# Acetyl hexapeptide-3 and retinoid blend

Page: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-retinoid-blend

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Keep them apart

Use them at different times of day by applying the peptide [serum](https://lovi.care/skincare/es/ingredients/serum) in the morning and the retinoid at night to prevent skin irritation. Using both active ingredients together can cause extra skin irritation and redness because they are both very strong. The shopper can switch to a gentler product strength or wait longer between applying them.

- [All about acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3)
- [All about retinoid blend](https://lovi.care/skincare/es/ingredients/retinoid-blend)

### [Acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3) products

- [The Ordinary Multi-Peptide + Copper Peptides 1% Serum](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-copper-peptides-1-serum/for/mature-skin) — High fit — [€27.95 at Amazon](https://www.amazon.de/dp/B0C9DXGXZ3?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [The Ordinary Multi-Peptide + HA Serum](https://lovi.care/skincare/es/p/the-ordinary/multi-peptide-ha-serum/for/dry-skin) — Superior fit — [€16.90 at Amazon](https://www.amazon.de/dp/B0BLHW7JZM?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Medik8 Liquid Peptides](https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€102.00 at Amazon](https://www.amazon.de/dp/B0DYV9VSDV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [La Mer The Treatment Lotion](https://lovi.care/skincare/es/p/la-mer/the-treatment-lotion/for/mature-skin) — Superior fit — [€79.90 at Amazon](https://www.amazon.de/dp/B0B61KKT4K?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Rhode Peptide Glazing Fluid](https://lovi.care/skincare/es/p/rhode/peptide-glazing-fluid/for/mature-skin) — High fit
- [The Ordinary Argireline Solution 10%](https://lovi.care/skincare/es/p/the-ordinary/argireline-solution-10/for/mature-skin) — Average fit — [€8.96 at Amazon](https://www.amazon.de/dp/B072JH13CD?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Good Molecules Super Peptide Serum](https://lovi.care/skincare/es/p/good-molecules/super-peptide-serum/for/mature-skin) — High fit — [€23.20 at Amazon](https://www.amazon.de/dp/B091MTKS35?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Clinique Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/es/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€71.30 at Lookfantastic](https://www.lookfantastic.es/p/clinique-smart-clinical-repair-wrinkle-correcting-serum-various-sizes/13279421/)
- [La Mer The Renewal Oil](https://lovi.care/skincare/es/p/la-mer/the-renewal-oil/for/mature-skin) — High fit — [€189.00 at Amazon](https://www.amazon.de/dp/B0163GAMI4?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Estée Lauder Micro Essence Treatment Lotion](https://lovi.care/skincare/es/p/estee-lauder/micro-essence-treatment-lotion/for/oily-acne-prone-skin) — Superior fit — [€109.00 at Notino](https://www.notino.es/estee-lauder/micro-essence-treatment-lotion-locion-embellecedora-para-iluminar-la-piel/p-16118523/)
- [The INKEY List Collagen Peptide Serum](https://lovi.care/skincare/es/p/the-inkey-list/collagen-peptide-serum/for/dry-sensitive-skin) — High fit
- [La Mer The Eye Concentrate](https://lovi.care/skincare/es/p/la-mer/the-eye-concentrate/for/mature-skin) — High fit — [€124.58 at Amazon](https://www.amazon.de/dp/B085614WX5?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

### [Retinoid blend](https://lovi.care/skincare/es/ingredients/retinoid-blend) products

- [Sunday Riley A+ High-Dose Retinoid Serum](https://lovi.care/skincare/es/p/sunday-riley/a-high-dose-retinoid-serum/for/oily-acne-prone-skin) — High fit

## Questions and answers

### Can you use acetyl hexapeptide-3 and retinoid blend together?

Keep [acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3) and [retinoid blend](https://lovi.care/skincare/es/ingredients/retinoid-blend) apart because combining them may increase irritation. Instead, alternate their usage by applying the retinoid in the PM and the peptides in the AM.

### Which goes first, acetyl hexapeptide-3 or retinoid blend?

Keep acetyl hexapeptide-3 and retinoid blend apart because combined stimulation may increase irritation. Alternate their usage by applying the retinoid in the PM and the peptides in the AM.

### Are acetyl hexapeptide-3 and retinoid blend good for sensitive skin?

Acetyl hexapeptide-3 and retinoid blend should be kept apart to avoid increased irritation on sensitive skin. Alternate your routine by using the retinoid in the evening and peptides in the morning.

## Research on acetyl hexapeptide-3 and retinoid blend

- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-3 · American Journal of Clinical Dermatology, 2013
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-3 · Annals of Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-3 · Journal of Cosmetic Dermatology, 2017
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-3 · Journal of Cosmetic and Laser Therapy, 2013

## Other combinations

- Keep them apart: [Adapalene and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/adapalene-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and granactive retinoid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-granactive-retinoid)
- Keep them apart: [Acetyl hexapeptide-3 and hydroxypinacolone retinoate](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-hydroxypinacolone-retinoate)
- Keep them apart: [Pro-retinol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/pro-retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Retinal and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/retinal-and-acetyl-hexapeptide-3)
- Depends on the strength: [Retinol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/retinol-and-acetyl-hexapeptide-3)
- Keep them apart: [Tretinoin and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/tretinoin-and-acetyl-hexapeptide-3)
- Keep them apart: [Vitamin A and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/vitamin-a-and-acetyl-hexapeptide-3)
- Keep them apart: [Bio-placenta peptides and retinoid blend](https://lovi.care/skincare/es/ingredients/bio-placenta-peptides-and-retinoid-blend)
- Keep them apart: [Retinoid blend and collagen peptide](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-collagen-peptide)
- Keep them apart: [Retinoid blend and copper peptide](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-copper-peptide)
- Keep them apart: [Hexapeptide and retinoid blend](https://lovi.care/skincare/es/ingredients/hexapeptide-and-retinoid-blend)
- Keep them apart: [Retinoid blend and hexapeptide-9](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-hexapeptide-9)
- Keep them apart: [Retinoid blend and palmitoyl pentapeptide-4](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-palmitoyl-pentapeptide-4)
- Keep them apart: [Retinoid blend and palmitoyl tripeptide-1](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-palmitoyl-tripeptide-1)
- Keep them apart: [Retinoid blend and peptide-rich plasma](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-peptide-rich-plasma)
- Keep them apart: [Retinoid blend and triple peptide blend](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-triple-peptide-blend)
- Work well together: [Liposome and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/liposome-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and microcapsule](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-microcapsule)
- Depends on the strength: [Vitamin C and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/vitamin-c-and-acetyl-hexapeptide-3)
- Depends on the strength: [Niacinamide and retinoid blend](https://lovi.care/skincare/es/ingredients/niacinamide-and-retinoid-blend)
- Work well together: [Acetyl hexapeptide-3 and betaine](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-betaine)
- Work well together: [Glycerin and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/glycerin-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and hyaluronic acid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-hyaluronic-acid)
- Depends on the strength: [Niacinamide and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/niacinamide-and-acetyl-hexapeptide-3)
- Work well together: [Panthenol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/panthenol-and-acetyl-hexapeptide-3)
- Work well together: [Bakuchiol and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/bakuchiol-and-acetyl-hexapeptide-3)
- Work well together: [Arginine and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/arginine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and GABA](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-gaba)
- Work well together: [Silk amino acids and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/silk-amino-acids-and-acetyl-hexapeptide-3)
- Work well together: [Taurine and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/taurine-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and theanine](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-theanine)
- Keep them apart: [AHA blend glycolic and citric acids and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and citric acid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-citric-acid)
- Keep them apart: [Glycolic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Lactic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/lactic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and mandelic acid](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-mandelic-acid)
- Work well together: [Coenzyme Q10 and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/coenzyme-q10-and-acetyl-hexapeptide-3)
- Work well together: [Green tea and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/green-tea-and-acetyl-hexapeptide-3)
- Work well together: [Vitamin E and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/vitamin-e-and-acetyl-hexapeptide-3)
- Keep them apart: [AHA blend glycolic and citric acids and retinoid blend](https://lovi.care/skincare/es/ingredients/aha-blend-glycolic-and-citric-acids-and-retinoid-blend)
- Keep them apart: [Retinoid blend and citric acid](https://lovi.care/skincare/es/ingredients/retinoid-blend-and-citric-acid)
- Keep them apart: [Glycolic acid and retinoid blend](https://lovi.care/skincare/es/ingredients/glycolic-acid-and-retinoid-blend)
- Keep them apart: [Lactic acid and retinoid blend](https://lovi.care/skincare/es/ingredients/lactic-acid-and-retinoid-blend)
- Keep them apart: [Mandelic acid and retinoid blend](https://lovi.care/skincare/es/ingredients/mandelic-acid-and-retinoid-blend)
- Work well together: [Acetyl hexapeptide-3 and beta-sitosterol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-beta-sitosterol)
- Work well together: [Ceramide-building complex and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/ceramide-building-complex-and-acetyl-hexapeptide-3)
- Work well together: [Acetyl hexapeptide-3 and cholesterol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-cholesterol)
- Work well together: [Acetyl hexapeptide-3 and phytosphingosine](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-phytosphingosine)
- Work well together: [Acetyl hexapeptide-3 and phytosterol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-phytosterol)
- Work well together: [Acetyl hexapeptide-3 and squalene](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-squalene)
- Work well together: [Acetyl hexapeptide-3 and tri-ceramide complex](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-tri-ceramide-complex)
- Keep them apart: [Salicylic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Salicylic acid and retinoid blend](https://lovi.care/skincare/es/ingredients/salicylic-acid-and-retinoid-blend)
- Keep them apart: [Vitamin C and retinoid blend](https://lovi.care/skincare/es/ingredients/vitamin-c-and-retinoid-blend)
- Keep them apart: [Acetyl hexapeptide-3 and baking soda](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-baking-soda)
- Keep them apart: [Acetyl hexapeptide-3 and bleach](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-bleach)
- Keep them apart: [Acetyl hexapeptide-3 and potassium hydroxide](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-potassium-hydroxide)
- Keep them apart: [Acetyl hexapeptide-3 and behenyl alcohol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-behenyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and isopropyl alcohol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-isopropyl-alcohol)
- Keep them apart: [Acetyl hexapeptide-3 and polyvinyl alcohol](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-polyvinyl-alcohol)
- Keep them apart: [Copper and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/copper-and-acetyl-hexapeptide-3)
- Keep them apart: [Benzoyl peroxide and retinoid blend](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-retinoid-blend)
- Keep them apart: [Magnesium and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/magnesium-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and zinc](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-zinc)
- Keep them apart: [Acetyl hexapeptide-3 and zinc sulfate](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-zinc-sulfate)
- Keep them apart: [Benzoyl peroxide and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/benzoyl-peroxide-and-acetyl-hexapeptide-3)
- Keep them apart: [Azelaic acid and acetyl hexapeptide-3](https://lovi.care/skincare/es/ingredients/azelaic-acid-and-acetyl-hexapeptide-3)
- Keep them apart: [Acetyl hexapeptide-3 and protease](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-protease)
- Keep them apart: [Acetyl hexapeptide-3 and superoxide dismutase](https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-superoxide-dismutase)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi checks every pairing with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this pairing advice: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- United Kingdom: https://lovi.care/skincare/uk/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Ireland: https://lovi.care/skincare/ie/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Germany: https://lovi.care/skincare/de/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- France: https://lovi.care/skincare/fr/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Italy: https://lovi.care/skincare/it/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Netherlands: https://lovi.care/skincare/nl/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Spain: https://lovi.care/skincare/es/ingredients/acetyl-hexapeptide-3-and-retinoid-blend (this page)
- Canada: https://lovi.care/skincare/ca/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Australia: https://lovi.care/skincare/au/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Singapore: https://lovi.care/skincare/sg/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- Saudi Arabia: https://lovi.care/skincare/sa/ingredients/acetyl-hexapeptide-3-and-retinoid-blend
- United Arab Emirates: https://lovi.care/skincare/ae/ingredients/acetyl-hexapeptide-3-and-retinoid-blend