# Vichy Liftactiv Pure Retinol Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Vichy](https://lovi.care/skincare/de/brands/vichy)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as retinol and sodium hyaluronate provide collagen stimulation and hydration, which are supportive but not specifically targeted for wrinkles and fine lines.
- Glycerin and hydrolyzed rice protein offer general skincare advantages, contributing to overall skin health without directly addressing your primary concerns.
- The product is safe for your normal skin, with no identified risks of irritation due to the absence of harsh or prohibited ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/dry-skin): Caution
- [Combination skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/sensitive-skin): Low
- [Acne-prone skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/dry-sensitive-skin): Caution
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Retinol, Sodium Hyaluronate, Palmitoyl Tetrapeptide-7, Hydrolyzed Rice Protein, Glycerin

## What the research says

- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle. ([Archives of Dermatological Research, 2017](https://pubmed.ncbi.nlm.nih.gov/28247017/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- A multi-modal methodology combining MALDI-MSI, in vivo RCM, echography, and histology revealed age-related decreases in extracellular matrix and epidermal-dermal junction proteins and undulation depth, while a blend of palmitoyl oligopeptide and palmitoyl tetrapeptide-7 improved subepidermal low-echogenic band thickness, density, and extracellular matrix structure compared to placebo. ([Journal of Cosmetic Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25817264/))
- Palmitoyl tetrapeptide-7, acetyl hexapeptide-8, palmitoyl tripeptide-1, and palmitoyl tetrapeptide-10 significantly increased type III collagen levels in human dermal fibroblasts following UV exposure, with their combination demonstrating a greater effect in vitro and enhancing type I, III, and IV collagen levels in ex vivo skin tissues compared to individual components. ([International Journal of Cosmetic Science, 2026](https://pubmed.ncbi.nlm.nih.gov/42683869/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- A topical serum containing vitamin C, vitamin E, and raspberry leaf cell culture extract improved skin color, elasticity, radiance, smoothness, scaliness, and wrinkles compared to the untreated contralateral side in fifty female volunteers. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Vichy Liftactiv Pure Retinol work for mature skin?

Vichy Liftactiv Pure Retinol Serum works moderately well for mature skin, offering helpful hydration and collagen stimulation through retinol and sodium hyaluronate. A treatment of this type needs high concentrations of potent antioxidants, peptides, and skin-repairing ingredients to effectively target wrinkles and fine lines for this skin type.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Which ingredients make this serum a good fit for mature skin?

Retinol and sodium hyaluronate make this serum a good fit for mature skin by helping smooth lines and keep skin hydrated. To work best for mature skin, a product of this type needs high concentrations of potent antioxidants, peptides, and skin-repairing ingredients that target wrinkles and improve elasticity.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### What does Retinol do for mature skin?

Retinol helps smooth out fine lines and wrinkles while improving overall skin thickness and firmness over time. It may also cause temporary dryness, scaling, or stinging as your skin gets used to it.
Sources: [Archives of Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17515510/), [The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/)

### What does Hyaluronic Acid do for mature skin?

Hyaluronic acid helps mature skin by deeply boosting moisture, improving elasticity, and smoothing the appearance of fine lines and wrinkles. Regular use keeps the skin looking plump and soft while supporting overall firmness and hydration.
Sources: [Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/), [Skin Research and Technology, 2024](https://pubmed.ncbi.nlm.nih.gov/38591218/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in your evening routine, applied after cleansing and before moisturizing. Putting treatments at night keeps things simple and avoids extra safety worries around sun exposure.

### Can I use it with vitamin C, and in what order?

You can use this treatment alongside vitamin C by applying vitamin C in the morning and this retinol product at night. Using them at different times of day helps prevent potential skin irritation from combining two strong active ingredients.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### How often should I use this serum?

Use this treatment serum in your evening routine. Mature skin needs ingredients that directly boost collagen and target wrinkles and fine lines, such as stronger retinoids and specialized peptides.

### Can it clog pores, cause breakouts or purging for mature skin?

This product is unlikely to clog pores or cause breakouts on mature skin, though active ingredients like retinol may sometimes cause mild initial purging as skin adjusts. It has a safe profile for normal skin without harsh ingredients that typically trigger irritation. A product for mature skin needs targeted wrinkle-smoothing ingredients and rich moisturizers to better firm and soften fine lines.
Sources: [International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/)

### Is this serum fragrance-free and alcohol-free?

It has no fragrance and contains drying alcohol (alcohol denat).

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/de/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €730.48 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €51.50 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Glycerin, Pentylene Glycol, Isononyl Isononanoate, Alcohol Denat, Dicaprylyl Ether, Glycine Soja Oil, Soybean Oil, Propylene Glycol, Peg-6 Caprylic Capric Glycerides, Hydrolyzed Rice Protein, Hydroxyacetophenone, Palmitoyl Tetrapeptide-7, Palmitoyl Tripeptide-1, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Sodium Hyaluronate, Sodium Hydroxide, Trisodium Ethylenediamine Disuccinate, Vitreoscilla Ferment, Retinol, Dicaprylyl Carbonate, Ammonium Polyacryloyldimethyl Taurate, Butylene Glycol, Caprylyl Glycol, Carbomer, Glyceryl Isostearate, Polysorbate 20, Ppg-6-Decyltetradeceth-30, Sodium Lactate, Tocopherol, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/vichy/liftactiv-pure-retinol-serum/for/mature-skin