# Sesderma vs Rilastil Page: https://lovi.care/skincare/es/compare/sesderma-vs-rilastil The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain. Sesderma and Rilastil are esteemed European skincare brands founded on pharmaceutical expertise and dermatological dedication. Sesderma is beloved for its advanced [serums](https://lovi.care/skincare/es/ingredients/serum) and meticulously engineered formulas, suiting sensitive, hyperpigmented, and aging skin types best with standalone solutions like the Azelac RU Serum for acne-prone skin, while the brand is warmly loved for its targeted serums and meticulously balanced formulas that suit sensitive, dry, and mature skin types best through gentle, deeply nourishing compositions such as the Acnestil for acne-prone skin. Both brands differ in their regional roots and specific active profiles, as botanical [extracts](https://lovi.care/skincare/es/ingredients/extract) and active compounds refine texture and promote radiance in the former, whereas careful restorative compositions restore daily comfort and enhance natural resilience in the latter. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular Sesderma and Rilastil products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg58ccdeafac). ### Popular Sesderma vs Rilastil products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) #### Rilastil - [Acnestil](https://lovi.care/skincare/es/p/rilastil/acnestil/for/oily-skin) — Average fit ### Sesderma vs Rilastil [serums](https://lovi.care/skincare/es/ingredients/serum) and treatments #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) #### Rilastil - [Acnestil](https://lovi.care/skincare/es/p/rilastil/acnestil/for/oily-skin) — Average fit ## Questions and answers ### Sesderma or Rilastil: which is better? For acne-prone skin and dark spots, Sesderma offers higher Lovi fit levels than Rilastil on this page, with its Azelac RU [Serum](https://lovi.care/skincare/es/ingredients/serum) rated High for those concerns. However, Azelac RU Serum contains fragrance, while Rilastil products on this page list no fragrance. [Azelaic acid](https://lovi.care/skincare/es/ingredients/azelaic-acid) helps improve acne vulgaris. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### What is the difference between Sesderma and Rilastil? For acne-prone skin and skin with dark spots, Sesderma earns a High Lovi fit with its Azelac RU Serum, whereas Rilastil earns an Average fit with Acnestil. The products on this page from Sesderma contain fragrance, while Rilastil products list no fragrance. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Which is more affordable, Sesderma or Rilastil? The page facts do not mention the prices of Sesderma or Rilastil, so we cannot tell which brand is more affordable. ### Which causes fewer breakouts, Sesderma or Rilastil? For acne-prone skin, Lovi rates Sesderma's Azelac RU Serum as High, while Rilastil's Acnestil is rated Average. Azelaic acid helps improve acne vulgaris. [Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) ### Which brand was founded earlier, Sesderma or Rilastil? Rilastil was founded earlier, in 1972, while Sesderma was founded in 1989. ### Do products from Sesderma or Rilastil contain fragrance? Sesderma includes fragrance in its Azelac RU Serum on this page. Rilastil products on this page list no fragrance in their ingredients. ### Who owns Sesderma and Rilastil? Grupo Sesderma owns Sesderma, and Istituto Ganassini owns Rilastil. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020 - [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020 - [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023 - [Chemical peels for acne vulgaris: a systematic review of randomised controlled trials](https://pubmed.ncbi.nlm.nih.gov/29705755/) Mandelic acid · BMJ Open, 2018 - [Randomized prospective study of low-dose isotretinoin alone and combination with salicylic acid and mandelic peel against acne tarda](https://pubmed.ncbi.nlm.nih.gov/35388606/) Mandelic acid · Journal of Cosmetic Dermatology, 2022 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Spanish skincare: [Sesderma](https://lovi.care/skincare/es/brands/sesderma) - Skincare: [Rilastil](https://lovi.care/skincare/es/brands/rilastil) ## More comparisons - [SKIN1004 vs Sesderma](https://lovi.care/skincare/es/compare/skin1004-vs-sesderma) - [SKIN1004 vs Rilastil](https://lovi.care/skincare/es/compare/skin1004-vs-rilastil) - [Anua vs Sesderma](https://lovi.care/skincare/es/compare/anua-vs-sesderma) - [Anua vs Rilastil](https://lovi.care/skincare/es/compare/anua-vs-rilastil) - [Medicube vs Sesderma](https://lovi.care/skincare/es/compare/medicube-vs-sesderma) - [Medicube vs Rilastil](https://lovi.care/skincare/es/compare/medicube-vs-rilastil) - [The Ordinary vs Sesderma](https://lovi.care/skincare/es/compare/the-ordinary-vs-sesderma) - [The Ordinary vs Rilastil](https://lovi.care/skincare/es/compare/the-ordinary-vs-rilastil) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-sesderma) - [Beauty of Joseon vs Rilastil](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-rilastil) - [COSRX vs Sesderma](https://lovi.care/skincare/es/compare/cosrx-vs-sesderma) - [COSRX vs Rilastil](https://lovi.care/skincare/es/compare/cosrx-vs-rilastil) - [CeraVe vs Sesderma](https://lovi.care/skincare/es/compare/cerave-vs-sesderma) - [CeraVe vs Rilastil](https://lovi.care/skincare/es/compare/cerave-vs-rilastil) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/es/compare/la-roche-posay-vs-sesderma) - [La Roche-Posay vs Rilastil](https://lovi.care/skincare/es/compare/la-roche-posay-vs-rilastil) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/es/compare/dr-althea-vs-sesderma) - [Dr. Althea vs Rilastil](https://lovi.care/skincare/es/compare/dr-althea-vs-rilastil) - [Some By Mi vs Sesderma](https://lovi.care/skincare/es/compare/some-by-mi-vs-sesderma) - [Some By Mi vs Rilastil](https://lovi.care/skincare/es/compare/some-by-mi-vs-rilastil) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/sesderma-vs-rilastil - United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-rilastil - Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-rilastil - Germany: https://lovi.care/skincare/de/compare/sesderma-vs-rilastil - France: https://lovi.care/skincare/fr/compare/sesderma-vs-rilastil - Italy: https://lovi.care/skincare/it/compare/sesderma-vs-rilastil - Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-rilastil - Spain: https://lovi.care/skincare/es/compare/sesderma-vs-rilastil (this page) - Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-rilastil - Australia: https://lovi.care/skincare/au/compare/sesderma-vs-rilastil - Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-rilastil - Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-rilastil - United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-rilastil