Rael Beauty Miracle Patch for skin with dark spots

How to apply

Questions and answers

What the research says

• Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer.

  The British Journal of Dermatology, 2002

• Topical treatment of nicotinamide, alone or in combination with other active ingredients, reduces the progression of skin aging and hyperpigmentation in clinical trials while being well tolerated.

  Antioxidants, 2021

• Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.

  Journal of Cosmetic Dermatology, 2021

• Daily application of hydrocolloid dressing completely prevented nasogastric tube-related pressure injuries, whereas skin care interventions showed no significant preventive effect compared to the control group in intensive care unit patients.

  Journal of Tissue Viability, 2024

• Hydration of scars for 2 months resulted in significantly reduced itching, somewhat reduced pain, and increased pliability by 10% for both hydrocolloid dressing and moisturizer treatments in patients with keloids or hypertrophic scars, with no change in physical parameters.

  Dermatologic Surgery, 1996

• Adjunctive hydrocolloid dressing with 0.1% mometasone furoate cream significantly increased treatment efficacy and cost-effectiveness compared to topical steroid alone in patients with moderate to severe lichen simplex chronicus.

  Skin Health and Disease, 2023

• Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.

  The Journal of Investigative Dermatology, 2008

• Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.

  Dermatologic Surgery, 2005

• Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline.

  Journal of Cosmetic and Laser Therapy, 2006

• Treatment with a facial cream gel containing a biotechnological phytocomplex, niacinamide, and succinic acid increased skin microbial diversity and reduced C. acnes abundance, lesion counts, sebum, and acne severity in 44 subjects with mild-moderate acne over 56 days.

  Journal of Cosmetic Dermatology, 2024

• Treatment with a lotion containing a phytocomplex, niacinamide, and succinic acid increased skin microbial alpha diversity, reduced Cutibacterium acnes relative abundance, and improved acne severity and clinical symptoms in 43 subjects with truncal mild-moderate acne.

  Skin Research and Technology, 2024

• Treatment with plant-derived exosomes combined with non-cross-linked hyaluronic acid and succinic acid improved facial hyperpigmentation in two patients.

  Cureus, 2026

• Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.

  Journal of Drugs in Dermatology, 2011

• Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.

  Clinical Oral Investigations, 2022

• Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.

  BMC Oral Health, 2019

• Topical lycopene-enriched virgin olive oil provides effective pain relief similar to a placebo in patients with burning mouth syndrome, showing a strong placebo effect.

  Journal of Oral Rehabilitation, 2014

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.