# ISDIN vs FRE

Page: https://lovi.care/skincare/es/compare/isdin-vs-fre

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

ISDIN and FRE are two skincare brands known for their nourishing formulas and targeted product types. The Spanish brand founded in 1975 and owned by Puig is beloved for its thoughtful moisturizers, advanced sunscreens, targeted [serums](https://lovi.care/skincare/es/ingredients/serum), and soothing eye products driven by expert formulas, while the other is widely loved for its similar offerings. Both brands suit acne-prone skin best, though the former also suits mature skin best with options like the Fusion [Water](https://lovi.care/skincare/es/ingredients/water) for acne-prone skin, the Eryfotona Actinica for skin with dark spots, and the K-Ox Eyes, whereas the latter features standout products like the [Argan Oil](https://lovi.care/skincare/es/ingredients/argan-oil) for acne-prone skin. They differ in their specific compositions and the broader range of skin types they accommodate, with the former delivering reliable daily support that maintains skin health with quiet elegance and the latter working to gently balance and support the complexion.

ISDIN is a Spanish skincare brand founded in 1975 and owned by Puig.

[puig.com](https://www.puig.com/en/newsroom/new-chapter-for-Isdin-Puig-to-assume-full-ownership/) [beautymatter.com](https://beautymatter.com/articles/puig-to-take-full-ownership-of-isdin-in-1-39-billion-deal) [uploads.puig.com](https://uploads.puig.com/uploads/Puig_NP_Sept_14_EN_fc21e2f47a.pdf)

This page compares some of the most popular ISDIN and FRE products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg32af97cc66).

### Popular ISDIN vs FRE products

#### ISDIN

- [Eryfotona Actinica](https://lovi.care/skincare/es/p/isdin/eryfotona-actinica/for/mature-skin) — Superior fit — [€32.49 at Amazon](https://www.amazon.de/dp/B0875W6QQG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Fusion Water](https://lovi.care/skincare/es/p/isdin/fusion-water/for/dry-sensitive-skin) — Superior fit — [€25.99 at Amazon](https://www.amazon.de/dp/B00Z72U6JQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [K-Ox Eyes](https://lovi.care/skincare/es/p/isdin/k-ox-eyes/for/dry-skin) — High fit — [€49.00 at Amazon](https://www.amazon.de/dp/B01BMLQ4JQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Hyaluronic Concentrate](https://lovi.care/skincare/es/p/isdin/hyaluronic-concentrate/for/sensitive-skin) — High fit
- [Hyaluronic Moisture](https://lovi.care/skincare/es/p/isdin/hyaluronic-moisture/for/dry-sensitive-skin) — Average fit
- [Flavo-C Serum](https://lovi.care/skincare/es/p/isdin/flavo-c-serum/for/sensitive-skin) — High fit — [€44.30 at Amazon](https://www.amazon.de/dp/B01BMLQ086?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Uradin Lotion 10](https://lovi.care/skincare/es/p/isdin/uradin-lotion-10/for/dry-skin) — High fit
- [Retinal Intense Serum](https://lovi.care/skincare/es/p/isdin/retinal-intense-serum/for/acne-prone-skin) — High fit — [€59.55 at Amazon](https://www.amazon.de/dp/B0BD9DK6SC?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

#### FRE

- [Argan Oil](https://lovi.care/skincare/es/p/fre/argan-oil/for/dry-sensitive-skin) — High fit

## Questions and answers

### ISDIN or FRE: which is better?

ISDIN is the better option here, as the products on this page offer superior or high Lovi fit levels for a wide range of skin types and concerns like mature and sensitive skin. In comparison, FRE has only one product on this page with a limited fit. Additionally, topical [argan oil](https://lovi.care/skincare/es/ingredients/argan-oil) helps improve skin hydration.

[International Journal of Nanomedicine, 2014](https://pubmed.ncbi.nlm.nih.gov/25143733/)

### What is the difference between ISDIN and FRE?

ISDIN offers a larger variety of products on this page with different fit levels across skin types, whereas FRE features only Argan Oil with no added fragrance across its range. ISDIN products on this page often feature ultralight sunscreens and lightweight moisturizers alongside a higher price point.

### Which is more affordable, ISDIN or FRE?

The products on this page for ISDIN are often noted by reviewers for having a high price point, while FRE is represented on this page by only a single product, Argan Oil, so a direct affordability comparison across both ranges is not possible here.

### Which causes fewer breakouts, ISDIN or FRE?

FRE features only Argan Oil on this page, which has an Average fit for acne-prone skin, while the products on this page from ISDIN range from High to Caution or Warning for acne-prone skin.

### How does the founding year and ownership of ISDIN compare to FRE?

ISDIN was founded in 1975 in Spain and is owned by Puig, whereas FRE was founded in 2016 and is independently owned.

### Which brand has more fragrance-free products, ISDIN or FRE?

ISDIN has more fragrance-free products on this page than FRE, with three completely fragrance-free items compared to FRE's one. However, FRE's single product lists no fragrance, whereas five of ISDIN's eight products contain added fragrance.

### What are the best-rated skin types for ISDIN products versus FRE products?

ISDIN products on this page have a High to Superior Lovi fit for sensitive, mature, and dry skin types, whereas FRE products on this page have a High fit only for dry sensitive skin and average or low fit for others.

## Research behind their key ingredients

- [Skin delivery of epigallocatechin-3-gallate (EGCG) and hyaluronic acid loaded nano-transfersomes for antioxidant and anti-aging effects in UV radiation induced skin damage](https://pubmed.ncbi.nlm.nih.gov/28155509/) Antioxidants · Drug Delivery, 2017
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate, Hyaluronic acid · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid, Tocopherol · Journal of Cosmetic Dermatology, 2020
- [Prospective, randomized, double-blind assessment of topical bakuchiol and retinol for facial photoageing](https://pubmed.ncbi.nlm.nih.gov/29947134/) Bakuchiol · The British Journal of Dermatology, 2019
- [Antiaging efficacy of melatonin-based day and night creams: a randomized, split-face, assessor-blinded proof-of-concept trial](https://pubmed.ncbi.nlm.nih.gov/29416368/) Melatonin · Clinical, Cosmetic and Investigational Dermatology, 2018
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Design, characterization, and clinical evaluation of argan oil nanostructured lipid carriers to improve skin hydration](https://pubmed.ncbi.nlm.nih.gov/25143733/) Argania spinosa kernel oil argan kernel oil · International Journal of Nanomedicine, 2014
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [Randomized controlled study for the anti-aging effect of human adipocyte-derived mesenchymal stem cell media combined with niacinamide after laser therapy](https://pubmed.ncbi.nlm.nih.gov/33103316/) Niacinamide · Journal of Cosmetic Dermatology, 2021
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol · The Journal of Dermatological Treatment, 2017
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Senomorphic activity of a combination of niacinamide and hyaluronic acid: correlation with clinical improvement of skin aging](https://pubmed.ncbi.nlm.nih.gov/39009698/) Niacinamide · Scientific Reports, 2024
- [Biomimetic hyaluronic acid-stabilized zinc oxide nanoparticles in acne treatment: A preclinical and clinical approach](https://pubmed.ncbi.nlm.nih.gov/40254135/) Zinc oxide · Journal of Controlled Release, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid · Journal of Cosmetic Dermatology, 2024
- [Evaluation of dermal extracellular matrix and epidermal-dermal junction modifications using matrix-assisted laser desorption/ionization mass spectrometric imaging, in vivo reflectance confocal microscopy, echography, and histology: effect of age and peptide applications](https://pubmed.ncbi.nlm.nih.gov/25817264/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · Journal of Cosmetic Dermatology, 2015
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Botulinum toxin injection as a single or combined treatment with non-cross-linked high molecular weight and low molecular weight hyaluronic acid gel for neck rejuvenation: A randomized clinical trial](https://pubmed.ncbi.nlm.nih.gov/35775872/) Hydrolyzed hyaluronic acid · Dermatologic Therapy, 2022
- [Comparison of methods for assessing photoprotection against ultraviolet A in vivo](https://pubmed.ncbi.nlm.nih.gov/3819071/) Butyl methoxydibenzoylmethane · Journal of the American Academy of Dermatology, 1987
- [Using ordered mesoporous silica SBA-15 to limit cutaneous penetration and transdermal permeation of organic UV filters](https://pubmed.ncbi.nlm.nih.gov/31437563/) Butyl methoxydibenzoylmethane · International Journal of Pharmaceutics, 2019
- [Topical Zinc Oxide Nanoparticle Formulations for Acne Vulgaris: A Systematic Review of Pre-Clinical and Early-Phase Clinical Evidence](https://pubmed.ncbi.nlm.nih.gov/41007718/) Zinc oxide · Biomedicines, 2025
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Enhancing Photoprotection and Mitigating Ex Vivo Stratum Corneum Oxidative Stress: A Multifunctional Strategy Combining Rosmarinic Acid with UVB Filters](https://pubmed.ncbi.nlm.nih.gov/40227214/) Octocrylene · Antioxidants, 2025
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol · Journal of Cosmetic Dermatology, 2025
- [TiO2-embedded mesoporous silica with lower porosity is beneficial to adsorb the pollutants and retard UV filter absorption: A possible application for outdoor skin protection](https://pubmed.ncbi.nlm.nih.gov/36455708/) Butyl methoxydibenzoylmethane · European Journal of Pharmaceutical Sciences, 2023
- [Efficacy and Tolerability of Stable Hybrid Cooperative Complexes of High- and Low-Molecular Weight Hyaluronic Acid in Asian Patients: An Open-Label Study](https://pubmed.ncbi.nlm.nih.gov/40921777/) Hydrolyzed hyaluronic acid · Aesthetic Plastic Surgery, 2026
- [Ginkgo biloba leaves extract's cosmeceutical evaluation: a preliminary assessments on human volunteers towards achieving improved skin condition and rejuvenation](https://pubmed.ncbi.nlm.nih.gov/37074796/) Ginkgo biloba leaf extract · Drug Development and Industrial Pharmacy, 2023
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Nanocomplex of quaternized cyclodextrin grafted chitosan and hyaluronic acid for a skin delivery](https://pubmed.ncbi.nlm.nih.gov/36279763/) Hydrolyzed hyaluronic acid · Colloids and Surfaces. B, Biointerfaces, 2022
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [Facial disbiosis and UV filters](https://pubmed.ncbi.nlm.nih.gov/39499337/) Ethylhexyl salicylate · Archives of Dermatological Research, 2024
- [The clinical efficacy of a new emulsion for acne and conspicuous facial pore amelioration](https://pubmed.ncbi.nlm.nih.gov/38140770/) Lens esculenta seed extract · Journal of Cosmetic Dermatology, 2024
- [Retrospective Review of Dermal Safety Studies of Organic Sunscreens](https://pubmed.ncbi.nlm.nih.gov/40911743/) Ethylhexyl salicylate · Journal of Drugs in Dermatology, 2025
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Palmitoyl tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Mechanistic understanding and peptide ingredient screening for type III collagen via biological knowledge graph and molecular docking](https://pubmed.ncbi.nlm.nih.gov/42683869/) Palmitoyl tripeptide-1, Palmitoyl tetrapeptide-7 · International Journal of Cosmetic Science, 2026
- [Prospective, Randomized, Double-Blind Assessment of Supramolecular Bakuchiol and Terminalia Chebula Extract for Facial Photoaging in Chinese Sensitive Skin Population](https://pubmed.ncbi.nlm.nih.gov/41424674/) Bakuchiol · Health Science Reports, 2025

## The brands

- Spanish skincare: [ISDIN](https://lovi.care/skincare/es/brands/isdin)
- Skincare: [FRE](https://lovi.care/skincare/es/brands/fre)

## More comparisons

- [SKIN1004 vs ISDIN](https://lovi.care/skincare/es/compare/skin1004-vs-isdin)
- [SKIN1004 vs FRE](https://lovi.care/skincare/es/compare/skin1004-vs-fre)
- [Anua vs ISDIN](https://lovi.care/skincare/es/compare/anua-vs-isdin)
- [Anua vs FRE](https://lovi.care/skincare/es/compare/anua-vs-fre)
- [Medicube vs ISDIN](https://lovi.care/skincare/es/compare/medicube-vs-isdin)
- [Medicube vs FRE](https://lovi.care/skincare/es/compare/medicube-vs-fre)
- [The Ordinary vs ISDIN](https://lovi.care/skincare/es/compare/the-ordinary-vs-isdin)
- [The Ordinary vs FRE](https://lovi.care/skincare/es/compare/the-ordinary-vs-fre)
- [Beauty of Joseon vs ISDIN](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-isdin)
- [Beauty of Joseon vs FRE](https://lovi.care/skincare/es/compare/beauty-of-joseon-vs-fre)
- [COSRX vs ISDIN](https://lovi.care/skincare/es/compare/cosrx-vs-isdin)
- [COSRX vs FRE](https://lovi.care/skincare/es/compare/cosrx-vs-fre)
- [CeraVe vs ISDIN](https://lovi.care/skincare/es/compare/cerave-vs-isdin)
- [CeraVe vs FRE](https://lovi.care/skincare/es/compare/cerave-vs-fre)
- [La Roche-Posay vs ISDIN](https://lovi.care/skincare/es/compare/la-roche-posay-vs-isdin)
- [La Roche-Posay vs FRE](https://lovi.care/skincare/es/compare/la-roche-posay-vs-fre)
- [Dr. Althea vs ISDIN](https://lovi.care/skincare/es/compare/dr-althea-vs-isdin)
- [Dr. Althea vs FRE](https://lovi.care/skincare/es/compare/dr-althea-vs-fre)
- [Some By Mi vs ISDIN](https://lovi.care/skincare/es/compare/some-by-mi-vs-isdin)
- [Some By Mi vs FRE](https://lovi.care/skincare/es/compare/some-by-mi-vs-fre)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/isdin-vs-fre
- United Kingdom: https://lovi.care/skincare/uk/compare/isdin-vs-fre
- Ireland: https://lovi.care/skincare/ie/compare/isdin-vs-fre
- Germany: https://lovi.care/skincare/de/compare/isdin-vs-fre
- France: https://lovi.care/skincare/fr/compare/isdin-vs-fre
- Italy: https://lovi.care/skincare/it/compare/isdin-vs-fre
- Netherlands: https://lovi.care/skincare/nl/compare/isdin-vs-fre
- Spain: https://lovi.care/skincare/es/compare/isdin-vs-fre (this page)
- Canada: https://lovi.care/skincare/ca/compare/isdin-vs-fre
- Australia: https://lovi.care/skincare/au/compare/isdin-vs-fre
- Singapore: https://lovi.care/skincare/sg/compare/isdin-vs-fre
- Saudi Arabia: https://lovi.care/skincare/sa/compare/isdin-vs-fre
- United Arab Emirates: https://lovi.care/skincare/ae/compare/isdin-vs-fre