# Medicube Zero Pore One Day Serum for mature skin

**Lovi Fit: High fit for mature skin.**
Normal Skin Fit: High · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/mature-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Exfoliants](https://lovi.care/skincare/de/best/exfoliators)

This fit is calculated for the concerns frequently associated with mature skin: fine lines, wrinkles, and loss of firmness. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for mature skin; a few products fit it even better.

## Why this fit

- Offers excellent pore treatment for your normal skin due to gluconolactone, lactic acid, and glycolic acid providing effective chemical exfoliation to refine texture and minimize pore appearance.
- Provides moderate exfoliation for wrinkles and fine lines with gluconolactone and salicylic acid, while niacinamide further aids in pore refinement.
- The product is safe for your normal skin, featuring soothing Centella Asiatica Extract and niacinamide with no harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/dry-skin): Low
- [Combination skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/mature-skin): High (this page)
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/dry-sensitive-skin): Low
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/oily-acne-prone-skin): Average

## Key ingredients

Aha, Bha, Pha, Niacinamide, Salicylic Acid

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Cryotherapy with liquid nitrogen achieved a higher cure rate (39%) than salicylic acid (24%) and a wait-and-see approach (16%) for cutaneous warts at 13 weeks in primary care patients. ([CMAJ, 2010](https://pubmed.ncbi.nlm.nih.gov/20837684/))
- A moisturizer containing licochalcone A, 1,2-decanediol, L-carnitine, and salicylic acid significantly reduced noninflammatory, inflammatory, and total acne lesion counts compared to a vehicle control in Thai patients during a 12-week maintenance phase. ([BioMed Research International, 2020](https://pubmed.ncbi.nlm.nih.gov/33150170/))
- Treatment with 2% supramolecular salicylic acid hydrogel resulted in a regression and markedly improvement rate of 51.01% compared to 43.10% for Adapaline gel in patients with mild to moderate facial acne vulgaris, showing no significant difference in efficacy. ([Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38590107/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))

## What reviewers say

Based on a very large amount of data, users with oily and combination skin frequently praise this serum for refining rough texture and minimizing enlarged pores, often describing a blurring effect that serves as a good makeup base. While the 'one day' claim is often viewed as marketing hyperbole, consistent use reportedly yields smoother skin and reduced sebum production, though the product's sticky finish is a polarizing feature.

- Liked: Smoothes texture (mostly mentioned)
- Disliked: Sticky finish (mostly mentioned)
- Liked: Tightens pores (often mentioned)
- Liked: Controls oil (sometimes noted)
- Liked: Hydrating formula (sometimes noted)
- Disliked: Causes irritation (sometimes noted)
- Disliked: Price vs quantity (rarely noted)
- Disliked: Unpleasant scent (rarely noted)

## How to apply

- Use this exfoliant product in your PM routine once a week to start, increasing frequency only if your skin tolerates it well. Always apply SPF the next morning to protect your skin.
- Apply this exfoliant product after cleansing and toner, but before your moisturizer. This ensures the best absorption into your skin.
- Gently press 2-3 drops of the exfoliant product into your face, avoiding any rubbing. Let it absorb for a minute before moving to the next step.
- Apply this exfoliant product on completely dry skin to get the best results. This helps your normal skin accept the product smoothly.
- Avoid the sensitive eye area while using this exfoliant product. Do a patch test before your first use and avoid mixing it with strong acids.
- Video: https://storage.pora.ai/028e5e793422a3b665c02ff502cf5a68.mp4

## Questions and answers

### What makes Medicube Zero Pore One Day Serum a great fit for mature skin?

Medicube Zero Pore One Day Serum is a great fit because it helps smooth fine lines and refine texture using a mix of acids like salicylic acid and gluconolactone. It also keeps mature skin calm and comfortable with soothing ingredients like niacinamide and Centella Asiatica extract.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### Which ingredients make this serum a good fit for mature skin?

This serum is a great fit for mature skin because it contains gluconolactone and salicylic acid to gently smooth wrinkles and fine lines, alongside niacinamide to help refine your pores and improve signs of aging. It is very safe and gentle to use thanks to soothing Centella Asiatica extract and a formula free of harsh ingredients.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/)

### What does Alpha Hydroxy Acid do for mature skin?

Alpha hydroxy acid helps smooth and firm mature skin by gently clearing away dull surface flakes and encouraging collagen production. Regular use may visibly soften fine lines, improve texture, and fade dark spots over time.
Sources: [Journal of the American Academy of Dermatology, 1996](https://pubmed.ncbi.nlm.nih.gov/8642081/), [The Journal of Dermatology, 2006](https://pubmed.ncbi.nlm.nih.gov/16469079/)

### What does Bha do for mature skin?

BHA helps mature skin by smoothing out fine lines and increasing collagen to keep the face firm and elastic. Clinical studies show that regular use of ingredients like salicylic acid can improve skin thickness and reduce visible signs of aging.
Sources: [Journal of Cosmetic Dermatology, 2010](https://pubmed.ncbi.nlm.nih.gov/20883290/), [Aesthetic Plastic Surgery, 2025](https://pubmed.ncbi.nlm.nih.gov/38926250/)

### Where does this serum go in a skincare routine for mature skin?

This serum is used in the evening routine, starting at once a week and slowly increasing frequency if your skin tolerates it well. It helps refine texture and minimize pores while remaining gentle on mature skin.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol by applying them on alternate nights to help prevent dry or irritated skin. Because both ingredients renew the skin surface, separating them keeps your routine gentle and safe.

### How often should I use this serum?

Start using this serum once a week in your evening routine, and if your skin feels comfortable and you see good results, you can carefully use it more often. Chemical exfoliants help refine texture and smooth fine lines, but starting slowly helps avoid irritation.
Sources: [Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/32356917/), [Journal of Cosmetic Dermatology, 2024](https://pubmed.ncbi.nlm.nih.gov/38406974/)

### Can this serum clog pores, cause breakouts or purging for mature skin?

This serum is unlikely to clog pores or cause breakouts for mature skin, as it contains chemical exfoliants like salicylic acid, lactic acid, and glycolic acid that help keep pores clear and refine texture. However, it may cause irritation for some people.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for mature skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/mature-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/mature-skin) — Superior fit — €169.99 at Amazon
- [La Prairie Skin Caviar Liquid Lift](https://lovi.care/skincare/de/p/la-prairie/skin-caviar-liquid-lift/for/mature-skin) — High fit — €730.48 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/mature-skin) — Superior fit — €39.99 at Amazon
- Hydrating Toner: [COSRX Propolis Synergy Toner](https://lovi.care/skincare/de/p/cosrx/full-fit-propolis-synergy-toner/for/mature-skin) — Superior fit — €14.00 at Amazon
- Moisturizer: [Elizabeth Arden Ceramide Lift and Firm Night Cream](https://lovi.care/skincare/de/p/elizabeth-arden/advanced-ceramide-lift-and-firm-night-cream/for/mature-skin) — Superior fit — €51.50 at Amazon

## Where to buy

- Amazon.de: €21.99 (https://www.amazon.de/dp/B09G267W27?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €15.50 (https://www.notino.de/medicube/zero-pore-one-day-serum-beruhigendes-und-hydratisierendes-serum-zur-verfeinerung-der-poren/p-16299735/)
Prices checked 16 Oct – 6 Nov 2026.

## Ingredients

Water, Gluconolactone, Methylpropanediol, Glycerin, Propanediol, Tromethamine, Polyglycerin-3, Niacinamide, 1,2-Hexanediol, Citric Acid, Dimethicone, Butylene Glycol, C12-14 Pareth-12, Hydroxyethylcellulose, Salicylic Acid, Ammonium Acryloyldimethyltaurate Vp Copolymer, Sodium Polyacryloyldimethyl Taurate, Lecithin, Allantoin, Lactic Acid, Glycolic Acid, Ethylhexylglycerin, Adenosine, Dextrin, Indigofera Tinctoria Extract, Sodium Hyaluronate, Sodium Citrate, Hemerocallis Fulva Flower Extract, Gardenia Fruit Extract, Hydrolyzed Hyaluronic Acid, Hydrolyzed Sodium Hyaluronate, Sodium Hyaluronate Crosspolymer, Trisodium Phosphate, Of Myosotis Sylvatica Extract, Pentylene Glycol, Hydroxypropyltrimonium Hyaluronate, Sodium Acetylated Hyaluronate, Centella Asiatica Extract, Madecassoside, Lactobacillus Lysate Ferment, Dandelion Leaf Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/zero-pore-one-day-serum/for/mature-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Germany: https://lovi.care/skincare/de/p/medicube/zero-pore-one-day-serum/for/mature-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Italy: https://lovi.care/skincare/it/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Spain: https://lovi.care/skincare/es/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Australia: https://lovi.care/skincare/au/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/zero-pore-one-day-serum/for/mature-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/zero-pore-one-day-serum/for/mature-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/zero-pore-one-day-serum/for/mature-skin