# Medimine Phyto Enzyme Powder Wash for sensitive skin

**Lovi Fit: Superior fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: Superior · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: Medimine
Category: [Exfoliants](https://lovi.care/skincare/de/best/exfoliators)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

One of the best products for sensitive skin.

## Why this fit

- Excellent suitability for your normal, sensitive skin as papain and sodium cocoyl isethionate effectively cleanse and decongest pores while chamomile and licorice root extracts calm inflammation and redness. Niacinamide and betaine further support skin hydration and barrier function, creating a synergistic effect for your skin concerns.
- The gentle yet effective formulation ensures a thorough cleanse without compromising your skin's delicate balance.
- This product is exceptionally safe for your sensitive skin, containing no harsh ingredients and featuring soothing extracts that actively reduce irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/oily-skin): Superior
- [Dry skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin): Superior (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/dark-spots): Superior
- [Mature skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/mature-skin): Superior
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/oily-acne-prone-skin): Superior

## Key ingredients

Papain, Pearl Extract, Niacinamide, Licorice Root Extract, Chamomile Flower Extract

## What the research says

- A combination of Aloe barbadensis leaf extract and trimethylglycine in a 1:1 mass ratio synergistically increased aquaporin 3 expression by up to 380% in keratinocytes and safely improved skin hydration in healthy volunteers. ([Molecules, 2024](https://pubmed.ncbi.nlm.nih.gov/38611819/))
- Sodium cocoyl isethionate micelles are too large to penetrate stratum corneum aqueous pores, resulting in significant steric hindrance that prevents skin barrier perturbation and explains its skin mildness. ([Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Topical papain treatment may slightly decrease pain within 30 minutes in humans stung by Chrysaora chinensis compared to placebo. ([Wilderness & Environmental Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/26827260/))
- A fixed combination of hydroxypinacolone retinoate, retinol glycospheres, and papain glycospheres in aqueous gel applied once daily for 12 weeks achieved a 41% mean reduction in GAGS score and a 40.8% mean reduction in total lesions, with 15.3% of patients experiencing mild to moderate local side effects, in 94 evaluable patients with comedonal-papular, mild to moderate acne of the face. ([Giornale Italiano Di Dermatologia E Venereologia, 2015](https://pubmed.ncbi.nlm.nih.gov/25876142/))
- Reflux extraction of Carica papaya leaves yielded higher antioxidant capacity and superior in vitro wound-healing activities including fibroblast proliferation, cell migration, and collagen synthesis in human skin fibroblasts compared to ultrasonic-assisted extraction and agitation. ([Molecules, 2020](https://pubmed.ncbi.nlm.nih.gov/31991676/))
- Micro and nanosized pearl powders increased skin cell proliferation and migration, accelerated wound closure, enhanced biomechanical strength, improved collagen deposition, and promoted angiogenesis in rats, with nanoscale pearl powder showing the highest efficiency. ([Drug Development and Industrial Pharmacy, 2019](https://pubmed.ncbi.nlm.nih.gov/30950303/))
- Topical pearl extract gel inhibited UV-irritated skin wrinkles, laxity, thickness, and dryness, upregulated antioxidant enzyme activities, decreased MDA levels, and suppressed inflammatory factors in UV-irradiated mice compared to untreated controls, with high-dose PEG showing superior effects to Vitamin E. ([Chemistry & Biodiversity, 2022](https://pubmed.ncbi.nlm.nih.gov/35098641/))
- Seawater pearl powder treatment significantly improves UV-induced photoaging and restores skin tissue structure in mice by reducing MMP-1, enhancing collagen I, inhibiting the MAPK signaling pathway, and scavenging reactive oxygen species. ([Evidence-based Complementary and Alternative Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/34925534/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Combining 755 nm alexandrite laser with topical licorice gel significantly reduces terminal hair counts compared to alexandrite laser with placebo in women with idiopathic hirsutism. ([Evidence-based Complementary and Alternative Medicine, 2015](https://pubmed.ncbi.nlm.nih.gov/26273313/))
- Bioactive glycyrrhizic acid and oxymatrine ionic liquid self-assembled nanomicelles significantly promoted the transdermal permeation, subcutaneous retention, and anti-photoaging efficacy of palmitoyl pentapeptide-4 in cellular and animal models compared to unformulated peptide. ([Advanced Science, 2025](https://pubmed.ncbi.nlm.nih.gov/39783908/))
- Topical application of Glycyrrhiza glabra and Sophora japonica flavonoid-rich fractions individually and in combination significantly increased the wound healing rate and reduced oxidative stress compared to wound and Nolaver-treated groups. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37049756/))
- Apigenin protects against UVA-induced cytotoxicity and senescence in normal human dermal fibroblasts, decreases MMP-1 expression, and when applied topically as a cream in human subjects, increases dermal density and elasticity while reducing fine wrinkle length, skin evenness, moisture content, and transepidermal water loss compared to control cream. ([International Journal of Molecular Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27279007/))
- Topical chamomile oil combined with a night splint significantly improved the symptomatic and functional status of patients with severe carpal tunnel syndrome compared to placebo, while electrodiagnostic parameters showed no significant changes. ([Complementary Therapies in Clinical Practice, 2015](https://pubmed.ncbi.nlm.nih.gov/26573447/))
- German chamomile solution applied twice a day healed peristomal skin lesions significantly faster than once-a-day 1% hydrocortisone ointment in colostomy patients, with a mean healing time of 8.89 days versus 14.53 days. ([Ostomy/wound Management, 2011](https://pubmed.ncbi.nlm.nih.gov/21617262/))

## What reviewers say

Based on limited data, users generally praise this powder wash for its ability to dramatically improve skin texture and brightness without causing tightness, often describing it as a "holy grail" for smoothing rough skin. However, experiences are polarized regarding sensitivity; while many find it gentle, a minority report significant irritation and redness, and some struggle with the powder packaging.

- Liked: Smoothes skin texture (mostly mentioned)
- Liked: Brightening effect (often mentioned)
- Liked: Non-stripping (often mentioned)
- Liked: Clears bumps/acne (sometimes noted)
- Disliked: Packaging issues (sometimes noted)
- Disliked: High price (rarely noted)
- Disliked: Makeup removal (rarely noted)
- Disliked: Potential irritation (rarely noted)

## How to apply

- Could be used as part of your PM routine once a week. Start slowly and increase usage only if your skin feels comfortable.
- Apply this enzyme powder cleanser after your regular cleanser, and before your hydrating toner and moisturizer.
- Pour a small amount into wet hands, lather into a foam, and gently massage onto your face without harsh rubbing.
- For sensitive skin, apply this product on slightly damp skin to ensure better tolerance and comfort.
- Avoid the eye area and do a patch test before your very first use to prevent irritation.
- Video: https://storage.pora.ai/2d8db6e67371d665a6a7736b5ed5d762.mp4

## Questions and answers

### What makes Medimine Phyto Enzyme Powder Wash one of the best fits for sensitive skin?

Medimine Phyto Enzyme Powder Wash is one of the best fits for your sensitive skin because papain and sodium cocoyl isethionate gently clean and clear pores while chamomile and licorice root extracts calm redness and irritation. Niacinamide and betaine help keep your skin hydrated and support your skin barrier without disturbing its delicate balance. It is exceptionally safe for your skin type, featuring soothing ingredients that prevent discomfort.
Sources: [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### Which ingredients make this cleanser a good fit for sensitive skin?

Papain and sodium cocoyl isethionate make this cleanser a good fit because they clean and unclog pores gently, while chamomile and licorice root extracts help calm redness and irritation. Niacinamide and betaine also support skin moisture and barrier strength, keeping the face soft and comfortable.

### What does Papain do for sensitive skin?

Papain is not a good fit for sensitive skin because it can disrupt the skin barrier, cause inflammation, and act as a strong allergen. Sensitive skin needs gentle, soothing, and repairing ingredients that protect the outer layer rather than break it down.
Sources: [The Journal of Investigative Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25705851/)

### What does Pearl Extract do for sensitive skin?

Pearl Extract helps calm sensitive skin and keeps it feeling soft and smooth. It is unlikely to cause irritation and supports a healthy, balanced look.

### Where does it go in a skincare routine for sensitive skin?

This enzyme powder cleanser goes in your weekly routine for sensitive skin, used once a week to gently clean and smooth pores without causing irritation. Lovi routines start exfoliating steps like this once a week, and you can carefully use it more often if your skin tolerates it well and sees good results.

### Can I use this cleanser with retinol, and in what order?

You can use this cleanser with retinol by applying the cleanser first, followed by your retinol treatment in your evening routine. This enzyme powder wash provides a gentle clean that is unlikely to compromise your skin barrier, helping your skin stay calm when using strong ingredients.

### How often should I use it?

Start by using this cleanser once a week, and if your skin feels comfortable and tolerates it well, you may carefully use it more often. The gentle formulation helps clean pores thoroughly without disrupting your skin's delicate balance or causing irritation.

### Can this cleanser clog pores, cause breakouts or purging for sensitive skin?

This cleanser is unlikely to clog pores or cause breakouts on sensitive skin, as it gently clears out pores without disrupting your skin's balance or barrier. Because it is a wash-off product that cleans without harsh ingredients, it typically does not cause purging.
Sources: [Journal of Cosmetic Science, 2007](https://pubmed.ncbi.nlm.nih.gov/17598025/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [By Wishtrend Green Tea & Enzyme Powder Wash](https://lovi.care/skincare/de/p/by-wishtrend/green-tea-and-enzyme-powder-wash/for/sensitive-skin) — High fit — €17.32 at Amazon
- [NEEDLY Mild Enzyme Cleansing Powder](https://lovi.care/skincare/de/p/needly/mild-enzyme-cleansing-powder/for/sensitive-skin) — High fit — €37.40 at Amazon
- [SKINFOOD Black Sugar Perfect Enzyme Powder Wash](https://lovi.care/skincare/de/p/skinfood/black-sugar-perfect-enzyme-powder-wash/for/sensitive-skin) — High fit — €27.00 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Zea Mays Starch, Sodium Cocoyl Isethionate, Sodium Lauroyl Glutamate, Sorbitol, Papain, Pearl Extract, Chamomilla Recutita Flower Extract Matricaria Flower Extract, Glycyrrhiza Glabra Root Extract Licorice Root Extract, Allantoin, Citric Acid, Disodium Edta, Isopropyl Palmitate, Niacinamide, Betaine
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medimine/phyto-enzyme-powder-wash/for/sensitive-skin