# numbuzin 5 Glutathione Vitamin Concentrated Serum for skin with dark spots

**Lovi Fit: High fit for skin with dark spots.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [numbuzin](https://lovi.care/skincare/de/brands/numbuzin)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with dark spots: hyperpigmentation, sun spots, and uneven skin tone. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for skin with dark spots; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin, this serum effectively targets pigmentation concerns with key ingredients like Tranexamic Acid and Alpha-Arbutin, which work to visibly brighten and even out skin tone.
- Niacinamide and Panthenol further support your skin barrier and provide essential hydration, enhancing the overall efficacy for your complexion.
- The formulation is safe for your skin, containing no harsh or irritating ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots): High (this page)
- [Mature skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/oily-acne-prone-skin): High

## Key ingredients

Glutathione, Niacinamide, 3-O-Ethyl Ascorbic Acid, Tranexamic Acid, Alpha-Arbutin

## What the research says

- Encapsulation of alpha arbutin in an optimized ethosomal gel significantly improved skin melanin reduction, moisture content, and elasticity in human volunteers compared to conventional formulations. ([Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40613435/))
- A topical gel containing chitosan, chlorhexidine, allantoin, and dexpanthenol significantly reduced postoperative pain, trismus, swelling, and analgesic consumption, while improving wound healing after third molar surgery compared to a placebo. ([Medicina Oral, Patologia Oral Y Cirugia Bucal, 2020](https://pubmed.ncbi.nlm.nih.gov/32683390/))
- Glutathione amino acid precursors effectively increase cellular glutathione levels, reducing oxidative stress, ATP depletion, and DNA damage in human keratinocytes, clinical subjects, and ex vivo skin compared to controls. ([Journal of the European Academy of Dermatology and Venereology, 2024](https://pubmed.ncbi.nlm.nih.gov/38189670/))
- Topical oxidized glutathione significantly decreases the skin melanin index and improves moisture content, smoothness, wrinkle formation, and elasticity compared to placebo in healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2014](https://pubmed.ncbi.nlm.nih.gov/25378941/))
- Topical glutathione improves hyperpigmentation, reduces ultraviolet-induced erythema and wrinkles, decreases transepidermal water loss, and enhances antioxidant capacity. ([The Journal of Clinical and Aesthetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41416233/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers. ([Experimental Dermatology, 2003](https://pubmed.ncbi.nlm.nih.gov/12823436/))
- Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation. ([Journal of Periodontology, 2009](https://pubmed.ncbi.nlm.nih.gov/19186973/))
- Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/34910367/))
- A non-hydroquinone topical formulation (SKNB19) improved hyperpigmentation by 28.5% in patient self-assessment and 27% in independent reviewer assessment compared with 4% hydroquinone in 18 adult subjects, while showing significantly less irritation and better tolerability. ([Journal of Cosmetic Science, 2020](https://pubmed.ncbi.nlm.nih.gov/33022197/))
- Combining a home-based radiofrequency device and arbutin cream reduced mMASI scores by 25.6% and melanin index by 22.8% at 8 weeks compared to baseline in 38 participants. ([Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39918262/))
- Polyvinyl pyrrolidone-K90/Eudragit RL100 dissolving microneedle patches loaded with alpha-arbutin and resveratrol enhanced intradermal delivery by approximately 2.6 times compared to cream and slightly decreased the melanin index in human participants without causing skin irritation. ([Biomaterials Science, 2023](https://pubmed.ncbi.nlm.nih.gov/37183632/))

## What reviewers say

Based on a very large amount of data, users with dullness, hyperpigmentation, and sensitive skin frequently praise this serum for its ability to fade acne scars and even out skin tone without causing irritation. The majority report a "glass skin" glow and rapid absorption, while a small minority experienced breakouts or found the brightening effects too slow to appear.

- Liked: Fades dark spots (mostly mentioned)
- Liked: Gentle on skin (often mentioned)
- Liked: Lightweight texture (often mentioned)
- Liked: Hydrating glow (sometimes noted)
- Disliked: Caused breakouts (rarely noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Slow results (rarely noted)
- Disliked: Tacky finish (rarely noted)

## How to apply

- Apply this serum as part of your PM routine starting 3x/week and build up to daily use if your skin likes it.
- Place the serum after cleansing and toning, but before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and wait a minute for it to absorb.
- Apply the serum on dry skin to help fade pigmentation effectively.
- Avoid the eye area and always use SPF 30+ during the day.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes numbuzin 5 Serum a great fit for skin with dark spots?

This serum is a great fit because it uses key ingredients like Tranexamic Acid and Alpha-Arbutin to visibly brighten and even out skin tone. Niacinamide and Panthenol further support your skin barrier and provide essential hydration to help improve your complexion.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### Which ingredients make this serum a good fit for skin with dark spots?

This serum is a great fit for skin with dark spots because it features Tranexamic Acid and Alpha-Arbutin to visibly brighten and even out your skin tone. Niacinamide and Panthenol further support your skin barrier and provide essential hydration to enhance your complexion.
Sources: [Heliyon, 2023](https://pubmed.ncbi.nlm.nih.gov/37681127/), [The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/)

### What does Glutathione do for skin with dark spots?

Glutathione helps brighten skin with dark spots and evens out skin color. Topical and oral use may reduce dark patches and protect against environmental stress with a good safety profile.
Sources: [Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30895708/), [International Journal of Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/39444151/)

### What does Niacinamide do for skin with dark spots?

Niacinamide helps fade dark spots and uneven pigmentation by slowing down the transfer of pigment in the skin. It is generally well tolerated and may improve overall skin brightness with consistent use.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34439563/)

### Where does this serum go in a skincare routine for skin with dark spots?

This serum goes in your evening routine as a treatment step after cleansing and toning, and before your moisturizer. Using treatments in the evening helps keep things simple and provides extra safety around sun exposure.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying the serum first and following it with your retinol. Because this formula is gentle and free of harsh ingredients, it is unlikely to irritate your skin when combined.

### How often should I use this serum?

You can use this serum in your evening routine, and some people also use it in the morning or twice a day. It has a great fit for skin with dark spots, and its formulation is safe and free of harsh or irritating ingredients.

### Can this serum clog pores, cause breakouts or purging for skin with dark spots?

This serum is unlikely to cause breakouts, as very few reviewers report this issue and the formula contains no harsh ingredients. It helps brighten dark spots while supporting your skin barrier without clogging pores.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol. Behenyl alcohol is a fatty alcohol, which soften the skin.

## Alternatives for skin with dark spots

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dark-spots) — Superior fit — €57.00 at Amazon
- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dark-spots) — High fit — €9.99 at Amazon
- [Guerlain Abeille Royale Double R Renew & Repair Serum](https://lovi.care/skincare/de/p/guerlain/abeille-royale-double-r-renew-and-repair-advanced-serum/for/dark-spots) — High fit — €122.90 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/dark-spots) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [Pyunkang Yul Calming Deep Moisture Toner](https://lovi.care/skincare/de/p/pyunkang-yul/calming-deep-moisture-toner/for/dark-spots) — Superior fit — €11.30 at Amazon
- Moisturizer: [Isntree Green Tea Fresh Serum](https://lovi.care/skincare/de/p/isntree/green-tea-fresh-serum/for/dark-spots) — Superior fit — €12.56 at Amazon

## Where to buy

- Amazon.de: €22.99 (https://www.amazon.de/dp/B09158RQ79?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
Prices checked 6 Nov 2026.

## Ingredients

Vaccinium Vitis-Idaea Fruit Extract, Butylene Glycol, Niacinamide, Panthenol, Tranexamic Acid, Water, 1,2-Hexanediol, Neopentyl Glycol Dicaprate, Caprylic Capric Triglyceride, Sorbitol, Bifida Ferment Filtrate, Chondrus Crispus Extract, Butyrospermum Parkii Butter, Saccharum Officinarum Extract, Alpha-Arbutin, Sodium Hyaluronate, Melia Azadirachta Flower Extract, Ocimum Sanctum Leaf Extract, Melia Azadirachta Leaf Extract, Curcuma Longa Root Extract, Corallina Officinalis Extract, Tremella Fuciformis Extract, Pentylene Glycol, Glycerin, 3-O-Ethyl Ascorbic Acid, Alpha Bisabolol, Tromethamine, Ethylhexylglycerin, Adenosine, Hydrogenated Lecithin, Allantoin, Glutathione, Ceramide Np, Beta-Glucan, Dipotassium Glycyrrhizate, Tocopherol, L Ascorbic Acid, Ascorbyl Glucoside, Tocopheryl Acetate, Hydroxypropyl Cyclodextrin, Ubiquinone, Alpha Lipoic Acid, Potassium Hydroxide, Behenyl Alcohol, Carbomer, Xanthan Gum, Disodium Edta
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- United Kingdom: https://lovi.care/skincare/uk/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Ireland: https://lovi.care/skincare/ie/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Germany: https://lovi.care/skincare/de/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots (this page)
- France: https://lovi.care/skincare/fr/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Italy: https://lovi.care/skincare/it/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Netherlands: https://lovi.care/skincare/nl/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Spain: https://lovi.care/skincare/es/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Canada: https://lovi.care/skincare/ca/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Australia: https://lovi.care/skincare/au/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Singapore: https://lovi.care/skincare/sg/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- Saudi Arabia: https://lovi.care/skincare/sa/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots
- United Arab Emirates: https://lovi.care/skincare/ae/p/numbuzin/5-glutathione-vitamin-concentrated-serum/for/dark-spots