# Wellage Real Hyaluronic Blue 100 Ampoule for acne-prone skin

**Lovi Fit: High fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Wellage](https://lovi.care/skincare/de/brands/wellage)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for acne-prone skin; a few moisturizers fit it even better.

## Why this fit

- Highly suitable for your combination skin, this product offers excellent moisturizing due to multiple forms of hyaluronic acid, which provide deep hydration and support barrier repair with ingredients like glycerin and saccharide isomerate.
- It also provides moderate benefits for your acne, blemishes, and breakouts through the anti-inflammatory properties of Centella Asiatica Extract and Melia Azadirachta Leaf Extract.
- The safety profile is excellent, with no risks of irritation for your combination skin due to the absence of harsh ingredients and the presence of soothing agents like Centella Asiatica Extract and Beta-Glucan.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/acne-prone-skin): High (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/wellage/real-hyaluronic-blue-100-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Sodium Hyaluronate, Β-Glucan, Panthenol Vitamin B5, Centella Asiatica Extract, Glycerin

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A novel moisturizer containing saccharide isomerate accelerates skin barrier recovery, improves hydration, reduces erythema, and alleviates discomfort compared to a control moisturizer following intense pulsed light treatment in subjects with skin aging. ([The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/41211697/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans. ([Arzneimittel-Forschung, 2000](https://pubmed.ncbi.nlm.nih.gov/10965426/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Treatment with an asiaticoside-containing cream applied twice daily for 12 weeks significantly improved periorbital wrinkles in 65% of 27 female volunteers compared to a vehicle control cream. ([International Journal of Cosmetic Science, 2008](https://pubmed.ncbi.nlm.nih.gov/18452433/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## What reviewers say

This ampoule is highly regarded for its ability to hydrate dehydrated and oily skin types, owing to its very lightweight, water-like consistency that absorbs rapidly without any stickiness. It effectively delivers deep, buildable hydration, leading to plumper skin and reduced redness. However, individuals with very dry skin may find it insufficient on its own and may need to layer it with a richer cream or apply multiple layers for optimal results.

- Liked: Extremely lightweight (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Non-sticky finish (often mentioned)
- Liked: Gentle and soothing (sometimes noted)
- Liked: Good value (sometimes noted)
- Disliked: Insufficient for dry skin (sometimes noted)
- Disliked: Lacks dramatic results (rarely noted)
- Disliked: Potential breakouts (rarely noted)
- Disliked: Too runny texture (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### What makes Wellage Real Hyaluronic Blue 100 Ampoule a great fit for acne-prone skin?

This product is a great fit because it provides deep hydration with multiple forms of hyaluronic acid while using soothing ingredients like Centella Asiatica Extract and Beta-Glucan to keep acne-prone skin calm without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for acne-prone skin?

This serum is a great fit for acne-prone skin because it contains Centella Asiatica Extract and Melia Azadirachta Leaf Extract, which provide helpful anti-inflammatory benefits to calm breakouts. It also has a very safe and soothing formula with Beta-Glucan and no harsh ingredients, meaning it is unlikely to cause irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### What does Beta Glucan do for acne-prone skin?

Beta-glucan helps calm irritated skin and supports skin recovery. It is unlikely to clog pores and may improve overall skin hydration while keeping the skin barrier healthy.
Sources: [Food Science & Nutrition, 2025](https://pubmed.ncbi.nlm.nih.gov/40291929/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### Where does it go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it before your retinol to keep your skin calm and hydrated. Using a moisturizing treatment helps reduce dryness and irritation while supporting your skin barrier during active treatments.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37276158/), [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this treatment daily in the evening as part of your routine. Daily application helps keep your skin deeply hydrated and calm while supporting your skin barrier.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/), [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to clog pores or cause breakouts for acne-prone skin. It features soothing and anti-inflammatory ingredients like Centella Asiatica Extract that help calm the skin without heavy oils.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Can I use it around the eyes or on my body?

This product is a great fit for your acne-prone skin because it provides deep hydration and calms breakouts without causing irritation. It is safe to use around the eyes, though the very thin skin in that area may benefit from an extra layer of a richer cream to lock in moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [The Journal of Dermatological Treatment, 2025](https://pubmed.ncbi.nlm.nih.gov/41211697/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — €29.98 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/de/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — €17.99 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — €22.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/de/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — €65.41 at Amazon

## Where to buy

- Amazon.de: €41.00 (https://www.amazon.de/dp/B0989SSG5Q?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Propanediol, Pentylene Glycol, Glycerin, 1,2-Hexanediol, Panthenol, Dioscorea Japonica Root Extract, Melia Azadirachta Leaf Extract, Melia Azadirachta Flower Extract, Coccinia Indica Fruit Extract, Piper Methysticum Stem Extract Root Leaf, Centella Asiatica Extract, Panax Ginseng Extract Berry, Solanum Melongena Fruit Extract, Aloe Barbadensis Flower Extract, Ocimum Sanctum Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Alpinia Galanga Extract, Hydrogenated Lecithin, Methylpropanediol, Sodium Acrylic Acid Ma Copolymer, Butylene Glycol, Xanthan Gum, Sodium Citrate, Glycosyl Trehalose, Hydrogenated Hydrolysate Starch, Adenosine, Citric Acid, Raffinose, Lecithin, Polyquaternium-51, Beta-Glucan, Saccharide Isomerate, Cyanocobalamin, Biosaccharide Gum-1, Caprylic Capric Triglyceride, Sodium Stearoyl Glutamate, Sucrose Laurate, Glycine, Serine, Arginine, Histidine, Lysolecithin, Hydrolyzed Sodium Hyaluronate, Tocopherol, Benzyl Glycol, Hydrolyzed Glycosaminoglycans, Sodium Acetylated Hyaluronate, Sodium Hyaluronate Crosspolymer, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Hyaluronate, Ethylhexylglycerin, Caprylyl Glycol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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- United Kingdom: https://lovi.care/skincare/uk/p/wellage/real-hyaluronic-blue-100-ampoule/for/acne-prone-skin
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