# Sesderma vs Bio-Oil

Page: https://lovi.care/skincare/es/compare/sesderma-vs-bio-oil

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Sesderma and Bio-Oil are popular skincare options known for distinct formulations that address various dermatological needs. The Spanish brand founded in 1989 is beloved for its advanced [serums](https://lovi.care/skincare/es/ingredients/serum) and meticulously engineered formulas, such as the Azelac RU Serum, making it best suited for sensitive, hyperpigmented, and aging skin types. Meanwhile, the second option is beloved for its specialized product types and expertly blended formulas, including the Skincare Oil, which suit dry, mature, and uneven skin types best. These offerings differ as both botanical [extracts](https://lovi.care/skincare/es/ingredients/extract) and active compounds work synergistically to refine skin texture, or thoughtful formulations deliver balanced moisture without feeling heavy.

Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026.

[skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html)

This page compares some of the most popular Sesderma and Bio-Oil products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pgfe8b32f181).

### Popular Sesderma vs Bio-Oil products

#### Sesderma

- [Azelac RU Serum](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Bio-Oil

- [Skincare Oil](https://lovi.care/skincare/es/p/bio-oil/skincare-oil/for/dry-skin) — Average fit — [€14.95 at Amazon](https://www.amazon.de/dp/B00KWCQHZ8?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## Questions and answers

### Sesderma or Bio-Oil: which is better?

Sesderma is better than Bio-Oil for acne-prone, dark spot, and combination skin, where Lovi fit is High, while Bio-Oil only reaches Average fit for dry skin and dark spots and warns against oily skin.

### What is the difference between Sesderma and Bio-Oil?

Sesderma offers targeted care with a High Lovi fit for acne-prone skin and dark spots, whereas Bio-Oil generally provides Average to Caution fits across those same skin types. Both brands include fragrance in the products on this page.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/) [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which is more affordable, Sesderma or Bio-Oil?

I am sorry, but the provided page facts and studies do not contain pricing or affordability information for either Sesderma or Bio-Oil.

### Which causes fewer breakouts, Sesderma or Bio-Oil?

For acne-prone skin, Lovi rates Sesderma as High and Bio-Oil with Caution, meaning Sesderma is much less likely to cause breakouts.

[Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/)

### Between Sesderma and Bio-Oil, which brand has been on the market longer?

Bio-Oil has been on the market longer, having been founded in 1987 compared to Sesderma, which was founded in 1989.

### Which company owns Sesderma, and which company owns Bio-Oil?

Sesderma is owned by Grupo Sesderma, and Bio-Oil is owned by Union-Swiss (Pty) Ltd. Both companies have been under their current ownership since the years 2026 and 2000 respectively.

### Do either Sesderma's Azelac RU Serum or Bio-Oil's Skincare Oil contain fragrance?

Both Sesderma's Azelac RU [Serum](https://lovi.care/skincare/es/ingredients/serum) and Bio-Oil's Skincare Oil contain fragrance, as all products on this page list it.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021
- [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007
- [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024
- [Comedogenicity in rabbit: some cosmetic ingredients/vehicles](https://pubmed.ncbi.nlm.nih.gov/18058303/) Isopropyl myristate · Cutaneous and Ocular Toxicology, 2007
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate vitamin e · Arzneimittel-Forschung, 1998
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate vitamin a · Journal of Cosmetic Dermatology, 2013
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024

## The brands

- Spanish skincare: [Sesderma](https://lovi.care/skincare/es/brands/sesderma)
- Skincare: [Bio-Oil](https://lovi.care/skincare/es/brands/bio-oil)

## More comparisons

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- [SKIN1004 vs Bio-Oil](https://lovi.care/skincare/es/compare/skin1004-vs-bio-oil)
- [Anua vs Sesderma](https://lovi.care/skincare/es/compare/anua-vs-sesderma)
- [Anua vs Bio-Oil](https://lovi.care/skincare/es/compare/anua-vs-bio-oil)
- [Medicube vs Sesderma](https://lovi.care/skincare/es/compare/medicube-vs-sesderma)
- [Medicube vs Bio-Oil](https://lovi.care/skincare/es/compare/medicube-vs-bio-oil)
- [The Ordinary vs Sesderma](https://lovi.care/skincare/es/compare/the-ordinary-vs-sesderma)
- [The Ordinary vs Bio-Oil](https://lovi.care/skincare/es/compare/the-ordinary-vs-bio-oil)
- [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-sesderma)
- [Beauty of Joseon vs Bio-Oil](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-bio-oil)
- [COSRX vs Sesderma](https://lovi.care/skincare/es/compare/cosrx-vs-sesderma)
- [COSRX vs Bio-Oil](https://lovi.care/skincare/es/compare/cosrx-vs-bio-oil)
- [CeraVe vs Sesderma](https://lovi.care/skincare/es/compare/cerave-vs-sesderma)
- [CeraVe vs Bio-Oil](https://lovi.care/skincare/es/compare/cerave-vs-bio-oil)
- [La Roche-Posay vs Sesderma](https://lovi.care/skincare/es/compare/la-roche-posay-vs-sesderma)
- [La Roche-Posay vs Bio-Oil](https://lovi.care/skincare/es/compare/la-roche-posay-vs-bio-oil)
- [Dr. Althea vs Sesderma](https://lovi.care/skincare/es/compare/dr-althea-vs-sesderma)
- [Dr. Althea vs Bio-Oil](https://lovi.care/skincare/es/compare/dr-althea-vs-bio-oil)
- [Some By Mi vs Sesderma](https://lovi.care/skincare/es/compare/some-by-mi-vs-sesderma)
- [Some By Mi vs Bio-Oil](https://lovi.care/skincare/es/compare/some-by-mi-vs-bio-oil)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/sesderma-vs-bio-oil
- United Kingdom: https://lovi.care/skincare/uk/compare/sesderma-vs-bio-oil
- Ireland: https://lovi.care/skincare/ie/compare/sesderma-vs-bio-oil
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- Italy: https://lovi.care/skincare/it/compare/sesderma-vs-bio-oil
- Netherlands: https://lovi.care/skincare/nl/compare/sesderma-vs-bio-oil
- Spain: https://lovi.care/skincare/es/compare/sesderma-vs-bio-oil (this page)
- Canada: https://lovi.care/skincare/ca/compare/sesderma-vs-bio-oil
- Australia: https://lovi.care/skincare/au/compare/sesderma-vs-bio-oil
- Singapore: https://lovi.care/skincare/sg/compare/sesderma-vs-bio-oil
- Saudi Arabia: https://lovi.care/skincare/sa/compare/sesderma-vs-bio-oil
- United Arab Emirates: https://lovi.care/skincare/ae/compare/sesderma-vs-bio-oil