# Sesderma vs Blue Lizard

Page: https://lovi.care/skincare/es/compare/sesderma-vs-blue-lizard

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Sesderma and Blue Lizard are respected skincare lines with distinct formulations tailored to different complexions. Sesderma is known for advanced [serums](https://lovi.care/skincare/es/ingredients/serum) featuring botanical [extracts](https://lovi.care/skincare/es/ingredients/extract) and active compounds that suit sensitive, hyperpigmented, and aging skin types best. Conversely, the second brand is celebrated for thoughtful mineral sunscreens and gentle formulations ideal for sensitive skin. They differ primarily in their core offerings, as the Spanish brand refines skin texture and promotes radiance, while the Australian-rooted brand focuses on reliable sun protection with a soothing feel.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and Blue Lizard products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pge156f204b5).

### Popular Sesderma vs Blue Lizard products

#### Blue Lizard

- [Sensitive Mineral Sunscreen SPF 50+](https://lovi.care/skincare/es/p/blue-lizard/sensitive-mineral-sunscreen-spf-50/for/sensitive-skin) — Superior fit — [€12.62 at Amazon](https://www.amazon.de/dp/B083VTP119?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Sesderma or Blue Lizard: which is better?

Blue Lizard is a better overall fit for sensitive and dry skin, earning a Superior Lovi fit level for those skin types compared to the Low ratings for Sesderma's Azelac RU [Serum](https://lovi.care/skincare/es/ingredients/serum). Blue Lizard also has no fragrance across the products on this page, whereas Sesderma includes fragrance.

### What is the difference between Sesderma and Blue Lizard?

Blue Lizard has a Superior Lovi fit for sensitive skin and dry sensitive skin, and the products on this page list no fragrance. Sesderma features a High fit for acne-prone skin, skin with dark spots, and combination skin, but its Azelac RU Serum contains fragrance.

### Which is more affordable, Sesderma or Blue Lizard?

The provided page facts do not contain pricing information for either Sesderma or Blue Lizard, so it is not possible to determine which brand is more affordable.

### Which causes fewer breakouts, Sesderma or Blue Lizard?

For acne-prone skin, Lovi rates Blue Lizard at High fit and Sesderma's products on this page at Average to High fit. Blue Lizard has the advantage of being fragrance-free across its products on this page, while Sesderma's Azelac RU Serum contains fragrance.

### Which brand was founded earlier, Sesderma or Blue Lizard?

Sesderma was founded earlier in 1989, while Blue Lizard was founded in 1995.

### How does the fragrance content compare between Sesderma's and Blue Lizard's products on this page?

Blue Lizard's products on this page list no fragrance, whereas the Azelac RU Serum by Sesderma includes fragrance.

### Which brand's product offers a superior fit for sensitive skin according to the Lovi ratings?

Blue Lizard provides a superior fit for sensitive skin according to the Lovi ratings with its Sensitive Mineral Sunscreen SPF 50+. In comparison, Sesderma offers an average fit for sensitive skin with its Azelac RU Serum.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Skin penetration and stabilization of formulations containing microfine titanium dioxide as physical UV filter](https://pubmed.ncbi.nlm.nih.gov/18503414/) Titanium dioxide · International Journal of Cosmetic Science, 2000
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [The human stratum corneum layer: an effective barrier against dermal uptake of different forms of topically applied micronised titanium dioxide](https://pubmed.ncbi.nlm.nih.gov/11509913/) Titanium dioxide · Skin Pharmacology and Applied Skin Physiology, 2001
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate vitamin e · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate vitamin e · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/es/brands/sesderma)
- Skincare: [Blue Lizard](https://lovi.care/skincare/es/brands/blue-lizard)

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-blue-lizard
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-blue-lizard
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-blue-lizard
- Germany: https://lovi.care/skincare/de/compare/sesderma-vs-blue-lizard
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- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-blue-lizard
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-blue-lizard
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-blue-lizard (this page)
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-blue-lizard
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-blue-lizard
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-blue-lizard
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-blue-lizard
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-blue-lizard