Perricone MD Vitamin C Ester Photo-Brightening Moisturizer SPF 30 for skin with dark spots

How to apply

Questions and answers

What the research says

• Combining oral and topical astaxanthin in 30 healthy females improved skin wrinkles, age spots, elasticity, texture, and moisture, while 6 mg daily oral supplementation in 36 healthy males improved crow's feet wrinkles, elasticity, and transepidermal water loss.

  Acta Biochimica Polonica, 2012

• Application of an alpha-bisabolol-containing cream produced a significant skin-lightening effect in pigmented skin compared to a vehicle control in the majority of female subjects after 8 weeks.

  International Journal of Cosmetic Science, 2010

• Twice-daily application of a novel topical antioxidant formulation safe, well-tolerated, and effective in improving overall skin quality, fine lines, wrinkles, radiance, and hyperpigmentation in 32 healthy female subjects over 12 weeks.

  Journal of Cosmetic Dermatology, 2023

• Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.

  Experimental Dermatology, 2003

• Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.

  Journal of Periodontology, 2009

• Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.

  Journal of Cosmetic Dermatology, 2022

• Topical 30% P407 gel loaded with ALA cubosomes reduced facial lines, nearly resolved fine lines in the periorbital and upper lip areas, and improved skin color and texture without irritation or peeling in volunteers.

  European Journal of Pharmaceutics and Biopharmaceutics, 2014

• Application of 5% cubosomal alpha lipoic acid gel twice daily for 6 months significantly improved global aesthetic scores and increased epidermal thickness compared to placebo in 20 aging female faces.

  Journal of Cosmetic Dermatology, 2017

• Treatment with a cream containing 5% alpha-lipoic acid for 12 weeks reduces skin roughness by an average of 50.8% compared to 40.7% with placebo in women with photoaged facial skin.

  The British Journal of Dermatology, 2003

• Microfine titanium dioxide does not penetrate human skin when formulated in an oil-in-water emulsion with the pigment dispersed in the aqueous phase, compared to oily dispersions and liposomal encapsulation which allow deeper skin penetration.

  International Journal of Cosmetic Science, 2000

• Replacing microsized titanium dioxide and zinc oxide with nanoparticles in sunscreens eliminates opaqueness and alters UV protection balance while inducing (photo)cyto- and genotoxicity and penetrating viable skin layers during long-term exposures.

  Nanotechnology, Science and Applications, 2011

• Microfine zinc oxide and titanium dioxide do not penetrate the stratum corneum of porcine skin in vitro, indicating that their use in sunscreens does not pose a health risk from internal exposure.

  Toxicology in Vitro, 2006

• Oral astaxanthin supplementation significantly restored moisture content and improved elasticity but did not significantly decrease wrinkle depth compared to placebo in humans.

  Nutrients, 2021

• Astaxanthin prevents UV-induced cutaneous inflammation, abnormal keratinization, wrinkling, and pigmentation in human skin even when applied postirradiation.

  Photochemistry and Photobiology, 2019

• Astaxanthin-betaine ionic liquid liposomes exhibit improved stability, skin permeability, and antioxidant and anti-inflammatory effects by regulating the TGF-β1/smad2/smad3 pathway compared to free astaxanthin.

  ACS Applied Bio Materials, 2025

• A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.

  Clinical, Cosmetic and Investigational Dermatology, 2017

• The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol.

  Journal of Cosmetic Dermatology, 2020

• Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant.

  International Journal of Cosmetic Science, 2001

Ingredients

Water, Glycerin, Cyclopentasiloxane, Dimethicone, Pentylene Glycol, Ethylhexyl Methoxycrylene, Polyester-8, Polyglyceryl-3 Polydimethylsiloxyethyl Dimethicone, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Benzyl Alcohol, Aluminum Hydroxide, Stearic Acid, Diethylhexyl Syringylidenemalonate, Hydrogenated Lecithin, Isohexadecane, Bisabolol, Tetrahexyldecyl Ascorbate, Phenoxyethanol, Polysilicone-11, Polysorbate 60, Caprylic Capric Triglyceride, Sodium Benzoate, Potassium Sorbate, Xanthan Gum, Hydrogenated Phosphatidylcholine, Thioctic Acid, Astaxanthin, Titanium Dioxide

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.