# Jole vs Sesderma Page: https://lovi.care/skincare/es/compare/jole-vs-sesderma The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain. Sesderma is a Spanish skincare brand founded in 1989 and owned by Grupo Sesderma since 2026. [skinexpert.sesderma.com](https://skinexpert.sesderma.com/en/jb-capital-joins-the-shareholding-of-sesderma-group-as-a-strategic-partner/) [sesderma.com](https://www.sesderma.com/us_en/about-us.html) This page compares some of the most popular Jole and Sesderma products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg76f579eb38). ### Popular Jole vs Sesderma products #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) #### Jole - [Azelaic Acid 10% Serum](https://lovi.care/skincare/es/p/jole/azelaic-acid-10-serum/for/combination-skin) — High fit ### Jole vs Sesderma [serums](https://lovi.care/skincare/es/ingredients/serum) and treatments #### Sesderma - [Azelac RU Serum](https://lovi.care/skincare/es/p/sesderma/azelac-ru-serum/for/acne-prone-skin) — High fit — [€35.16 at Amazon](https://www.amazon.de/dp/B00987RKWW?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1) #### Jole - [Azelaic Acid 10% Serum](https://lovi.care/skincare/es/p/jole/azelaic-acid-10-serum/for/combination-skin) — High fit ## Questions and answers ### Jole or Sesderma: which is better? Both brands have strong picks, but Jole fits sensitive skin better with a High Lovi rating across the products on this page and zero fragrance. Sesderma's Azelac RU [Serum](https://lovi.care/skincare/es/ingredients/serum) also earns a High Lovi fit for acne-prone skin and dark spots, though it contains fragrance. ### What is the difference between Jole and Sesderma? Jole has no fragrance in the products on this page, whereas Sesderma includes fragrance in its Azelac RU Serum. For sensitive skin, Lovi fit is High with Jole and Average with Sesderma. ### Which is more affordable, Jole or Sesderma? This page does not provide pricing information for either Jole or Sesderma, so affordability cannot be compared here. ### Which brand has been established longer, Jole or Sesderma? Sesderma has been established longer, having been founded in Spain in 1989, whereas Jole was founded more recently in 2019. ### Do products from Jole or Sesderma contain fragrance? Every product on this page from Jole lists no fragrance in its ingredients, whereas the Azelac RU Serum from Sesderma contains fragrance. ## Research behind their key ingredients - [Vitamin A antagonizes decreased cell growth and elevated collagen-degrading matrix metalloproteinases and stimulates collagen accumulation in naturally aged human skin](https://pubmed.ncbi.nlm.nih.gov/10692106/) Retinol · The Journal of Investigative Dermatology, 2000 - [The effect of niacinamide on reducing cutaneous pigmentation and suppression of melanosome transfer](https://pubmed.ncbi.nlm.nih.gov/12100180/) Niacinamide · The British Journal of Dermatology, 2002 - [Improvement of naturally aged skin with vitamin A (retinol)](https://pubmed.ncbi.nlm.nih.gov/17515510/) Retinol · Archives of Dermatology, 2007 - [Nicotinic acid/niacinamide and the skin](https://pubmed.ncbi.nlm.nih.gov/17147561/) Niacin · Journal of Cosmetic Dermatology, 2004 - [Molecular basis of retinol anti-ageing properties in naturally aged human skin in vivo](https://pubmed.ncbi.nlm.nih.gov/27261203/) Retinol · International Journal of Cosmetic Science, 2017 - [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Retinol · The British Journal of Dermatology, 2019 - [Effects of glyceryl glucoside on AQP3 expression, barrier function and hydration of human skin](https://pubmed.ncbi.nlm.nih.gov/22584263/) Glyceryl glucoside · Skin Pharmacology and Physiology, 2012 - [Efficacy and Safety of Azelaic Acid Nanocrystal-Loaded In Situ Hydrogel in the Treatment of Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/33923739/) Azelaic acid · Pharmaceutics, 2021 - [A topical lipophilic niacin derivative increases NAD, epidermal differentiation and barrier function in photodamaged skin](https://pubmed.ncbi.nlm.nih.gov/17518989/) Niacin · Experimental Dermatology, 2007 - [Treatment of xerosis with a topical formulation containing glyceryl glucoside, natural moisturizing factors, and ceramide](https://pubmed.ncbi.nlm.nih.gov/22916312/) Glyceryl glucoside · The Journal of Clinical and Aesthetic Dermatology, 2012 - [Effects of 15% Azelaic Acid Gel in the Management of Post-Inflammatory Erythema and Post-Inflammatory Hyperpigmentation in Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/38734843/) Azelaic acid · Dermatology and Therapy, 2024 - [The usefulness of a dermocosmetic containing Myrtus communis extract and azelaic acid for maintenance phase of adult female acne: Results from a randomized exploratory investigator-blinded comparative study](https://pubmed.ncbi.nlm.nih.gov/36729399/) Azelaic acid · Journal of the European Academy of Dermatology and Venereology, 2023 - [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998 - [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025 - [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021 - [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024 ## The brands - Skincare: [Jole](https://lovi.care/skincare/es/brands/jole) - Spanish skincare: [Sesderma](https://lovi.care/skincare/es/brands/sesderma) ## More comparisons - [SKIN1004 vs Jole](https://lovi.care/skincare/es/compare/skin1004-vs-jole) - [SKIN1004 vs Sesderma](https://lovi.care/skincare/es/compare/skin1004-vs-sesderma) - [Anua vs Jole](https://lovi.care/skincare/es/compare/anua-vs-jole) - [Anua vs Sesderma](https://lovi.care/skincare/es/compare/anua-vs-sesderma) - [Medicube vs Jole](https://lovi.care/skincare/es/compare/medicube-vs-jole) - [Medicube vs Sesderma](https://lovi.care/skincare/es/compare/medicube-vs-sesderma) - [The Ordinary vs Jole](https://lovi.care/skincare/es/compare/the-ordinary-vs-jole) - [The Ordinary vs Sesderma](https://lovi.care/skincare/es/compare/the-ordinary-vs-sesderma) - [Beauty of Joseon vs Jole](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-jole) - [Beauty of Joseon vs Sesderma](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-sesderma) - [COSRX vs Jole](https://lovi.care/skincare/es/compare/cosrx-vs-jole) - [COSRX vs Sesderma](https://lovi.care/skincare/es/compare/cosrx-vs-sesderma) - [CeraVe vs Jole](https://lovi.care/skincare/es/compare/cerave-vs-jole) - [CeraVe vs Sesderma](https://lovi.care/skincare/es/compare/cerave-vs-sesderma) - [La Roche-Posay vs Jole](https://lovi.care/skincare/es/compare/la-roche-posay-vs-jole) - [La Roche-Posay vs Sesderma](https://lovi.care/skincare/es/compare/la-roche-posay-vs-sesderma) - [Dr. Althea vs Jole](https://lovi.care/skincare/es/compare/dr-althea-vs-jole) - [Dr. Althea vs Sesderma](https://lovi.care/skincare/es/compare/dr-althea-vs-sesderma) - [Some By Mi vs Jole](https://lovi.care/skincare/es/compare/some-by-mi-vs-jole) - [Some By Mi vs Sesderma](https://lovi.care/skincare/es/compare/some-by-mi-vs-sesderma) ## About the Lovi Fit Lovi: Unbiased, science-based skincare AI trained on real user outcomes. Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning. Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board). Page built Nov 8, 2026. More from Lovi: https://lovi.care/skincare/llms.txt ## This page in other countries - United States: https://lovi.care/skincare/compare/jole-vs-sesderma - United Kingdom: https://lovi.care/skincare/uk/compare/jole-vs-sesderma - Ireland: https://lovi.care/skincare/ie/compare/jole-vs-sesderma - Germany: https://lovi.care/skincare/de/compare/jole-vs-sesderma - France: https://lovi.care/skincare/fr/compare/jole-vs-sesderma - Italy: https://lovi.care/skincare/it/compare/jole-vs-sesderma - Netherlands: https://lovi.care/skincare/nl/compare/jole-vs-sesderma - Spain: https://lovi.care/skincare/es/compare/jole-vs-sesderma (this page) - Canada: https://lovi.care/skincare/ca/compare/jole-vs-sesderma - Australia: https://lovi.care/skincare/au/compare/jole-vs-sesderma - Singapore: https://lovi.care/skincare/sg/compare/jole-vs-sesderma - Saudi Arabia: https://lovi.care/skincare/sa/compare/jole-vs-sesderma - United Arab Emirates: https://lovi.care/skincare/ae/compare/jole-vs-sesderma