Sulwhasoo The Ultimate S Cream for sensitive skin

How to apply

Questions and answers

What the research says

• Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group.

  American Journal of Clinical Dermatology, 2013

• Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects.

  Journal of Cosmetic and Laser Therapy, 2013

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• Topical beta-carotene provided protection for the human skin of healthy volunteers against IR radiation by acting as a superficial antioxidant, though dermal carotenoid degradation was significantly higher for standard infrared radiator than for water filter infrared irradiation.

  Experimental Dermatology, 2011

• Enzyme-modified ginseng extract cream significantly reduced the global photo-damage score and various roughness measures including total roughness, smoothness depth, and arithmetic roughness average compared to placebo in 23 human subjects.

  Rejuvenation Research, 2015

• A red ginseng hydrogel formulation with 1,2-hexanediol promoted selective growth of Staphylococcus epidermidis and decreased Cutibacterium acnes in 20 female subjects.

  Journal of Ginseng Research, 2022

• A 1% fermented black ginseng cream significantly reduced eye wrinkles and brightened skin color in twenty-three human subjects compared to control cream and baseline.

  Journal of Toxicology and Environmental Health. Part A, 2020

• A combination cream of stimu-tex AS and saccharide isomerate reduced erythema, increased skin capacitance, and reduced transepidermal water loss compared to placebo in 20 subjects after fractional CO2 laser procedure without causing serious adverse events.

  Lasers in Medical Science, 2025

• A skin barrier restoring cream with shea butter, silkflo, and vitamin E increased type I procollagen synthesis, enhanced antioxidant enzyme activity, decreased reactive oxygen species generation, and promoted hyaluronic acid production in H2O2-stimulated human keratinocyte cells compared to untreated cells.

  International Journal of Cosmetic Science, 2025

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days.

  Annals of Dermatology, 2019

• Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear.

  Journal of Cosmetic Dermatology, 2017

• Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy.

  European Journal of Neurology, 2013

• Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls.

  Journal of Cosmetic Dermatology, 2025

• Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate.

  Contemporary Clinical Trials Communications, 2021

• Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin.

  Journal of Cosmetic Dermatology, 2024

Ingredients

Water, Butylene Glycol, Triethylhexanoin, Glycerin, Dimethicone, Squalane, Pentaerythrityl Tetraethylhexanoate, Cetyl Ethylhexanoate, Polyglyceryl-3 Methylglucose Distearate, Trisiloxane, 2-Hexanediol, Diisostearyl Malate, Hydrogenated Polyisobutene, Glyceryl Stearate, Peg-100 Stearate, Cetearyl Alcohol, Pentaerythrityl Distearate, Behenyl Alcohol, Polyglycerin-3, Butyrospermum Parkii Butter Shea Butter, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Parfum, Ammonium Acryloyldimethyltaurate Vp Copolymer, Hydroxypropyl Phosphate Starch, Hydrolyzed Ginseng Saponins Enzyme-Treated Red Ginseng Saponins, Glyceryl Caprylate, Helianthus Annuus Seed Oil Sunflower Seed Oil, Ethylhexylglycerin, Disodium Edta, Hydroxypropyl Cyclodextrin, Propanediol, Sorbitan Isostearate, Polysorbate 60, Methoxy Peg-114 Polyepsilon Caprolactone, Daucus Carota Sativa Root Extract Carrot Root Extract, Benzyl Salicylate, Bioflavonoids, Hydrolyzed Proanthocyanidin, Honey, Miel, Limonene, Hydrogenated Lecithin, Rehmannia Glutinosa Root Extract, Paeonia Albiflora Root Extract, Lilium Candidum Bulb Extract, Polygonatum Odoratum Extract Rhizome, Linalool, Panax Ginseng Extract Berry, Nelumbo Nucifera Flower Extract, Panax Ginseng Root Extract, Beta-Carotene, Tocopherol, Phytosphingosine, Sodium Polyaspartate, Caprylyl Glycol, Sodium Methyl Stearoyl Taurate, Acetyl Heptapeptide-4, Citric Acid, Acetyl Hexapeptide-8, Sodium Hydroxide, Acetyl Octapeptide-3

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.