Skintific 5X Ceramide Barrier Moisture Gel for skin with dark spots

How to apply

Questions and answers

What the research says

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin.

  Skin Pharmacology and Physiology, 2022

• Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion.

  International Journal of Dermatology, 2008

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing.

  Journal of Alternative and Complementary Medicine, 2020

• Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.

  Journal of Cosmetic Dermatology, 2019

• Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline.

  Experimental Dermatology, 2008

• Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.

  Molecules, 2025

• Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.

  Antioxidants, 2025

• Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris.

  Journal of Cosmetic Dermatology, 2022

• Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks.

  International Journal of Molecular Sciences, 2022

• Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers.

  Marine Drugs, 2023

Why other moisturizers fit skin with dark spots better

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2014

• Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.

  International Journal of Medical Sciences, 2021

Ingredients

Water, Glycerin, Ceramide Np, Ceramide Ap, Ceramide Eop, Phytosphingosine, Cholesterol, Hyaluronic Acid, Caprylic Capric Triglyceride, Cetearyl Alcohol, Cetearyl Glucoside, Dimethicone, Butyrospermum Parkii Butter Shea Butter, Squalane, Tocopherol, Phenoxyethanol, Ethylhexylglycerin, Butylene Glycol, Hydrogenated Polyisobutene, Propylene Glycol, 1,2-Hexanediol, Hydroxyacetophenone, Peg-400, Ammonium Acryloyldimethyltaurate Vp Copolymer, Hydrogenated Lecithin, Panthenol, Phytosteryl Octyldodecyl Lauroyl Glutamate, Carbomer, Allantoin, Pca, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Ceramide Ns, Ceramide Ng, Ceramide, Sodium Hydroxide, Witch Hazel Extract, Trehalose, Ectoin, Sophora Flavescens Root Extract, Opuntia Ficus-Indica Stem Extract, Ophiopogon Japonicus Root Extract, Yeast Polysaccharides, Pentylene Glycol, Disodium Edta-Copper, Polysorbate 60, T-Butyl Alcohol, Citrus Aurantium Amara Oil Flower, Sorbitan Isostearate, Bergamot Oil Fruit, Lemon Peel Oil

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.