# iS Clinical skincare

Page: https://lovi.care/skincare/es/brands/is-clinical

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Spain.

iS Clinical is an American skincare brand founded in 2000 and owned by Science of Skincare, LLC.

[isclinicalskincare.co.za](https://isclinicalskincare.co.za/about-is-clinical/) [isclinical.com](https://www.isclinical.com/pages/terms-and-conditions) [isclinical.ie](https://www.isclinical.ie/pages/why-is-clinical) [tracxn.com](https://tracxn.com/d/companies/innovative-skincare/__0lp3tQ0x8B1Ahd5i2QYDKkJFHnGImaTjmOMHp3Az7WI)

Skincare enthusiasts love iS Clinical for its targeted [serums](https://lovi.care/skincare/es/ingredients/serum), nourishing moisturizers, gentle cleansers, and restorative eye products, all powered by meticulously crafted formulas. Its products suit sensitive, acne-prone, hyperpigmented, and aging skin types best. The standout products for particular concerns include the Cleansing [Complex](https://lovi.care/skincare/es/ingredients/complex) for acne-prone skin, the Super Serum Advance+ for skin with dark spots, and the Youth Eye Complex for mature skin. While specific study findings on key ingredients are not highlighted, the brand consistently delivers botanical-driven results that nurture the complexion.

- [Hyaluronic acid](https://lovi.care/skincare/es/ingredients/hyaluronic-acid)

This page covers some of the most popular iS Clinical products; for the whole iS Clinical range, with a fit score for every product, [use the Lovi app](https://app.pora.ai/vqqJ/j1xj2b6o?af_sub2=brand&af_sub3=selection_note&af_sub4=pg2ab6f2d38d).

### Other iS Clinical products

#### Other products

- [Cleansing Complex](https://lovi.care/skincare/es/p/is-clinical/cleansing-complex/for/oily-acne-prone-skin) — Superior fit
- [Reparative Moisture Emulsion](https://lovi.care/skincare/es/p/is-clinical/reparative-moisture-emulsion/for/dry-skin) — High fit
- [Hydra-Cool Serum](https://lovi.care/skincare/es/p/is-clinical/hydra-cool-serum/for/sensitive-skin) — High fit
- [Active Serum](https://lovi.care/skincare/es/p/is-clinical/active-serum/for/combination-skin) — High fit
- [Super Serum Advance+](https://lovi.care/skincare/es/p/is-clinical/super-serum-advance/for/dry-skin) — Superior fit
- [Brightening Complex](https://lovi.care/skincare/es/p/is-clinical/brightening-complex/for/dry-sensitive-skin) — High fit
- [Youth Eye Complex](https://lovi.care/skincare/es/p/is-clinical/youth-eye-complex/for/mature-skin) — Superior fit

## People Say

★4.7

Overall rating based on 4.4k+ reviews

Reviewers most often praise iS Clinical for gentle hydration, effective acne management, and lightweight textures. The most common complaints are high price points and insufficient hydration for dry skin.

### Highlights

- Lightweight, non-greasy moisturizers Mostly Mentioned “Absorbs beautifully — Reparative Moisture Emulsion” “Drink of water — Hydra-Cool Serum”
- Texture-improving serums Mostly Mentioned “skin feels softer — Active Serum” “Fades acne scars — Super Serum Advance+”
- Anti-aging serums Often Mentioned “Reduces fine lines — Super Serum Advance+” “softens fine lines — Active Serum”
- Non-irritating serums Often Mentioned “Good for sensitive skin — Super Serum Advance+” “It is not oily or pore clogging and hasn't irritated my acne prone skin. — Brightening Complex”
- High price point Mostly Mentioned “expensive for small bottle — Active Serum” “Definitely pricey — Reparative Moisture Emulsion” “Just expensive — Hydra-Cool Serum”

Sources: lovi.care, dermstore.com, lovelyskin.com, bluemercury.com, spacenk.com, walmart.com, and more

## Questions and answers

### Is iS Clinical worth it?

Deciding if iS Clinical is worth it depends on your budget, as the brand has a high price point. Reviewers frequently praise its lightweight, non-greasy moisturizers and texture-improving [serums](https://lovi.care/skincare/es/ingredients/serum), and the iS Clinical products on this page list no fragrance. Lovi rates the iS Clinical-focused routine Superior for dry, oily, sensitive, combination, and acne-prone skin.

### What are iS Clinical's best products?

iS Clinical's best products depend on your skin type, with Lovi rating Cleansing [Complex](https://lovi.care/skincare/es/ingredients/complex) Superior for oily, acne-prone, and sensitive skin, and Youth Eye Complex Superior for mature skin. Super Serum Advance+ also earns a Superior fit for dry skin, while Reparative Moisture Emulsion is a top pick for dry or aging skin.

### Which iS Clinical moisturizer is best for dry skin?

Hydra-Cool Serum is the best choice among the iS Clinical moisturizers on this page for dry skin, followed by Reparative Moisture Emulsion.

### Does iS Clinical cause breakouts?

iS Clinical is unlikely to cause breakouts, and Lovi rates Cleansing Complex, Active Serum, Super Serum Advance+, and Youth Eye Complex High for acne-prone skin. The iS Clinical products on this page are lightweight, non-greasy moisturizers and non-irritating serums.

### Is iS Clinical fragrance-free?

Yes, every one of the iS Clinical products on this page lists no fragrance in its ingredients. Reviewers frequently mention that the serums are non-irritating.

### What are the key ingredients in iS Clinical products?

The key ingredient in iS Clinical products is [hyaluronic acid](https://lovi.care/skincare/es/ingredients/hyaluronic-acid), which helps keep skin hydrated and smooth. Hyaluronic acid is supported by clinical research for improving skin quality and signs of aging.

[Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### How do I build a iS Clinical skincare routine?

To build an iS Clinical skincare routine, start by washing with Cleansing Complex, then apply a targeted serum like Active Serum or Super Serum Advance+, and finish with a moisturizer such as Reparative Moisture Emulsion or Hydra-Cool Serum depending on your skin type.

### What are good alternatives to iS Clinical?

CeraVe, Cetaphil, Paula's Choice, Neutrogena, Kiehl's, and Dermalogica are good alternatives to iS Clinical on Lovi. For example, CeraVe offers high to superior fit routines for all main skin types.

### iS Clinical vs CeraVe: which is better?

iS Clinical rates Superior for dry skin, oily skin, sensitive skin, combination skin, and acne-prone skin, while CeraVe rates High for dry skin and Superior for oily, sensitive, combination, and acne-prone skin. Lovi rates iS Clinical-focused routines Superior across all these skin types, while CeraVe-focused routines rate High for dry skin and Superior for the others.

### Who owns iS Clinical, and where is it from?

iS Clinical is an American brand founded in 2000, owned by Science of Skincare, LLC.

[isclinicalskincare.co.za](https://isclinicalskincare.co.za/about-is-clinical/) [isclinical.com](https://www.isclinical.com/pages/terms-and-conditions) [isclinical.ie](https://www.isclinical.ie/pages/why-is-clinical) [tracxn.com](https://tracxn.com/d/companies/innovative-skincare/__0lp3tQ0x8B1Ahd5i2QYDKkJFHnGImaTjmOMHp3Az7WI)

### Is iS Clinical cruelty-free?

PETA, Leaping Bunny, and Cruelty Free International, the registries Lovi checks, do not list iS Clinical as cruelty-free.

### Which iS Clinical cleanser is best for oily skin?

Cleansing Complex is the best choice, as Lovi rates it Superior for oily skin.

## Research behind iS Clinical's key ingredients

- [Benefits of topical hyaluronic acid for skin quality and signs of skin aging: From literature review to clinical evidence](https://pubmed.ncbi.nlm.nih.gov/36200921/) Sodium hyaluronate · Dermatologic Therapy, 2022
- [Topical use of dexpanthenol in skin disorders](https://pubmed.ncbi.nlm.nih.gov/12113650/) Panthenol · American Journal of Clinical Dermatology, 2002
- [Anti-aging and brightening effects of a topical treatment containing vitamin C, vitamin E, and raspberry leaf cell culture extract: A split-face, randomized controlled trial](https://pubmed.ncbi.nlm.nih.gov/31975502/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [Effects of menthol and cold on histamine-induced itch and skin reactions in man](https://pubmed.ncbi.nlm.nih.gov/7624016/) Menthol · Neuroscience Letters, 1995
- [Psychophysical study of the effects of topical application of menthol in healthy volunteers](https://pubmed.ncbi.nlm.nih.gov/16527405/) Menthol · Pain, 2006
- [Combination of microneedling and glycolic acid peels for the treatment of acne scars in dark skin](https://pubmed.ncbi.nlm.nih.gov/22151943/) Saccharum officinarum extract, Saccharum officinarum extract extrait de canne à sucre extract · Journal of Cosmetic Dermatology, 2011
- [Moisturizing and Antiinflammatory Properties of Cosmetic Formulations Containing Centella asiatica Extract](https://pubmed.ncbi.nlm.nih.gov/27168678/) Madecassic acid, Asiaticoside, Centella asiatica extract · Indian Journal of Pharmaceutical Sciences, 2016
- [Effect of a topical antioxidant serum containing vitamin C, vitamin E, and ferulic acid after Q-switched 1064-nm Nd:YAG laser for treatment of environment-induced skin pigmentation](https://pubmed.ncbi.nlm.nih.gov/32052907/) Ascorbic acid · Journal of Cosmetic Dermatology, 2020
- [A double-blind, placebo-controlled randomized trial of Serratulae quinquefoliae folium, a new source of β-arbutin, in selected skin hyperpigmentations](https://pubmed.ncbi.nlm.nih.gov/26119285/) Arbutin · Journal of Cosmetic Dermatology, 2015
- [Tailoring of Retinyl Palmitate-Based Ethosomal Hydrogel as a Novel Nanoplatform for Acne Vulgaris Management: Fabrication, Optimization, and Clinical Evaluation Employing a Split-Face Comparative Study](https://pubmed.ncbi.nlm.nih.gov/34211271/) Retinyl palmitate · International Journal of Nanomedicine, 2021
- [Green tea extract reduces induction of p53 and apoptosis in UVB-irradiated human skin independent of transcriptional controls](https://pubmed.ncbi.nlm.nih.gov/18631247/) Camellia sinensis leaf extract · Experimental Dermatology, 2009
- [The 24-hour skin hydration and barrier function effects of a hyaluronic 1%, glycerin 5%, and Centella asiatica stem cells extract moisturizing fluid: an intra-subject, randomized, assessor-blinded study](https://pubmed.ncbi.nlm.nih.gov/28860834/) Glycerin, Madecassic acid · Clinical, Cosmetic and Investigational Dermatology, 2017
- [The Effects of a Standardized Extract of Centella asiatica on Postlaser Resurfacing Wound Healing on the Face: A Split-Face, Double-Blind, Randomized, Placebo-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/32310680/) Madecassic acid, Asiaticoside · Journal of Alternative and Complementary Medicine, 2020
- [Old Plant, New Possibilities: Wild Bilberry (Vaccinium myrtillus L., Ericaceae) in Topical Skin Preparation](https://pubmed.ncbi.nlm.nih.gov/33809607/) Vaccinium myrtillus leaf extract fruit · Antioxidants, 2021
- [High-Concentration L-Menthol Exhibits Counter-Irritancy to Neurogenic Inflammation, Thermal and Mechanical Hyperalgesia Caused by Trans-cinnamaldehyde](https://pubmed.ncbi.nlm.nih.gov/27260636/) Menthol · The Journal of Pain, 2016
- [A new topical panthenol-containing emollient: Results from two randomized controlled studies assessing its skin moisturization and barrier restoration potential, and the effect on skin microflora](https://pubmed.ncbi.nlm.nih.gov/27425824/) Panthenol, Pantothenic acid · The Journal of Dermatological Treatment, 2017
- [Microneedling by dermapen and glycolic acid peel for the treatment of acne scars: Comparative study](https://pubmed.ncbi.nlm.nih.gov/30548170/) Saccharum officinarum extract extrait de canne à sucre extract · Journal of Cosmetic Dermatology, 2019
- [Structural characterization and in vivo evaluation of retinyl palmitate in non-ionic lamellar liquid crystalline system](https://pubmed.ncbi.nlm.nih.gov/21411295/) Retinyl palmitate · Colloids and Surfaces. B, Biointerfaces, 2011
- [The efficacy of glycolic acid, salicylic acid, gluconolactone, and licochalcone A combined with 0.1% adapalene vs adapalene monotherapy in mild-to-moderate acne vulgaris: a double-blinded within-person comparative study](https://pubmed.ncbi.nlm.nih.gov/30858720/) Saccharum officinarum extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [Sunscreens and Cosmetic Formulations Containing Ascorbyl Tetraisopalmitate and Rice Peptides for the Improvement of Skin Photoaging: A Double-blind, Randomized Placebo-controlled Clinical Study](https://pubmed.ncbi.nlm.nih.gov/33529350/) Tetrahexyldecyl ascorbate · Photochemistry and Photobiology, 2021
- [Clinical evidence of the efficacy and safety of a new 3-in-1 anti-aging topical night serum-in-oil containing melatonin, bakuchiol, and ascorbyl tetraisopalmitate: 103 females treated from 28 to 84 days](https://pubmed.ncbi.nlm.nih.gov/30924254/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2019
- [Systematic Study of Paeonol/Madecassoside Co-Delivery Nanoemulsion Transdermal Delivery System for Enhancing Barrier Repair and Anti-Inflammatory Efficacy](https://pubmed.ncbi.nlm.nih.gov/37446936/) Centella asiatica extract · Molecules, 2023
- [High-Payload Nanosuspension of Centella asiatica Extract for Improved Skin Delivery with No Irritation](https://pubmed.ncbi.nlm.nih.gov/34764648/) Asiaticoside · International Journal of Nanomedicine, 2021
- [Topical application of superoxide dismutase mediated by HIV-TAT peptide attenuates UVB-induced damages in human skin](https://pubmed.ncbi.nlm.nih.gov/27460952/) Superoxide dismutase · European Journal of Pharmaceutics and Biopharmaceutics, 2016
- [Efficacy and safety of moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese versus 0.02% triamcinolone acetonide cream in decreasing adverse reaction and downtime after ablative fractional carbon dioxide laser resurfacing: A split-face, double-blinded, randomized, controlled trial](https://pubmed.ncbi.nlm.nih.gov/30945430/) Pantothenic acid · Journal of Cosmetic Dermatology, 2019
- [Encapsulation of alpha arbutin, a depigmenting agent, in nanosized ethosomes: Invitro and invivo human studies](https://pubmed.ncbi.nlm.nih.gov/37681127/) Alpha-arbutin · Heliyon, 2023
- [Evaluating the Safety and Efficacy of a Topical Formulation Containing Epidermal Growth Factor, Tranexamic Acid, Vitamin C, Arbutin, Niacinamide and Other Ingredients as Hydroquinone 4% Alternatives to Improve Hyperpigmentation: A Prospective, Randomized, Controlled Split Face Study](https://pubmed.ncbi.nlm.nih.gov/33022197/) Arbutin · Journal of Cosmetic Science, 2020
- [Antiacne and antiblotch activities of a formulated combination of Aloe barbadensis leaf powder, Garcinia mangostana peel extract, and Camellia sinensis leaf extract](https://pubmed.ncbi.nlm.nih.gov/31239743/) Camellia sinensis leaf extract · Clinical, Cosmetic and Investigational Dermatology, 2019
- [The efficacy study of the combination of tripeptide-10-citrulline and acetyl hexapeptide-3. A prospective, randomized controlled study](https://pubmed.ncbi.nlm.nih.gov/28150423/) Tripeptide-10 citrulline, Tripeptide-10 · Journal of Cosmetic Dermatology, 2017
- [Effect of a botanical cleansing lotion on skin sebum and erythema of the face: A randomized controlled blinded half-side comparison](https://pubmed.ncbi.nlm.nih.gov/30022595/) Willow bark extract · Journal of Cosmetic Dermatology, 2019
- [Anti-Inflammatory Effect of a Novel Topical Herbal Composition (VEL-091604) Consisting of Gentian Root, Licorice Root and Willow Bark Extract](https://pubmed.ncbi.nlm.nih.gov/30690691/) Willow bark extract · Planta Medica, 2019
- [An evaluation of the effect of a topical product containing salicin on the visible signs of human skin aging](https://pubmed.ncbi.nlm.nih.gov/20883292/) Willow bark extract · Journal of Cosmetic Dermatology, 2010
- [Assessment of Combined Ascorbyl Palmitate (AP) and Sodium Ascorbyl Phosphate (SAP) on Facial Skin Sebum Control in Female Healthy Volunteers](https://pubmed.ncbi.nlm.nih.gov/27756097/) Ascorbyl palmitate · Drug Research, 2017
- [Development of solid lipid microparticles (SLMs) containing asiatic acid for topical treatment of acne: Characterization, stability, in vitro and in vivo anti-acne assessment](https://pubmed.ncbi.nlm.nih.gov/38460769/) Asiatic acid · International Journal of Pharmaceutics, 2024
- [Influence of vitamin E acetate on stratum corneum hydration](https://pubmed.ncbi.nlm.nih.gov/9706379/) Tocopheryl acetate · Arzneimittel-Forschung, 1998
- [Salicin and Hederacoside C-Based Extracts and UV-Absorbers Co-Loaded into Bioactive Lipid Nanocarriers with Promoted Skin Antiaging and Hydrating Efficacy](https://pubmed.ncbi.nlm.nih.gov/35889587/) Willow bark extract · Nanomaterials, 2022
- [Evaluation of the Efficacy and Safety of a Panthenol-Enriched Mask for Skin Barrier Recovery After Facial Laser Treatment: Results of a Double-Blind Randomized Controlled Study](https://pubmed.ncbi.nlm.nih.gov/40613435/) Panthenol, Pantothenic acid · Journal of Cosmetic Dermatology, 2025
- [Topically applied GHK as an anti-wrinkle peptide: Advantages, problems and prospective](https://pubmed.ncbi.nlm.nih.gov/39963574/) Tripeptide-1 · BioImpacts, 2025
- [The effect of a vitamin A palmitate and antioxidant-containing oil-based moisturizer on photodamaged skin of several body sites](https://pubmed.ncbi.nlm.nih.gov/23438139/) Retinyl palmitate · Journal of Cosmetic Dermatology, 2013
- [Chitosan derivative nanocarrier: safety evaluation,antibacterial property and ascorbyl palmitate encapsulation](https://pubmed.ncbi.nlm.nih.gov/19566395/) Ascorbyl palmitate · Journal of Microencapsulation, 2010
- [Effect of an Emollient Emulsion Containing 15.0% of Caprylic/Capric Triglyceride on the Urocanic Acid of the Stratum Corneum](https://pubmed.ncbi.nlm.nih.gov/37109405/) Caprylic capric triglyceride · Life, 2023
- [Prospective randomized double-blind comparative study of topical acetyl zingerone with tetrahexyldecyl ascorbate versus tetrahexyldecyl ascorbate alone on facial photoaging](https://pubmed.ncbi.nlm.nih.gov/38525606/) Tetrahexyldecyl ascorbate · Journal of Cosmetic Dermatology, 2024
- [Targeting Circadian Rhythm for the Regulation of Skin Collagen Metabolism](https://pubmed.ncbi.nlm.nih.gov/41527525/) Tripeptide-1 · Journal of Cosmetic Dermatology, 2026
- [Efficacy of a Topical Formulation on Skin Hydration and Barrier Function in Individuals With Xerosis: A 28-Day Randomized, Split-Leg, Untreated-Controlled Trial](https://pubmed.ncbi.nlm.nih.gov/42108609/) Dipotassium glycyrrhizate · Journal of Cosmetic Dermatology, 2026

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## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi rates every product from its full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind these ratings: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

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- United Kingdom: https://lovi.care/skincare/uk/brands/is-clinical
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