# Medik8 vs Shiseido

Page: https://lovi.care/skincare/es/compare/medik8-vs-shiseido

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Medik8 and Shiseido are distinguished skin care houses that offer [serums](https://lovi.care/skincare/es/ingredients/serum), moisturizers, cleansers, and sunscreens built around hydrating ingredients like [hyaluronic acid](https://lovi.care/skincare/es/ingredients/hyaluronic-acid) and [glycerin](https://lovi.care/skincare/es/ingredients/glycerin). The British brand Medik8 suits dry and dry sensitive skin best with hyaluronic acid to help lengthen toxin wrinkle effect duration, while the Japanese brand Shiseido suits sensitive and mature skin best with glycerin to significantly improve stratum corneum hydration. Each line addresses targeted concerns such as acne-prone skin, dark spots, and aging through distinct formulations and expert ratings. Ultimately, they differ in their foundational ingredients and regional heritage, giving users unique ways to care for their complexion.

Medik8 is a British skincare brand founded in 2009 and owned by L'Oréal Groupe since 2025.

[loreal.com](https://www.loreal.com/en/press-release/group/l-oreal-groupe-to-acquire-a-majority-stake-in-medik8/) [medik8.com](https://www.medik8.com/pages/founders-story) [tracxn.com](https://tracxn.com/d/companies/medik8/__vqs3N9eL3EfvIq0IoeUPADts7CrlGbzm7kjy9M9QY8o)

Shiseido is a Japanese skincare brand founded in 1872 and owned by Shiseido Company, Limited.

[corp.shiseido.com](https://corp.shiseido.com/en/company/info/) [en.wikipedia.org](https://en.wikipedia.org/wiki/Shiseido) [marketscreener.com](https://www.marketscreener.com/quote/stock/SHISEIDO-COMPANY-LIMITED-6492328/news/Shiseido-Company-Limited-Announces-CEO-Changes-Effective-January-1-2025-47501230/)

This page compares some of the most popular Medik8 and Shiseido products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg4b822bd21b).

### Popular Medik8 vs Shiseido products

#### Medik8

- [Liquid Peptides](https://lovi.care/skincare/es/p/medik8/liquid-peptides/for/oily-acne-prone-skin) — Average fit — [€102.00 at Amazon](https://www.amazon.de/dp/B0DYV9VSDV?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [CRYSTAL RETINAL 3](https://lovi.care/skincare/es/p/medik8/crystal-retinal-3/for/mature-skin) — High fit — [€65.00 at Amazon](https://www.amazon.de/dp/B0DWN2WFLJ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [C-Tetra Serum](https://lovi.care/skincare/es/p/medik8/c-tetra-serum/for/dry-sensitive-skin) — Average fit — [€56.00 at Amazon](https://www.amazon.de/dp/B0DYV7HDTH?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Bakuchiol Peptides](https://lovi.care/skincare/es/p/medik8/bakuchiol-peptides/for/dry-skin) — Superior fit — [€50.76 at Lookfantastic](https://www.lookfantastic.es/p/medik8-bakuchiol-peptides-30ml/12660650/)
- [Crystal Retinal Ceramide Eye 3](https://lovi.care/skincare/es/p/medik8/crystal-retinal-ceramide-eye-3/for/mature-skin) — High fit — [€53.00 at Amazon](https://www.amazon.de/dp/B0DWMZF2GT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Oxy-R Peptides](https://lovi.care/skincare/es/p/medik8/oxy-r-peptides/for/mature-skin) — Superior fit — [€76.50 at Notino](https://www.notino.es/medik8/oxy-r-peptides-serum-intensivo/p-16151739/)
- [Total Moisture Daily Facial Cream](https://lovi.care/skincare/es/p/medik8/total-moisture-daily-facial-cream/for/mature-skin) — High fit — [€60.00 at Amazon](https://www.amazon.de/dp/B0DVLQVYFT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Hydr8 B5 Intense](https://lovi.care/skincare/es/p/medik8/hydr8-b5-intense/for/dry-skin) — Superior fit — [€78.95 at Amazon](https://www.amazon.de/dp/B0DWN2BL3T?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### Shiseido

- [Benefiance Wrinkle Smoothing Eye Cream](https://lovi.care/skincare/es/p/shiseido/benefiance-wrinkle-smoothing-eye-cream/for/mature-skin) — High fit — [€43.69 at Amazon](https://www.amazon.de/dp/B07XWL3TJ6?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/es/p/shiseido/ultimune-power-infusing-concentrate/for/sensitive-skin) — Average fit — [€57.45 at Amazon](https://www.amazon.de/dp/B0F5YYYNGW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [VITAL PERFECTION](https://lovi.care/skincare/es/p/shiseido/vital-perfection/for/mature-skin) — Average fit — [€65.01 at Amazon](https://www.amazon.de/dp/B0CP67VGG7?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Clarifying Cleansing Foam](https://lovi.care/skincare/es/p/shiseido/clarifying-cleansing-foam/for/mature-skin) — Average fit — [€29.63 at Amazon](https://www.amazon.de/dp/B0HD83216K?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Essential Energy Hydrating Cream](https://lovi.care/skincare/es/p/shiseido/essential-energy-hydrating-cream/for/mature-skin) — Superior fit — [€36.00 at Amazon](https://www.amazon.de/dp/B09SBSPXTY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Activating Essence](https://lovi.care/skincare/es/p/shiseido/activating-essence/for/dry-skin) — High fit
- [FUTURE SOLUTION LX](https://lovi.care/skincare/es/p/shiseido/future-solution-lx/for/sensitive-skin) — High fit
- [Bio-Performance Advanced Super Revitalizing Cream](https://lovi.care/skincare/es/p/shiseido/bio-performance-advanced-super-revitalizing-cream/for/dry-skin) — Warning fit — [€57.79 at Amazon](https://www.amazon.de/dp/B00ASQ8H9C?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## People Say

Medik8

Shiseido

- Deep hydration and moisturization Often Mentioned Mostly Mentioned “Immediate sensation of comfort — Shiseido Benefiance Wrinkle Smoothing Eye Cream” “skin feels plump, soft and nourished, eliminates dryness, bouncy feel — Shiseido VITAL PERFECTION” “Skin feels more hydrated — Shiseido Activating Essence” “Restores moisture — Medik8 Liquid Peptides”
- Lightweight and elegant texture Often Mentioned Mostly Mentioned “silky smooth, rich but non-greasy, absorbs quickly, melts into skin — Shiseido VITAL PERFECTION” “Airy-soft texture — Shiseido Essential Energy Hydrating Cream” “absorbs quickly — Shiseido White Lucent Brightening Gel Cream” “absorbed effortlessly — Medik8 Total Moisture Daily Facial Cream”
- Acne clearing and glowing skin Often Mentioned Often Mentioned “I wake up glowing. It adds back that youthful bloom that I've lost. — Medik8 Sleep Glycolic” “unlocked a serious glow — Medik8 C-Tetra Serum” “Skin looks brighter, more radiant, and "glowy." — Shiseido Ultimune Power Infusing Concentrate” “faded pimple marks — Shiseido White Lucent Brightening Gel Cream”
- Skin plumping, smoothing, and firming Often Mentioned Often Mentioned “My skin was smoother, my skin texture felt more resurfaced. — Medik8 Sleep Glycolic” “Reduces fine lines — Medik8 Liquid Peptides” “Smoothed out crow's feet — Shiseido Benefiance Wrinkle Smoothing Eye Cream” “tighter jawline, lifted appearance, improved elasticity, less sagging — Shiseido VITAL PERFECTION”
- Gentle formulation and no irritation Mostly Mentioned Rarely Noted “zero irritation or peeling — Medik8 CRYSTAL RETINAL 3” “only Vitamin C my sensitive skin can tolerate — Medik8 C-Tetra Serum” “Best retinol replacement — Medik8 Bakuchiol Peptides” “No irritation — Shiseido Essential Energy Hydrating Cream”
- Hydrating texture and pleasant scent Rarely Noted Sometimes Noted “Pleasant floral fragrance, relaxing, luxurious smell. — Shiseido Ultimune Power Infusing Concentrate” “spa-like scent, high-quality packaging, little goes a long way — Shiseido VITAL PERFECTION” “Fresh floral scent — Shiseido Essential Energy Hydrating Cream” “sinks in beautifully — Medik8 C-Tetra Serum”
- High price point and value Often Mentioned Mostly Mentioned “Expensive per bottle — Medik8 Liquid Peptides” “very expensive for amount — Medik8 CRYSTAL RETINAL 3” “hefty price tag — Medik8 C-Tetra Serum” “Very expensive for the size — Shiseido Benefiance Wrinkle Smoothing Eye Cream”
- Strong fragrance and alcohol content Not noted Often Mentioned “old lady smell — Shiseido Eudermine Revitalizing Essence”
- Packaging issues and fragility Sometimes Noted Sometimes Noted “Glass bottle breaks easily — Medik8 Liquid Peptides” “hard to get last bit — Medik8 CRYSTAL RETINAL 3” “heavy to travel — Shiseido Eudermine Revitalizing Essence” “Heavy bottle but plastic pump, cannot see remaining product, straw too short to get last drops. — Shiseido Ultimune Power Infusing Concentrate”

### Medik8 vs Shiseido routines for dry skin

#### Medik8-focused routine

- Cleanser: [CeraVe Hydrating Facial Cleanser](https://lovi.care/skincare/es/p/cerave/hydrating-facial-cleanser/for/dry-skin) — Superior fit — [€8.85 at Amazon](https://www.amazon.de/dp/B07C5R51Q9?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Advanced Replenishing Toner](https://lovi.care/skincare/es/p/paula-s-choice/advanced-replenishing-toner/for/dry-skin) — Superior fit — [€34.00 at Amazon](https://www.amazon.de/dp/B07P57D5SX?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Moisturizer: [Hydr8 B5 Intense](https://lovi.care/skincare/es/p/medik8/hydr8-b5-intense/for/dry-skin) — Superior fit — [€78.95 at Amazon](https://www.amazon.de/dp/B0DWN2BL3T?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/es/p/purito/daily-soft-touch-sunscreen/for/dry-skin) — Superior fit — [€12.98 at Amazon](https://www.amazon.de/dp/B0CYCBVBTR?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/es/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€10.97 at Amazon](https://www.amazon.de/dp/B084Q16G8D?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Bakuchiol Peptides](https://lovi.care/skincare/es/p/medik8/bakuchiol-peptides/for/dry-skin) — Superior fit — [€50.76 at Lookfantastic](https://www.lookfantastic.es/p/medik8-bakuchiol-peptides-30ml/12660650/) — Evening · Once a week
- Nourishing Mask: [Abib Rice Probiotics Overnight Mask](https://lovi.care/skincare/es/p/abib/rice-probiotics-overnight-mask/for/dry-skin) — Superior fit — [€15.30 at Amazon](https://www.amazon.de/dp/B09Z81FRRF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

#### Shiseido-focused routine

- Cleanser: [Clarifying Cleansing Foam](https://lovi.care/skincare/es/p/shiseido/clarifying-cleansing-foam/for/dry-skin) — Caution fit — [€29.63 at Amazon](https://www.amazon.de/dp/B0HD83216K?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Eudermine Revitalizing Essence](https://lovi.care/skincare/es/p/shiseido/eudermine-revitalizing-essence/for/dry-skin) — Average fit — [€44.50 at Notino](https://www.notino.es/shiseido/eudermine-activating-essence-tonico-revitalizante-con-efecto-humectante/p-16178707/) — Morning
- Moisturizer: [Essential Energy Hydrating Cream](https://lovi.care/skincare/es/p/shiseido/essential-energy-hydrating-cream/for/dry-skin) — High fit — [€36.00 at Amazon](https://www.amazon.de/dp/B09SBSPXTY?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [Purito Daily Soft Touch Sunscreen](https://lovi.care/skincare/es/p/purito/daily-soft-touch-sunscreen/for/dry-skin) — Superior fit — [€12.98 at Amazon](https://www.amazon.de/dp/B0CYCBVBTR?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/es/p/missha/ultra-hyalon-cleansing-cream/for/dry-skin) — Superior fit — [€10.97 at Amazon](https://www.amazon.de/dp/B084Q16G8D?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Serum or Treatment: [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/es/p/shiseido/ultimune-power-infusing-concentrate/for/dry-skin) — Low fit — [€57.45 at Amazon](https://www.amazon.de/dp/B0F5YYYNGW?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Nourishing Mask: [Abib Rice Probiotics Overnight Mask](https://lovi.care/skincare/es/p/abib/rice-probiotics-overnight-mask/for/dry-skin) — Superior fit — [€15.30 at Amazon](https://www.amazon.de/dp/B09Z81FRRF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 97% fit](https://lovi.care/skincare/es/skin/dry-skin)

### Medik8 vs Shiseido routines for oily skin

#### Medik8-focused routine

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/es/p/cerave/foaming-facial-cleanser/for/oily-skin) — Superior fit — [€20.50 at Amazon](https://www.amazon.de/dp/B01N1LL62W?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-skin) — Superior fit — [€36.00 at Amazon](https://www.amazon.de/dp/B07P7VZ2J9?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Hydr8 B5 Intense](https://lovi.care/skincare/es/p/medik8/hydr8-b5-intense/for/oily-skin) — High fit — [€78.95 at Amazon](https://www.amazon.de/dp/B0DWN2BL3T?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/es/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/oily-skin) — Superior fit — [€16.99 at Amazon](https://www.amazon.de/dp/B091T7JKQJ?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [€97.52 at Amazon](https://www.amazon.de/dp/B0DNJRC1L4?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Press & Glow](https://lovi.care/skincare/es/p/medik8/press-and-glow/for/oily-skin) — Average fit — [€33.50 at Notino](https://www.notino.es/medik8/press-glow-tonico-exfoliante-limpiador/p-16157170/) — Evening
- Serum or Treatment: [Oxy-R Peptides](https://lovi.care/skincare/es/p/medik8/oxy-r-peptides/for/oily-skin) — High fit — [€76.50 at Notino](https://www.notino.es/medik8/oxy-r-peptides-serum-intensivo/p-16151739/) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/es/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/es/p/vt-cosmetics/cica-purifying-mask/for/oily-skin) — High fit — [€16.79 at Amazon](https://www.amazon.de/dp/B083X5R6VR?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

#### Shiseido-focused routine

- Cleanser: [Deep Cleansing Foam](https://lovi.care/skincare/es/p/shiseido/deep-cleansing-foam/for/oily-skin) — High fit — [€35.99 at Amazon](https://www.amazon.de/dp/B07HYQXNKF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Eudermine Revitalizing Essence](https://lovi.care/skincare/es/p/shiseido/eudermine-revitalizing-essence/for/oily-skin) — Average fit — [€44.50 at Notino](https://www.notino.es/shiseido/eudermine-activating-essence-tonico-revitalizante-con-efecto-humectante/p-16178707/) — Morning · Once a week
- Moisturizer: [Essential Energy Hydrating Cream](https://lovi.care/skincare/es/p/shiseido/essential-energy-hydrating-cream/for/oily-skin) — Average fit — [€36.00 at Amazon](https://www.amazon.de/dp/B09SBSPXTY?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- SPF: [d'Alba UVessence Mild Waterfull Sun Cream SPF 50](https://lovi.care/skincare/es/p/d-alba/uvessence-mild-waterfull-sun-cream-spf-50/for/oily-skin) — Superior fit — [€16.99 at Amazon](https://www.amazon.de/dp/B091T7JKQJ?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/oily-skin) — Superior fit — [€97.52 at Amazon](https://www.amazon.de/dp/B0DNJRC1L4?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Caudalie Vinopure Purifying Toner](https://lovi.care/skincare/es/p/caudalie/vinopure-purifying-toner/for/oily-skin) — Superior fit — [€16.90 at Amazon](https://www.amazon.de/dp/B0FJ8STLLW?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/es/p/shiseido/ultimune-power-infusing-concentrate/for/oily-skin) — Average fit — [€57.45 at Amazon](https://www.amazon.de/dp/B0F5YYYNGW?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/es/p/dermalogica/daily-microfoliant/for/oily-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [VT Cosmetics Cica Purifying Mask](https://lovi.care/skincare/es/p/vt-cosmetics/cica-purifying-mask/for/oily-skin) — High fit — [€16.79 at Amazon](https://www.amazon.de/dp/B083X5R6VR?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 95% fit](https://lovi.care/skincare/es/skin/oily-skin)

### Medik8 vs Shiseido routines for combination skin

#### Medik8-focused routine

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/es/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — [€39.80 at Amazon](https://www.amazon.de/dp/B00AU9EBTC?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Paula's Choice Skin Balancing Pore-Reducing Toner](https://lovi.care/skincare/es/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — [€36.00 at Amazon](https://www.amazon.de/dp/B07P7VZ2J9?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Once a week
- Moisturizer: [Hydr8 B5 Intense](https://lovi.care/skincare/es/p/medik8/hydr8-b5-intense/for/combination-skin) — High fit — [€78.95 at Amazon](https://www.amazon.de/dp/B0DWN2BL3T?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [€97.52 at Amazon](https://www.amazon.de/dp/B0DNJRC1L4?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Press & Glow](https://lovi.care/skincare/es/p/medik8/press-and-glow/for/combination-skin) — High fit — [€33.50 at Notino](https://www.notino.es/medik8/press-glow-tonico-exfoliante-limpiador/p-16157170/) — Evening
- Serum or Treatment: [Oxy-R Peptides](https://lovi.care/skincare/es/p/medik8/oxy-r-peptides/for/combination-skin) — High fit — [€76.50 at Notino](https://www.notino.es/medik8/oxy-r-peptides-serum-intensivo/p-16151739/) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/es/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Origins Original Skin Retexturizing Mask with Rose Clay](https://lovi.care/skincare/es/p/origins/original-skin-retexturizing-mask-with-rose-clay/for/combination-skin) — Superior fit — [€28.50 at Amazon](https://www.amazon.de/dp/B0DV8YNCC5?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

#### Shiseido-focused routine

- Cleanser: [Deep Cleansing Foam](https://lovi.care/skincare/es/p/shiseido/deep-cleansing-foam/for/combination-skin) — High fit — [€35.99 at Amazon](https://www.amazon.de/dp/B07HYQXNKF?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Hydrating Toner: [Eudermine Revitalizing Essence](https://lovi.care/skincare/es/p/shiseido/eudermine-revitalizing-essence/for/combination-skin) — High fit — [€44.50 at Notino](https://www.notino.es/shiseido/eudermine-activating-essence-tonico-revitalizante-con-efecto-humectante/p-16178707/) — Morning · Once a week
- Moisturizer: [Essential Energy Hydrating Cream](https://lovi.care/skincare/es/p/shiseido/essential-energy-hydrating-cream/for/combination-skin) — Average fit — [€36.00 at Amazon](https://www.amazon.de/dp/B09SBSPXTY?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Morning · Evening · Once a week
- Pre-Cleanser: [Shu Uemura Ultime8 Sublime Beauty Cleansing Oil](https://lovi.care/skincare/es/p/shu-uemura/ultime8-sublime-beauty-cleansing-oil/for/combination-skin) — Superior fit — [€97.52 at Amazon](https://www.amazon.de/dp/B0DNJRC1L4?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Cleansing Toner: [Medicube Zero Pore Pad 2.0](https://lovi.care/skincare/es/p/medicube/zero-pore-pad-2-0/for/combination-skin) — Superior fit — [€16.98 at Amazon](https://www.amazon.de/dp/B09V7Z4TJG?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening
- Serum or Treatment: [Ultimune Power Infusing Concentrate](https://lovi.care/skincare/es/p/shiseido/ultimune-power-infusing-concentrate/for/combination-skin) — Average fit — [€57.45 at Amazon](https://www.amazon.de/dp/B0F5YYYNGW?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Evening · Once a week
- Enzyme Powder: [Dermalogica Daily Microfoliant](https://lovi.care/skincare/es/p/dermalogica/daily-microfoliant/for/combination-skin) — Superior fit — [€48.55 at Amazon](https://www.amazon.de/dp/B0D1YJN279?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week
- Cleansing Mask: [Origins Original Skin Retexturizing Mask with Rose Clay](https://lovi.care/skincare/es/p/origins/original-skin-retexturizing-mask-with-rose-clay/for/combination-skin) — Superior fit — [€28.50 at Amazon](https://www.amazon.de/dp/B0DV8YNCC5?tag=lovi-care-web-routine01-21&linkCode=osi&th=1&psc=1) — Once a week

[See multi-brand routine · 96% fit](https://lovi.care/skincare/es/skin/combination-skin)

## Questions and answers

### Medik8 or Shiseido: which is better?

Medik8 is generally better for gentle and fragrance-free routines, offering a Superior fit for dry, dry sensitive, combination, and sensitive skin types. Shiseido excels more in deep hydration and luxurious textures across the products on this page, but it frequently includes added fragrance.

### What is the difference between Medik8 and Shiseido?

Medik8 tends to focus on gentle formulations with less fragrance, while Shiseido offers deep hydration and luxurious textures across the products on this page.

### Medik8 or Shiseido for dry skin?

Medik8 is the better choice for dry skin, achieving a Superior routine fit compared to Shiseido's Average fit on this page. The products on this page help deliver deep hydration with key ingredients like [hyaluronic acid](https://lovi.care/skincare/es/ingredients/hyaluronic-acid).

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/) [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Medik8 or Shiseido: which cleanser is better?

Medik8 cleansers perform better on this page, with Surface Radiance Cleanse achieving a Superior fit for acne-prone skin, oily acne-prone skin, and skin with dark spots. Shiseido cleansers tend to show lower fit levels for dry and sensitive skin types.

### Which is more affordable, Medik8 or Shiseido?

When it comes to price, reviewers note that both Medik8 and Shiseido have a high price point. However, Medik8 does better in review themes regarding price point and value.

### Between Medik8 and Shiseido, which brand has better options for dry sensitive skin?

Medik8 has better options for dry sensitive skin, offering a superior routine fit compared to Shiseido's high fit. The products on this page help provide deep hydration and are generally gentle and non-irritating.

### How do the fragrance inclusions compare between Medik8 and Shiseido products?

Medik8 products on this page are generally fragrance-free, with only one product listing fragrance, whereas the majority of Shiseido products on this page contain fragrance.

### Which brand performs better when it comes to gentle formulations and avoiding skin irritation?

Medik8 performs better than Shiseido for gentle formulations and avoiding irritation, as reviewers frequently highlight its gentle and non-irritating [serums](https://lovi.care/skincare/es/ingredients/serum). In contrast, Shiseido reviewers sometimes note skin irritation and strong fragrance across the products on this page.

### Medik8 or Shiseido for oily skin?

Medik8 and Shiseido are both a good match for oily skin, with both brands receiving a High fit rating for this skin type.

### Medik8 or Shiseido: which moisturizer is better?

Medik8 stands out for dry skin and dry sensitive skin with a superior fit for its moisturizers on this page, while Shiseido provides deep hydration and a strong routine fit for mature and sensitive skin. Reviewers note that Shiseido features luxurious and lightweight textures, whereas Medik8 offers gentle formulations.

### Medik8 or Shiseido for sensitive skin?

Medik8 is the better choice for sensitive skin because its routine fit level is Superior, whereas Shiseido achieves a High fit. Shoppers also note that Medik8 offers a more gentle formulation and no irritation, while Shiseido products often feature a strong fragrance.

### Medik8 or Shiseido for acne-prone skin?

Both Medik8 and Shiseido fit acne-prone skin at a High level on the products on this page. Reviewers note that Medik8 offers a more gentle formulation with less irritation, while Shiseido provides deep-cleansing and efficient cleansers.

## Research behind their key ingredients

- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Hyaluronic acid · Drug Delivery, 2017
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/16778793/) Squalane · The Journal of Investigative Dermatology, 2006
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol · Journal of Cosmetic Dermatology, 2020
- [A topical antioxidant solution containing vitamins C and E stabilized by ferulic acid provides protection for human skin against damage caused by ultraviolet irradiation](https://pubmed.ncbi.nlm.nih.gov/18603326/) Ferulic acid · Journal of the American Academy of Dermatology, 2008
- [Protective effects of a topical antioxidant mixture containing vitamin C, ferulic acid, and phloretin against ultraviolet-induced photodamage in human skin](https://pubmed.ncbi.nlm.nih.gov/19146606/) Ferulic acid · Journal of Cosmetic Dermatology, 2008
- [Psychophysical study of the effects of topical application of menthol in healthy volunteers](https://pubmed.ncbi.nlm.nih.gov/16527405/) Menthol · Pain, 2006
- [Production and characterization of cosmetic nanoemulsions containing Opuntia ficus-indica (L.) mill extract as moisturizing agent](https://pubmed.ncbi.nlm.nih.gov/25648593/) Hydrolyzed opuntia ficus-indica flower extract · Molecules, 2015
- [Topical anti-inflammatory effects of isorhamnetin glycosides isolated from Opuntia ficus-indica](https://pubmed.ncbi.nlm.nih.gov/25821823/) Hydrolyzed opuntia ficus-indica flower extract · BioMed Research International, 2015
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Evaluation of efficacy and tolerance of a nighttime topical antioxidant containing resveratrol, baicalin, and vitamin e for treatment of mild to moderately photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/25607790/) Scutellaria baicalensis root extract · Journal of Drugs in Dermatology, 2014
- [Ethanol extracts of Sanguisorba officinalis L. suppress TNF-α/IFN-γ-induced pro-inflammatory chemokine production in HaCaT cells](https://pubmed.ncbi.nlm.nih.gov/26655409/) Sanguisorba officinalis root extract · Phytomedicine, 2015
- [Skin barrier disruption by sodium lauryl sulfate-exposure alters the expressions of involucrin, transglutaminase 1, profilaggrin, and kallikreins during the repair phase in human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/18007579/) Sodium lauryl sulfate · The Journal of Investigative Dermatology, 2008
- [Topical delivery of tetrahydrocurcumin lipid nanoparticles effectively inhibits skin inflammation: in vitro and in vivo study](https://pubmed.ncbi.nlm.nih.gov/29938544/) Tetrahydrodiferuloylmethane · Drug Development and Industrial Pharmacy, 2018
- [Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling](https://pubmed.ncbi.nlm.nih.gov/16890388/) Panax ginseng root extract · Journal of Ethnopharmacology, 2007
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin](https://pubmed.ncbi.nlm.nih.gov/22584263/) Glyceryl glucoside · Skin Pharmacology and Physiology, 2012
- [Antioxidant Opuntia ficus-indica Extract Activates AHR-NRF2 Signaling and Upregulates Filaggrin and Loricrin Expression in Human Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/26061570/) Hydrolyzed opuntia ficus-indica flower extract · Journal of Medicinal Food, 2015
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol vitamin e, Ferulic acid · Journal of Cosmetic Dermatology, 2020
- [Inhibitory effect of mulberroside A and its derivatives on melanogenesis induced by ultraviolet B irradiation](https://pubmed.ncbi.nlm.nih.gov/21946069/) Hydroxyresveratrol · Food and Chemical Toxicology, 2011
- [Clinical, biometric and structural evaluation of the long-term effects of a topical treatment with ascorbic acid and madecassoside in photoaged human skin](https://pubmed.ncbi.nlm.nih.gov/18503551/) Centella asiatica leaf extract · Experimental Dermatology, 2008
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia](https://pubmed.ncbi.nlm.nih.gov/23963768/) Menthol · European Journal of Pain, 2014
- [Design, preparation, and evaluation of liposomal gel formulations for treatment of acne: in vitro and in vivo studies](https://pubmed.ncbi.nlm.nih.gov/30442066/) Lauric acid · Drug Development and Industrial Pharmacy, 2019
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [In vitro antioxidant, collagenase inhibition, and in vivo anti-wrinkle effects of combined formulation containing Punica granatum, Ginkgo biloba, Ficus carica, and Morus alba fruits extract](https://pubmed.ncbi.nlm.nih.gov/26203268/) Ginkgo biloba leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2015
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide](https://pubmed.ncbi.nlm.nih.gov/22916312/) Moisturizing factors nmf, Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012
- [Comparative study of efficacy and safety of 45% mandelic acid versus 30% salicylic acid peels in mild-to-moderate acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/31553119/) Mandelic acid · Journal of Cosmetic Dermatology, 2020
- [Another Reason for Using Caffeine in Dermocosmetics: Sunscreen Adjuvant](https://pubmed.ncbi.nlm.nih.gov/31130869/) Caffeine · Frontiers in Physiology, 2019
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone, Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin, Panthenol · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel leaf extract · Phytochemistry, 2001
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica leaf extract · Molecules, 2023
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2015
- [Changes in Skin Barrier Function after Repeated Exposition to Phospholipid-Based Surfactants and Sodium Dodecyl Sulfate In Vivo and Corneocyte Surface Analysis by Atomic Force Microscopy](https://pubmed.ncbi.nlm.nih.gov/33804924/) Sodium lauryl sulfate · Pharmaceutics, 2021
- [Efficacy of a topical serum containing L-ascorbic acid, neohesperidin, pycnogenol, tocopherol, and hyaluronic acid in relation to skin aging signs](https://pubmed.ncbi.nlm.nih.gov/35150043/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Antioxidant-based topical formulations influence on the inflammatory response of Japanese skin: A clinical study using non-invasive techniques](https://pubmed.ncbi.nlm.nih.gov/28385617/) Tetrahexyldecyl ascorbate · European Journal of Pharmaceutics and Biopharmaceutics, 2017
- [A dermocosmetic containing bakuchiol, Ginkgo biloba extract and mannitol improves the efficacy of adapalene in patients with acne vulgaris: result from a controlled randomized trial](https://pubmed.ncbi.nlm.nih.gov/25914553/) Bakuchiol · Clinical, Cosmetic and Investigational Dermatology, 2015
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Centella asiatica leaf extract · Journal of Cosmetic Dermatology, 2019
- [Retaining Skin Barrier Function Properties of the Stratum Corneum with Components of the Natural Moisturizing Factor-A Randomized, Placebo-Controlled Double-Blind In Vivo Study](https://pubmed.ncbi.nlm.nih.gov/33809557/) Moisturizing factors nmf · Molecules, 2021
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [A novel model of inflammatory pain in human skin involving topical application of sodium lauryl sulfate](https://pubmed.ncbi.nlm.nih.gov/20358390/) Sodium lauryl sulfate · Inflammation Research, 2010
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Evaluation of moisturizing and irritation potential of sacha inchi oil](https://pubmed.ncbi.nlm.nih.gov/31441999/) Plukenetia volubilis seed oil · Journal of Cosmetic Dermatology, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [A randomized, double-blind, vehicle-controlled study of a preparation containing undecylenoyl phenylalanine 2% in the treatment of solar lentigines](https://pubmed.ncbi.nlm.nih.gov/19874316/) Undecylenoyl phenylalanine · Clinical and Experimental Dermatology, 2010
- [In vivo and in vitro evaluation of octyl methoxycinnamate liposomes](https://pubmed.ncbi.nlm.nih.gov/24376350/) Ethylhexyl methoxycinnamate · International Journal of Nanomedicine, 2013
- [A retrospective assessment and comparison of the effectiveness of benzoyl peroxide; the combination of topical niacinamide, gallic acid, and lauric acid; and the combination of benzoyl peroxide and erythromycin in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/32390309/) Lauric acid · Dermatologic Therapy, 2020
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Centella asiatica leaf extract · International Journal of Pharmaceutics, 2024
- [Synergetic Effects of Aloe Vera Extract with Trimethylglycine for Targeted Aquaporin 3 Regulation and Long-Term Skin Hydration](https://pubmed.ncbi.nlm.nih.gov/38611819/) Betaine · Molecules, 2024
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 2-o-ethyl ascorbic acid · Polymers, 2023
- [Fractional microneedle radiofrequency with the application of vitamin C, E, and ferulic acid serum for neck skin rejuvenation: a prospective, double-blinded, split-neck, placebo-controlled trial](https://pubmed.ncbi.nlm.nih.gov/40464749/) Ferulic acid · The Journal of Dermatological Treatment, 2025
- [Microbicidal activity of tripotassium phosphate and fatty acids toward spoilage and pathogenic bacteria associated with poultry](https://pubmed.ncbi.nlm.nih.gov/16013388/) Myristic acid · Journal of Food Protection, 2005
- [Synergistic approach for acne vulgaris treatment using glycerosomes loaded with lincomycin and lauric acid: Formulation, in silico, in vitro, LC-MS/MS skin deposition assay and in vivo evaluation](https://pubmed.ncbi.nlm.nih.gov/37805147/) Lauric acid · International Journal of Pharmaceutics, 2023
- [Depth-dependent hydration dynamics in human skin: Vehicle-controlled efficacy assessment of a functional 10% urea plus NMF moisturizer by near-infrared confocal spectroscopic imaging (KOSIM IR) and capacitance method complemented by volunteer perception](https://pubmed.ncbi.nlm.nih.gov/35034387/) Moisturizing factors nmf · Skin Research and Technology, 2022
- [Effect of hydroxypropyl-β-cyclodextrin in fluid and semi-solid submicron emulsions on physiological skin parameters during regular in vivo application](https://pubmed.ncbi.nlm.nih.gov/33236374/) Cyclodextrin · International Journal of Cosmetic Science, 2021
- [Formulation of Ascorbic Acid and Betaine-based Therapeutic Deep Eutectic System for Enhanced Transdermal Delivery of Ascorbic Acid](https://pubmed.ncbi.nlm.nih.gov/38794349/) Betaine · Pharmaceutics, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Emulgels Containing Perilla frutescens Seed Oil, Moringa oleifera Seed Oil, and Mixed Seed Oil: Microemulsion and Safety Assessment](https://pubmed.ncbi.nlm.nih.gov/35745923/) Moringa oleifera seed oil · Polymers, 2022
- [Assessment of the efficacy and safety of a new complex skin cream in Asian women: A controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/28512843/) Hydroxyresveratrol · Journal of Cosmetic Dermatology, 2017
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Lactobionic acid in a natural alkylpolyglucoside-based vehicle: assessing safety and efficacy aspects in comparison to glycolic acid](https://pubmed.ncbi.nlm.nih.gov/20367666/) Pha polyhydroxy acid · Journal of Cosmetic Dermatology, 2010
- [Anatomical site differences of sodium lauryl sulfate-induced irritation: randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/30637727/) Sodium lauryl sulfate · The British Journal of Dermatology, 2019
- [A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants](https://pubmed.ncbi.nlm.nih.gov/16439809/) Dimethicone · Ostomy/wound Management, 2005
- [The use of different concentrations of betaine as a reducing irritation agent in soaps monitored visually and non-invasively](https://pubmed.ncbi.nlm.nih.gov/12535284/) Betaine · Skin Research and Technology, 2003
- [Skin recovery by Lavandula angustifolia leaf callus extract: Redox control of Nrf2 signaling](https://pubmed.ncbi.nlm.nih.gov/40345503/) Lavandula angustifolia oil lavender oil · Free Radical Biology & Medicine, 2025
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Moisturizing Effects of Diglycerol Combined with Glycerol on Human Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/27430380/) Diglycerin · Journal of Oleo Science, 2016
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Combining Topical and Oral Botanicals for Skin Redness, Pigmentation, Sleep, and Mood: A Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/36431167/) Theanine · Journal of Clinical Medicine, 2022
- [Antioxidant and membrane-protective effects of the 3-O-ethyl ascorbic acid-cannabigerol system on UVB-irradiated human keratinocytes](https://pubmed.ncbi.nlm.nih.gov/39778604/) 2-o-ethyl ascorbic acid · Free Radical Biology & Medicine, 2025
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [Transdermal Delivery of Baicalin Based on Bio-Vesicles and Its Efficacy in Antiaging of the Skin](https://pubmed.ncbi.nlm.nih.gov/39946269/) Scutellaria baicalensis root extract · Journal of Cosmetic Dermatology, 2025
- [Effect of isosecotanapartholide isolated from Artemisia princeps Pampanini on IL‑33 production and STAT‑1 activation in HaCaT keratinocytes](https://pubmed.ncbi.nlm.nih.gov/28447741/) Artemisia princeps leaf extract · Molecular Medicine Reports, 2017
- [Liposomal formulation of a vitamin C derivative: a promising strategy to increase skin permeability](https://pubmed.ncbi.nlm.nih.gov/39985147/) 2-o-ethyl ascorbic acid · Journal of Liposome Research, 2025
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 2-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [A Randomized Controlled Trial of the Genistein Plus Bakuchiol and Vitamins (GEN+) Product for Male Facial Skin: Effects on Skin Appearance and Properties](https://pubmed.ncbi.nlm.nih.gov/41562471/) Bakuchiol · Skin Research and Technology, 2026
- [A polyhydroxy acid skin care regimen provides antiaging effects comparable to an alpha-hydroxyacid regimen](https://pubmed.ncbi.nlm.nih.gov/15002657/) Pha polyhydroxy acid · Cutis, 2004
- [Potassium 4-Methoxysalicylate (4MSK) Exerts a Skin Lightening Effect by Acting on Melanocytes and Keratinocytes](https://pubmed.ncbi.nlm.nih.gov/40071590/) Potassium methoxysalicylate · Journal of Cosmetic Dermatology, 2025
- [New Chalcone-Derived Molecule for the Topical Regulation of Hyperpigmentation and Skin Aging](https://pubmed.ncbi.nlm.nih.gov/39598529/) Angelica keiskei leaf extract · Pharmaceutics, 2024
- [Mitigation of ultraviolet-induced erythema and inflammation by para-hydroxycinnamic acid in human skin](https://pubmed.ncbi.nlm.nih.gov/39138602/) Ethylhexyl methoxycinnamate · International Journal of Cosmetic Science, 2025
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl methoxycinnamate, Octocrylene · Archives of Dermatological Research, 2024
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025
- [Preclinical Safety Evaluation of Dual Drug-Loaded Nanolipidic Carriers of Dissolvable Patches: In-Vitro and In-Vivo Safety Assessment](https://pubmed.ncbi.nlm.nih.gov/41186117/) Tetrahydrodiferuloylmethane · Molecular Pharmaceutics, 2025
- [Acai Oil-Based Organogel Containing Hyaluronic Acid for Topical Cosmetic: In Vitro and Ex Vivo Assessment](https://pubmed.ncbi.nlm.nih.gov/39339231/) Euterpe oleracea fruit extract · Pharmaceutics, 2024
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026
- [Efficacy of anti-sebum moisturizing cream containing 2% l-carnitine and 5% epigallocatechin gallate in seborrhea: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/37194909/) Uji green tea extract · Journal of Cosmetic Dermatology, 2023
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Homosalate · Journal of Drugs in Dermatology, 2025

## The brands

- British skincare: [Medik8](https://lovi.care/skincare/es/brands/medik8)
- Japanese skincare: [Shiseido](https://lovi.care/skincare/es/brands/shiseido)

## More comparisons

- [SKIN1004 vs Medik8](https://lovi.care/skincare/es/compare/skin1004-vs-medik8)
- [SKIN1004 vs Shiseido](https://lovi.care/skincare/es/compare/skin1004-vs-shiseido)
- [Anua vs Medik8](https://lovi.care/skincare/es/compare/anua-vs-medik8)
- [Anua vs Shiseido](https://lovi.care/skincare/es/compare/anua-vs-shiseido)
- [Medicube vs Medik8](https://lovi.care/skincare/es/compare/medicube-vs-medik8)
- [Medicube vs Shiseido](https://lovi.care/skincare/es/compare/medicube-vs-shiseido)
- [The Ordinary vs Medik8](https://lovi.care/skincare/es/compare/the-ordinary-vs-medik8)
- [The Ordinary vs Shiseido](https://lovi.care/skincare/es/compare/the-ordinary-vs-shiseido)
- [Beauty of Joseon vs Medik8](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-medik8)
- [Beauty of Joseon vs Shiseido](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-shiseido)
- [COSRX vs Medik8](https://lovi.care/skincare/es/compare/cosrx-vs-medik8)
- [COSRX vs Shiseido](https://lovi.care/skincare/es/compare/cosrx-vs-shiseido)
- [CeraVe vs Medik8](https://lovi.care/skincare/es/compare/cerave-vs-medik8)
- [CeraVe vs Shiseido](https://lovi.care/skincare/es/compare/cerave-vs-shiseido)
- [La Roche-Posay vs Medik8](https://lovi.care/skincare/es/compare/la-roche-posay-vs-medik8)
- [La Roche-Posay vs Shiseido](https://lovi.care/skincare/es/compare/la-roche-posay-vs-shiseido)
- [Dr. Althea vs Medik8](https://lovi.care/skincare/es/compare/dr-althea-vs-medik8)
- [Dr. Althea vs Shiseido](https://lovi.care/skincare/es/compare/dr-althea-vs-shiseido)
- [Some By Mi vs Medik8](https://lovi.care/skincare/es/compare/some-by-mi-vs-medik8)
- [Some By Mi vs Shiseido](https://lovi.care/skincare/es/compare/some-by-mi-vs-shiseido)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/medik8-vs-shiseido
- United Kingdom: https://lovi.care/skincare/uk/compare/medik8-vs-shiseido
- Ireland: https://lovi.care/skincare/ie/compare/medik8-vs-shiseido
- Germany: https://lovi.care/skincare/de/compare/medik8-vs-shiseido
- France: https://lovi.care/skincare/fr/compare/medik8-vs-shiseido
- Italy: https://lovi.care/skincare/it/compare/medik8-vs-shiseido
- Netherlands: https://lovi.care/skincare/nl/compare/medik8-vs-shiseido
- Spain: https://lovi.care/skincare/es/compare/medik8-vs-shiseido (this page)
- Canada: https://lovi.care/skincare/ca/compare/medik8-vs-shiseido
- Australia: https://lovi.care/skincare/au/compare/medik8-vs-shiseido
- Singapore: https://lovi.care/skincare/sg/compare/medik8-vs-shiseido
- Saudi Arabia: https://lovi.care/skincare/sa/compare/medik8-vs-shiseido
- United Arab Emirates: https://lovi.care/skincare/ae/compare/medik8-vs-shiseido