# MISSHA Super Aqua Ultra Hyalron Ampoule for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [MISSHA](https://lovi.care/skincare/de/brands/missha)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate hydration for your combination skin, with glycerin and multiple forms of hyaluronic acid providing humectant action, while niacinamide helps regulate oil production.
- While it provides excellent moisturizing benefits, it lacks targeted ingredients to address your specific concerns of acne, blemishes, and breakouts.
- The safety profile is good, with Tocopherol and Beta-Glucan offering soothing benefits and no harsh ingredients that would irritate your acne-prone skin.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

10x Hyaluronic Acid, Niacinamide, Avena Sativa Kernel Extract Oat Kernel Extract, Cynara Scolymus Leaf Extract, Beta-Glucan

## What the research says

- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Skin care regimens containing beta-glucan improved hemoglobin index, skin hydration, and transepidermal water loss compared to vehicle control in 20 patients undergoing fractional laser therapy. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- A repair cream containing Rhealba oat plantlets extract, l-ALA-l-GLU dipeptide, and hyaluronic acid provided immediate relief and was judged by doctors as good or very good in 96.8% of cases for wound healing in 2,363 patients following dermatological acts. ([Clinical, Cosmetic and Investigational Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/30519069/))
- Topically applied Avena sativa and Avena Rhealba oatmeal extracts significantly reduced skin irritation parameters including a* parameter increase and blood flow increase compared to vehicle in 12 healthy individuals subjected to the sodium lauryl sulfate irritation model. ([Skin Pharmacology and Applied Skin Physiology, 2002](https://pubmed.ncbi.nlm.nih.gov/11867969/))
- Colloidal oat extracts diminished pro-inflammatory cytokines in vitro and colloidal oat lotion improved skin dryness, scaling, roughness, and itch intensity in healthy female subjects compared to baseline. ([Journal of Drugs in Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25607907/))
- An artichoke extract cosmetic formulation enhanced skin roughness by 19.74% and elasticity by 11.45% in human subjects compared to a placebo cream, alongside exhibiting antioxidant, anti-inflammatory, and anti-aging cellular effects. ([Molecules, 2018](https://pubmed.ncbi.nlm.nih.gov/30360471/))
- Luteolin inhibited the mRNA expression of antimicrobial peptides and increased cornified envelope proteins in TNF-alpha/IL-17A/IFN-gamma-stimulated HaCaT cells by regulating the TRAF6/IkappaB/NF-kappaB signaling pathway. ([Food Science and Biotechnology, 2025](https://pubmed.ncbi.nlm.nih.gov/40655288/))
- Antioxidants and luteolin topically applied decrease UV-B induced apoptosis and downregulate pro-inflammatory cytokines in kindler syndrome keratinocyte cultures. ([Human Molecular Genetics, 2016](https://pubmed.ncbi.nlm.nih.gov/27798104/))
- Treatment with topical formulations containing beta-glucan combined with nanofractional radiofrequency plus magnetic nanofractional radiofrequency showed the best efficacy and was tolerable and effective in Chinese women with abdominal stretch marks compared to control groups. ([Dermatology and Therapy, 2023](https://pubmed.ncbi.nlm.nih.gov/37171578/))
- Topical beta-glucan mildly improved striae gravidarum, 1565-nm non-ablative fractional laser showed better results than topical beta-glucan, and the combined strategy further improved striae gravidarum atrophy compared to single treatment. ([The Journal of Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35570397/))
- Topical application of oat beta-glucan ameliorates epidermal hyperplasia and accelerates epidermal barrier recovery by promoting keratinocyte differentiation through dectin-1-mediated ERK and p38 signaling pathways that upregulate CaSR expression. ([International Journal of Biological Macromolecules, 2021](https://pubmed.ncbi.nlm.nih.gov/34237364/))

## Why other moisturizers fit acne-prone skin better

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))

## What reviewers say

Users consistently praise this ampoule for its deep, non-sticky hydration and lightweight texture that absorbs quickly, making it highly suitable for sensitive, dehydrated, and dry skin types. While the majority report a "plumping" effect and a gentle experience, a small minority mention mild tingling or frustration with the dropper packaging when the product runs low.

- Liked: Deep hydration (mostly mentioned)
- Liked: Lightweight texture (mostly mentioned)
- Liked: Gentle formula (often mentioned)
- Liked: Generous size (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: Mild irritation (rarely noted)
- Disliked: Price concerns (rarely noted)
- Disliked: Scent concerns (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does Super Aqua Ultra Hyalron Ampoule work for acne-prone skin?

This product works for your skin, though other products fit it better because it offers moderate hydration without containing targeted ingredients to address breakouts. A moisturizing treatment for acne-prone skin needs effective ingredients like niacinamide and hyaluronic acid that clear blemishes, control excess oil, and provide soothing benefits without causing irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/)

### Which ingredients make this serum a good fit for acne-prone skin?

This moisturizing treatment works for acne-prone skin because it contains niacinamide, which helps regulate oil, along with soothing beta-glucan and tocopherol that are unlikely to irritate. However, a product of this type needs targeted blemish-fighting ingredients to be a great fit for breakouts.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33128496/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps smooth out deep acne scars and delivers targeted treatments directly to pores when combined with active ingredients. It is generally well tolerated on acne-prone skin, though injected treatments should be performed by a professional.
Sources: [Journal of Drugs in Dermatology, 2013](https://pubmed.ncbi.nlm.nih.gov/23884503/), [Dermatologic Surgery, 2018](https://pubmed.ncbi.nlm.nih.gov/30358630/)

### What does Niacinamide do for acne-prone skin?

Niacinamide helps acne-prone skin by reducing both inflamed and uninflamed breakouts and calming redness. It is also very helpful for keeping oily skin balanced by cutting down on excess oil production, and it is well tolerated by most people.
Sources: [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38299457/), [Cureus, 2024](https://pubmed.ncbi.nlm.nih.gov/38725769/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before moisturizing. It may also be used in the morning or twice a day when your skin tolerates it well.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying it before your retinol step to help keep your skin comfortable. This type of product works best for acne-prone skin when it also includes targeted blemish-fighting ingredients and skin-soothing agents to help keep breakouts calm.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use this serum?

This treatment works best in your evening routine for simplicity and extra safety around sun exposure. It helps keep your skin soft and balanced, though acne-prone skin also needs targeted blemish-clearing ingredients to get the best results.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This moisturizing treatment is unlikely to clog pores or cause breakouts on acne-prone skin, as it has a good safety profile with soothing ingredients and no harsh irritants. However, because it lacks targeted ingredients for blemishes, acne-prone skin needs products with blemish-fighting ingredients and oil-balancing components.

### Can I use this serum around the eyes or on my body?

This moisturizing treatment is safe to use on the delicate skin around your eyes and on your body, as it has a good safety profile and is unlikely to irritate. However, because skin thickness varies across different body areas, a product for acne-prone skin needs targeted blemish-fighting ingredients and oil-balancing agents to work best on those specific concerns.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is this serum fragrance-free and alcohol-free?

It has no drying alcohol and contains fragrance (limonene and linalool).

## Alternatives for acne-prone skin

- [Allies of Skin Peptides & Antioxidants Firming Daily Treatment](https://lovi.care/skincare/de/p/allies-of-skin/peptides-and-antioxidants-firming-daily-treatment/for/acne-prone-skin) — High fit — €92.00 at Amazon
- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — €29.98 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/de/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — €17.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/de/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — €65.41 at Amazon

## Where to buy

- Amazon.de: €22.75 (https://www.amazon.de/dp/B0BNB38ZLT?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €22.50 (https://www.notino.de/missha/super-aqua-10x-ultra-hyalron-ampoule-intensives-feuchtigkeitsspendendes-gesichtsserum-mit-beruhigender-wirkung/p-16400748/)
Prices checked 17 Oct – 5 Nov 2026.

## Ingredients

Water, Methylpropanediol, Glycerin, Cyclohexasiloxane, 1,2-Hexanediol, Niacinamide, Polyglycerin-3, Octyldodeceth-16, Ammonium Acryloyldimethyltaurate Vp Copolymer, Xanthan Gum, Ethylhexylglycerin, Pentylene Glycol, Adenosine, Methyl Diisopropyl Propionamide, Carbomer, Disodium Edta, Tromethamine, Cynara Scolymus Leaf Extract, Avena Sativa Kernel Extract Oat Kernel Extract, Sodium Hyaluronate, Polyquaternium-51, Camellia Sinensis Leaf Water, Hydrogenated Lecithin, Beta-Glucan, Citrus Aurantium Dulcis Peel Oil, Bergamot Oil Fruit, Lavandula Angustifolia Oil Lavender Oil, Anthemis Nobilis Oil Flower, Tocopherol, Hydroxypropyltrimonium Hyaluronate, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Sodium Acetylated Hyaluronate, Propanediol, Tetradecyl Aminobutyroylvalylaminobutyric Urea Trifluoroacetate, Sodium Hyaluronate Crosspolymer, Magnesium Chloride, Potassium Hyaluronate, Glycine Soja Seed Extract Soybean Seed Extract, Tetrahydropiperine, Phloretin, Arginine, Limonene, Linalool
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin