NATURIUM Multi-Peptide Moisturizer for acne-prone skin
Multi-Peptide Blend
3-O-Ethyl Ascorbic Acid Ethylated Vitamin C
Panthenol Vitamin B5
Squalane
Niacinamide
Average
- HighCombination Skin Fit
- AverageEffectiveness
- HighSafety
Works for acne-prone skin; other moisturizers fit it better.
- Clinical, Cosmetic and Investigational Dermatology, 2017
- International Journal of Biological Macromolecules, 2026
This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate benefits for your combination skin, with glycerin, squalane, and sodium hyaluronate providing excellent moisturization and barrier support, while niacinamide helps with oil regulation.
- The formula includes peptides and antioxidants like 3-O-Ethyl Ascorbic Acid that offer general skincare advantages, though they are not specifically targeted for significant acne or blemish improvement.
- The product is safe for your combination skin, as it contains no harsh or prohibited ingredients that would cause irritation.
How to apply
- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
People Say
★4.5Overall rating based on 600+ reviewsThis moisturizer is highly praised for its lightweight and absorbent texture, making it suitable for oily and combination skin types. It effectively plumps fine lines and improves skin texture, providing a smooth base for makeup. However, users with very dry skin may find it insufficient for their hydration needs and might require additional layering. A small number of reviews mention issues with the pump packaging or experiencing breakouts.
Highlights
Lightweight & Absorbent Mostly Mentioned
- “glides on”
- “sinks effortlessly”
- “non-greasy”
- “drinks it up”
Makeup Compatibility Often Mentioned
- “perfect under makeup”
- “acts like a primer”
- “no pilling”
- “smooth canvas”
Sanitary Packaging Sometimes Noted
- “love the pump”
- “hygienic”
- “airless pump”
- “easy to dispense”
Skin Texture & Plumping Sometimes Noted
- “plumps fine lines”
- “smoother skin”
- “glowy finish”
- “bouncy feel”
Value for Money Sometimes Noted
- “affordable”
- “great ingredients for price”
- “beats high-end”
- “budget friendly”
Not hydrating enough Sometimes Noted
- “too light for dry skin”
- “need more moisture”
- “felt tight later”
- “better for summer”
Breakouts/Irritation Rarely Noted
- “caused cystic acne”
- “tiny red bumps”
- “reaction to niacinamide”
- “broke me out”
Packaging malfunctions Rarely Noted
- “pump arrived broken”
- “stopped pumping”
- “had to cut open”
- “mechanism failed”
Pilling issues Rarely Noted
- “pills with toner”
- “rolled off skin”
- “clumped with serum”
- “didn't layer well”
Small quantity Rarely Noted
- “runs out fast”
- “tube is small”
- “wish it was bigger”
- “finished in weeks”
Sources: lovi.care, naturium.com, target.com, influenster.com, spacenk.com, skinsort.com, and more
Questions and answers
How well does Naturium Multi-Peptide Moisturizer work for acne-prone skin?
This moisturizer works reasonably well for acne-prone skin, providing moderate moisture and oil control, though other products fit this skin type better. A product of this type needs soothing ingredients, effective blemish-fighting benefits, and a gentle formula without allergens to truly excel on acne-prone skin.
Which ingredients make this cream a good fit for acne-prone skin?
Glycerin, squalane, and sodium hyaluronate help make this cream a good fit by providing moisture and supporting the skin barrier, while niacinamide assists with oil regulation. To better suit acne-prone skin, a product of this type needs targeted ingredients that directly help with blemishes and breakouts without causing irritation.
What do Peptides do for acne-prone skin?
Peptides help acne-prone skin by fighting acne-causing bacteria and calming redness and swelling. They may also support the skin barrier, which is often delicate when you deal with breakouts.
What does 3-O-Ethyl Ascorbic Acid do for acne-prone skin?
3-O-Ethyl Ascorbic Acid helps calm breakouts and brightens the marks left behind on acne-prone skin. Vitamin C derivatives like this one also provide antioxidant protection, though stability and how well they sink into the skin depend on the formula.
Journal of Cosmetic Dermatology, 2012Journal of Cosmetic Dermatology, 2010
Where does this cream go in a skincare routine for acne-prone skin?
This cream goes in your morning routine after a hydrating toner and before sunscreen, and in your evening routine as the final step after your treatment. Acne-prone skin works best with products that combine lightweight hydration with targeted blemish-fighting ingredients like salicylic acid or benzoyl peroxide.
Can I use it with retinol, and in what order?
You can use this moisturizer with retinol by applying your retinol treatment first and following with the moisturizer. This helps keep skin soft and supported while minimizing dryness or irritation.
How often should I use this cream?
You can use this moisturizing treatment twice daily as part of your morning and evening routine. Regular daily application helps maintain skin hydration and barrier support while remaining safe and gentle for your skin.
Journal of Cosmetic Dermatology, 2020Health Science Reports, 2021
Can it clog pores, cause breakouts or purging for acne-prone skin?
This moisturizer is unlikely to cause severe breakouts or irritation on your acne-prone skin, though it only offers an average fit since its ingredients are not specifically targeted for blemish improvement. Skin of this type works best with a product that provides lightweight hydration, oil regulation, and soothing ingredients to keep pores clear and calm.
Can I use it around the eyes or on my body?
You can use this moisturizing treatment around your eyes and on your body, as its safe formula is well tolerated by delicate skin areas. To properly care for the thin skin around the eyes or the skin on the body, a product of this type needs lightweight hydrators and barrier-supporting ingredients that keep the skin soft and smooth without causing irritation.
Surgical and Radiologic Anatomy, 2002Clinical, Cosmetic and Investigational Dermatology, 2017
Is this cream fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol. Cetyl alcohol and stearyl alcohol are fatty alcohols, which soften the skin.
What the research says
A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women.
Clinical, Cosmetic and Investigational Dermatology, 2017Dissolving microneedles loaded with 3-O-ethyl ascorbic acid and acetyl hexapeptide-8 achieved higher cumulative transdermal delivery than aqueous solutions and significantly reduced photoaging signs while restoring oxidative balance in a UV/D-galactose-induced mouse model.
International Journal of Biological Macromolecules, 2026A multi-component dissolving microneedle patch loaded with glabridin, 3-O-ethyl-L-ascorbic acid, and tranexamic acid effectively reduced chloasma and age spots while demonstrating safety in clinical evaluation, alongside significant antioxidant, anti-tyrosinase, and melanin-reduction effects in vitro and in vivo.
Polymers, 2023A topical serum with a peptide blend showed superior or comparable skin recovery to a moisturizer following fractional CO2 laser and radiofrequency microneedling in Asian subjects.
Dermatology and Therapy, 2026Topical application of 5% vitamin C cream significantly improved global clinical scores, increased skin microrelief density, and induced elastic tissue repair in photoaged skin compared to excipient control in healthy female volunteers.
Experimental Dermatology, 2003Ascorbic acid 2-glucoside gel significantly reduced gingival melanin pigmentation after 4 weeks compared to placebo in 73 subjects with symmetric pigmentation.
Journal of Periodontology, 2009Topical application of VC-IP cream twice daily for 8 weeks reduces periorbital wrinkles in female subjects compared to a placebo cream.
Journal of Cosmetic Dermatology, 2022Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.
Journal of Cosmetic Dermatology, 2019Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.
Arzneimittel-Forschung, 2000Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts.
Molecules, 2025Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway.
Antioxidants, 2025Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005
Why other moisturizers fit acne-prone skin better
Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components.
Molecules, 2023A facial serum containing snail secretion filtrate, Calendula officinalis, and Glycyrrhiza glabra root extract significantly reduced inflammatory acne lesions compared to placebo in 66 participants with mild-to-moderate maskne over 12 weeks.
Journal of Cosmetic Dermatology, 2022
Ingredients
Water, Glycerin, Dimethicone, Jojoba Seed Oil, Squalane, Glyceryl Stearate, Cetyl Alcohol, Niacinamide, Stearyl Alcohol, Palmitoyl Tripeptide-5, Pantolactone, Palmitoyl Tripeptide-1, Palmitoyl Tetrapeptide-7, Hydrolyzed Plukenetia Volubilis Seed Extract, Dunaliella Salina Extract, Sodium Hyaluronate, 3-O-Ethyl Ascorbic Acid, Panthenol, Caryodendron Orinocense Seed Oil, Honokiol, Magnolol, Palmitic Acid, Sorbitan Oleate, Aluminum Octenylsuccinate Starch, Hydroxyacetophenone, Stearic Acid, Acrylamide Sodium Acryloyldimethyltaurate Copolymer, Polyglyceryl-6 Laurate, 1,2-Hexanediol, Boron Nitride, Caprylyl Glycol, Polyglyceryl-10 Oleate, Isohexadecane, Butylene Glycol, Chlorphenesin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Tocopheryl Acetate, Polysorbate 80, Sorbitan Palmitate, Sodium Hydroxide, Sodium Benzoate, Carbomer, Sodium Lactate, Phenoxyethanol, Polysorbate 20, Citric Acid, Ethylhexylglycerin, Potassium Sorbate
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
How does it fit your skin?
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