# Numbuzin No.2 Protein 43% Creamy Serum for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: Average · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Numbuzin](https://lovi.care/skincare/de/brands/numbuzin)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate suitability for your combination skin, as the multiple protein ingredients like oat extract protein and rice seed protein provide emollient action and hydration, which is generally beneficial for acne-prone skin.
- While the serum offers excellent moisturizing and elasticity benefits, it lacks specialized ingredients for direct acne treatment and sufficient seboregulation for your concerns.
- The product is safe for your combination skin due to the absence of harsh ingredients and the inclusion of soothing hydrolyzed proteins.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/numbuzin/no-2-protein-43-creamy-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Content Protein, Rice Seed Protein, Hydrolyzed Protein, Ceramide Np, Cholesterol

## What the research says

- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- Topical application of oyster protein hydrolysates peptides protected against UVB-induced skin photodamage in mice by alleviating moisture loss, epidermal hyperplasia, and fiber degradation through antioxidant and anti-inflammatory mechanisms. ([Marine Drugs, 2020](https://pubmed.ncbi.nlm.nih.gov/32486363/))
- Cellulose acetate and soy protein hydrolysate nanofibrous dressings promote fibroblast proliferation in vitro and accelerate wound healing with reduced scar formation in vivo. ([Advanced Healthcare Materials, 2018](https://pubmed.ncbi.nlm.nih.gov/29359866/))
- Rice protein hydrolysate and its characteristic peptides Leu-Leu-Lys, Leu-Pro-Lys, and pyroGlu-Lys reduced melanin content, tyrosinase activity, and ROS production in UVB-induced human epidermal melanocyte PIG1 cells by regulating the JNK/Β-Trcp/NFΗB-p65/MITF signaling pathway and lowering TRP-1 and TRP-2 expression. ([Food & Function, 2020](https://pubmed.ncbi.nlm.nih.gov/32955075/))
- A liquid formulation containing hydrolyzed collagen demonstrated structural stability, peptide mass distribution between 0.5 and 19.5 kDa, and faded forehead wrinkles in five volunteers while proving to be non-irritating and hypoallergenic. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32390321/))
- Combined treatment with human umbilical cord mesenchymal stem cell-derived exosomes and hydrolyzed collagen oligopeptides enhanced proliferation and migration, reduced reactive oxygen species and senescence-associated beta-galactosidase activity, increased type I and type III collagen expression, and decreased metalloproteinases, inflammatory cytokines, and senescence markers in human skin fibroblasts compared to either treatment alone. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611748/))
- Collagen peptides induced cell proliferation and pro-collagen-1α expression, increased TGF-β and VEGF, and suppressed the LPS-induced inflammatory response in human skin fibroblasts and keratinocytes. ([Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/))
- Botulinum toxin-A encapsulated in phosphatidylcholine/cholesterol nanoliposomes delivered transdermally achieved a diffusion depth of 380 μm and showed a nonsignificant advantage in relieving post-acne scarring compared to hyaluronic acid hydrogel treatment in 12 facial patients. ([Journal of Materials Science. Materials in Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/39073502/))
- Topical application of cholesterol sulfate increases stratum corneum thickness and inhibits protease-induced cell dissociation by competitively inhibiting serine proteases in mice and human stratum corneum. ([The Journal of Investigative Dermatology, 1998](https://pubmed.ncbi.nlm.nih.gov/9699715/))
- Topical lovastatin treatment impairs the recovery of cutaneous permeability barrier function and stratum corneum cholesterol levels after acetone disruption in mice, an effect normalized by simultaneous treatment with mevalonate or cholesterol. ([The Journal of Clinical Investigation, 1990](https://pubmed.ncbi.nlm.nih.gov/2243142/))

## Why other moisturizers fit acne-prone skin better

- A peel-off facial mask containing myoinositol and trehalose-loaded liposomes improved adult female acne by decreasing lesion counts, sebum production, GAGS scores, and local androgen levels while increasing beclin-1 levels. ([Journal of Cosmetic Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28342238/))
- A Tris/Arg-formulated cleanser significantly decreased noninflammatory and inflammatory acne and pore size with keratotic plugs compared to an AEC/AC cleanser in male Thai subjects with mild to moderate acne over 4 weeks. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31347768/))

## What reviewers say

This serum is widely praised as a "winter savior" for dry, sensitive, and dehydrated skin, effectively repairing damaged barriers and alleviating flakiness. Users consistently report a plump, healthy glow and deep "inner" hydration, though its rich, protein-heavy formula can be too heavy or potentially pore-clogging for oily or acne-prone skin types.

- Liked: Deep barrier repair (mostly mentioned)
- Liked: Long-lasting hydration (often mentioned)
- Liked: Rich creamy texture (often mentioned)
- Liked: Glowy finish (sometimes noted)
- Disliked: Not for oily skin (sometimes noted)
- Disliked: Potential breakouts (sometimes noted)
- Disliked: Stickiness/tackiness (sometimes noted)
- Disliked: Packaging issues (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Numbuzin No.2 Protein 43% Creamy Serum work for acne-prone skin?

Numbuzin No.2 Protein 43% Creamy Serum works moderately well for acne-prone skin by providing hydration and soothing care with multiple proteins, but it lacks direct acne-fighting ingredients and oil control. A moisturizing treatment for this skin needs effective hydrating ingredients like niacinamide and hyaluronic acid to manage breakouts and balance oily and dry areas without irritation.
Sources: [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/)

### Which ingredients make this serum a good fit for acne-prone skin?

Numbuzin No.2 Protein 43% Creamy Serum is a fair fit for acne-prone skin because it contains multiple proteins like oat and rice seed protein along with ceramide np, which provide hydration and help soothe the skin safely. To work best for this skin type, a product of this type needs ingredients like niacinamide and sodium hyaluronate to control excess oil and improve texture.
Sources: [International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/)

### What does Content Protein do for acne-prone skin?

Whey protein supplements are linked to breakouts because they can increase insulin and hormone levels that trigger acne. This reaction may cause pimples to flare up, but the skin generally clears after you stop taking the supplement.
Sources: [Dermatology Online Journal, 2020](https://pubmed.ncbi.nlm.nih.gov/32941710/)

### What does Rice Seed Protein do for acne-prone skin?

Rice Seed Protein helps calm acne-prone skin by supporting a healthy skin barrier and reducing irritation. This ingredient is unlikely to clog pores, making it a gentle choice for skin that is prone to breakouts.

### Where does this serum go in a skincare routine for acne-prone skin?

This moisturizing treatment goes in the evening routine after cleansing and before moisturizing, though some serums can also be used in the morning or twice a day. A product of this type for acne-prone skin needs specialized ingredients for direct blemish treatment and oil control, alongside soothing proteins and ceramides to keep skin soft.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide by applying niacinamide first and following with this moisturizing treatment. This product helps keep your skin soft and hydrated, though acne-prone skin needs specialized blemish-fighting ingredients and oil control to work best.

### How often should I use this serum?

You can use this serum in the evening as part of your routine. It provides moderate hydration for acne-prone skin, but a product of this type for this skin needs specialized ingredients for direct acne treatment and oil control.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/)

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

Yes, this serum may cause breakouts on acne-prone skin, as reviewers moderately complain about potential blemishes. While it provides good moisture and soothing proteins, it lacks direct blemish-fighting ingredients and oil control. Products for this skin need targeted blemish treatments and oil-balancing ingredients to work best.

### Can I use this serum around the eyes or on my body?

This serum works for the delicate skin around the eyes as well as body skin, provided it is well tolerated by your complexion. The eyelid skin is among the thinnest on the body, making gentle moisturizing treatments appropriate for everyday care.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [Revision Skincare Hydrating Serum](https://lovi.care/skincare/de/p/revision-skincare/hydrating-serum/for/acne-prone-skin) — Superior fit — €237.70 at Amazon
- [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/de/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/acne-prone-skin) — High fit — €37.64 at Amazon
- [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/de/p/isntree/green-tea-fresh-serum/for/acne-prone-skin) — High fit — €12.56 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/de/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — €65.41 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Voat Extract Protein, Water, Cyclopentasiloxane, Butylene Glycol, Cetearyl Ethyl Hexanoate, Cyclohexasiloxane, Phenyl Trimethicone, Cetyl Pg, Sebum-10 1 Dimethicone, Hydrogenate Tid Poly, Rice Seed Protein, Prunus Amygdalus Dulcis Protein, Hydrolyzed Corn Protein, Hydrolyzed Protein, Hydrolyzed Pea Protein, Hydrolyzed Milk Protein, Glycine Soja Protein Soybean Protein, Hydrolyzed Lupine Protein, Ceramide Np, Cholesterol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

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