# Sesderma Azelac RU Liposomal Serum for combination skin

**Lovi Fit: High fit for combination skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Sesderma](https://lovi.care/skincare/de/brands/sesderma)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for combination skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your combination skin, azelaic acid and tranexamic acid regulate melanogenesis and provide anti-inflammatory action, addressing your main goal of evening skin tone. While these ingredients are beneficial for your skin type, the formula lacks targeted ingredients for oil control, which is a primary concern for your oily shine.
- The presence of 4-butylresorcinol and tranexamic acid effectively inhibits melanin production, offering excellent treatment for uneven skin tone.
- The product is safe for your combination skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin): High (this page)
- [Sensitive skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/oily-acne-prone-skin): High

## Key ingredients

Azelaic Acid, Tranexamic Acid, Retinol, Niacin, 4-Butylresorcinol

## What the research says

- Application of 15% azelaic acid gel significantly reduced post-inflammatory erythema and hyperpigmentation, decreased hemoglobin and melanin content, improved quality of life, and contributed to acne improvement in patients with mild to moderate acne compared to placebo. ([Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/))
- Azelaic acid nanocrystal hydrogel 10% achieved a higher success rate and greater lesion reduction than azelaic acid cream 20% in patients with mild to moderate facial acne. ([Pharmaceutics, 2021](https://pubmed.ncbi.nlm.nih.gov/33923739/))
- Topical application of a dermocosmetic containing Myrtus communis extract and azelaic acid reduced acne relapses and helped maintain remission compared to a light moisturizing cream in adult females in the acne maintenance phase over 16 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2023](https://pubmed.ncbi.nlm.nih.gov/36729399/))
- Topical administration of 20% azelaic acid cream and 5% tranexamic acid solution comparably improved acne-related postinflammatory hyperpigmentation in patients with acne vulgaris, while tranexamic acid demonstrated a significantly better safety profile at week 4. ([Journal of Research in Medical Sciences, 2023](https://pubmed.ncbi.nlm.nih.gov/37213446/))
- Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle. ([International Journal of Cosmetic Science, 2017](https://pubmed.ncbi.nlm.nih.gov/27261203/))
- Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging. ([The British Journal of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/29947134/))
- Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity. ([Journal of Controlled Release, 2018](https://pubmed.ncbi.nlm.nih.gov/29604311/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- The 4-n-butylresorcinol dissolving microneedle patch demonstrated safety and was more than two times more effective than the control patch in skin depigmentation among 45 subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/26341915/))
- 4-n-butylresorcinol inhibits human tyrosinase and melanin production more potently than hydroquinone, arbutin, and kojic acid, and visibly reduces age spots within 8 weeks. ([Journal of the European Academy of Dermatology and Venereology, 2013](https://pubmed.ncbi.nlm.nih.gov/23205541/))
- Combined application of dissolving microneedle patches on serum-treated skin successfully delivered more 4-n-butylresorcinol and showed higher efficacy in reducing patients' melanin index and hyperpigmented regions compared to traditional DMN-only and serum-only applications. ([Molecular Pharmaceutics, 2017](https://pubmed.ncbi.nlm.nih.gov/28447799/))

## What reviewers say

Based on limited data, users frequently report this serum effectively brightens the complexion and reduces hyperpigmentation like melasma, sun spots, and acne marks, leading to smoother and more luminous skin. Many appreciate its fast absorption and lightweight feel. Some users with sensitive or dry skin find it can be drying and recommend using a moisturizer.

- Liked: Fast absorption (mostly mentioned)
- Liked: Fades dark spots (often mentioned)
- Liked: Improves texture (often mentioned)
- Liked: Acne control (sometimes noted)
- Disliked: Drying effect (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Sesderma Azelac RU Liposomal Serum a great fit for combination skin?

This serum is a great fit for your combination skin because azelaic acid and tranexamic acid help even out your skin tone and calm redness safely without irritation. The 4-butylresorcinol and tranexamic acid effectively target and fade dark spots, making this formula wonderfully suited for your skin.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Which ingredients make this serum a good fit for combination skin?

This serum is a great fit for your combination skin because azelaic acid and tranexamic acid help even out your skin tone and calm inflammation. The formula also includes 4-butylresorcinol, retinol, and niacin, which work together to safely target dark spots and make your skin smooth without causing irritation.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### What does Azelaic Acid do for combination skin?

Azelaic acid helps combination skin by calming redness, clearing breakouts, and fading dark spots while keeping the skin smooth. It is unlikely to irritate dry areas while working on oily spots. Combination skin of this type needs a balanced routine with gentle exfoliants and soothing hydrators.
Sources: [Postepy Dermatologii I Alergologii, 2023](https://pubmed.ncbi.nlm.nih.gov/38282869/), [Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/26355614/)

### What does Tranexamic Acid do for combination skin?

Tranexamic acid helps fade dark spots and uneven areas across different parts of combination skin while improving overall brightness. This ingredient is generally well-tolerated and may help target unwanted pigment without causing widespread irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38549196/), [Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/)

### Where does this serum go in a skincare routine for combination skin?

This serum goes in your evening routine, applied after cleansing and before your moisturizer. Putting it at night helps keep your skin safe around sun exposure, though some serums of this type can also be used in the morning or twice a day.

### Can I use this serum with vitamin C, and in what order?

You can use this serum with vitamin C by applying vitamin C in your morning routine and this treatment at night. This formula is safe for your combination skin and is unlikely to cause irritation.

### How often should I use this serum?

This treatment is typically used in the evening, following your cleansing step. It is unlikely to cause irritation on your combination skin and helps even out your skin tone over time.
Sources: [Dermatology and Therapy, 2024](https://pubmed.ncbi.nlm.nih.gov/38734843/)

### Can this serum clog pores, cause breakouts or purging for combination skin?

This serum is unlikely to cause breakouts or clog pores on combination skin, as it is safe with no harsh ingredients that typically trigger irritation. Reviewers occasionally note a moderate drying effect, but it does not cause purging.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (parfum) and drying alcohol (alcohol and alcohol denat).

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.29 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/de/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/de/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — €13.67 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Water, Lecithin, Propanediol, Alcohol, Bellis Perennis Flower Extract, Polymethyl Methacrylate, Peg-40 Hydrogenated Castor Oil, Propylene Glycol, Pentaerythrityl Tetra-Di-T-Butyl Hydroxyhydrocinnamate, 4-Butylresorcinol, Alcohol Denat, Ascorbyl Glucoside, Azelaic Acid, Bha, Bht, Caprylic Capric Triglyceride, Carbomer, Citronellyl Methylcrotonate, Grapefruit Fruit Extract, Diacetyl Boldine, Dipotassium Phosphate, Disodium Edta, Disodium Phosphate, Ethylhexylglycerin, Glycerin, Glycyrrhetinic Acid, Hydrochloric Acid, Hydroxypropyl Cyclodextrin, Melissa Officinalis Leaf Extract, Morus Alba Root Extract, Niacin, Nicotiana Benthamiana Sh-Polypeptide-7, Parfum, Peg Ppg-20 6 Dimethicone, Phenethyl Alcohol, Phenoxyethanol, Polysorbate 20, Potassium Phosphate, Potassium Sorbate, Retinal, Retinol, Sodium Chloride, Sodium Cholate, Sodium Hydroxide, Tocopheryl Acetate, Tranexamic Acid, Triethanolamine, Triisopropanolamine, Undecylenoyl Phenylalanine, Xanthan Gum
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin (this page)
- France: https://lovi.care/skincare/fr/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/sesderma/azelac-ru-liposomal-serum/for/combination-skin