# Paula's Choice Niacinamide 20% Treatment for combination skin

**Lovi Fit: Superior fit for combination skin.**
Combination Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Paula's Choice](https://lovi.care/skincare/de/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with combination skin: an oily T-zone, enlarged pores, and dry cheeks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best serums for combination skin.

## Why this fit

- Excellent suitability for your combination skin and oily shine concerns is provided by the high concentration of niacinamide, which effectively controls oil production and enhances barrier resilience, complemented by ascorbyl glucoside for skin brightening.
- Panthenol and licorice root extract further support your skin by offering humectant benefits and soothing properties, respectively, ensuring a balanced and comfortable feel.
- The product is safe for your skin, containing no harsh ingredients and featuring soothing components that minimize irritation risk.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin): Superior (this page)
- [Sensitive skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Portulaca Oleracea Extract Purslane Extract

## What the research says

- Treatment with ascorbyl glucoside-arginine complex lotion significantly decreased pigmentation scores and melanin index while increasing lightness in solar lentigos of Japanese females compared to placebo over 24 weeks. ([International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- Facial masks containing low-temperature extracted Portulaca oleracea protect sensitive skin from photothermal stimulation and improve skin barrier function during photorejuvenation. ([Cutaneous and Ocular Toxicology, 2025](https://pubmed.ncbi.nlm.nih.gov/41182319/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% N-acetyl glucosamine reduced facial hyperpigmentation in an 8-week split-face clinical test, with an even greater effect observed when combined with 4% niacinamide. ([Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/))
- N-acetyl-glucosamine-loaded nanostructured lipid carriers successfully delivered the hydrophilic agent through the skin and reduced melanin distribution in healthy volunteers. ([Advanced Pharmaceutical Bulletin, 2016](https://pubmed.ncbi.nlm.nih.gov/28101465/))
- Topical cosmetic products containing hyaluronic acid, N-acetyl glucosamine, and gamma-amino butyric acid improved skin hydration by 24.28% to 33.60%, elasticity by 11.98%, and skin lightening by 5.26% over 2 months in 20 female participants. ([Journal of Cosmetic and Laser Therapy, 2019](https://pubmed.ncbi.nlm.nih.gov/30040516/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical purslane at 5% and 10% concentrations achieved alleviation of symptoms and lesion remission comparable to topical 0.1% triamcinolone acetonide in 34 subjects with oral lichen planus over 90 days. ([BMC Oral Health, 2023](https://pubmed.ncbi.nlm.nih.gov/37726676/))
- Portulaca oleracea extract ameliorated skin barrier damage and inflammation induced by combined exposure to glycolic acid and UVB in HaCaT cells. ([Cutaneous and Ocular Toxicology, 2022](https://pubmed.ncbi.nlm.nih.gov/35920724/))
- Topical application of a crude extract of Portulaca oleracea accelerates wound healing by decreasing wound surface area and increasing tensile strength in Mus musculus JVI-1, with the greatest contraction achieved at a single dose of 50mg compared to other dosages. ([Journal of Ethnopharmacology, 2003](https://pubmed.ncbi.nlm.nih.gov/12963132/))

## What reviewers say

Based on a very large amount of data, users with oily, combination, and aging skin frequently report significant improvements in skin texture and a visible reduction in the appearance of enlarged pores and "orange-peel" skin. Many praise its ability to smooth and brighten the complexion. A notable minority with sensitive skin experienced irritation, redness, or burning due to the high concentration of niacinamide.

- Liked: Minimizes enlarged pores (often mentioned)
- Liked: Smoother skin texture (often mentioned)
- Liked: Brightens skin tone (sometimes noted)
- Liked: Lightweight non-sticky texture (sometimes noted)
- Disliked: Causes skin irritation (sometimes noted)
- Disliked: Expensive price point (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: No visible results (rarely noted)

## How to apply

- Use your serum as part of your PM routine. Start using it 3 times a week and move to daily use if your skin likes it.
- Apply the serum after cleansing and toner, and right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏳for it to soak in.
- Apply the serum on clean and dry skin since your skin is not sensitive.
- Always do a patch test before using the serum for the first time, and avoid the eye area .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Paula's Choice 20% Niacinamide Treatment one of the best fits for combination skin?

This treatment is one of the best fits because its high concentration of niacinamide effectively controls oil production and strengthens your skin barrier, while vitamin C brightens the skin. Panthenol and licorice root extract add comforting moisture and soothing care, helping keep your combination skin balanced and calm with a low risk of irritation.
Sources: [International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for combination skin?

A high concentration of niacinamide controls oil and strengthens your skin, while ascorbyl glucoside helps brighten it. Panthenol and licorice root extract also support a balanced, comfortable feel by keeping your skin hydrated and calm.
Sources: [International Journal of Molecular Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/39769217/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Niacinamide do for combination skin?

Niacinamide helps balance oily areas by reducing excess shine and pore size while keeping dry patches hydrated and smooth. It also works to calm redness and even out skin tone, making it very suitable for combination skin.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### What does Acetyl Glucosamine do for combination skin?

Acetyl Glucosamine helps keep combination skin hydrated and smooth while evening out dark spots and patchiness. It also increases water content and supports skin renewal, making dry areas feel soft and oily zones balanced.
Sources: [Journal of Cosmetic Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17348991/), [The British Journal of Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19845667/)

### Where does this serum go in a skincare routine for combination skin?

This treatment goes in your evening routine after cleansing and toning, and before moisturizing. Putting treatments in the evening keeps your routine simple and adds safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying this treatment first and following with your retinol once your skin is used to it. The product's gentle formula helps keep your skin comfortable and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/)

### How often should I use this serum?

This treatment is best applied in the evening as part of your routine. It is very safe for your combination skin, using soothing components to help minimize any irritation.

### Can this serum clog pores, cause breakouts or purging for combination skin?

This treatment is a very good fit for combination skin and is unlikely to clog pores or cause breakouts, though a small number of reviewers have reported breakouts. The formula uses a high concentration of niacinamide to help control oil production while soothing ingredients help keep your skin calm and balanced.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for combination skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/combination-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/combination-skin) — Superior fit — €35.29 at Amazon
- [Augustinus Bader The Serum](https://lovi.care/skincare/de/p/augustinus-bader/the-serum/for/combination-skin) — Superior fit — €333.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/combination-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/de/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/combination-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/combination-skin) — Superior fit — €13.67 at Amazon

## Where to buy

- Amazon.de: €63.00 (https://www.amazon.de/dp/B08SW6VPJL?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Niacinamide, Pentylene Glycol, Butylene Glycol, Glycerin, Acetyl Glucosamine, Ascorbyl Glucoside, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Spiraea Ulmaria Extract, Portulaca Oleracea Extract Purslane Extract, Camellia Japonica Flower Extract, Epigallocatechin Gallate, Boerhavia Diffusa Root Extract, Camellia Sinensis Leaf Extract, Allantoin, Lecithin, Pullulan, Panthenol, Silica, Xanthan Gum, Sclerotium Gum, Propanediol, Sodium Phytate, Phenoxyethanol, Ethylhexylglycerin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin (this page)
- France: https://lovi.care/skincare/fr/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/niacinamide-20-treatment/for/combination-skin