MISSHA Time Revolution Night Repair Probio Ampoule for oily acne-prone skin
Bifida Lysate Ferment
Niacinamide
Sodium Hyaluronate
Probio Lactobacillus Complex
Panthenol
Average
- AverageOily Skin Fit
- AverageEffectiveness
- HighSafety
Works for oily acne-prone skin; other serums fit it better.
This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores and recommendations based on your full skin profile, including your 12D face scan results and any goals or preferences you have, please use the Lovi app.
Page built Nov 8, 2026How the Fit score works
Lovi Assistant explains
- Offers moderate suitability for your oily skin as Bifida Lysate Ferment and Niacinamide support skin barrier resilience and offer soothing benefits, though squalane can be mildly occlusive for your concerns.
- The formulation provides general hydration and soothing effects beneficial for oily and acne-prone skin, with supportive concentrations of key ingredients.
- The product is safe for your skin, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.
How to apply
- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
People Say
★4.6Overall rating based on 5.0k+ reviewsThis ampoule is frequently praised for delivering a 'glass skin' effect overnight, making dry and mature skin appear plump, hydrated, and glowing. A very large amount of data suggests that while it's a highly effective and affordable alternative to luxury serums, the high concentration of fermented ingredients may cause breakouts in individuals with fungal acne or sensitivities.
Highlights
Instant Glow Mostly Mentioned
- “woke up with a glow”
- “skin looks radiant”
- “gives glass skin effect”
- “banished dullness”
Deep Hydration Often Mentioned
- “plumps up fine lines”
- “skin feels baby soft”
- “very moisturizing for dry skin”
- “velvety finish”
Lightweight Texture Often Mentioned
- “sinks in immediately”
- “non-greasy finish”
- “layers well under cream”
- “lightweight consistency”
Texture Improvement Sometimes Noted
- “smoothed out texture”
- “pores look smaller”
- “skin feels stronger”
- “healed my barrier”
Value for Money Sometimes Noted
- “fraction of the price of ANR”
- “best affordable dupe”
- “great value for ingredients”
- “luxurious feel for cheap”
Breakouts & Reactions Sometimes Noted
- “caused cystic acne”
- “triggered fungal acne”
- “broke me out immediately”
- “tiny whiteheads appeared”
Fragrance & Oils Sometimes Noted
- “smell is too strong”
- “essential oils irritated my skin”
- “dislike the floral scent”
- “wish it was fragrance-free”
Dropper Issues Rarely Noted
- “dropper is finicky”
- “hard to get product out”
- “bottle design is annoying”
- “pipette doesn't work well”
Ineffective for Some Rarely Noted
- “did nothing for me”
- “weaker than the original”
- “just glorified water”
- “saw no difference”
Sticky Residue Rarely Noted
- “leaves a sticky film”
- “feels tacky”
- “takes time to dry down”
- “hair sticks to face”
Sources: lovi.care, iherb.com, amazon.com, sokoglam.com, yesstyle.com, youtube.com, and more
Questions and answers
How well does MISSHA Time Revolution Night Repair Probio Ampoule work for oily acne-prone skin?
This treatment works reasonably well for oily acne-prone skin because ingredients like niacinamide and probiotic ferments help soothe your skin and strengthen its barrier, though squalane can feel a bit heavy for this skin type. To work best for oily acne-prone skin, a treatment needs lightweight, oil-controlling ingredients and calming extracts that provide a balanced level of moisture without heavy or pore-clogging components.
International Journal of Medical Sciences, 2021Journal of Cosmetic Dermatology, 2022
Which ingredients make this serum a good fit for oily acne-prone skin?
Bifida Lysate Ferment and niacinamide help make this serum a good fit for oily skin because they support skin barrier resilience and offer soothing benefits. To work best for this skin type, a treatment needs effective ingredients like niacinamide and propolis or vitamin C that control excess oil and target blemishes without the risk of irritation, along with light hydrators that do not feel heavy.
What does Bifida Ferment Lysate do for oily acne-prone skin?
Bifida Ferment Lysate helps calm oily acne-prone skin by strengthening your skin barrier and lowering irritation. It is unlikely to clog pores and may help keep your skin feeling smooth and balanced.
Journal of Cosmetic Dermatology, 2023Experimental Dermatology, 2010
What does Niacinamide do for oily acne-prone skin?
Niacinamide helps balance oil production, calms redness, and is unlikely to irritate oily, acne-prone skin while improving blemishes. Clinical tests show it reduces excess oil and helps clear up both inflammatory and non-inflammatory acne breakouts.
Journal of Cosmetic and Laser Therapy, 2006Journal of Cosmetic Dermatology, 2024
Where does this serum go in a skincare routine for oily acne-prone skin?
This treatment goes in the evening routine after your cleansing toner and before your moisturizer. Putting it in the evening keeps things simple and provides extra safety around sun exposure. Oily acne-prone skin of this type needs lightweight hydrators and soothing ingredients that balance oil without heavy oils.
Can I use this serum with retinol, and in what order?
You can use this serum with retinol by applying the serum first, letting it absorb, and then following with your retinol. This product works reasonably well for your oily skin, though this skin type generally does better with lightweight, oil-free formulas containing niacinamide and salicylic acid to keep pores clear.
How often should I use this serum?
This treatment is used in the evening routine. Oily acne-prone skin needs a product of this type that balances hydration and soothing benefits with lightweight, non-greasy ingredients that do not clog pores.
Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?
This serum offers moderate suitability for oily and acne-prone skin, but it contains squalane which may be mildly heavy for your concerns and has a moderate risk of breakouts and reactions according to reviewers. Oily skin often does better with lightweight, oil-free hydration and soothing ingredients that balance oil without adding heaviness.
Is this serum fragrance-free and alcohol-free?
Yes, it has no fragrance and no drying alcohol.
What the research says
Peroxidated squalene induces an early activation of NF-kappaB, an increase in PPARalpha levels, and an upregulation of IL-6 production in HaCaT keratinocytes, which is subsequently counteracted by PPARalpha activation.
The Journal of Investigative Dermatology, 2006Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment.
American Journal of Clinical Dermatology, 2002Topical application of Lactobacillus plantarum-GMNL6 enhanced collagen synthesis and SPTSSA gene expression while reducing melanin synthesis, Staphylococcus aureus biofilm, and Cutibacterium acnes proliferation, leading to clinical improvements in skin moisture, color, spots, wrinkles, UV spots, and porphyrins in human volunteers.
International Journal of Medical Sciences, 2021Probiotic-derived lotion successfully reduced inflammatory acne lesion counts and erythema index comparably to 2.5% benzoyl peroxide in patients with mild-to-moderate acne vulgaris, while causing fewer side effects.
Journal of Cosmetic Dermatology, 2022A panthenol-enriched mask significantly decreased erythema and hyperpigmentation, increased sebum and stratum corneum moisture, and reduced transepidermal water loss compared to a saline dressing in 60 subjects undergoing facial laser treatment.
Journal of Cosmetic Dermatology, 2025Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro.
Journal of Cosmetic Dermatology, 2023Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin.
Journal of Cosmetic Dermatology, 2021Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women.
The Journal of Investigative Dermatology, 2008Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging.
Dermatologic Surgery, 2005Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control.
Journal of Drugs in Dermatology, 2011Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction.
Clinical Oral Investigations, 2022Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days.
BMC Oral Health, 2019Lactobacillus plantarum extracellular vesicles modulated extracellular matrix related gene expression in vitro and suppressed wrinkle formation and pigmentation in clinical trials.
Current Issues in Molecular Biology, 2022Topical application of a postbiotic Saccharomyces and Lactobacillus ferment complex for 28 days significantly modulated the scalp microbiome and achieved a 100% sensitive scalp syndrome alleviation effect in Chinese women with sensitive scalp syndrome.
Clinical, Cosmetic and Investigational Dermatology, 2023Topical application of live Lactobacillus reuteri DSM 17938 and its lysate reduced proinflammatory IL-6 and IL-8 in UVB-R-induced inflammation models, with live bacteria also increasing aquaporin 3 expression and exhibiting antimicrobial activity against skin pathogens.
Experimental Dermatology, 2019Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects.
Journal of Cosmetic Dermatology, 2019Topical dexpanthenol formulated in lipophilic vehicles improved stratum corneum hydration and reduced transepidermal water loss compared to vehicle control in humans.
Arzneimittel-Forschung, 2000Hyaluronic acid, hyaluronic acid plus dexpanthenol, and isotonic saline nasal sprays all significantly improved dry nose symptoms over four weeks in 240 patients, with hyaluronic acid plus dexpanthenol providing superior nasal moisturisation compared to the other two.
Auris, Nasus, Larynx, 2020
Ingredients
Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Soybean Extract Ferment, Leuconostoc Radish Root Ferment Filtrate, Bifida Ferment Filtrate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Pelargonium Graveolens Oil Flower, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol
Behind this fit score
Lovi calculates every fit score from the full ingredient list with brand-independent rules our dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update.
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Co-founder, Medical Director
Cosmetic chemist, cosmetologist, aesthetic products developer
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Co-founder, CEO and CTO
PhD in computer science, 3x US patent holder, ex-Google, ex-Yandex
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Dr. Sofía Perea Pérez, MD, MSc
Medical Board
Aesthetic medicine practitioner, MSc in Longevity and Anti-Aging Medicine
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Medical Board
Specialist dermatologist, MBBS, MD, IFAAD
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Medical Board
Cosmetic chemist, SCS, IFSCC member
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Medical Board, Medical Advisor
Dermatology MD
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Elina Nazarenko, MD
Medical Board
Dermatology and diagnostic consultant
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Victoria Derkova, MS
Medical Board
Cosmetic chemist, cosmetic development technologist
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