# Perricone MD Cold Plasma Plus+ for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Perricone MD](https://lovi.care/skincare/de/brands/perricone-md)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate benefits for your normal skin, as Glycerin and Sodium Hyaluronate provide hydration while Tetrahexyldecyl Ascorbate and Retinyl Palmitate offer antioxidant support, though they are not specialized for targeting wrinkles and fine lines.
- The presence of Acetyl Hexapeptide-8 and Glycolic Acid contributes to smoothing texture and minimizing fine lines, enhancing the product's overall efficacy for general skincare.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid Ester, Copper Tripeptide, Acetyl Hexapeptide-8, Omega 3, Glycolic Acid

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Argireline treatment twice daily for 4 weeks produced a significant anti-wrinkle effect with 48.9% total efficacy and decreased skin roughness in Chinese subjects compared with 0% efficacy and no decrease in roughness in the placebo group. ([American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/))
- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Acetyl hexapeptide-3 and tripeptide-10 citrulline demonstrated antiwrinkle efficacy and decreased transepidermal water loss in twenty-four healthy volunteers compared to control groups, though synergistic effects between the two peptides remained unclear. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28150423/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- A novel regimen combining a hydroxy acid-based scrub and copper tripeptide serum significantly reduced adherent scalp flaking by 61.24%, increased hair density by 12.48%, increased hair thickness by 25.36%, and improved scalp skin hydration by 76.24% in adults with mild to moderate dandruff over 15 days. ([Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/39449909/))
- The combination of Thermus thermophilus and Bacillus subtilis mixed-culture ferment extract and copper tripeptide-1 GHK-Cu reduced inflammatory cytokines, protected skin explants from UV-induced damage, and improved wrinkles and skin barrier conditions compared to individual components or controls. ([Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/))
- Daily topical acetyl hexapeptide-8 showed a trend toward a longer time until return to baseline Jankovic Blepharospasm Rating Scale scores compared to placebo (3.7 months vs. 3.0 months) in 24 patients with blepharospasm receiving botulinum toxin therapy. ([European Journal of Neurology, 2013](https://pubmed.ncbi.nlm.nih.gov/23146065/))
- Argireline applied twice daily for 4 weeks achieved a total anti-wrinkle efficiency of 48.9% and notably reduced wrinkle depth compared to placebo in Chinese subjects. ([Journal of Cosmetic and Laser Therapy, 2013](https://pubmed.ncbi.nlm.nih.gov/23607739/))
- Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model. ([International Journal of Biological Macromolecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41628877/))
- Repeated short-contact 70% glycolic acid peels provided superior results in atrophic acne scars compared to daily low-strength glycolic acid cream or placebo in 58 women over 24 weeks. ([International Journal of Dermatology, 2000](https://pubmed.ncbi.nlm.nih.gov/11095203/))
- Serial glycolic acid peels combined with a modified Kligman formula significantly reduced facial PIH severity in Indian patients compared to the modified Kligman formula alone. ([Dermatologic Surgery, 2017](https://pubmed.ncbi.nlm.nih.gov/28114204/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Encapsulation of ferulic acid in phosphorylated rice starch enhanced its stability against heat and light and improved skin lightening, elasticity, smoothness, roughness, scaliness, and wrinkles compared to free ferulic acid in 16 volunteers over 1 month. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35684401/))

## What reviewers say

Based on a very large amount of data, users frequently praise this serum for its ability to dramatically smooth rough texture and minimize the appearance of pores, often delivering visible results within a few weeks. While many report firmer, more radiant skin and improved tone, a significant number of reviewers struggle with its distinct scent and high price point.

- Disliked: Unpleasant scent (mostly mentioned)
- Liked: Improves skin texture (often mentioned)
- Disliked: High price tag (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Liked: Increases radiance (sometimes noted)
- Liked: Reduces fine lines (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Skin irritation (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Cold Plasma Plus+ work for mature skin?

Perricone MD Cold Plasma Plus+ works as an average fit for mature skin, providing hydration and smoothing texture while lacking specialized ingredients for targeting wrinkles and fine lines. To truly care for mature skin, a product of this type needs high-quality ingredients that effectively target wrinkles and fine lines, offer strong anti-aging functions, and improve skin elasticity.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### Which ingredients make this treatment a good fit for mature skin?

Acetyl hexapeptide-8 and glycolic acid help smooth texture and minimize fine lines, while glycerin and sodium hyaluronate keep your skin hydrated. To fit mature skin best, a product of this type needs specialized ingredients that strongly target wrinkles and fine lines, along with potent antioxidants and skin-repairing components.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [American Journal of Clinical Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23417317/)

### What does Ascorbic Acid do for mature skin?

Ascorbic acid helps make mature skin look smoother and firmer while reducing fine lines and wrinkles. It supports collagen building and helps protect against daily skin damage.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32383548/), [Archives of Otolaryngology--head & Neck Surgery, 1999](https://pubmed.ncbi.nlm.nih.gov/10522500/)

### What does Copper Tripeptide do for mature skin?

Copper Tripeptide helps smooth fine lines and firms mature skin by boosting collagen and calming irritation. It also supports skin elasticity and overall barrier health, making it a great addition to anti-aging routines.
Sources: [Skin Research and Technology, 2026](https://pubmed.ncbi.nlm.nih.gov/42573538/), [Oxidative Medicine and Cellular Longevity, 2012](https://pubmed.ncbi.nlm.nih.gov/22666519/)

### Where does this treatment go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. Mature skin needs products with specialized peptides, retinoids, and antioxidants that deeply target fine lines and firmness.

### Can I use this treatment with niacinamide, and in what order?

You can use this treatment with niacinamide by applying niacinamide first and following with this treatment once it absorbs, which helps keep your skin calm and smooth. This product is unlikely to irritate your skin since it lacks harsh ingredients.

### How often should I use this treatment?

This treatment fits into your evening routine once a week to start, as Lovi routines start exfoliating steps cautiously with once a week. People who tolerate them well and see good results can carefully use them more often.

### Can this treatment clog pores, cause breakouts or purging for mature skin?

This treatment is unlikely to clog pores or cause breakouts for mature skin, as it has a very low risk of skin irritation and features gentle hydrating ingredients. To properly care for mature skin, a product of this type needs firming peptides and specialized ingredients that directly target wrinkles and fine lines.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetearyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/de/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €730.48 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €51.50 at Amazon

## Where to buy

- Amazon.de: €145.79 (https://www.amazon.de/dp/B077394HRR?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €25.00 (https://www.notino.de/perricone-md/cold-plasma-plus-hand-therapy-pflegende-handcreme/p-16078159/)
- Lookfantastic: €80.25 (https://www.lookfantastic.de/p/perricone-md-cold-plasma-plus-advanced-eye-cream/13033797/)
Prices checked 10 Oct – 5 Nov 2026.

## Ingredients

Water, Glycerin, Isopropyl Palmitate, Cetearyl Alcohol, Glyceryl Stearate, Peg-100 Stearate, Butylene Glycol, Phosphatidylcholine, Tetrahexyldecyl Ascorbate, Dimethyl Mea, Acetyl Hexapeptide-8, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-3, Tyrosine, Glycolic Acid, Helianthus Annuus Seed Oil Sunflower Seed Oil, Magnesium Aspartate, Zinc Gluconate, Rosaminus Officinalis Leaf Extract Rosemary Leaf Extract, Copper Gluconate, Sodium Hyaluronate, Retinyl Palmitate, Echium Plantagineum Seed Oil, Hydrolyzed Myrtus Communis Leaf Extract, Copper Tripeptide-1, Dimethicone, Disodium Edta, Carbomer, Ceteareth-20, Cyclopentasiloxane, Caprylyl Glycol, Cyclohexasiloxane, Polysorbate 20, Zea Mays Oil, Phenoxyethanol, Sorbic Acid
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/perricone-md/cold-plasma-plus/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/perricone-md/cold-plasma-plus/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/perricone-md/cold-plasma-plus/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/perricone-md/cold-plasma-plus/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/perricone-md/cold-plasma-plus/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/perricone-md/cold-plasma-plus/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/perricone-md/cold-plasma-plus/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/perricone-md/cold-plasma-plus/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/perricone-md/cold-plasma-plus/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/perricone-md/cold-plasma-plus/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/perricone-md/cold-plasma-plus/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/perricone-md/cold-plasma-plus/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/perricone-md/cold-plasma-plus/for/mature-skin