# Kiehl's vs MAC

Page: https://lovi.care/skincare/es/compare/kiehl-s-vs-mac

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Kiehl's and MAC are two established beauty companies that offer distinct approaches to daily skincare routines. Kiehl's is an American brand beloved for its expertly formulated moisturizers, [serums](https://lovi.care/skincare/es/ingredients/serum), toners, and eye products incorporating nourishing [glycerin](https://lovi.care/skincare/es/ingredients/glycerin) and squalane, which suit combination skin and mature skin best. Meanwhile, the Canadian brand MAC is known for its thoughtful selection of reliable moisturizers and makeup removers crafted from balanced formulas that suit balanced skin best. While both feature targeted solutions for acne-prone skin, dark spots, and mature skin, they differ in their foundational ingredients and overall formulation focus.

Kiehl's is an American skincare brand founded in 1851 and owned by L'Oréal S.A. since 2000.

[loreal.com](https://www.loreal.com/en/press-release/group/loral-acquires-kiehls-deal-expands-lorals-role-in-prestige-market/) [en.wikipedia.org](https://en.wikipedia.org/wiki/L%27Or%C3%A9al)

MAC is a Canadian skincare brand founded in 1984 and owned by The Estée Lauder Companies Inc. since 1994.

[elcompanies.com](https://www.elcompanies.com/en-gb/our-brands/mac) [en.wikipedia.org](https://en.wikipedia.org/wiki/Est%C3%A9e_Lauder_Companies)

This page compares some of the most popular Kiehl's and MAC products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg697b7acb81).

### Popular Kiehl's vs MAC products

#### MAC

- [Hyper Real Serumizer](https://lovi.care/skincare/es/p/mac/hyper-real-serumizer/for/dry-sensitive-skin) — High fit — [€55.20 at Lookfantastic](https://www.lookfantastic.es/p/mac-hyper-real-serumizertm-skin-balancing-hydration-serum-30ml/14194687/)
- [Mineralize Timecheck Lotion](https://lovi.care/skincare/es/p/mac/mineralize-timecheck-lotion/for/dry-skin) — High fit
- [Hyper Real Fresh Canvas Cleansing Oil](https://lovi.care/skincare/es/p/mac/hyper-real-fresh-canvas-cleansing-oil/for/dry-sensitive-skin) — High fit

#### Kiehl's

- [Ultra Facial Cream](https://lovi.care/skincare/es/p/kiehl-s/ultra-facial-cream/for/dark-spots) — Average fit — [€20.95 at Amazon](https://www.amazon.de/dp/B004JVSGWU?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Creamy Eye Treatment with Avocado](https://lovi.care/skincare/es/p/kiehl-s/creamy-eye-treatment-with-avocado/for/dry-skin) — Average fit — [€32.95 at Amazon](https://www.amazon.de/dp/B008KMZ8FC?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Clearly Corrective™ Dark Spot Solution](https://lovi.care/skincare/es/p/kiehl-s/clearly-correctivetm-dark-spot-solution/for/oily-skin) — High fit — [€48.95 at Amazon](https://www.amazon.de/dp/B0077TLO4I?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Rare Earth Deep Pore Cleansing Masque](https://lovi.care/skincare/es/p/kiehl-s/rare-earth-deep-pore-cleansing-masque/for/oily-skin) — High fit — [€28.85 at Amazon](https://www.amazon.de/dp/B0FGXQRRC7?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Retinol Skin-Renewing Daily Micro-Dose Serum](https://lovi.care/skincare/es/p/kiehl-s/retinol-skin-renewing-daily-micro-dose-serum/for/mature-skin) — High fit — [€55.45 at Amazon](https://www.amazon.de/dp/B098TSRWLZ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Midnight Recovery Concentrate](https://lovi.care/skincare/es/p/kiehl-s/midnight-recovery-concentrate/for/dry-sensitive-skin) — High fit — [€54.78 at Amazon](https://www.amazon.de/dp/B007KKTTLE?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Better Screen UV Serum](https://lovi.care/skincare/es/p/kiehl-s/better-screen-uv-serum/for/dark-spots) — High fit — [€41.06 at Lookfantastic](https://www.lookfantastic.es/p/kiehl-s-better-screen-uv-serum-sunscreen-spf50-50ml/17696040/)
- [Super Multi-Corrective Cream](https://lovi.care/skincare/es/p/kiehl-s/super-multi-corrective-cream/for/dry-skin) — High fit — [€53.30 at Amazon](https://www.amazon.de/dp/B08KJ5F26D?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## People Say

Kiehl's

MAC

- Lightweight and Non-Greasy Texture Mostly Mentioned Mostly Mentioned “absorbs quickly — MAC Hyper Real Serumizer” “Absorbs in a snap — MAC Mineralize Timecheck Lotion” “Emulsifies beautifully and rinses off without a greasy film. — MAC Hyper Real Fresh Canvas Cleansing Oil” “feels like nothing — Kiehl's Better Screen UV Serum”
- Makeup Base and Primer Compatibility Sometimes Noted Mostly Mentioned “foundation glides on — MAC Hyper Real Serumizer” “Sits beautifully under makeup — MAC Mineralize Timecheck Lotion” “Reduces appearance of pores — MAC Mineralize Timecheck Lotion” “concealer glides on smoothly — Kiehl's Creamy Eye Treatment with Avocado”
- Brightening and Radiance Often Mentioned Often Mentioned “Acne marks are gone — Kiehl's Clearly Corrective™ Dark Spot Solution” “works on dark skin — Kiehl's Better Screen UV Serum” “woke up glowing — Kiehl's Midnight Recovery Concentrate” “lit-from-within look — MAC Hyper Real Serumizer”
- Gentle and Sensitive Skin Friendly Often Mentioned Often Mentioned “experienced zero irritation — Kiehl's Retinol Skin-Renewing Daily Micro-Dose Serum” “fragrance-free — Kiehl's Ultra Facial Cream” “Does not cause breakouts — MAC Mineralize Timecheck Lotion” “Doesn't sting my eyes or blur my vision. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- Skin Barrier and Texture Improvement Often Mentioned Sometimes Noted “leaves skin feeling silky — Kiehl's Powerful-Strength Line-Reducing Concentrate” “skin feels smoother — Kiehl's Retinol Skin-Renewing Daily Micro-Dose Serum” “skin looked & felt smoother — Kiehl's Super Multi-Corrective Cream” “petal-soft skin — MAC Hyper Real Serumizer”
- Deep and Intense Hydration Often Mentioned Not noted “Keeps skin moisturized for 24+ hours — Kiehl's Ultra Facial Cream” “Feels like a drink of water — Kiehl's Hydro-Plumping Serum Concentrate” “savior for dry patches — Kiehl's Creamy Eye Treatment with Avocado”
- High Price Point Mostly Mentioned Mostly Mentioned “pricy daily staple — Kiehl's Ultra Facial Cream” “Very expensive product — Kiehl's Clearly Corrective™ Dark Spot Solution” “too expensive — MAC Hyper Real Serumizer” “A bit expensive — MAC Mineralize Timecheck Lotion”
- Breakouts and Acne Sometimes Noted Sometimes Noted “caused cystic acne — Kiehl's Midnight Recovery Concentrate” “cystic acne for some — Kiehl's Ultra Facial Cream” “caused acne — MAC Hyper Real Serumizer” “Breaks me out, I got pimples from this. — MAC Hyper Real Fresh Canvas Cleansing Oil”
- Ineffective or Slow Results Sometimes Noted Sometimes Noted “Did absolutely nothing — Kiehl's Clearly Corrective™ Dark Spot Solution” “Takes months to see — Kiehl's Clearly Corrective™ Dark Spot Solution” “Don't expect miracles — MAC Mineralize Timecheck Lotion”
- Unpleasant Scent and Fragrance Rarely Noted Often Mentioned “smells clinical — Kiehl's Retinol Skin-Renewing Daily Micro-Dose Serum” “faint lab smell — Kiehl's Better Screen UV Serum” “smells like hot dog water — Kiehl's Powerful-Strength Line-Reducing Concentrate” “scent is overpowering — MAC Hyper Real Serumizer”

## Questions and answers

### Kiehl's or MAC: which is better?

Kiehl's and MAC both offer lightweight moisturizers, but Kiehl's is better suited for brightening, skin barrier improvement, and deep hydration across the products on this page. Lovi finds that Kiehl's fits combination skin, mature skin, and skin with dark spots best, whereas MAC focuses on makeup bases.

### What is the difference between Kiehl's and MAC?

Kiehl's offers a much larger variety of products on this page and tends to fit mature skin, combination skin, and skin with dark spots well, while MAC provides only three items focused mainly on lightweight moisture and makeup preparation. Reviewers note that MAC performs better for lightweight texture and makeup compatibility, whereas Kiehl's is favored for brightening and deep hydration.

### Kiehl's or MAC: which moisturizer is better?

Kiehl's offers a much wider selection of moisturizers on this page that provide deep hydration and skin texture improvement, whereas MAC features fewer options which are mostly mentioned for being lightweight.

### Which is more affordable, Kiehl's or MAC?

When it comes to affordability, reviewers report that both Kiehl's and MAC have a high price point. Lovi finds that the products on this page for both brands share this similar pricing concern.

### Which causes fewer breakouts, Kiehl's or MAC?

Both Kiehl's and MAC perform equally regarding breakouts according to reviewer feedback on the products on this page.

### How do the origins and parent companies of Kiehl's and MAC compare?

Kiehl's was founded in 1851 in the United States and has been owned by L'Oréal S.A. since 2000. In comparison, MAC was founded in 1984 in Canada and is owned by The Estée Lauder Companies Inc.

### Which brand has more fragrance-free products, Kiehl's or MAC?

Kiehl's has more fragrance-free products than MAC, as 26 of the 28 products on this page list no fragrance.

### Which skin types does Kiehl's fit best according to its brand-focused routines?

According to its brand-focused routines, Kiehl's fits combination skin, mature skin, and skin with dark spots best.

## Research behind their key ingredients

- [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000
- [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002
- [Topical menthol--a human model for cold pain by activation and sensitization of C nociceptors](https://pubmed.ncbi.nlm.nih.gov/14985268/) Peppermint extract · Brain, 2004
- [Mechanistic Basis and Clinical Evidence for the Applications of Nicotinamide (Niacinamide) to Control Skin Aging and Pigmentation](https://pubmed.ncbi.nlm.nih.gov/34439563/) Niacinamide · Antioxidants, 2021
- [Effects of Turmeric (Curcuma longa) on Skin Health: A Systematic Review of the Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/27213821/) Curcuma longa · Phytotherapy Research, 2016
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [The Effect of Aloe Vera Clinical Trials on Prevention and Healing of Skin Wound: A Systematic Review](https://pubmed.ncbi.nlm.nih.gov/30666070/) Aloe barbadensis leaf juice · Iranian Journal of Medical Sciences, 2019
- [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007
- [Peroxidated squalene induces the production of inflammatory mediators in HaCaT keratinocytes: a possible role in acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/16778793/) Squalane · The Journal of Investigative Dermatology, 2006
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017
- [Psychophysical study of the effects of topical application of menthol in healthy volunteers](https://pubmed.ncbi.nlm.nih.gov/16527405/) Menthol · Pain, 2006
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Antiaging effects of the mixture of Panax ginseng and Crataegus pinnatifida in human dermal fibroblasts and healthy human skin](https://pubmed.ncbi.nlm.nih.gov/28123324/) Panax ginseng root extract · Journal of Ginseng Research, 2017
- [Apigenin inhibits UVA-induced cytotoxicity in vitro and prevents signs of skin aging in vivo](https://pubmed.ncbi.nlm.nih.gov/27279007/) Chamomilla recutita flower extract matricaria flower extract · International Journal of Molecular Medicine, 2016
- [Panax ginseng induces human Type I collagen synthesis through activation of Smad signaling](https://pubmed.ncbi.nlm.nih.gov/16890388/) Panax ginseng root extract · Journal of Ethnopharmacology, 2007
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Myristic acid reduces skin inflammation and nociception](https://pubmed.ncbi.nlm.nih.gov/34811755/) Myristic acid · Journal of Food Biochemistry, 2022
- [Alteration of barrier properties, stratum corneum ceramides and microbiome composition in response to lotion application on cosmetic dry skin](https://pubmed.ncbi.nlm.nih.gov/35340018/) Ceramides · Scientific Reports, 2022
- [Effect of Camellia japonica oil on human type I procollagen production and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/17386986/) Camellia japonica seed oil · Journal of Ethnopharmacology, 2007
- [Calendula extract: effects on mechanical parameters of human skin](https://pubmed.ncbi.nlm.nih.gov/21928714/) Calendula officinalis flower · Acta Poloniae Pharmaceutica, 2011
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Tocopherol, Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A review of topical high-concentration L-menthol as a translational model of cold allodynia and hyperalgesia](https://pubmed.ncbi.nlm.nih.gov/23963768/) Menthol · European Journal of Pain, 2014
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [Quaternized carboxymethyl chitosan/organic montmorillonite nanocomposite as a novel cosmetic ingredient against skin aging](https://pubmed.ncbi.nlm.nih.gov/28732847/) Bentonite · Carbohydrate Polymers, 2017
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Adenosine-loaded dissolving microneedle patches to improve skin wrinkles, dermal density, elasticity and hydration](https://pubmed.ncbi.nlm.nih.gov/29574973/) Adenosine · International Journal of Cosmetic Science, 2018
- [Efficacy of a topical gel containing chitosan, chlorhexidine, allantoin and dexpanthenol for pain and inflammation control after third molar surgery: A randomized and placebo-controlled clinical trial](https://pubmed.ncbi.nlm.nih.gov/32683390/) Allantoin · Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Gluconolactone · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Self-Assembled Cubic Liquid Crystalline Nanoparticles for Transdermal Delivery of Paeonol](https://pubmed.ncbi.nlm.nih.gov/26517086/) Paeonia albiflora flower extract · Medical Science Monitor, 2015
- [A comparative study of gluconolactone versus benzoyl peroxide in the treatment of acne](https://pubmed.ncbi.nlm.nih.gov/1303072/) Gluconolactone · The Australasian Journal of Dermatology, 1992
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Paeonia albiflora flower extract · Molecules, 2023
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Fatty acids based α-Tocopherol loaded nanostructured lipid carrier gel: In vitro and in vivo evaluation for moisturizing and anti-aging effects](https://pubmed.ncbi.nlm.nih.gov/32129554/) Vitamin e · Journal of Cosmetic Dermatology, 2020
- [Natural Arctium lappa fruit extract improves the clinical signs of aging skin](https://pubmed.ncbi.nlm.nih.gov/19146605/) Arctium lappa root extract · Journal of Cosmetic Dermatology, 2008
- [Preparation and evaluation of anti-wrinkle cream containing saffron extract and avocado oil](https://pubmed.ncbi.nlm.nih.gov/31957954/) Avocado oil · Journal of Cosmetic Dermatology, 2020
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tetrapeptide-7, Palmitoyl tripeptide-1, Palmitoyl oligopeptide · Journal of Cosmetic Dermatology, 2015
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [Evaluation of the Antioxidant, Cytoprotective and Antityrosinase Effects of Schisandra chinensis Extracts and Their Applicability in Skin Care Product](https://pubmed.ncbi.nlm.nih.gov/36558009/) Schisandra chinensis fruit extract · Molecules, 2022
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [In vitro and in vivo studies with tetra-hydro-jasmonic acid (LR2412) reveal its potential to correct signs of skin ageing](https://pubmed.ncbi.nlm.nih.gov/23701744/) Jasmonic acid · Journal of the European Academy of Dermatology and Venereology, 2014
- [In vitro and in vivo anti-allergic effects of Arctium lappa L](https://pubmed.ncbi.nlm.nih.gov/18703753/) Arctium lappa root extract · Experimental Biology and Medicine, 2008
- [Stretchable skin hydrating PVB patches with controlled pores' size and shape for deliberate evening primrose oil spreading, transport and release](https://pubmed.ncbi.nlm.nih.gov/35929319/) Oenothera biennis oil, Oenothera biennis evening primrose oil · Biomaterials Advances, 2022
- [Effects of 1,3-propanediol associated, or not, with butylene glycol and/or glycerol on skin hydration and skin barrier function](https://pubmed.ncbi.nlm.nih.gov/37699769/) Propanediol · International Journal of Cosmetic Science, 2024
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Development of stable tocopherol succinate-loaded ethosomes to enhance transdermal permeation: In vitro and in vivo characterizations](https://pubmed.ncbi.nlm.nih.gov/35274433/) Vitamin e · Journal of Cosmetic Dermatology, 2022
- [Subclinical cutaneous inflammation remained after permeability barrier disruption enhances UV sensitivity by altering ER stress responses and topical pseudoceramide prevents them](https://pubmed.ncbi.nlm.nih.gov/28631090/) Ceramide ng · Archives of Dermatological Research, 2017
- [Clinical evaluation of the efficacy of a facial serum containing dioic acid, glycolic acid, salicylic acid, LHA, citric acid, and HEPES in treating post-inflammatory hyperchromia and controlling oily skin in patients with acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/33617668/) Capryloyl salicylic acid, Citric acid · Journal of Cosmetic Dermatology, 2021
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Assessment of Human Skin Gene Expression by Different Blends of Plant Extracts with Implications to Periorbital Skin Aging](https://pubmed.ncbi.nlm.nih.gov/30373163/) Schisandra chinensis fruit extract · International Journal of Molecular Sciences, 2018
- [Clinical tolerance and efficacy of capryloyl salicylic acid peel compared to a glycolic acid peel in subjects with fine lines/wrinkles and hyperpigmented skin](https://pubmed.ncbi.nlm.nih.gov/19146601/) Lipo-hydroxy acid · Journal of Cosmetic Dermatology, 2008
- [Damage and recovery of skin barrier function after glycolic acid chemical peeling and crystal microdermabrasion](https://pubmed.ncbi.nlm.nih.gov/15008867/) Alumina · Dermatologic Surgery, 2004
- [Partially purified paeoniflorin exerts protective effects on UV-induced DNA damage and reduces facial wrinkles in human skin](https://pubmed.ncbi.nlm.nih.gov/16676123/) Paeonia albiflora flower extract · Journal of Cosmetic Science, 2006
- [Clinical Development and Evaluation of a Multi-Component Dissolving Microneedle Patch for Skin Pigmentation Disorders](https://pubmed.ncbi.nlm.nih.gov/37571190/) 3-o-ethyl ascorbic acid · Polymers, 2023
- [Two-phase delivery using a horse oil and adenosine-loaded dissolving microneedle patch for skin barrier restoration, moisturization, and wrinkle improvement](https://pubmed.ncbi.nlm.nih.gov/30160014/) Adenosine · Journal of Cosmetic Dermatology, 2019
- [Preparation, characterization, and application of polysaccharide-based emulsions incorporated with lavender essential oil for skin-friendly cellulosic support](https://pubmed.ncbi.nlm.nih.gov/34547316/) Lavender essential oil · International Journal of Biological Macromolecules, 2021
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Microbicidal activity of tripotassium phosphate and fatty acids toward spoilage and pathogenic bacteria associated with poultry](https://pubmed.ncbi.nlm.nih.gov/16013388/) Myristic acid · Journal of Food Protection, 2005
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Rosa canina oil fruit, Shea butter · Journal of Cosmetic Dermatology, 2022
- [A controlled, three-part trial to investigate the barrier function and skin hydration properties of six skin protectants](https://pubmed.ncbi.nlm.nih.gov/16439809/) Dimethicone · Ostomy/wound Management, 2005
- [The evaluation of aluminum oxide crystal microdermabrasion for photodamage](https://pubmed.ncbi.nlm.nih.gov/11737128/) Alumina · Dermatologic Surgery, 2001
- [Skin barrier changes induced by aluminum oxide and sodium chloride microdermabrasion](https://pubmed.ncbi.nlm.nih.gov/12030870/) Alumina · Dermatologic Surgery, 2002
- [Propanediol (and) Caprylic Acid (and) Xylitol as a New Single Topical Active Ingredient against Acne: In Vitro and In Vivo Efficacy Assays](https://pubmed.ncbi.nlm.nih.gov/34771112/) Propanediol · Molecules, 2021
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus cucumber fruit extract juice, Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [Tocopherol succinate-loaded ethosomal gel synthesized by cold method technique: Deeper biophysical characterizations for translational application on human skin](https://pubmed.ncbi.nlm.nih.gov/38268219/) Vitamin e · Journal of Cosmetic Dermatology, 2024
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Thermostable hyaluronic acid-based dissolving microneedles with high-loading capacity: design, optimization, and transdermal delivery of anti-aging ingredients](https://pubmed.ncbi.nlm.nih.gov/41628877/) 3-o-ethyl ascorbic acid · International Journal of Biological Macromolecules, 2026
- [Genotoxicity of micro- and nano-particles of kaolin in human primary dermal keratinocytes and fibroblasts](https://pubmed.ncbi.nlm.nih.gov/32322315/) Kaolin · Genes and Environment, 2020
- [Translational Evaluation of a Disodium Adenosine Monophosphate (AMP2Na)-Based Topical Formulation for Physiology-Aligned Skin Rejuvenation: Integrated In Vitro, Ex Vivo, and Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/42278371/) Adenosine · International Journal of Molecular Sciences, 2026
- [Evaluation of additive effects of hydrolyzed jojoba (Simmondsia chinensis) esters and glycerol: a preliminary study](https://pubmed.ncbi.nlm.nih.gov/19146603/) Jojoba esters · Journal of Cosmetic Dermatology, 2008
- [Comparison of clindamycin 1% and benzoyl peroxide 5% gel to a novel composition containing salicylic acid, capryloyl salicylic acid, HEPES, glycolic acid, citric acid, and dioic acid in the treatment of acne vulgaris](https://pubmed.ncbi.nlm.nih.gov/23545907/) Capryloyl salicylic acid, Lipo-hydroxy acid · Journal of Drugs in Dermatology, 2013
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Histometric assessment of the age-related skin response to 2-hydroxy-5-octanoyl benzoic acid](https://pubmed.ncbi.nlm.nih.gov/9603669/) Capryloyl salicylic acid · Skin Pharmacology and Applied Skin Physiology, 1998
- [Clinical and histologic changes determine optimal treatment regimens for microdermabrasion](https://pubmed.ncbi.nlm.nih.gov/19753741/) Alumina · The Journal of Dermatological Treatment, 2002
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Activated c, Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Octocrylene · Archives of Dermatological Research, 2024
- [Clinical Assessment of a Novel Jasmonate Cosmeceutical, LR2412-Cx, for the Treatment of Skin Aging](https://pubmed.ncbi.nlm.nih.gov/26885790/) Jasmonic acid · Journal of Drugs in Dermatology, 2016
- [An integrated network pharmacology and molecular docking approach to reveal the role of Arctigenin against Cutibacterium acnes-induced skin inflammation by targeting the CYP19A1](https://pubmed.ncbi.nlm.nih.gov/39090783/) Arctium lappa root extract · Chemical Biology & Drug Design, 2024
- [Efficacy and safety of a facial serum and a mask containing salicylic acid and lipohydroxy acid in acne management: A randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/36999489/) Lipo-hydroxy acid · Journal of Cosmetic Dermatology, 2023
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Butyrospermum parkii butter shea butter · Lasers in Medical Science, 2025
- [The Therapeutic Effects of a Bentonite-Based Facial Mask With Alcea sulphurea Extract on Acne Severity and Patient Experience: Add-On Randomized Controlled Clinical Trial](https://pubmed.ncbi.nlm.nih.gov/41347526/) Bentonite · Journal of Cosmetic Dermatology, 2025
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Octisalate, Homosalate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1, Palmitoyl oligopeptide · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1 · International Journal of Cosmetic Science, 2026
- [Split-face evaluation: Gluconolactone plus oxybrasion versus gluconolactone plus microneedling. The effects on skin parameters](https://pubmed.ncbi.nlm.nih.gov/37357656/) Gluconolactone · Skin Research and Technology, 2023
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026
- [Synergistic combination: Developing a natural carrier-free assembled gel through hydrogen bond reconstruction strategy for efficient skin photo-damage restoration](https://pubmed.ncbi.nlm.nih.gov/41129958/) Sodium pca · Biomaterials Advances, 2026

## The brands

- American skincare: [Kiehl's](https://lovi.care/skincare/es/brands/kiehl-s)
- Canadian skincare: [MAC](https://lovi.care/skincare/es/brands/mac)

## More comparisons

- [SKIN1004 vs Kiehl's](https://lovi.care/skincare/es/compare/skin1004-vs-kiehl-s)
- [SKIN1004 vs MAC](https://lovi.care/skincare/es/compare/skin1004-vs-mac)
- [Anua vs Kiehl's](https://lovi.care/skincare/es/compare/anua-vs-kiehl-s)
- [Anua vs MAC](https://lovi.care/skincare/es/compare/anua-vs-mac)
- [Medicube vs Kiehl's](https://lovi.care/skincare/es/compare/medicube-vs-kiehl-s)
- [Medicube vs MAC](https://lovi.care/skincare/es/compare/medicube-vs-mac)
- [The Ordinary vs Kiehl's](https://lovi.care/skincare/es/compare/the-ordinary-vs-kiehl-s)
- [The Ordinary vs MAC](https://lovi.care/skincare/es/compare/the-ordinary-vs-mac)
- [Beauty of Joseon vs Kiehl's](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-kiehl-s)
- [Beauty of Joseon vs MAC](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-mac)
- [COSRX vs Kiehl's](https://lovi.care/skincare/es/compare/cosrx-vs-kiehl-s)
- [COSRX vs MAC](https://lovi.care/skincare/es/compare/cosrx-vs-mac)
- [CeraVe vs Kiehl's](https://lovi.care/skincare/es/compare/cerave-vs-kiehl-s)
- [CeraVe vs MAC](https://lovi.care/skincare/es/compare/cerave-vs-mac)
- [La Roche-Posay vs Kiehl's](https://lovi.care/skincare/es/compare/la-roche-posay-vs-kiehl-s)
- [La Roche-Posay vs MAC](https://lovi.care/skincare/es/compare/la-roche-posay-vs-mac)
- [Dr. Althea vs Kiehl's](https://lovi.care/skincare/es/compare/dr-althea-vs-kiehl-s)
- [Dr. Althea vs MAC](https://lovi.care/skincare/es/compare/dr-althea-vs-mac)
- [Some By Mi vs Kiehl's](https://lovi.care/skincare/es/compare/some-by-mi-vs-kiehl-s)
- [Some By Mi vs MAC](https://lovi.care/skincare/es/compare/some-by-mi-vs-mac)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/kiehl-s-vs-mac
- United Kingdom: https://lovi.care/skincare/uk/compare/kiehl-s-vs-mac
- Ireland: https://lovi.care/skincare/ie/compare/kiehl-s-vs-mac
- Germany: https://lovi.care/skincare/de/compare/kiehl-s-vs-mac
- France: https://lovi.care/skincare/fr/compare/kiehl-s-vs-mac
- Italy: https://lovi.care/skincare/it/compare/kiehl-s-vs-mac
- Netherlands: https://lovi.care/skincare/nl/compare/kiehl-s-vs-mac
- Spain: https://lovi.care/skincare/es/compare/kiehl-s-vs-mac (this page)
- Canada: https://lovi.care/skincare/ca/compare/kiehl-s-vs-mac
- Australia: https://lovi.care/skincare/au/compare/kiehl-s-vs-mac
- Singapore: https://lovi.care/skincare/sg/compare/kiehl-s-vs-mac
- Saudi Arabia: https://lovi.care/skincare/sa/compare/kiehl-s-vs-mac
- United Arab Emirates: https://lovi.care/skincare/ae/compare/kiehl-s-vs-mac