SENTÉ Bio Complete Serum for sensitive skin
Sodium Hyaluronate
Retinol
Glycosaminoglycans
Heparan Sulfate
NiacinamideAverage
- HighNormal Skin Fit
- AverageEffectiveness
- HighSafety
Works for sensitive skin; other serums fit it better.
- International Journal of Cosmetic Science, 2017
- Clinical, Cosmetic and Investigational Dermatology, 2017
This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- This serum offers moderate benefits for normal skin, with retinol and sodium ascorbyl phosphate providing antioxidant activity and supporting collagen synthesis, though it does not specifically target your redness and irritation.
- Ingredients like glycerin and allantoin offer general hydration and soothing effects, which are supportive for your skin concerns.
- The formulation is safe for your sensitive skin, as it lacks harsh ingredients and includes soothing components like allantoin and panthenol.
How to apply
- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
People Say
★4.7Overall rating based on 100+ reviewsBased on limited data, this serum is highly praised for its anti-aging effects, improving skin texture and firmness while reducing fine lines. Some users experienced a greasy feel or slow results, and a negligible number mentioned the presence of fragrance.
Highlights
Gentle formula Mostly Mentioned
- “Most tolerated retinol for my sensitive skin.”
- “Does not make my skin peel.”
- “Gentle enough for sensitive skin.”
- “No irritation at all.”
Improves texture Often Mentioned
- “Noticeable difference in my skin texture.”
- “Skin is soft and supple.”
- “Skin texture and tone are so much better.”
- “Smoother and firmer skin.”
Anti-aging benefits Sometimes Noted
- “Reduced the appearance of fine lines.”
- “Appearance is quite youthful for my age.”
- “Helped with clear discolored spots.”
- “Boosts collagen and elastin production.”
Hydrating Sometimes Noted
- “Deep hydration to prevent redness.”
- “Plenty of hydration.”
- “Keeps skin comfortably moisturized.”
Contains fragrance Rarely Noted
- “It does have fragrance.”
Greasy feel Rarely Noted
- “Very silicone based so it's really greasy feeling.”
- “Texture feels a bit heavy.”
Slow results Rarely Noted
- “Unfortunately didn't see any changes.”
- “Need more time to see benefits.”
- “Too early to speak to results.”
Sources: lovi.care, lovelyskin.com, dermstore.com, dermavenue.com, harbenhouse.com, skinelite.com, and more
Questions and answers
How well does SENTÉ Bio Complete Serum work for sensitive skin?
This serum works moderately well for sensitive skin, offering hydration and soothing effects from glycerin, allantoin, and panthenol along with retinol for collagen support, though it does not specifically target redness and irritation. To fit sensitive skin better, a treatment of this type needs dedicated calming ingredients and antioxidants that reduce redness while avoiding irritation.
Which ingredients make this serum a good fit for sensitive skin?
Glycerin, allantoin, and panthenol help make this serum a good fit for sensitive skin by offering gentle hydration and soothing effects. To be a better fit for sensitive skin, a treatment of this type needs calming ingredients that specifically target redness and irritation without harsh components.
What does Hyaluronic Acid do for sensitive skin?
Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Journal of Drugs in Dermatology, 2025Journal of Cosmetic Dermatology, 2018
What does Retinol do for sensitive skin?
Retinol is generally too harsh for sensitive skin and may cause stinging, scaling, and irritation. A product for this skin needs gentle ingredients that smooth and calm without causing redness.
The British Journal of Dermatology, 2019Toxicology Letters, 2003
Where does it go in a skincare routine for sensitive skin?
This treatment goes in your evening routine, as treatments with active ingredients are best used then for extra safety around sun exposure. This serum works for sensitive skin, though this skin type needs products that include soothing ingredients and gentle hydrators like glycerin and allantoin.
Can I use this serum with glycolic acid, and in what order?
It is best to avoid using this serum in the same routine as glycolic acid, because combining strong active ingredients like retinol and acids may easily irritate sensitive skin. Instead, alternate them on different nights or use glycolic acid in the morning and this treatment at night, always following up with a gentle moisturizer.
How often should I use it?
This treatment works well in the evening routine for sensitive skin. To keep your skin calm while using retinol, start by applying it once a week and slowly increase frequency only if your skin handles it well.
Can this serum clog pores, cause breakouts or purging for sensitive skin?
This serum is unlikely to clog pores or cause breakouts for sensitive skin, though strong ingredients like retinol may cause a mild adjustment period with temporary flaking. Its formulation avoids heavy pore-clogging oils and includes soothing components like allantoin and panthenol to keep skin calm.
Is it fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Topical 0.4% retinol significantly increased epidermal thickness, dermal vascularity, and extracellular matrix production by stimulating keratinocyte proliferation, endothelial cell proliferation, and fibroblast activation in naturally aged human skin compared to vehicle.
International Journal of Cosmetic Science, 2017A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Topical bakuchiol 0.5% applied twice daily compared with retinol 0.5% applied daily significantly decreased wrinkle surface area and hyperpigmentation with no statistical difference between the compounds in 44 patients over 12 weeks, while retinol users reported more facial skin scaling and stinging.
The British Journal of Dermatology, 2019Silicone particles encapsulating retinol increased its half-life by 9-fold and yielded 12-23% lower skin irritation in human subjects compared to Microsponge particles while maintaining biological activity.
Journal of Controlled Release, 2018Topical stabilized retinol treatment induced HAS gene expression and increased hyaluronic acid production in human skin in vitro, ex vivo, and in vivo compared to vehicle.
Archives of Dermatological Research, 2017Topical treatment with sphingolipids and glycosaminoglycans attenuated clinical worsening and reduced CADESI and PVAS scores compared to the untreated control group in house dust mite-allergic beagle dogs.
BMC Veterinary Research, 2020Glycosaminoglycans restored type I collagen synthesis, reduced matrix metalloproteinase-1 levels, upregulated tissue inhibitor of metalloproteinase-1, and attenuated apoptosis in tumor necrosis factor-alpha-stimulated human dermal fibroblasts by inhibiting extracellular signal-regulated kinase/activator protein-1 signaling.
International Journal of Molecular Medicine, 2018Fraction 3 of glycosaminoglycans from Liparis tessellatus eggs showed 20.1% tyrosinase inhibition at 50mg/mL and effective skin regeneration activities at 200mg/mL against skin fibroblast CCD-986sk cell lines.
International Journal of Biological Macromolecules, 2017A topical eye cream containing low molecular weight heparan sulfate and naturally derived extracts improved periorbital hyperpigmentation, fine and coarse wrinkles, puffiness, and dark circles in 15 subjects over 12 weeks.
Journal of Cosmetic Dermatology, 2019Topical low molecular weight heparan sulfate improved periorbital discoloration and wrinkles starting at week two with continuous improvement up to week 12.
Journal of Cosmetic Dermatology, 2020Topical low molecular weight heparan sulfate improved skin hydration, firmness, elasticity, barrier function, and fine lines and wrinkles in 15 patients over 8 weeks.
Journal of Drugs in Dermatology, 2015Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005
Why other serums fit sensitive skin better
Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control.
European Journal of Pharmaceutics and Biopharmaceutics, 2016
Ingredients
Water, Butylene Glycol, Dipropylene Glycol, Cyclopentasiloxane, Peg-12 Dimethicone Crosspolymer, Dimethicone Crosspolymer, Dimethicone Vinyl Dimethicone Crosspolymer, Dimethiconol, Dimethicone, Laureth-23, Laureth-4, Glycerin, Heparan Sulfate, Pentylene Glycol, Retinyl Safflowerate, Retinol, Lysophosphatidic Acid, Myristoyl Nonapeptide-3, Myristoyl Pentapeptide-17, Ethyl Safflowerate, Ethyl Flaxseedate, Dipalmitoyl Hydroxyproline, Allantoin, Panthenol, Sodium Hyaluronate, Sodium Ascorbyl Phosphate, Alanine, Arginine Hcl, Asparagine, Aspartic Acid, Cystine, Glutamic Acid, Glutamine, Histidine Hcl, Isoleucine, Leucine, Lysine Hcl, Acetyl Methionine, Phenylalanine, Proline, Serine, Threonine, Tryptophan, Tyrosine, Valine, Calcium Pantothenate, Folic Acid, Inositol, Niacinamide, Pyridoxal Hcl, Riboflavin, Thiamine Hcl, Calcium Chloride, Magnesium Sulfate, Potassium Chloride, Sodium Chloride, Sodium Phosphate, Beta-Carotene, Polysorbate 80, Polyaminopropyl Biguanide, Tromethamine
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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