# Skin Better Science Alto Advanced Defense and Repair Serum for combination skin

**Lovi Fit: Average fit for combination skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Skin Better Science](https://lovi.care/skincare/de/brands/skin-better-science)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for combination skin; other serums fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as niacinamide helps with seboregulation and glycerin provides hydration, though it may not fully address concerns with oily shine due to a lack of stronger oil-controlling ingredients.
- The serum provides excellent protection against environmental stressors with ergothioneine and arabidopsis thaliana extract, offering general skincare benefits like antioxidant protection.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin): Average (this page)
- [Sensitive skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Niacinamide, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Carnosine, Ceramide Ap

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Topical application of photolyase-containing liposomes followed by photoreactivating light decreased UVB-induced dimers by 40-45% and prevented immunosuppression, erythema, and sunburn-cell formation in healthy human subjects. ([Proceedings of the National Academy of Sciences of the United States of America, 2000](https://pubmed.ncbi.nlm.nih.gov/10660687/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))
- Topical treatment with the synthetic SOD/catalase mimetic EUK-134 reduced lipid peroxide levels both at baseline on non-irradiated human skin and at the surface of UVA-exposed skin when applied before or after irradiation, compared to controls. ([International Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/18492138/))
- Topical superoxide dismutase formulations maintained physical stability and enzymatic activity for 6 months at 4 and 30 degrees C, and effectively inhibited UVB-induced skin erythema for 48 hours, whereas formulations combined with alpha-tocopherol were unstable. ([European Journal of Pharmaceutics and Biopharmaceutics, 2007](https://pubmed.ncbi.nlm.nih.gov/17196809/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A night cream containing melatonin, carnosine, and Helichrysum italicum extract reduced oxidative stress ex vivo and improved hydration, reduced transepidermal water loss, decreased wrinkles and spots, and lowered skin reactivity in 117 individuals over up to 12 weeks of nightly use. ([Dermatology and Therapy, 2020](https://pubmed.ncbi.nlm.nih.gov/32915393/))
- Supramolecular carnosine improves skin reactivity, upregulates Nrf2 expression, activates antioxidant defenses, and reduces AGE levels while demonstrating whitening efficacy in cells and clinical tests compared to conventional carnosine. ([Advanced Healthcare Materials, 2024](https://pubmed.ncbi.nlm.nih.gov/39279568/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))

## Why other serums fit combination skin better

- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))
- A panthenol-enriched mask improved skin hydration, regulated sebum, and reduced redness and TEWL across dry sensitive, oily sensitive, and oily acne skin subgroups with excellent tolerance and no adverse reactions. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38366684/))

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Alto Advanced Defense and Repair Serum work for combination skin?

This serum offers moderate suitability for your combination skin because niacinamide helps balance oil while glycerin provides hydration, though it may not fully control shiny areas due to a lack of stronger oil-controlling ingredients like zinc PCA. A treatment for this skin needs effective ingredients that regulate oiliness and provide balanced hydration without causing excess oiliness or dryness.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for combination skin?

Niacinamide helps balance oil production, and glycerin provides hydration, making this serum a moderate fit for combination skin. To work best for this skin type, a product of this type needs additional oil-controlling ingredients like propolis or zinc PCA to manage oily shine.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Superoxide Dismutase do for combination skin?

Superoxide dismutase helps protect combination skin from daily sun damage and free radicals while supporting a balanced, calm complexion. It maintains a healthy antioxidant balance to keep skin looking youthful and resilient.
Sources: [European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/), [Antioxidants, 2023](https://pubmed.ncbi.nlm.nih.gov/37759978/)

### Where does this serum go in a skincare routine for combination skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing. Combination skin needs products that balance oil and hydration with ingredients like niacinamide and glycerin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying it during your morning routine before your moisturizer and sunscreen, or saving your retinol for the evening. Combination skin of this type needs stronger oil-controlling ingredients to properly manage oily shine alongside these treatments.

### How often should I use this serum?

This treatment serum is typically used in the evening routine, though some formulas can also be used in the morning or twice a day. It works for combination skin, but to better control oily shine, this skin type needs a product with stronger oil-balancing ingredients.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to clog pores or cause breakouts for your combination skin, as it has a safe profile with no harsh ingredients. However, to better manage oily shine, combination skin needs stronger oil-controlling ingredients.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.29 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/de/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/de/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — €13.67 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Acacia Decurrens Wax Flower, Acacia Senegal Gum, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Water, Arabidopsis Thaliana Extract, Arginine, Benzylidene Dimethoxydimethylindanone, Bisabolol, Buddleja Officinalis Flower Extract, Butylene Glycol, Camellia Sinensis Leaf Extract, Carbomer, Carnosine, Ceramide Ap, Ceramide Eop, Ceramide Np, Cetearyl Alcohol, Ceteth-20 Phosphate, Chlorogenic Acids, Cholesterol, Citric Acid, Coffea Arabica Extract Cell Leaf Coffee Extract Cell Leaf, Crocus Sativus Extract Cell Leaf Culture, Curcuma Longa Root Extract, Dextran, Dicetyl Phosphate, Diisostearyl Malate, Dimethyl Isosorbide, Ergothioneine, Ethylhexyl Olivate, Ethylhexylglycerin, Euterpe Oleracea Fruit Extract, Glycerin, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Helianthus Annuus Wax Seed Sunflower Wax Seed, Hydrolyzed Sodium Hyaluronate, Jojoba Esters, Lauryl Lactate, Lecithin, Linoleic Acid, Linolenic Acid, Methyl Gluceth-20, Micrococcus Lysate, Niacinamide, Olea Europaea Fruit Extract Olive Fruit Extract, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, Pentylene Glycol, Phenoxyethanol, Phytosphingosine, Plankton Extract, Polyglycerin-3, Propanediol, Propanediol Dicaprylate Caprate, Pyrroloquinoline Quinone Allyl Ester, Ricinoleth-40, Sea Whip Extract, Sodium Hydroxide, Sodium Lauroyl Lactylate, Sodium Pca, Sodium Phytate, Steareth-2, Superoxide Dismutase, Tetrahexyldecyl Ascorbate, Theobroma Cacao Seed Extract, Tocopherol, Tocopheryl Acetate, Trifluoroacetyl Tripeptide-2, Ubiquinone, Vitis Vinifera Seed Extract Grape Seed Extract, Xanthan Gum, Zingiber Officinale Root Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin (this page)
- France: https://lovi.care/skincare/fr/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/skin-better-science/alto-advanced-defense-and-repair-serum/for/combination-skin