StriVectin SD Advanced PLUS Intensive Moisturizing Concentrate for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A novel moisturizer containing saccharide isomerate accelerates skin barrier recovery, improves hydration, reduces erythema, and alleviates discomfort compared to a control moisturizer following intense pulsed light treatment in subjects with skin aging.

  The Journal of Dermatological Treatment, 2025

• A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability.

  The Journal of Dermatological Treatment, 2017

• Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.

  American Journal of Clinical Dermatology, 2002

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.

  Journal of Cosmetic Dermatology, 2022

• Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.

  International Journal of Molecular Sciences, 2022

• Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.

  Marine Drugs, 2023

• Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality.

  Archives of Facial Plastic Surgery, 2006

• A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days.

  Cureus, 2024

• The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls.

  Skin Research and Technology, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

Why other moisturizers fit skin with dark spots better

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.

  International Journal of Medical Sciences, 2021

Ingredients

Glycerin, Pentaerythrityl Tetraisostearate, Trimethylolpropane Tricaprylate Tricaprate, Neopentyl Glycol Diheptanoate, Propanediol, Myristyl Nicotinate, Cetearyl Alcohol, Butylene Glycol, Bis-Stearyl Dimethicone, Glyceryl Stearate, Theobroma Grandiflorum Seed Butter, Dimethicone, Sorbitan Stearate, Stearoxymethicone Dimethicone Copolymer, 1,2-Hexanediol, Palmitoyl Tripeptide-38, Rice Bran Extract, Palmitoyl Tetrapeptide-7, Astrocaryum Murumuru Seed Butter, Palmitoyl Tripeptide-1, Copper Tripeptide-1, Saccharide Isomerate, Panthenol, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Peg-40 Stearate, Astrocaryum Vulgare Kernel Oil, Polysilicone-11, Butyrospermum Parkii Butter Shea Butter, Ceteareth-20, Bisabolol, Caprylhydroxamic Acid, Nicotiana Benthamiana Hexapeptide-40 Sh-Oligopeptide-1, Phaseolus Lunatus Seed Extract Green Bean Seed Extract, Aloe Barbadensis Leaf Juice, Bacillus Sea Salt Ferment Filtrate, Zingiber Officinale Root Extract, Rosamarinus Officinalis Leaf Extract Rosemary Leaf Extract, Polyglyceryl-4 Diisostearate Polyhydroxystearate Sebacate, Pentaclethra Macroloba Behenic Acid Aminopropanediol Amides Esters Seed Oil, Helianthus Annuus Extract Sunflower Extract, Hydrolyzed Hyaluronic Acid, Evodia Rutaecarpa Fruit Extract, Sodium Hyaluronate Crosspolymer, Nymphaea Alba Flower Extract, Methylglucoside Phosphate, Cetyl Hydroxyethylcellulose, Adenosine, Isohexadecane, Sorbitan Isostearate, Hydroxypropyl Cyclodextrin, Copper Lysinate Prolinate, Aminomethyl Propanol, Dicaprylyl Ether, Dipotassium Phosphate, Ethylhexyl Stearate, Sodium Isostearate, Polysorbate 60, Resveratrol, Xanthan Gum, Disodium Edta, Parfum, Lactic Acid, Mica, Rutin, Tocopherol, Sodium Citrate, Citric Acid, Ci 77891 Titanium Dioxide, Ci 77491 Iron Oxides

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.