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Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer for skin with dark spots

Rated by Lovi · Unbiased, science-based skincare AI trained on real user outcomes

Perricone MD Essential Fx Acyl-Glutathione Rejuvenating Moisturizer

High

  • HighNormal Skin Fit
  • AverageEffectiveness
  • HighSafety

A great choice for skin with dark spots; a few moisturizers fit it even better.

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.

Page built Nov 8, 2026How the Fit score works

Lovi Assistant explains

  • Highly suitable for your normal skin due to the presence of Palmitoyl Glycine and S-Palmitathione, which offer antioxidant activity and support collagen synthesis.
  • It provides excellent moisturizing treatment with glycerin and Macadamia Ternifolia Seed Oil, though it lacks specialized ingredients to effectively address your main goal of pigmentation.
  • The safety profile is excellent, with no risks of irritation for your normal skin due to the absence of prohibited or harsh ingredients.

How to apply

  • Could be used as part of your AM and PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
  • Apply this moisturizer after your cleanser and toner, right before your morning SPF.
  • Gently press a small amount of the moisturizer into your skin. Avoid rubbing it too hard so it absorbs nicely.
  • For the best moisture, you can apply it when your skin is slightly damp. This helps your skin stay soft and happy.
  • Remember to avoid the eye area when applying. Always do a patch test before your first use.

People Say

★4.5Overall rating based on 500+ reviews

This moisturizer is highly praised for its rich, velvety texture that absorbs quickly to provide intense hydration, making it a favorite for dry and mature skin types. Users frequently report a visible improvement in skin softness, radiance, and a firmer, more supple appearance, though some note that it may not fully erase deep-set wrinkles.

Highlights

  • Deeply hydrating Mostly Mentioned
    • “Keeps skin hydrated all day.”
    • “Great for dry patches.”
    • “Feels very moisturizing.”
  • Fast absorbing Often Mentioned
    • “Absorbs fast, not greasy.”
    • “No residue feel afterwards.”
    • “Absorbs quickly without stickiness.”
  • Pleasant texture Often Mentioned
    • “Light, velvety texture.”
    • “Not too heavy, not too light.”
    • “Creamy, not greasy.”
  • Expensive price Often Mentioned
    • “On the steep side.”
    • “More expensive side.”
    • “Price is quite high.”
  • Improves radiance Sometimes Noted
    • “Produces a radiant glow.”
    • “Skin looks healthier.”
    • “Imparts a beautiful radiance.”
  • Limited wrinkle results Sometimes Noted
    • “Haven't noticed much difference.”
    • “Not as good as advertised.”
    • “Deep lines remain.”
  • Strong fragrance Rarely Noted
    • “Fragrance too strong.”
    • “Concerned about fragrance.”
    • “Experienced minor irritation.”

Sources: lovi.care, perriconemd.com, mecca.com.au, macys.com, nordstrom.com, ipsy.com, and more

Questions and answers

What makes Perricone MD Rejuvenating Moisturizer a great fit for skin with dark spots?

This moisturizer is a great fit for your skin with dark spots because it provides excellent moisturizing treatment with glycerin and Macadamia Ternifolia Seed Oil, alongside antioxidant ingredients that support collagen synthesis. It has an excellent safety profile with no risks of irritation for your skin due to the absence of harsh ingredients.

Clinical, Cosmetic and Investigational Dermatology, 2017

Which ingredients make this cream a good fit for skin with dark spots?

Tetrahexyldecyl Ascorbate and Lactic Acid make this cream a good fit for skin with dark spots by brightening the complexion and gently exfoliating. It also helps keep the skin feeling soft and smooth.

What does Acyl-Glutathione do for skin with dark spots?

Acyl-Glutathione helps fade dark spots and brightens your overall skin tone while smoothing out the surface. This ingredient has a safe profile and works by improving pigmentation, though individual results may vary.

The Journal of Clinical and Aesthetic Dermatology, 2025Molecules, 2026

What does Vitamin C do for skin with dark spots?

Vitamin C helps fade dark spots and brightens uneven skin tone by slowing down pigment production. Daily use also helps calm redness and protects against further sun damage.

Journal of Cosmetic Dermatology, 2023Dermatologic Surgery, 2005

Where does this cream go in a skincare routine for skin with dark spots?

This moisturizing treatment goes near the end of your morning and evening routines, right before sunscreen in the morning and after your treatment step at night. It helps keep your skin soft and smooth while fitting comfortably into your daily regimen.

The Journal of Dermatological Treatment, 2022Clinical, Cosmetic and Investigational Dermatology, 2017

Can I use this cream with retinol, and in what order?

You can use this cream alongside retinol by applying it either before or after your retinol treatment to help keep your skin comfortable. Because this moisturizer has an exceptionally gentle safety profile with no harsh ingredients, it is unlikely to cause irritation when combined with active treatments.

Cutis, 2006

How often should I use this cream?

You can use this moisturizing treatment twice daily to keep your skin soft and well-hydrated. Regular daily application helps improve overall skin brightness and texture while supporting your skin barrier.

Journal of Cosmetic Dermatology, 2020Journal of Drugs in Dermatology, 2015

Can this cream clog pores, cause breakouts or purging for skin with dark spots?

This moisturizing treatment is unlikely to cause breakouts or clogged pores on skin with dark spots because it has an excellent safety profile with no harsh ingredients. It helps keep skin soft and smooth while remaining gentle on your face.

Can I use this cream around the eyes or on my body?

You can use this moisturizing treatment around the eyes and on the body because it features a very safe formula with gentle ingredients like glycerin and macadamia seed oil. These ingredients help keep skin soft and hydrated without causing irritation in delicate areas.

Is this cream fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (citronellol, limonene, and linalool). Cetearyl alcohol is a fatty alcohol, which soften the skin.

What the research says

Ingredients

Water, Ethylhexyl Palmitate, Glycerin, Dimethicone, Cetearyl Alcohol, Glyceryl Stearate, Polysorbate 60, Palmitoyl Glycine, S-Palmitoylglutathione, Tetrahexyldecyl Ascorbate, Peg-100 Stearate, Ribose, Lactic Acid, Linum Usitatissimum Seed Oil, Macadamia Ternifolia Seed Oil, Polyglyceryl-10 Stearate, Ethylhexylglycerin, Salvia Hispanica Seed Oil, Tocopherol, Helianthus Annuus Seed Oil Sunflower Seed Oil, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Tetrasodium Glutamate Diacetate, Sodium Hydroxide, Polyacrylamide, Sodium Acrylates Copolymer, Polysilicone-11, Hydrogenated Polyisobutene, C13-14 Isoparaffin, Laureth-7, Phenoxyethanol, Citronellol, Hydroxycitronellal, Limonene, Linalool

Behind this fit score

Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.

  • Nadia Kapleva, MS

    Nadia Kapleva, MS

    Co-founder, Medical Director

    Cosmetic chemist, cosmetologist, aesthetic products developer

  • Alexey Shagraev, PhD

    Alexey Shagraev, PhD

    Co-founder, CEO and CTO

    PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex

  • Dr. Sofía Perea Pérez, MD, MSc

    Dr. Sofía Perea Pérez, MD, MSc

    Medical Board

    Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine

  • Aishani Shah, MD

    Aishani Shah, MD

    Medical Board

    Specialist dermatologist, MBBS, MD, IFAAD

  • Asya Zubkova, MS

    Asya Zubkova, MS

    Medical Board

    Cosmetic chemist, SCS, IFSCC member

  • Hanna Kurets, MD

    Hanna Kurets, MD

    Medical Board, Medical Advisor

    Dermatology MD

  • Elina Nazarenko, MD

    Elina Nazarenko, MD

    Medical Board

    Dermatology and diagnostic consultant

  • Victoria Derkova, MS

    Victoria Derkova, MS

    Medical Board

    Cosmetic chemist, cosmetic development technologist

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How does it fit your skin?

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