# MISSHA Time Revolution Night Repair Ampoule 5X for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [MISSHA](https://lovi.care/skincare/de/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin treatment for your normal skin with sensitivity, as Bifida Lysate Ferment and Niacinamide work synergistically to enhance barrier resilience and improve skin tone, addressing your concerns of redness and irritation.
- The formulation provides moderate benefits for redness and irritation by soothing and strengthening the skin barrier, with additional humectant action from ingredients like Glycerin and Propanediol.
- The safety profile is excellent, with no risks of irritation due to the absence of harsh ingredients and the presence of soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/oily-acne-prone-skin): Average

## Key ingredients

Bifida Lysate Ferment, Niacinamide, Sodium Hyaluronate, Squalane, Extreme Biome

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- Topical application of 1,3-propanediol at various concentrations, alone or combined with butylene glycol and/or glycerol, increased skin hydration and reduced trans epidermal water loss in 30 healthy female subjects over an 8-hour period, with the 15% concentration and the addition of glycerol providing greater benefits. ([International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Squalane at 0.005-0.015% counteracts UVA-induced oxidative stress, inflammation, and collagen metabolism inhibition while stimulating fibroblast migration in human dermal fibroblasts. ([Molecules, 2025](https://pubmed.ncbi.nlm.nih.gov/40363772/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Plant-derived squalane protected human dermal fibroblasts against UVA-induced damage by counteracting ROS formation, suppressing apoptosis-related proteins p53, caspase-3, caspase-9, and PARP, and restoring the pro-survival p-Akt/mTOR pathway. ([Antioxidants, 2025](https://pubmed.ncbi.nlm.nih.gov/40722956/))

## What reviewers say

Users consistently praise this ampoule as a powerful anti-aging treatment that delivers deep hydration and a "glass skin" glow overnight, often comparing it favorably to the much more expensive Estée Lauder Advanced Night Repair. It is particularly effective for dry, mature, and sensitive skin types, helping to smooth rough texture and plump fine lines, though a minority of users with sensitivities to fermented ingredients or essential oils experienced irritation.

- Liked: Hydration and glow (mostly mentioned)
- Liked: Estée Lauder dupe (often mentioned)
- Liked: Improves skin texture (often mentioned)
- Liked: Fast absorption (sometimes noted)
- Disliked: Scent irritation (sometimes noted)
- Disliked: Breakouts or irritation (rarely noted)
- Disliked: Opaque packaging (rarely noted)
- Disliked: Sticky finish (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes MISSHA Time Revolution Ampoule 5X a great fit for sensitive skin?

This ampoule is a great fit because ingredients like Bifida Lysate Ferment and niacinamide work together to strengthen your skin barrier and calm redness. Its gentle formula is very safe for sensitive skin and is unlikely to cause irritation.
Sources: [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this serum a good fit for sensitive skin?

Bifida Lysate Ferment and Niacinamide help make this serum a great fit by calming redness and strengthening sensitive skin, while ingredients like Glycerin and Propanediol add moisture to keep skin soft. The product is unlikely to cause irritation because it avoids harsh ingredients and includes soothing components.
Sources: [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Bifida Ferment Lysate do for sensitive skin?

Bifida Ferment Lysate helps calm reactive skin, making it less sensitive and more resistant to daily irritation and physical or chemical aggression. It achieves this by strengthening your skin barrier and keeping moisture locked in while decreasing redness.
Sources: [Experimental Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/19624730/), [Scientific Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37803101/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. Putting it in the evening helps keep your skin safe around sun exposure.

### Can I use this serum with retinol, and in what order?

This treatment is a great fit for your sensitive skin and helps calm redness and irritation when used in your evening routine. Apply it after your toner and before your moisturizer, but if you are using retinol, use this soothing treatment first to help protect your skin from potential irritation.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38102855/), [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/)

### How often should I use this serum?

This serum is used in your evening routine, applying it after your toner and before your moisturizer. It is very gentle on sensitive skin, making it suitable for regular daily use without causing irritation.
Sources: [International Journal of Cosmetic Science, 2024](https://pubmed.ncbi.nlm.nih.gov/37699769/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it has a very safe formula with gentle, soothing ingredients. Reviewers rarely report any breakouts or irritation from using it.

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (limonene).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Amazon.de: €18.75 (https://www.amazon.de/dp/B09648RPKJ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €53.90 (https://www.notino.de/missha/time-revolution-night-repair-ampoule-5x-intensive-nachtpflege-mit-antifalten-effekt/p-16145762/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Bifida Lysate Ferment, Butylene Glycol, Glycerin, Propanediol, Betaine, Water, Niacinamide, Pentylene Glycol, 1,2-Hexanediol, Diethoxyethyl Succinate, Chondrus Crispus Extract, Squalane, Panthenol, Polyglyceryl-10 Laurate, Saccharum Officinarum Extract, Hydrogenated Lecithin, Carbomer, Tromethamine, Xanthan Gum, Polyquaternium-51, Ethylhexylglycerin, Adenosine, Dextrin, Theobroma Cacao Extract, Bergamot Oil Fruit, Disodium Edta, Sodium Hyaluronate, Lactobacillus Ferment, Lactobacillus Lysate Ferment, Bifida Ferment Filtrate, Lactobacillus Acerola Cherry Ferment, Lactobacillus Punica Granatum Extract Fruit Ferment, Lactobacillus Soybean Extract Ferment, Lactococcus Ferment, Lactococcus Lysate Ferment, Leuconostoc Radish Root Ferment Filtrate, Pelargonium Graveolens Oil Flower, Beta Vulgaris Root Extract, Brassica Oleracea Capitata Leaf Extract, Daucus Carota Sativa Root Extract Carrot Root Extract, Solanum Melongena Fruit Extract, Blueberry Fruit Extract, Helianthus Annuus Seed Oil Sunflower Seed Oil, Citrus Aurantium Dulcis Peel Oil, Lavandula Angustifolia Oil Lavender Oil, Lupinus Albus Seed Extract, Aspergillus Ferment, Swiftlet Nest Extract, Anthemis Nobilis Oil Flower, Sandalwood Oil, Tocopherol, Ceramide Np, Cholesterol, Limonene
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/time-revolution-night-repair-ampoule-5x/for/sensitive-skin