# MISSHA The First Essence 5X for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [MISSHA](https://lovi.care/skincare/de/brands/missha)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Highly suitable for your normal skin and addresses redness and irritation with yeast extract ferment and niacinamide, which soothe and strengthen your skin barrier.
- Bifida lysate ferment and ceramide NP further enhance barrier resilience and provide humectant action, supporting overall skin health.
- The formula is safe for your sensitive skin, containing no harsh ingredients and including beneficial soothing components.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/oily-acne-prone-skin): High

## Key ingredients

Niacinamide, Yeast Extract Ferment, Bifida Lysate Ferment, Ceramide Np, Extreme Α Ferment, Ct

## What the research says

- Topical application of Bifida Ferment Lysate strengthens the skin barrier function by upregulating barrier and antimicrobial peptide genes, exhibiting strong antioxidant properties, and decreasing inflammatory cytokine secretion in vitro. ([Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/))
- A lipid mixture enriched by ceramide NP with fatty acids of diverse chain lengths significantly improved skin barrier recovery rate, stratum corneum integrity, and hydration compared to a vehicle cream in healthy adult male volunteers with corticosteroid-impaired skin. ([Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/))
- Emulsions containing ceramides 1 and 3 improved skin hydration and reduced transepidermal water loss in sodium lauryl sulfate-irritated skin of fifteen healthy Asian women compared to a control emulsion. ([International Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18717861/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical moisturizers improved skin barrier function and surface moisture, while a postbiotic moisturizer with yeast extract uniquely supported microbiome balance and modulated biomarkers of skin barrier, structure, and inflammation in participants and ex vivo explants exposed to environmental aggressors. ([Journal of Clinical Medicine, 2023](https://pubmed.ncbi.nlm.nih.gov/37763018/))
- A maintenance therapy with a cosmeceutical formulation containing hydroxyphenoxy propionic acid, ellagic acid, yeast extract, and salicylic acid over 20 weeks significantly improved even skin tone, spot intensity, spot size, and overall hyperpigmentation in 33 healthy subjects with moderate facial dyspigmentation. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25844613/))
- A methanol yeast extract increases proliferation and migration while decreasing entrance into senescence and apoptosis phases in 3T3 fibroblast cells. ([Journal of Cosmetic Science, 2014](https://pubmed.ncbi.nlm.nih.gov/25898765/))
- Topically formulated tea polyphenols show some benefit in reducing sebum secretion and treating acne vulgaris compared to baseline or control. ([Antioxidants, 2016](https://pubmed.ncbi.nlm.nih.gov/28036057/))
- Topical application of tannase-converted green tea extract (TGE) significantly improved skin wrinkle indices and self-assessed wrinkle reduction compared to normal green tea extract (NGE) in human subjects over 8 weeks. ([Journal of Cosmetic Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23725307/))
- An anti-acne hydrogel containing Aloe barbadensis, Garcinia mangostana, and Camellia sinensis extracts showed superior antiacne and antiblotch activities compared to 1% clindamycin gel in sixty subjects with mild-moderate acne. ([Clinical, Cosmetic and Investigational Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/31239743/))

## What reviewers say

Based on a very large amount of data, users consistently praise this essence for its lightweight, fast-absorbing hydration that visibly improves skin texture and radiance, often describing a healthy glow after consistent use. Some users report breakouts, likely due to fermented ingredients or niacinamide, and a segment of long-time fans express disappointment with the 5th generation reformulation, finding it less potent than previous versions.

- Liked: Lightweight & fast (mostly mentioned)
- Liked: Brightening & glow (often mentioned)
- Liked: Texture improvement (often mentioned)
- Liked: Gentle & fragrance-free (sometimes noted)
- Disliked: Reformulation disappointment (sometimes noted)
- Disliked: Breakouts & irritation (rarely noted)
- Disliked: Lack of visible results (rarely noted)
- Disliked: Packaging quality (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Missha The First Essence 5X a great fit for sensitive skin?

Missha The First Essence 5X is a great fit for sensitive skin because it uses yeast extract ferment and niacinamide to calm redness and irritation while strengthening your skin barrier. Ingredients like bifida lysate ferment and ceramide NP further boost barrier strength and keep your skin hydrated and healthy.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Which ingredients make this essence a good fit for sensitive skin?

Yeast extract ferment and niacinamide make this essence a great fit by soothing redness and irritation while strengthening your skin barrier. Bifida lysate ferment and ceramide NP further help by building up barrier resilience and keeping your skin healthy.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### What does Yeast Extract do for sensitive skin?

Yeast Extract helps calm sensitive skin by reducing irritation and strengthening the skin barrier. It also provides antioxidant support to protect against daily environmental stress.
Sources: [BioFactors, 2023](https://pubmed.ncbi.nlm.nih.gov/37317790/), [Dermatology Online Journal, 2020](https://pubmed.ncbi.nlm.nih.gov/33342171/)

### Where does this essence go in a skincare routine for sensitive skin?

This essence goes in the evening routine after your soothing toner and before your moisturizer. Placing treatments in the evening helps provide extra safety around sun exposure and keeps your routine simple.

### Can I use this essence with retinol, and in what order?

Yes, you can use this essence with retinol by applying the essence first to soothe and hydrate your skin, followed by your retinol product. This helps calm irritation while supporting your skin barrier during active treatments.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### How often should I use this essence?

You can use this treatment in your evening routine, applying it after your toner and before your moisturizer. It is safe for sensitive skin and helps soothe redness and strengthen your skin barrier.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Can this essence clog pores, cause breakouts or purging for sensitive skin?

Missha The First Essence 5X is unlikely to clog pores or cause breakouts for sensitive skin. The formula is free of harsh ingredients and features soothing components that help keep your skin calm and balanced.
Sources: [Skin Pharmacology and Physiology, 2022](https://pubmed.ncbi.nlm.nih.gov/34348350/), [Journal of Cosmetic Dermatology, 2023](https://pubmed.ncbi.nlm.nih.gov/37218728/)

### Is this essence fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Amazon.de: €27.99 (https://www.amazon.de/dp/B09646RFWJ?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €53.90 (https://www.notino.de/missha/time-revolution-the-first-treatment-essence-5x-extreme-ferment-konzentrierte-feuchtigkeitsspendende-essenz-fuer-die-regeneration-und-erneuerung-der-haut/p-16105472/)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Water, Glycerin, Propanediol, 1,2-Hexanediol, Niacinamide, Yeast Extract Ferment, Diethoxyethyl Succinate, Bifida Lysate Ferment, Sodium Pca, Butylene Glycol, Ethylhexylglycerin, Adenosine, Xanthan Gum, Ceramide Np, Hydrogenated Lecithin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/the-first-essence-5x/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/the-first-essence-5x/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/the-first-essence-5x/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/missha/the-first-essence-5x/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/missha/the-first-essence-5x/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/missha/the-first-essence-5x/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/the-first-essence-5x/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/missha/the-first-essence-5x/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/missha/the-first-essence-5x/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/missha/the-first-essence-5x/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/the-first-essence-5x/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/the-first-essence-5x/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/the-first-essence-5x/for/sensitive-skin