# SK-II vs Natura Bissé

Page: https://lovi.care/skincare/es/compare/sk-ii-vs-natura-bisse

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

SK-II and Natura Bissé are renowned skincare brands offering luxurious moisturizers and advanced formulas to address diverse complexions. The Japanese brand is celebrated for its potent [serums](https://lovi.care/skincare/es/ingredients/serum), rejuvenating masks, clarifying toners, and other meticulously crafted products powered by pitera, which suit combination, oily, normal, and dry skin best. Meanwhile, the Spanish brand is beloved for nourishing treatments that suit mature, dry, and sensitive skin best. While both brands elevate daily routines, they differ in their signature ingredients and ideal skin types.

SK-II is a Japanese skincare brand founded in 1980 and owned by The Procter & Gamble Company since 1991.

[en.wikipedia.org](https://en.wikipedia.org/wiki/SK-II) [discoversk-ii.wixsite.com](https://discoversk-ii.wixsite.com/home/brand-history) [glossy.co](https://www.glossy.co/beauty/despite-strong-results-in-beauty-in-the-first-quarter-pg-will-eliminate-thousands-of-jobs/)

Natura Bissé is a Spanish skincare brand founded in 1979 and owned by Natura Bissé International, S.A..

[naturabisse.com](https://www.naturabisse.com/int/en/our-story.html) [tracxn.com](https://tracxn.com/d/accelerator-incubator/ushopal/__yjGH7DKhQGNWnINKarEuFce6tilrPzGJv0PnASFLfpg)

This page compares some of the most popular SK-II and Natura Bissé products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgc9cc947bcb).

### Popular SK-II vs Natura Bissé products

#### Natura Bissé

- [Diamond Extreme](https://lovi.care/skincare/es/p/natura-bisse/diamond-extreme/for/mature-skin) — Superior fit — [€266.00 at Amazon](https://www.amazon.de/dp/B0BKLRMKZV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### SK-II

- [Facial Treatment Essence](https://lovi.care/skincare/es/p/sk-ii/facial-treatment-essence/for/dry-skin) — High fit
- [Facial Treatment Mask](https://lovi.care/skincare/es/p/sk-ii/facial-treatment-mask/for/dry-skin) — High fit
- [Facial Treatment Clear Lotion](https://lovi.care/skincare/es/p/sk-ii/facial-treatment-clear-lotion/for/oily-skin) — High fit
- [Skinpower Advanced Cream](https://lovi.care/skincare/es/p/sk-ii/skinpower-advanced-cream/for/mature-skin) — High fit
- [Genoptics Ultraura Essence](https://lovi.care/skincare/es/p/sk-ii/genoptics-ultraura-essence/for/acne-prone-skin) — Superior fit
- [Facial Treatment Cleansing Oil](https://lovi.care/skincare/es/p/sk-ii/facial-treatment-cleansing-oil/for/dry-skin) — High fit
- [Genoptics Spot Essence](https://lovi.care/skincare/es/p/sk-ii/genoptics-spot-essence/for/dark-spots) — Average fit

## Questions and answers

### SK-II or Natura Bissé: which is better?

SK-II offers a broader range of products on this page with fragrance-free formulas, while Natura Bissé provides options like Diamond Extreme that include fragrance. Both brands feature products that help moisturize the skin.

### What is the difference between SK-II and Natura Bissé?

SK-II offers a broader range of products on this page featuring Pitera and no added fragrance, whereas Natura Bissé has a single moisturizer listed that contains fragrance.

### SK-II or Natura Bissé: which moisturizer is better?

For moisturizers, SK-II offers options like Facial Treatment Essence and Skinpower Advanced Cream with High Lovi fit levels across many skin types, whereas Natura Bissé has Diamond Extreme, which has a Superior Lovi fit for mature skin but only a Low fit for oily acne-prone skin. Every SK-II product on this page lists no fragrance, while Natura Bissé Diamond Extreme includes fragrance.

### Which is more affordable, SK-II or Natura Bissé?

The provided page facts do not contain pricing information, so it is not possible to determine whether SK-II or Natura Bissé is more affordable.

### Which causes fewer breakouts, SK-II or Natura Bissé?

For preventing breakouts, SK-II is the better option because the products on this page have high to superior Lovi fit levels for acne-prone skin, whereas Natura Bissé's Diamond Extreme has only an average fit. SK-II's formulas also list no fragrance, which helps reduce the risk of irritation.

### How do the founding years and countries of origin compare between SK-II and Natura Bissé?

SK-II was founded in Japan in 1980, while Natura Bissé was founded in Spain a year earlier in 1979.

### Which brand offers products containing no added fragrance?

SK-II offers products on this page that list no fragrance in their ingredients. Natura Bissé includes fragrance in its Diamond Extreme moisturizer.

### What is the key shared ingredient across the SK-II products listed?

The key shared ingredient across the SK-II products on this page is Pitera.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Nicotinamide w, Niacinamide · The British Journal of Dermatology, 2002
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol, D-pantothenyl alcohol · American Journal of Clinical Dermatology, 2002
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) L-ascorbic acid 2-glucoside, Ascorbyl glucoside · Journal of Periodontology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Anti-Aging Effects of Leontopodium alpinum (Edelweiss) Callus Culture Extract Through Transcriptome Profiling](https://pubmed.ncbi.nlm.nih.gov/32098197/) Leontopodium alpinum leaf extract flower · Genes, 2020
- [Anti-inflammatory effects of concentrated ethanol extracts of Edelweiss (Leontopodium alpinum Cass.) callus cultures towards human keratinocytes and endothelial cells](https://pubmed.ncbi.nlm.nih.gov/23093820/) Leontopodium alpinum leaf extract flower · Mediators of Inflammation, 2012
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, D-pantothenyl alcohol · The Journal of Dermatological Treatment, 2017
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) D-pantothenyl alcohol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [Daily Fluctuation of Facial Pore Area, Roughness and Redness among Young Japanese Women; Beneficial Effects of Galactomyces Ferment Filtrate Containing Antioxidative Skin Care Formula](https://pubmed.ncbi.nlm.nih.gov/34198790/) Galactomyces ferment filtrate, Pitera essence, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Pitera ferment filtrate, Sk-ii pitera concentrate, Pitera · Journal of Clinical Medicine, 2021
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Rosmarinic Acid, as an NHE1 Activator, Decreases Skin Surface pH and Improves the Skin Barrier Function](https://pubmed.ncbi.nlm.nih.gov/35409270/) Rosamarinus officinalis leaf extract rosemary leaf extract · International Journal of Molecular Sciences, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Reduction in the appearance of facial hyperpigmentation by topical N-undecyl-10-enoyl-L-phenylalanine and its combination with niacinamide](https://pubmed.ncbi.nlm.nih.gov/19958429/) Undecylenoyl phenylalanine · Journal of Cosmetic Dermatology, 2009
- [Inhibitory effects of shell of Camellia oleifera Abel extract on mushroom tyrosinase and human skin melanin](https://pubmed.ncbi.nlm.nih.gov/31033161/) Butylene glycol · Journal of Cosmetic Dermatology, 2019
- [A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines](https://pubmed.ncbi.nlm.nih.gov/19874316/) Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhanced Fluctuations in Facial Pore Size, Redness, and TEWL Caused by Mask Usage Are Normalized by the Application of a Moisturizer](https://pubmed.ncbi.nlm.nih.gov/35456214/) Galactomyces ferment filtrate, Pitera essence, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate galactomyces ferment filtrate, Pitera ferment filtrate, Sk-ii pitera concentrate, Pitera · Journal of Clinical Medicine, 2022
- [Three clinical studies showing the anti-aging benefits of sodium salicylate in human skin](https://pubmed.ncbi.nlm.nih.gov/20883290/) Sodium salicylate · Journal of Cosmetic Dermatology, 2010
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, D-pantothenyl alcohol · Journal of Cosmetic Dermatology, 2025
- [Formulation and evaluation of exotic fat based cosmeceuticals for skin repair](https://pubmed.ncbi.nlm.nih.gov/20046792/) Mangifera indica seed butter · Indian Journal of Pharmaceutical Sciences, 2008
- [Glycerol crosslinked vitamin E loaded xanthan gum and gellan gum nanoemulgels for topical management of dry skin](https://pubmed.ncbi.nlm.nih.gov/41224059/) Xanthan gum · International Journal of Biological Macromolecules, 2025
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) L-ascorbic acid 2-glucoside, Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Significant Reversal of Facial Wrinkle, Pigmented Spot and Roughness by Daily Application of Galactomyces Ferment Filtrate-Containing Skin Products for 12 Months-An 11-Year Longitudinal Skin Aging Rejuvenation Study](https://pubmed.ncbi.nlm.nih.gov/36769815/) Galactomyces ferment filtrate, Pitera essence, Pitera ferment filtrate galactomyces ferment filtrate, Galactomyces ferment filtrate pitera ferment filtrate, Pitera ferment filtrate, Pitera · Journal of Clinical Medicine, 2023
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) L-ascorbic acid 2-glucoside, Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [The Effectiveness of Galactomyces Ferment Filtrate, Dexpanthenol, and Centella Asiatica Combination Serum in the Treatment of Post-Acne Hyperpigmentation in Subjects with Skin of Color](https://pubmed.ncbi.nlm.nih.gov/33938432/) Galactomyces ferment filtrate, Sk-ii pitera concentrate, Galactomyces ferment filtrate pitera ferment filtrate · Skinmed, 2021
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026

## The brands

- Japanese skincare: [SK-II](https://lovi.care/skincare/es/brands/sk-ii)
- Spanish skincare: [Natura Bissé](https://lovi.care/skincare/es/brands/natura-bisse)

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- [The Ordinary vs SK-II](https://lovi.care/skincare/es/compare/the-ordinary-vs-sk-ii)
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- [CeraVe vs SK-II](https://lovi.care/skincare/es/compare/cerave-vs-sk-ii)
- [CeraVe vs Natura Bissé](https://lovi.care/skincare/es/compare/cerave-vs-natura-bisse)
- [La Roche-Posay vs SK-II](https://lovi.care/skincare/es/compare/la-roche-posay-vs-sk-ii)
- [La Roche-Posay vs Natura Bissé](https://lovi.care/skincare/es/compare/la-roche-posay-vs-natura-bisse)
- [Dr. Althea vs SK-II](https://lovi.care/skincare/es/compare/dr-althea-vs-sk-ii)
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- [Some By Mi vs SK-II](https://lovi.care/skincare/es/compare/some-by-mi-vs-sk-ii)
- [Some By Mi vs Natura Bissé](https://lovi.care/skincare/es/compare/some-by-mi-vs-natura-bisse)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sk-ii-vs-natura-bisse
- United Kingdom: https://lovi.care/skincare/uk/compare/sk-ii-vs-natura-bisse
- Ireland: https://lovi.care/skincare/ie/compare/sk-ii-vs-natura-bisse
- Germany: https://lovi.care/skincare/de/compare/sk-ii-vs-natura-bisse
- France: https://lovi.care/skincare/fr/compare/sk-ii-vs-natura-bisse
- Italy: https://lovi.care/skincare/it/compare/sk-ii-vs-natura-bisse
- Netherlands: https://lovi.care/skincare/nl/compare/sk-ii-vs-natura-bisse
- Spain: https://lovi.care/skincare/es/compare/sk-ii-vs-natura-bisse (this page)
- Canada: https://lovi.care/skincare/ca/compare/sk-ii-vs-natura-bisse
- Australia: https://lovi.care/skincare/au/compare/sk-ii-vs-natura-bisse
- Singapore: https://lovi.care/skincare/sg/compare/sk-ii-vs-natura-bisse
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sk-ii-vs-natura-bisse
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sk-ii-vs-natura-bisse