# Peter Thomas Roth Peptide 21 Wrinkle Resist Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Peter Thomas Roth](https://lovi.care/skincare/de/brands/peter-thomas-roth)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your normal skin and concerns with wrinkles and fine lines is provided by multiple peptides like Tripeptide-10 Citrulline and Acetyl Octapeptide-3, which support collagen production and skin elasticity. Palmitoyl Hexapeptide-12 and Sodium Hyaluronate further enhance collagen stimulation and hydration, respectively, making this serum highly effective for your skin type. The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the inclusion of soothing components like Rosa Centifolia Flower Water and Glycerin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Complex Of 21 Peptides, Neuropeptides, Squalane, Sodium Hyaluronate, Ascorbic Acid, Retinyl Palmitate

## What the research says

- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Over-the-counter retinol products provided only weak evidence for a mild ameliorating effect on fine facial skin wrinkle lines in randomized, double-blind, vehicle-controlled trials, and major methodological flaws call the validity of positive results into question. ([The Journal of Clinical and Aesthetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/34980969/))
- A cosmetic niacinamide/peptide/retinyl propionate regimen significantly improved periorbital wrinkle appearance relative to a 0.02% tretinoin regimen at 8 weeks with comparable benefits at 24 weeks, while demonstrating significantly better tolerability in 196 women. ([The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20374604/))
- A novel triple-active cosmetic formulation containing 4-hexylresorcinol, retinyl propionate, and niacinamide improved the visual appearance of photoageing similarly to 0.02% tretinoin and reversed a consensus gene signature associated with ageing in female adults while causing less skin irritation. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/38685700/))

## What reviewers say

Users frequently praise this serum for its lightweight, fast-absorbing formula that effectively hydrates and plumps the skin, leading to a visible reduction in fine lines on the forehead and neck. Some users find the product expensive and complain about a sticky residue or a metallic scent.

- Liked: Hydrates and plumps (often mentioned)
- Liked: Reduces fine lines (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Improves texture (sometimes noted)
- Liked: Lightweight absorption (sometimes noted)
- Disliked: Sticky residue (sometimes noted)
- Disliked: Metallic scent (rarely noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Peter Thomas Roth Peptide 21 Wrinkle Resist Serum a great fit for mature skin?

This serum is a great fit because it uses multiple peptides to support collagen production and elasticity, helping smooth out wrinkles on mature skin. It also includes hydrating ingredients to keep skin plump, while omitting harsh additives to ensure a very low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin thanks to multiple peptides like Tripeptide-10 Citrulline and Acetyl Octapeptide-3 that help boost collagen and elasticity, alongside Sodium Hyaluronate for deep hydration. These ingredients work together to smooth out fine lines while keeping your skin feeling soft and well-hydrated.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Peptide Complex do for mature skin?

Peptide Complex helps mature skin by smoothing fine lines and wrinkles while boosting firmness, elasticity, and hydration. These ingredients support aging skin by signaling it to increase collagen production, leading to a visibly revitalized and firmer look.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37335808/), [International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39788697/)

### What do Neuropeptides do for mature skin?

Neuropeptides help mature skin by stimulating collagen production to keep it firm and smooth. They also help calm skin and support a healthy barrier against everyday stress.
Sources: [ACS Biomaterials Science & Engineering, 2025](https://pubmed.ncbi.nlm.nih.gov/40410664/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, following Lovi's simple approach for treatments with active ingredients. Using it this way helps avoid extra sensitivity from sun exposure, while letting the peptides work overnight to support skin elasticity and smooth out fine lines.
Sources: [Journal of Drugs in Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/36607762/), [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40327583/)

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying your retinol product first and then following with this peptide serum, or by using them on alternating nights to keep your skin calm. This product is unlikely to cause irritation because it leaves out harsh ingredients and includes soothing components like rose flower water and glycerin.

### How often should I use this serum?

You can use this serum in your evening routine, and some treatments like this may also be used in the morning or twice a day. It helps smooth wrinkles and keep skin hydrated with peptides and sodium hyaluronate with a very low risk of irritation.
Sources: [Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin. It features a gentle formulation with soothing ingredients like glycerin and rose flower water, ensuring an excellent safety profile without harsh components that typically trigger irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/de/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €730.48 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €51.50 at Amazon

## Where to buy

- Amazon.de: €70.19 (https://www.amazon.de/dp/B00YP582QA?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Glycerin, Rosa Centifolia Flower Water, Isopropyl Myristate, Squalane, Mannitol, Butylene Glycol, Natto Gum, Tripeptide-10 Citrulline, Acetyl Octapeptide-3, Palmitoyl Hexapeptide-12, Acetyl Tetrapeptide-11, Acetyl Hexapeptide-8, Acetyl Hexapeptide-1, Palmitoyl Oligopeptide, Acetyl Tetrapeptide-9, Acetyl Tetrapeptide-2, Tripeptide-1, Palmitoyl Tetrapeptide-7, Hexapeptide-11, Dipeptide Diaminobutyroyl Benzylamide Diacetate, Palmitoyl Tripeptide-5, Trifluoroacetyl Tripeptide-2, Palmitoyl Tripeptide-1, Sodium Polyglutamate, Sodium Hyaluronate, Tocopheryl Acetate, Retinyl Palmitate, Ascorbic Acid, Hydrolyzed Soy Protein, Hydrolyzed Wheat Protein, Lecithin, Pseudoalteromonas Extract Ferment, Acrylates Copolymer, Magnesium Chloride, Polysorbate 20, Dimethyl Isosorbide, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Leuconostoc Radish Root Ferment Filtrate, Peg-8 Dimethicone, Disodium Phosphate, Carbomer, Dextran, Sodium Lactate, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Xanthan Gum, Triethanolamine, Sodium Phosphate, Octyldodecanol, Silica, Sodium Propoxyhydroxypropyl Thiosulfate Silica, Sodium Hydroxide, Caprylyl Glycol, Potassium Sorbate, Sodium Benzoate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
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- Netherlands: https://lovi.care/skincare/nl/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
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- Canada: https://lovi.care/skincare/ca/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin
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- United Arab Emirates: https://lovi.care/skincare/ae/p/peter-thomas-roth/peptide-21-wrinkle-resist-serum/for/mature-skin