# Paula's Choice 25% Vitamin C + Glutathione Clinical Serum for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Paula's Choice](https://lovi.care/skincare/de/brands/paula-s-choice)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate brightening and evening of skin tone for your normal skin due to the presence of tetrahexyldecyl ascorbate and glutathione, which provide antioxidant protection and support collagen stimulation. Ascorbic acid further enhances these benefits by boosting radiance and improving skin texture.
- While the formula provides general hydration and antioxidant benefits suitable for normal skin, it lacks specialized ingredients to effectively target your wrinkles and fine lines.
- The product is safe for your normal skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Ascorbic Acid, Glutathione, Ergothioneine, Ascorbyl Glucoside, Tocopherol

## What the research says

- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- RayGel reduced skin reaction severity with a lower average score of 93.7 compared to 123.3 for the placebo group in patients undergoing whole breast external-beam irradiation. ([American Journal of Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/15862509/))
- A targeted skincare regimen containing active ingredients such as rhodophyceae extract, ergothioneine, and L-carnosine significantly reduced transepidermal water loss by 24.09%, improved skin elasticity, and decreased redness, dryness, and desquamation in thirty-five female Chinese participants over 4 weeks following advanced optimal pulse technology treatment. ([International Journal of Cosmetic Science, 2025](https://pubmed.ncbi.nlm.nih.gov/40497421/))
- A triple combination of ergothioneine, collagen peptides, and sodium hyaluronate attenuated UV-induced skin damage ex vivo and improved facial skin hydration, elasticity, barrier function, and wrinkles in Chinese women. ([Frontiers in Nutrition, 2026](https://pubmed.ncbi.nlm.nih.gov/42698538/))
- Ergothioneine at nanomolar concentrations ameliorated UVA-induced skin damage, reactive oxygen species, and apoptosis in human keratinocyte-derived HaCaT cells by upregulating Nrf2/ARE-mediated antioxidant genes. ([Free Radical Biology & Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26021820/))
- Topical application of an antioxidant serum containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented particulate matter-induced degradation of extracellular matrix components, inflammation, and oxidative stress in the skin of 15 female volunteers compared to untreated controls. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40642809/))
- Dermatological products containing d-alpha tocopheryl acetate showed non-comedogenic potential with less than a 50% increase in microcomedones in 12 healthy male subjects compared to octyl palmitate. ([Contemporary Clinical Trials Communications, 2021](https://pubmed.ncbi.nlm.nih.gov/34471722/))
- Topical application of an antioxidant mix containing 15% ascorbic acid, 0.5% ferulic acid, and 1% tocopherol prevented PM and UV-induced skin barrier perturbation, lipid peroxidation, inflammatory markers, MMP9 activation, and Type I collagen loss in 15 healthy females compared to untreated exposed skin. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590207/))

## Why other serums fit mature skin better

- Caviar oil enhanced adipocyte differentiation in vitro, reduced MMP expression while increasing collagen and elastin formation ex vivo, and improved skin moisture, elasticity, and density in 102 participants over four weeks of Cavi Balm usage compared to baseline. ([In Vivo, 2023](https://pubmed.ncbi.nlm.nih.gov/37652485/))
- Chronomodulated daytime application of baicalin and nighttime application of palmitoyl tripeptide-1 synergistically improved skin luminance by 16.29%, nasolabial fold depth by -36.35%, and firmness by 24.35% in 30 female participants. ([Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/41527525/))

## What reviewers say

Many reviewers report a noticeable glow, improved skin bounce, and the fading of stubborn sun spots and post-inflammatory hyperpigmentation after consistent use.

- Liked: Gentle & non-irritating (mostly mentioned)
- Liked: Effective brightening (often mentioned)
- Liked: Elegant texture (often mentioned)
- Disliked: High price point (often mentioned)
- Liked: Pleasant scent (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Heavy for oily (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Paula's Choice 25% Vitamin C + Glutathione Clinical Serum work for mature skin?

This serum works moderately well for mature skin, offering helpful antioxidant protection and brightening, but it lacks specialized ingredients to effectively target wrinkles and fine lines. A product of this type needs high-quality anti-aging ingredients, potent antioxidants, peptides, and humectants to smooth fine lines, improve elasticity, and maintain deep moisture.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### Which ingredients make this serum a good fit for mature skin?

This serum works for mature skin because it contains tetrahexyldecyl ascorbate, ascorbic acid, and glutathione, which brighten the skin, provide antioxidant protection, and help stimulate collagen. A treatment for mature skin needs potent antioxidants, hydrating components, and skin-repairing ingredients that target wrinkles and fine lines while keeping the skin soft and smooth.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/)

### What does Vitamin C do for mature skin?

Vitamin C helps mature skin by smoothing out wrinkles, brightening dark spots, and boosting firmness. It works by encouraging collagen production to keep skin looking youthful and radiant.
Sources: [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31975502/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37128827/)

### What does Glutathione do for mature skin?

Glutathione helps mature skin by improving moisture, smoothness, and elasticity while reducing wrinkles and age spots. It also protects skin cells from everyday oxidative stress and environmental damage with a very safe profile.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/), [Molecules, 2026](https://pubmed.ncbi.nlm.nih.gov/41900080/)

### Where does this serum go in a skincare routine for mature skin?

This serum goes in the evening routine after cleansing and before moisturizing, as Lovi routines put treatments in the evening for simplicity and extra safety around sun exposure. Mature skin also needs specialized ingredients that target wrinkles and fine lines.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the vitamin C first in your morning routine and your retinol at night. Because this product lacks specialized ingredients to smooth wrinkles, mature skin needs a routine that also includes firming peptides and deep moisturizers.

### How often should I use this serum?

This treatment works well in the evening routine, keeping things simple and safe around sun exposure. Mature skin of this type needs firming peptides and specialized anti-aging ingredients to properly smooth out wrinkles and fine lines.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to cause breakouts or clog pores for mature skin, as it has a very low likelihood of causing breakouts according to reviewer feedback and lacks harsh ingredients. To better care for mature skin, a product of this type needs specialized ingredients to smooth lines and target wrinkles.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Cetyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/de/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €730.48 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €51.50 at Amazon

## Where to buy

- Amazon.de: €73.00 (https://www.amazon.de/dp/B0CZ4BKT3T?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Water, Tetrahexyldecyl Ascorbate, Dimethicone, Glycerin, C9-12 Alkane, Ascorbyl Glucoside, Silica, Pyrus Malus Fruit Extract, Hydrogenated Lecithin, Polyglyceryl-6 Polyricinoleate, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Xanthan Gum, Rice Bran Extract, Hydroxyethyl Acrylate Sodium Acryloyldimethyl Taurate Copolymer, Cetyl Alcohol, Caprylyl Glycol, Lysine Carboxymethyl Cysteinate, Coco Caprylate Caprate, Tocopherol, Glutathione, Sodium Citrate, Sodium Phytate, Hexylene Glycol, Ethylhexylglycerin, Helianthus Annuus Seed Extract Sunflower Seed Extract, Urea, Mannitol, Caprylic Capric Triglyceride, Sodium Pca, Rosmarinus Officinalis Leaf Extract Rosemary Leaf Extract, Polysorbate 60, Sorbitan Isostearate, Trehalose, Ascorbic Acid, Glucose, Vanilla Planifolia Fruit Extract, Polyquaternium-51, Ergothioneine, Triacetin, Sodium Hyaluronate, Phenoxyethanol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/paula-s-choice/25-vitamin-c-glutathione-clinical-serum/for/mature-skin