# Clinique vs Trilogy

Page: https://lovi.care/skincare/es/compare/clinique-vs-trilogy

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

Clinique and Trilogy are two celebrated skincare lines known for offering thoughtful moisturizers, gentle cleansers, and targeted treatments designed to support varied dermatological needs. While the American brand incorporates hydrating [hyaluronic acid](https://lovi.care/skincare/es/ingredients/hyaluronic-acid), nourishing [glycerin](https://lovi.care/skincare/es/ingredients/glycerin), and invigorating [caffeine](https://lovi.care/skincare/es/ingredients/caffeine) to best comfort dry sensitive skin and oily skin, its counterpart builds high-performing formulas that suit dry, balanced, and sensitive skin types best. Both provide specialized solutions for specific concerns, yet they differ in their foundational ingredients and overall approach to daily maintenance.

Clinique is an American skincare brand founded in 1968 and owned by The Estée Lauder Companies Inc..

[en.wikipedia.org](https://en.wikipedia.org/wiki/Clinique) [elcompanies.com](https://www.elcompanies.com/en/who-we-are/our-heritage) [businesswire.com](https://www.businesswire.com/news/home/20261019083802/en/The-Este-Lauder-Companies-Appoints-Krista-Lee-Berger-Senior-Vice-President-Global-Marketing-Clinique) [glossy.co](https://www.glossy.co/beauty/glossy-pop-newsletter-clinique-launches-first-ever-creator-led-campaign/)

This page compares some of the most popular Clinique and Trilogy products; for every product of both brands, with a fit score for your own skin, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=compare&af_sub3=selection_note&af_sub4=pg7e2f005a25).

### Popular Clinique vs Trilogy products

#### Trilogy

- [Rosehip Cream Cleanser](https://lovi.care/skincare/es/p/trilogy/rosehip-cream-cleanser/for/sensitive-skin) — High fit
- [Line Smoothing Day Cream](https://lovi.care/skincare/es/p/trilogy/line-smoothing-day-cream/for/dry-skin) — High fit
- [Vitamin C Ceramide Night Cream](https://lovi.care/skincare/es/p/trilogy/vitamin-c-ceramide-night-cream/for/mature-skin) — High fit

#### Clinique

- [moisture surge](https://lovi.care/skincare/es/p/clinique/moisture-surge/for/sensitive-skin) — High fit
- [Take The Day Off Cleansing Balm](https://lovi.care/skincare/es/p/clinique/take-the-day-off-cleansing-balm/for/dry-skin) — Average fit — [€22.53 at Amazon](https://www.amazon.de/dp/B07D5C86RX?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Lotion+](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-lotion/for/dry-skin) — Average fit — [€20.97 at Amazon](https://www.amazon.de/dp/B00CVZ3NJ2?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [All About Eyes](https://lovi.care/skincare/es/p/clinique/all-about-eyes/for/dry-skin) — High fit — [€46.89 at Amazon](https://www.amazon.de/dp/B001IZ0ZFQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Dramatically Different Moisturizing Gel](https://lovi.care/skincare/es/p/clinique/dramatically-different-moisturizing-gel/for/oily-skin) — High fit — [€24.46 at Amazon](https://www.amazon.de/dp/B003JRI3OG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Smart Clinical Repair Wrinkle Correcting Serum](https://lovi.care/skincare/es/p/clinique/smart-clinical-repair-wrinkle-correcting-serum/for/mature-skin) — Average fit — [€71.30 at Lookfantastic](https://www.lookfantastic.es/p/clinique-smart-clinical-repair-wrinkle-correcting-serum-various-sizes/13279421/)
- [Moisture Surge Overnight Mask](https://lovi.care/skincare/es/p/clinique/moisture-surge-overnight-mask/for/dry-skin) — High fit — [€24.50 at Amazon](https://www.amazon.de/dp/B00HSZRQQQ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- [Clarifying Lotion 2](https://lovi.care/skincare/es/p/clinique/clarifying-lotion-2/for/oily-acne-prone-skin) — Average fit — [€34.39 at Amazon](https://www.amazon.de/dp/B01N184QGF?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)

## People Say

Clinique

Trilogy

- Effective Hydration Often Mentioned Mostly Mentioned “Keeps skin moisturized — Trilogy Vitamin C Ceramide Night Cream” “Leaves skin thoroughly moisturised — Trilogy Line Smoothing Day Cream” “Feels moisturizing — Trilogy Rosehip Cream Cleanser” “Keeps my dry patches at bay all day — Clinique Dramatically Different Moisturizing Lotion+”
- Sensitive Skin Friendly and Soothing Mostly Mentioned Sometimes Noted “never irritated my eyes — Clinique All About Eyes” “No stinging eyes — Clinique Take The Day Off Cleansing Balm” “keeps the redness at bay — Clinique Redness Solutions Daily Relief Cream” “Nothing irritated my skin — Trilogy Line Smoothing Day Cream”
- Luxurious Texture Rarely Noted Mostly Mentioned “Silky cream consistency — Trilogy Rosehip Cream Cleanser” “Luxuriously rich — Trilogy Vitamin C Ceramide Night Cream” “Silky balm-to-oil — Clinique Take The Day Off Cleansing Balm”
- Lightweight and Fast-Absorbing Often Mentioned Not noted “sinks in immediately — Clinique moisture surge” “sinks in instantly — Clinique Dramatically Different Moisturizing Gel” “Absorbs quickly without feeling sticky — Clinique Dramatically Different Moisturizing Lotion+”
- Plumping and Firming Effects Sometimes Noted Often Mentioned “Noticeable difference — Trilogy Line Smoothing Day Cream” “glass skin look — Clinique moisture surge”
- Morning Glow and Non-Greasy Rarely Noted Often Mentioned “Not greasy — Trilogy Line Smoothing Day Cream” “wake up glowing — Clinique Moisture Surge Overnight Mask”
- High Price and Value Often Mentioned Rarely Noted “Price to be high relative to performance — Trilogy Rosehip Cream Cleanser” “jar is too small for the cost — Clinique moisture surge”
- Too Thick, Heavy or Oily Not noted Often Mentioned “A little bit too thick — Trilogy Vitamin C Ceramide Night Cream”

## Questions and answers

### Clinique or Trilogy: which is better?

Clinique is better for sensitive skin and lightweight hydration, while Trilogy excels at effective hydration and plumping and firming effects. Lovi rates Clinique with a High fit for dry sensitive, oily, and mature skin types on this page.

### What is the difference between Clinique and Trilogy?

Clinique is fragrance-free across the products on this page and tends to be sensitive-skin friendly, whereas Trilogy features added fragrance in some of its formulas. Reviewers also note that Trilogy provides effective hydration and brightening, while Clinique is known for lightweight, fast-absorbing options.

### Clinique or Trilogy: which cleanser is better?

Clinique has a High Lovi fit for sensitive skin and dry skin with its Redness Solutions Soothing Cleanser, while Trilogy's [Rosehip](https://lovi.care/skincare/es/ingredients/rosehip-oil) Cream Cleanser also offers a High Lovi fit for dry and sensitive skin types.

### Which is more affordable, Clinique or Trilogy?

Reviewers note that Trilogy has a high price and value, whereas Clinique reviewers often mention a high price point as well, but the products on this page do not give direct price comparisons.

### Which causes fewer breakouts, Clinique or Trilogy?

Clinique may cause breakouts sometimes, as noted by reviewers. Trilogy has no specific breakout complaints listed on the page.

### Between Clinique and Trilogy, which brand is better suited for sensitive and dry skin types?

Clinique is better suited for sensitive skin, as Lovi rates its Redness Solutions Daily Relief Cream and Soothing Cleanser with a High fit for sensitive skin. Trilogy also offers strong hydration for dry skin, but Clinique features fragrance-free options across the products on this page.

### How do the founding years and corporate ownership of Clinique and Trilogy compare?

Clinique was founded in the United States in 1968 and is owned by The Estée Lauder Companies Inc., while Trilogy was founded in 2002 and has been owned by CITIC Capital Holdings Limited since 2018.

### Which brand offers products containing no fragrance, Clinique or Trilogy?

Clinique is the brand where every product on this page lists no fragrance in its ingredients, whereas only one of the three Trilogy products does.

### Clinique or Trilogy: which moisturizer is better?

When comparing moisturizers, Trilogy offers effective hydration and plumping and firming effects, while Clinique provides lightweight, fast-absorbing, and oil-controlling options that are fragrance-free across the products on this page. Lovi rates Clinique as having High fit for specific moisturizers like Smart Clinical Repair Lifting Face + Neck Cream on mature and dry skin, and Trilogy's [Vitamin C](https://lovi.care/skincare/es/ingredients/vitamin-c) Ceramide Night Cream as having High fit on mature and dry skin.

## Research behind their key ingredients

- [Biological and pharmacological activities of squalene and related compounds: potential uses in cosmetic dermatology](https://pubmed.ncbi.nlm.nih.gov/19169201/) Squalene · Molecules, 2009
- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Caffeine's mechanisms of action and its cosmetic use](https://pubmed.ncbi.nlm.nih.gov/23075568/) Caffeine · Skin Pharmacology and Physiology, 2013
- [Topical application of glycolic acid suppresses the UVB induced IL-6, IL-8, MCP-1 and COX-2 inflammation by modulating NF-κB signaling pathway in keratinocytes and mice skin](https://pubmed.ncbi.nlm.nih.gov/28330776/) Micro-acid complex · Journal of Dermatological Science, 2017
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Protecting skin photoaging by NF-kappaB inhibitor](https://pubmed.ncbi.nlm.nih.gov/20540695/) Magnolia officinalis bark extract · Current Drug Metabolism, 2010
- [Effects of ascorbic acid on gingival melanin pigmentation in vitro and in vivo](https://pubmed.ncbi.nlm.nih.gov/19186973/) Ascorbyl glucoside · Journal of Periodontology, 2009
- [Vitamin C-squalene bioconjugate promotes epidermal thickening and collagen production in human skin](https://pubmed.ncbi.nlm.nih.gov/33037252/) Squalane · Scientific Reports, 2020
- [Treatment of acne with a combination of propolis, tea tree oil, and Aloe vera compared to erythromycin cream: two double-blind investigations](https://pubmed.ncbi.nlm.nih.gov/30588129/) Aloe barbadensis leaf juice · Clinical Pharmacology, 2018
- [Urea: a comprehensive review of the clinical literature](https://pubmed.ncbi.nlm.nih.gov/24314769/) Urea · Dermatology Online Journal, 2013
- [Ceramide 1 and ceramide 3 act synergistically on skin hydration and the transepidermal water loss of sodium lauryl sulfate-irritated skin](https://pubmed.ncbi.nlm.nih.gov/18717861/) Ceramide np · International Journal of Dermatology, 2008
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [Effect of 30% Supramolecular Salicylic Acid Peel on Skin Microbiota and Inflammation in Patients with Moderate-to-Severe Acne Vulgaris](https://pubmed.ncbi.nlm.nih.gov/36350527/) Micro-acid complex · Dermatology and Therapy, 2023
- [Systematic Study of Resveratrol Nanoliposomes Transdermal Delivery System for Enhancing Anti-Aging and Skin-Brightening Efficacy](https://pubmed.ncbi.nlm.nih.gov/36985709/) Polygonum cuspidatum root extract · Molecules, 2023
- [Role of Resveratrol in Regulating Cutaneous Functions](https://pubmed.ncbi.nlm.nih.gov/32382280/) Polygonum cuspidatum root extract · Evidence-based Complementary and Alternative Medicine, 2020
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin · Clinical, Cosmetic and Investigational Dermatology, 2017
- [The anti-wrinkle efficacy of argireline, a synthetic hexapeptide, in Chinese subjects: a randomized, placebo-controlled study](https://pubmed.ncbi.nlm.nih.gov/23417317/) Acetyl hexapeptide-8 · American Journal of Clinical Dermatology, 2013
- [A Double-Blinded, Randomized, Vehicle-Controlled Study of the Efficacy of Moisturizer Containing Licochalcone A, Decanediol, L-Carnitine, and Salicylic Acid for Prevention of Acne Relapse in Asian Population](https://pubmed.ncbi.nlm.nih.gov/33150170/) Salicylic acid · BioMed Research International, 2020
- [Stable Ozonides with Vitamin E Acetate versus Corticosteroid in the Treatment of Lichen Sclerosus in Foreskin: Evaluation of Effects on Inflammation](https://pubmed.ncbi.nlm.nih.gov/30991399/) Tocopheryl acetate · Urologia Internationalis, 2019
- [Magnolia ovovata extract and its active component magnolol prevent skin photoaging via inhibition of nuclear factor kappaB](https://pubmed.ncbi.nlm.nih.gov/17346696/) Magnolia officinalis bark extract · European Journal of Pharmacology, 2007
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Glycolic acid · Clinical, Cosmetic and Investigational Dermatology, 2019
- [High molecular compounds (polysaccharides and proanthocyanidins) from Hamamelis virginiana bark: influence on human skin keratinocyte proliferation and differentiation and influence on irritated skin](https://pubmed.ncbi.nlm.nih.gov/11684194/) Witch hazel extract · Phytochemistry, 2001
- [Anti-Wrinkle Efficacy of Cross-Linked Hyaluronic Acid-Based Microneedle Patch with Acetyl Hexapeptide-8 and Epidermal Growth Factor on Korean Skin](https://pubmed.ncbi.nlm.nih.gov/33911590/) Acetyl hexapeptide-8 · Annals of Dermatology, 2019
- [Efficacy of Probiotic Supplements and Topical Applications in the Treatment of Acne: A Scoping Review of Current Results](https://pubmed.ncbi.nlm.nih.gov/39810881/) Probiotic technology · Journal of Experimental Pharmacology, 2025
- [Efficacy of a multitargeted, salicylic acid-based dermocosmetic cream compared to benzoyl peroxide 5% in Acne vulgaris: Results from a randomized study](https://pubmed.ncbi.nlm.nih.gov/37941097/) Salicylic acid, Micro-acid complex · Journal of Cosmetic Dermatology, 2024
- [Clay jojoba oil facial mask for lesioned skin and mild acne--results of a prospective, observational pilot study](https://pubmed.ncbi.nlm.nih.gov/22585103/) Jojoba seed oil · Forschende Komplementarmedizin, 2012
- [A Lipid Mixture Enriched by Ceramide NP with Fatty Acids of Diverse Chain Lengths Contributes to Restore the Skin Barrier Function Impaired by Topical Corticosteroid](https://pubmed.ncbi.nlm.nih.gov/34348350/) Ceramide np · Skin Pharmacology and Physiology, 2022
- [A Salicylic Acid-Based Dermocosmetic is Effective as an Adjunct to Benzoyl Peroxide for Mild to Moderate Acne and as Monotherapy in Maintenance Post Benzoyl Peroxide](https://pubmed.ncbi.nlm.nih.gov/38051857/) Salicylic acid · Journal of Drugs in Dermatology, 2023
- [Subclinical, non-erythematous irritation with an open assay model (washing): sodium lauryl sulfate (SLS) versus sodium laureth sulfate (SLES)](https://pubmed.ncbi.nlm.nih.gov/11278060/) Sodium laureth sulfate · Food and Chemical Toxicology, 2001
- [Topical application of jojoba (Simmondsia chinensis L.) wax enhances the synthesis of pro-collagen III and hyaluronic acid and reduces inflammation in the ex-vivo human skin organ culture model](https://pubmed.ncbi.nlm.nih.gov/38344180/) Jojoba seed oil · Frontiers in Pharmacology, 2024
- [Safety assessment of cyclomethicone, cyclotetrasiloxane, cyclopentasiloxane, cyclohexasiloxane, and cycloheptasiloxane](https://pubmed.ncbi.nlm.nih.gov/22247236/) Cyclopentasiloxane · International Journal of Toxicology, 2011
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Acetyl hexapeptide-8 · Journal of Cosmetic Dermatology, 2017
- [Whitening effect of alpha-bisabolol in Asian women subjects](https://pubmed.ncbi.nlm.nih.gov/20642768/) Bisabolol · International Journal of Cosmetic Science, 2010
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The synergistic effect of retinyl propionate and hydroxypinacolone retinoate on skin aging](https://pubmed.ncbi.nlm.nih.gov/36762391/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2023
- [Understanding Solar Skin Elastosis-Cause and Treatment](https://pubmed.ncbi.nlm.nih.gov/30052192/) Witch hazel extract · Journal of Cosmetic Science, 2018
- [Squalane as a Promising Agent Protecting UV-Induced Inhibition of Collagen Biosynthesis and Wound Healing in Human Dermal Fibroblast](https://pubmed.ncbi.nlm.nih.gov/40363772/) Squalane · Molecules, 2025
- [Epigallocatechin Gallate Enzymatic Alpha Glucosylation Potentiates Its Skin-Lightening Activity-Involvement of Skin Microbiota](https://pubmed.ncbi.nlm.nih.gov/39598779/) Camellia sinensis leaf extract · Molecules, 2024
- [Effects of Investigational Moisturizers on the Skin Barrier and Microbiome following Exposure to Environmental Aggressors: A Randomized Clinical Trial and Ex Vivo Analysis](https://pubmed.ncbi.nlm.nih.gov/37763018/) Yeast extract · Journal of Clinical Medicine, 2023
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Clinical efficacy and safety of nano-microneedle-assisted phenylethyl resorcinol for the treatment of infraorbital dark circles](https://pubmed.ncbi.nlm.nih.gov/32783330/) Dimethoxytolyl propylresorcinol · Journal of Cosmetic Dermatology, 2021
- [Synergistic action of a triple peptide complex on an essential extra-cellular matrix protein exhibits significant anti-aging benefits](https://pubmed.ncbi.nlm.nih.gov/20618556/) Multi-peptides · Journal of Cosmetic Dermatology, 2010
- [Algae extract protection effect on oxidized protein level in human stratum corneum](https://pubmed.ncbi.nlm.nih.gov/15247018/) Algae extract · Annals of the New York Academy of Sciences, 2004
- [Topical Almond Oil for Prevention of Pressure Injuries: A Single-Blinded Comparison Study](https://pubmed.ncbi.nlm.nih.gov/32379165/) Prunus amygdalus dulcis oil · Journal of Wound, Ostomy, and Continence Nursing, 2020
- [A randomized controlled trial to compare the effectiveness and safety of adsorbent lotion containing tapioca starch, spent grain wax, Butyrospermum parkii extract, argania spinosa kernel oil, aloe barbadensis, rosehip oil, and allantoin with a low-potency topical corticosteroid in the treatment of intertrigo](https://pubmed.ncbi.nlm.nih.gov/33811776/) Shea butter · Journal of Cosmetic Dermatology, 2022
- [Cucumber (Cucumis sativus L.) with heterologous poly-γ-glutamic acid has skin moisturizing, whitening and anti-wrinkle effects](https://pubmed.ncbi.nlm.nih.gov/38336313/) Cucumis sativus fruit extract · International Journal of Biological Macromolecules, 2024
- [Amended safety assessment of Sesamum indicum (sesame) seed oil, hydrogenated sesame seed oil, Sesamum indicum (sesame) oil unsaponifiables, and sodium sesameseedate](https://pubmed.ncbi.nlm.nih.gov/21772026/) Sesamum indicum oil · International Journal of Toxicology, 2011
- [The anti wrinkle efficacy of synthetic hexapeptide (Argireline) in Chinese Subjects](https://pubmed.ncbi.nlm.nih.gov/23607739/) Acetyl hexapeptide-8 · Journal of Cosmetic and Laser Therapy, 2013
- [Safety of a preservative system containing 1,2-hexanediol and caprylyl glycol](https://pubmed.ncbi.nlm.nih.gov/19514921/) Caprylyl glycol · Cutaneous and Ocular Toxicology, 2009
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride, Capric triglyceride · Life, 2023
- [Functional properties and skin care effects of sodium trehalose sulfate](https://pubmed.ncbi.nlm.nih.gov/38606717/) Trehalose · Skin Research and Technology, 2024
- [A Double-Blind, 12-Week Study to Evaluate the Antiaging Efficacy of a Cream Containing the NFκB Inhibitor 4-Hexyl-1, 3-Phenylenediol and Ascorbic Acid-2 Glucoside in Adult Females](https://pubmed.ncbi.nlm.nih.gov/27272084/) Ascorbyl glucoside · Journal of Drugs in Dermatology, 2016
- [Nanostructured Lipid Carrier Based Gel Containing α-Tocopherol and α-Tocopheryl Acetate for Synergistic Cutaneous Antiaging Efficacy](https://pubmed.ncbi.nlm.nih.gov/41309687/) Tocopheryl acetate · Scientific Reports, 2025
- [Evaulation of irritation potential of surfactant mixtures](https://pubmed.ncbi.nlm.nih.gov/18503452/) Sodium laureth sulfate · International Journal of Cosmetic Science, 1999
- [Effects of a Postbiotic Saccharomyces and Lactobacillus Ferment Complex on the Scalp Microbiome of Chinese Women with Sensitive Scalp Syndrome](https://pubmed.ncbi.nlm.nih.gov/37767337/) Lactobacillus ferment · Clinical, Cosmetic and Investigational Dermatology, 2023
- [Safety assessment on comedogenicity of dermatological products containing d-alpha tocopheryl acetate in Asian subjects: A double-blind randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/34471722/) Tocopheryl acetate · Contemporary Clinical Trials Communications, 2021
- [The efficacy of enoxolone in reducing erythema and pain after laser treatment: A randomized split-face pilot study](https://pubmed.ncbi.nlm.nih.gov/38622995/) Glycyrrhetinic acid · Journal of Cosmetic Dermatology, 2024
- [Efficacy of Topical Hydroxypinacolone Retinoate-Peptide Product Versus Fractional CO2 Laser in Facial Aging](https://pubmed.ncbi.nlm.nih.gov/39394831/) Hydroxypinacolone retinoate · Journal of Cosmetic Dermatology, 2025
- [Treatment with Ascorbyl Glucoside-Arginine Complex Ameliorates Solar Lentigos](https://pubmed.ncbi.nlm.nih.gov/39769217/) Ascorbyl glucoside · International Journal of Molecular Sciences, 2024
- [Impact of Hydrocolloid Dressing and Moisturizing Cream as Facial Skin Protectants Among Health Care Workers](https://pubmed.ncbi.nlm.nih.gov/38771104/) Dimethicone · Military Medicine, 2024
- [The effect of a serum containing acetyl hexapeptide-8, dipeptide diaminobutyroyl benzylamide diacetate and gluconolactone on skin biomarkers, wrinkles and skin texture: Ex vivo and clinical studies](https://pubmed.ncbi.nlm.nih.gov/41668671/) Laminaria digitata extract · International Journal of Cosmetic Science, 2026
- [Efficacy and safety of combination cream of stimu-tex AS™ (spent grain wax, Argania Spinosa Kernel oil, Butyrospermum Parkii (shea butter) extract), and saccharide isomerate after fractional CO2 laser procedure: split-face, double blinded, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/41134387/) Shea butter · Lasers in Medical Science, 2025
- [Clinical Efficacy of Topical Ascorbic Acid 2-Glucoside in Enhancing Outcomes of Laser Gingival Depigmentation: A Randomized Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42147661/) Ascorbyl glucoside · Cureus, 2026
- [Impact of dermal emulsions containing diacyl phospholipids, mono acyl phospholipids, sodium lauryl ether sulfate and polysorbate 80 in combination with UVA irradiation on human skin physiology in vivo: A pilot study](https://pubmed.ncbi.nlm.nih.gov/42617898/) Sodium laureth sulfate · International Journal of Pharmaceutics, 2026
- [Simmondsia chinensis (jojoba) cake fermentation: A new, sustainable technology for advanced skin and scalp care ingredients](https://pubmed.ncbi.nlm.nih.gov/42698229/) Lactobacillus ferment · International Journal of Cosmetic Science, 2026
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026
- [Monocentric, Vehicle-Controlled, Double-Blind Study to Assess the Short- and Long-Term Effects of a Ceramide NP C15-Containing Emollient on the Skin Microbiome and the Skin Barrier Function in Sensitive Skin](https://pubmed.ncbi.nlm.nih.gov/41758783/) Ceramide iii · Skin Pharmacology and Physiology, 2026

## The brands

- American skincare: [Clinique](https://lovi.care/skincare/es/brands/clinique)
- Skincare: [Trilogy](https://lovi.care/skincare/es/brands/trilogy)

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- [Dr. Althea vs Trilogy](https://lovi.care/skincare/es/compare/dr-althea-vs-trilogy)
- [Some By Mi vs Clinique](https://lovi.care/skincare/es/compare/some-by-mi-vs-clinique)
- [Some By Mi vs Trilogy](https://lovi.care/skincare/es/compare/some-by-mi-vs-trilogy)

## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi compares products by their fit scores, calculated from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this comparison: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/compare/clinique-vs-trilogy
- United Kingdom: https://lovi.care/skincare/uk/compare/clinique-vs-trilogy
- Ireland: https://lovi.care/skincare/ie/compare/clinique-vs-trilogy
- Germany: https://lovi.care/skincare/de/compare/clinique-vs-trilogy
- France: https://lovi.care/skincare/fr/compare/clinique-vs-trilogy
- Italy: https://lovi.care/skincare/it/compare/clinique-vs-trilogy
- Netherlands: https://lovi.care/skincare/nl/compare/clinique-vs-trilogy
- Spain: https://lovi.care/skincare/es/compare/clinique-vs-trilogy (this page)
- Canada: https://lovi.care/skincare/ca/compare/clinique-vs-trilogy
- Australia: https://lovi.care/skincare/au/compare/clinique-vs-trilogy
- Singapore: https://lovi.care/skincare/sg/compare/clinique-vs-trilogy
- Saudi Arabia: https://lovi.care/skincare/sa/compare/clinique-vs-trilogy
- United Arab Emirates: https://lovi.care/skincare/ae/compare/clinique-vs-trilogy