# Medicube Zero Pore Serum 2.0 for mature skin

**Lovi Fit: Average fit for mature skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for mature skin; other serums fit it better.

## Why this fit

- Offers moderate pore treatment for your normal skin, as Cinnamomum Zeylanicum Bark Extract and Fomes Officinalis Extract help decongest pores, while Butylene Glycol and Fomes Officinalis Extract provide general hydration and pore-minimizing effects.
- The presence of Mentha Rotundifolia Leaf Extract and Citrus Aurantifolia Peel Extract offers mild astringent and antioxidant benefits, which are suitable for your normal skin type.
- The product is safe for your normal skin due to the absence of harsh ingredients and the inclusion of soothing agents like Mentha Rotundifolia Leaf Extract and Camellia Japonica Flower Extract.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/oily-skin): Low
- [Dry skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/combination-skin): Low
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/mature-skin): Average (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/oily-acne-prone-skin): Caution

## Key ingredients

Dimethicone, Mentha Rotundifolia Leaf Extract, Citrus Aurantifolia Peel Extract, Fomes Officinalis Extract Mushroom Extract

## What the research says

- Dipropylene glycol, propylene glycol, and butylene glycol increased molecular mobility in stratum corneum lipids and affected keratin filaments, with butylene glycol and propylene glycol providing significant permeation enhancement. ([Journal of Controlled Release, 2022](https://pubmed.ncbi.nlm.nih.gov/35150813/))
- Aqueous extracts of apple mint leaves inhibited heat shock-induced production of reactive oxygen species, matrix metalloproteinases, interleukin-8, and mitogen-activated protein kinases in human dermal fibroblasts. ([Evidence-based Complementary and Alternative Medicine, 2018](https://pubmed.ncbi.nlm.nih.gov/30254686/))
- Camellia japonica oil activated the human COL1A2 promoter, induced type I procollagen synthesis, inhibited matrix metalloproteinase-1 activity, and reduced trans-epidermal water loss without inducing adverse reactions in human skin. ([Journal of Ethnopharmacology, 2007](https://pubmed.ncbi.nlm.nih.gov/17386986/))
- Camellia japonica flower extract protects against urban air pollutant-induced skin damage by scavenging radicals, inhibiting ROS generation, reducing MMP-1 and lipid peroxidation, and increasing collagen synthesis in in vitro and ex vivo models. ([BMC Complementary and Alternative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30691451/))
- Camellioside A attenuates UVA-induced production of MMP-1 and reverses the suppression of type Iα1 pro-collagen in HaCaT keratinocytes by inhibiting MAPK activation and downstream transcription factor phosphorylation. ([Experimental and Therapeutic Medicine, 2021](https://pubmed.ncbi.nlm.nih.gov/33235625/))
- Wearing an N95 mask alone compared to using dimethicone cream or hydrocolloid dressing caused more adverse skin reactions among 73 military health care workers, with no significant differences in fit test failure rates between groups. ([Military Medicine, 2024](https://pubmed.ncbi.nlm.nih.gov/38771104/))
- A dimethicone skin protectant lotion significantly decreased visual scoring and transepidermal water loss compared to vehicle control and SLS-only treated sites in 12 healthy humans exposed to sodium lauryl sulfate. ([Skin Research and Technology, 2000](https://pubmed.ncbi.nlm.nih.gov/11428946/))
- Treatment with a moisturizer containing dimethicone and glycerine increased epidermal thickness by 0.019 mm, improved barrier function by decreasing transepidermal water loss by 13%, decreased melanin intensity, and induced keratins 6 and 16 in fifteen women with moderately photoaged forearms. ([Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/))
- White button mushroom extract treatment increased VEGF densities, EGF, PCNA, and collagen fibers, while decreasing apoptotic cells and limiting TGF-beta and CD4 reactions in ICR mice and chorioallantoic culture, indicating beneficial effects on skin regeneration and injury. ([Microscopy Research and Technique, 2012](https://pubmed.ncbi.nlm.nih.gov/22581761/))

## Why other serums fit mature skin better

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Cosmetic eye and facial creams containing palmitoyl peptides, Silybum marianum seed oil, and vitamin E improve facial wrinkles, elasticity, dermal density, and skin tone in healthy volunteers with aged skin after 4 weeks of application compared to pre-application. ([Experimental and Therapeutic Medicine, 2016](https://pubmed.ncbi.nlm.nih.gov/27446338/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))

## What reviewers say

Users with oily and combination skin frequently report that this serum effectively regulates sebum and improves overall skin texture, creating a smoother base for makeup. While many users noticed a visible tightening of pores and a "glass skin" effect, results regarding actual pore size reduction are mixed, with some finding it highly effective and others seeing no significant change.

- Liked: Smoother skin texture (mostly mentioned)
- Liked: Lightweight absorption (often mentioned)
- Liked: Oil & sebum control (often mentioned)
- Disliked: Sticky texture (often mentioned)
- Liked: Pore tightening (sometimes noted)
- Disliked: Ineffective for some (sometimes noted)
- Disliked: Unpleasant fragrance (sometimes noted)
- Disliked: Price vs. quantity (rarely noted)

## How to apply

- Use this serum in your PM routine. Start by applying it 3 times a week, and work up to daily use if your skin likes it.
- Apply this serum after your toner and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- You can apply the serum on dry skin for the best results against fine lines.
- Always do a patch test before your first use and avoid the sensitive eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Zero Pore Serum work for mature skin?

Medicube Zero Pore Serum 2.0 works moderately well for mature skin, helping to decongest pores and provide hydration, though other treatments fit this skin type better. To truly thrive, mature skin needs targeted ingredients that smooth fine lines and boost firmness while deeply nourishing and protecting the skin barrier.

### Which ingredients make this serum a good fit for mature skin?

Camellia Japonica Flower Extract and Mentha Rotundifolia Leaf Extract help this serum fit mature skin by supporting collagen production and providing antioxidant protection. Mature skin needs treatments that target fine lines and deeply nourish the skin barrier with firming peptides, antioxidants, and rich hydrators to keep it plump and smooth.
Sources: [Journal of Ethnopharmacology, 2007](https://pubmed.ncbi.nlm.nih.gov/17386986/), [BMC Complementary and Alternative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30691451/)

### What does Water do for mature skin?

Water helps keep mature skin hydrated, which significantly lowers the severity of wrinkles and maintains elasticity. Because aging skin often loses moisture and firmness, it needs hydrating ingredients like glycerin and hyaluronic acid to stay plump and smooth.
Sources: [Skin Research and Technology, 2013](https://pubmed.ncbi.nlm.nih.gov/22672420/)

### What does Dimethicone do for mature skin?

Dimethicone helps keep mature skin feeling soft and smooth while protecting the skin barrier. When used regularly, it may improve skin firmness and keep the surface hydrated throughout the day.
Sources: [Dermatologic Therapy, 2012](https://pubmed.ncbi.nlm.nih.gov/22913439/), [Clinical and Experimental Dermatology, 2007](https://pubmed.ncbi.nlm.nih.gov/17137484/)

### Where does this serum go in a skincare routine for mature skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. Mature skin needs a product of this type that also delivers firming peptides and rich hydrators to smooth fine lines and boost resilience.

### Can I use this serum with niacinamide, and in what order?

You can use this serum with niacinamide by applying niacinamide first and following with this treatment once it absorbs. This combination is generally safe and helps keep mature skin smooth while supporting overall hydration.

### How often should I use this serum?

You can use this treatment in the evening as part of your routine. Mature skin needs products of this type that provide deep hydration, collagen support, and nourishing anti-aging ingredients to stay soft and smooth.

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains soothing and pore-decongesting extracts that help keep skin clear. However, because mature skin needs extra nourishment, this skin type benefits even more from products that include rich moisturizing ingredients and collagen-boosting agents.
Sources: [Journal of Ethnopharmacology, 2007](https://pubmed.ncbi.nlm.nih.gov/17386986/), [BMC Complementary and Alternative Medicine, 2019](https://pubmed.ncbi.nlm.nih.gov/30691451/)

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Clarins Double Serum](https://lovi.care/skincare/de/p/clarins/double-serum/for/mature-skin) — High fit — €74.99 at Amazon
- [SKIN1004 Madagascar Centella Asiatica Ampoule](https://lovi.care/skincare/de/p/skin1004/madagascar-centella-asiatica-ampoule/for/mature-skin) — Average fit — €13.88 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €51.50 at Amazon

## Where to buy

- Amazon.de: €21.99 (https://www.amazon.de/dp/B09G267W27?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €24.50 (https://www.notino.de/medicube/zero-pore-serum-2-0-serum-fuer-fettige-und-problematische-haut-fuer-reduktion-fettiger-haut/p-16329871/)
Prices checked 17 Oct – 6 Nov 2026.

## Ingredients

Water, Butylene Glycol, Dimethicone Vinyl Dimethicone Crosspolymer, Cyclopentasiloxane, Cetyl Ethylhexanoate, Cyclohexasiloxane, Polysorbate 60, Bis-Peg-18 Methyl Ether Dimethyl Silane, Glyceryl Stearate, Dimethicone, Peg-100 Stearate, Phenoxyethanol, Tromethamine, Chlorphenesin, Polyacrylate-13, Ethylhexylglycerin, Acrylates C10-30 Alkyl Acrylate Crosspolymer, Isoceteth-10, Caprylyl Glycol, Isoceteth-25, Carbomer, Polyisobutene, Disodium Edta, Mentha Rotundifolia Leaf Extract, Citrus Aurantifolia Peel Extract, Cymbopogon Schoenanthus Extract, Polysorbate 20, Sorbitan Isostearate, Camellia Japonica Flower Extract, Fomes Officinalis Extract Mushroom Extract, 1,2-Hexanediol, Cinnamomum Zeylanicum Bark Extract, Uncaria Gambir Extract, Nelumbo Nucifera Flower Extract, Pelargonium Graveolens Extract, Sanguisorba Officinalis Root Extract, Bht, Pinus Palustris Leaf Extract, Pueraria Lobata Root Extract, Ulmus Davidiana Root Extract, Oenothera Biennis Flower Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-serum-2-0/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-serum-2-0/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-serum-2-0/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-serum-2-0/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-serum-2-0/for/mature-skin