/ingredients/lactic-acid-and-collagen-peptide)
- Keep them apart: [Lactic acid and copper peptide](https://lovi.care/skincare/es/ingredients/lactic-acid-and-copper-peptide)
- Keep them apart: [Hexapeptide and lactic acid](https://lovi.care/skincare/es/ingredients/hexapeptide-and-lactic-acid)
- Keep them apart: [Lactic acid and hexapeptide-9](https://lovi.care/skincare/es/ingredients/lactic-acid-and-hexapeptide-9)
- Keep them apart: [Lactic acid and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/lactic-acid-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Lactic acid and palmitoyl tripeptide-1](https://lovi.care/skincare/es/ingredients/lactic-acid-and-palmitoyl-tripeptide-1)
- Keep them apart: [Lactic acid and triple peptide blend](https://lovi.care/skincare/es/ingredients/lactic-acid-and-triple-peptide-blend)
- Keep them apart: [Mandelic acid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/mandelic-acid-and-peptide-rich-plasma)
- Work well together: [Coenzyme Q10 and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/coenzyme-q10-and-peptide-rich-plasma)
- Work well together: [Green tea and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/green-tea-and-peptide-rich-plasma)
- Work well together: [Vitamin E and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/vitamin-e-and-peptide-rich-plasma)
- Keep them apart: [Adapalene and lactic acid](https://lovi.care/skincare/es/ingredients/adapalene-and-lactic-acid)
- Keep them apart: [Lactic acid and granactive retinoid](https://lovi.care/skincare/es/ingredients/lactic-acid-and-granactive-retinoid)
- Keep them apart: [Lactic acid and hydroxypinacolone retinoate](https://lovi.care/skincare/es/ingredients/lactic-acid-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and lactic acid](https://lovi.care/skincare/es/ingredients/pro-retinol-and-lactic-acid)
- Keep them apart: [Retinal and lactic acid](https://lovi.care/skincare/es/ingredients/retinal-and-lactic-acid)
- Keep them apart: [Lactic acid and retinoid blend](https://lovi.care/skincare/es/ingredients/lactic-acid-and-retinoid-blend)
- Keep them apart: [Tretinoin and lactic acid](https://lovi.care/skincare/es/ingredients/tretinoin-and-lactic-acid)
- Work well together: [Beta-sitosterol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/beta-sitosterol-and-peptide-rich-plasma)
- Work well together: [Ceramide-building complex and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/ceramide-building-complex-and-peptide-rich-plasma)
- Work well together: [Cholesterol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/cholesterol-and-peptide-rich-plasma)
- Work well together: [Phytosphingosine and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/phytosphingosine-and-peptide-rich-plasma)
- Work well together: [Phytosterol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/phytosterol-and-peptide-rich-plasma)
- Work well together: [Peptide-rich plasma and squalene](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-squalene)
- Work well together: [Peptide-rich plasma and tri-ceramide complex](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-tri-ceramide-complex)
- Work well together: [Lactic acid and gluconolactone](https://lovi.care/skincare/es/ingredients/lactic-acid-and-gluconolactone)
- Work well together: [Lactic acid and lactobionic acid](https://lovi.care/skincare/es/ingredients/lactic-acid-and-lactobionic-acid)
- Keep them apart: [Salicylic acid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-peptide-rich-plasma)
- Work well together: [Lactic acid and cholesterol](https://lovi.care/skincare/es/ingredients/lactic-acid-and-cholesterol)
- Work well together: [Lactic acid and lauric acid](https://lovi.care/skincare/es/ingredients/lactic-acid-and-lauric-acid)
- Work well together: [Linoleic acid and lactic acid](https://lovi.care/skincare/es/ingredients/linoleic-acid-and-lactic-acid)
- Keep them apart: [Lactic acid and tri-ceramide complex](https://lovi.care/skincare/es/ingredients/lactic-acid-and-tri-ceramide-complex)
- Work well together: [Arginine and lactic acid](https://lovi.care/skincare/es/ingredients/arginine-and-lactic-acid)
- Work well together: [Lactic acid and GABA](https://lovi.care/skincare/es/ingredients/lactic-acid-and-gaba)
- Work well together: [Silk amino acids and lactic acid](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-lactic-acid)
- Work well together: [Lactic acid and taurine](https://lovi.care/skincare/es/ingredients/lactic-acid-and-taurine)
- Work well together: [Lactic acid and theanine](https://lovi.care/skincare/es/ingredients/lactic-acid-and-theanine)
- Keep them apart: [Peptide-rich plasma and baking soda](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-baking-soda)
- Keep them apart: [Bleach and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/bleach-and-peptide-rich-plasma)
- Keep them apart: [Potassium hydroxide and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/potassium-hydroxide-and-peptide-rich-plasma)
- Keep them apart: [Peptide-rich plasma and behenyl alcohol](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-behenyl-alcohol)
- Keep them apart: [Isopropyl alcohol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/isopropyl-alcohol-and-peptide-rich-plasma)
- Keep them apart: [Polyvinyl alcohol and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/polyvinyl-alcohol-and-peptide-rich-plasma)
- Work well together: [Ferulic acid and lactic acid](https://lovi.care/skincare/es/ingredients/ferulic-acid-and-lactic-acid)
- Work well together: [Vitamin E and lactic acid](https://lovi.care/skincare/es/ingredients/vitamin-e-and-lactic-acid)
- Keep them apart: [Copper and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/copper-and-peptide-rich-plasma)
- Keep them apart: [Azelaic acid and lactic acid](https://lovi.care/skincare/es/ingredients/azelaic-acid-and-lactic-acid)
- Keep them apart: [Salicylic acid and lactic acid](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-lactic-acid)
- Work well together: [Allantoin and lactic acid](https://lovi.care/skincare/es/ingredients/allantoin-and-lactic-acid)
- Work well together: [Lactic acid and bisabolol](https://lovi.care/skincare/es/ingredients/lactic-acid-and-bisabolol)
- Work well together: [Panthenol and lactic acid](https://lovi.care/skincare/es/ingredients/panthenol-and-lactic-acid)
- Keep them apart: [Magnesium and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/magnesium-and-peptide-rich-plasma)
- Keep them apart: [Zinc and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/zinc-and-peptide-rich-plasma)
- Keep them apart: [Zinc sulfate and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/zinc-sulfate-and-peptide-rich-plasma)
- Keep them apart: [Benzoyl peroxide and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-peptide-rich-plasma)
- Keep them apart: [Azelaic acid and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/azelaic-acid-and-peptide-rich-plasma)
- Keep them apart: [Peptide-rich plasma and protease](https://lovi.care/skincare/es/ingredients/peptide-rich-plasma-and-protease)
- Keep them apart: [Superoxide dismutase and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/superoxide-dismutase-and-peptide-rich-plasma)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/lactic-acid-and-peptide-rich-plasma
- United Kingdom: https://lovi.care/skincare/uk/ingredients/lactic-acid-and-peptide-rich-plasma
- Ireland: https://lovi.care/skincare/ie/ingredients/lactic-acid-and-peptide-rich-plasma
- Germany: https://lovi.care/skincare/de/ingredients/lactic-acid-and-peptide-rich-plasma
- France: https://lovi.care/skincare/fr/ingredients/lactic-acid-and-peptide-rich-plasma
- Italy: https://lovi.care/skincare/it/ingredients/lactic-acid-and-peptide-rich-plasma
- Netherlands: https://lovi.care/skincare/nl/ingredients/lactic-acid-and-peptide-rich-plasma
- Spain: https://lovi.care/skincare/es/ingredients/lactic-acid-and-peptide-rich-plasma (this page)
- Canada: https://lovi.care/skincare/ca/ingredients/lactic-acid-and-peptide-rich-plasma
- Australia: https://lovi.care/skincare/au/ingredients/lactic-acid-and-peptide-rich-plasma
- Singapore: https://lovi.care/skincare/sg/ingredients/lactic-acid-and-peptide-rich-plasma
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/lactic-acid-and-peptide-rich-plasma
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/lactic-acid-and-peptide-rich-plasma