# Medicube Triple Collagen Serum 4.0 for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other serums fit it better.

## Why this fit

- Offers moderate plumping and elasticity improvement for your normal skin due to multiple forms of collagen and sodium hyaluronate, which support skin structure and hydration. Niacinamide further aids in barrier repair, complementing the collagen-boosting effects.
- While the formula provides general hydration with glycerin and sodium hyaluronate, it does not specifically target your concerns of redness and irritation.
- The product is safe for your sensitive skin, as it lacks harsh ingredients and carries no risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin): Average

## Key ingredients

Collagen Extract, Sodium Hyaluronate, Niacinamide, Adenosine, Glycerin

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Hyaluronic acid extracts are safe and efficacious products for skin repair when used in tissue regeneration alone or in combination with herbal or Western medicine. ([Journal of Pharmacy & Pharmaceutical Sciences, 2015](https://pubmed.ncbi.nlm.nih.gov/25877441/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))
- Niacinamide/glycerin body moisturizers provided better rapid and prolonged improvement of cosmetic xerosis through functional improvement of stratum corneum barrier function compared to no treatment and conventional moisturizers in female subjects. ([Journal of Drugs in Dermatology, 2012](https://pubmed.ncbi.nlm.nih.gov/22206073/))

## Why other serums fit sensitive skin better

- Topical application of TAT-SOD significantly suppresses UVB-induced erythema formation, blood flow rise, and apoptotic sunburn cell formation in human volunteers compared to a vehicle control. ([European Journal of Pharmaceutics and Biopharmaceutics, 2016](https://pubmed.ncbi.nlm.nih.gov/27460952/))

## What reviewers say

Users consistently praise this serum for delivering a "glass skin" finish and deep hydration, making it a favorite for those with dry, dull, or mature skin. While the plumping and glow-boosting effects are widely celebrated, some users with oily or sensitive skin find the formula slightly sticky or the fragrance too strong.

- Liked: Glass skin glow (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Silky texture (sometimes noted)
- Disliked: Added fragrance (sometimes noted)
- Disliked: Sticky or heavy (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Price vs. quantity (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Triple Collagen Serum work for sensitive skin?

Medicube Triple Collagen Serum works moderately well for sensitive skin because it is safe and provides general hydration, but it does not specifically target redness and irritation. Treatments that fit sensitive skin better need soothing ingredients that calm redness and irritation while keeping the skin hydrated and healthy.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Which ingredients make this serum a good fit for sensitive skin?

Niacinamide and glycerin make this serum a good fit for sensitive skin by helping repair the skin barrier and providing gentle hydration without harsh ingredients. To be an even better fit for sensitive skin, treatments like this need soothing ingredients that specifically calm redness and irritation.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Collagen Extract do for sensitive skin?

Collagen Extract helps keep sensitive skin calm and hydrated by supporting the skin barrier and easing inflammation. It may also improve skin elasticity and reduce irritation.
Sources: [Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/), [Journal of Medicinal Food, 2022](https://pubmed.ncbi.nlm.nih.gov/36516059/)

### What does Hyaluronic Acid do for sensitive skin?

Hyaluronic acid helps calm and hydrate sensitive skin while supporting the skin barrier to keep it soft and comfortable. Clinical studies show it improves surface moisture and reduces dryness, roughness, and redness without irritation.
Sources: [Journal of Drugs in Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/41037531/), [Journal of Cosmetic Dermatology, 2018](https://pubmed.ncbi.nlm.nih.gov/29356277/)

### Where does this serum go in a skincare routine for sensitive skin?

This treatment goes in the evening routine after your soothing toner and before your moisturizer. It is safe for sensitive skin because it lacks harsh ingredients, but a product for this skin also needs soothing ingredients to target redness and irritation.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying it after your retinol to help keep your skin hydrated and comfortable. This type of product needs soothing and calming ingredients like centella asiatica or green tea to actively target redness and irritation.

### How often should I use this serum?

You can use this serum in your evening routine, applying it after your toner and before your moisturizer. It is safe for sensitive skin and carries no risk of irritation, but because it does not target redness, sensitive skin needs a product that specifically calms irritation and reduces redness.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this serum clog pores, cause breakouts or purging for sensitive skin?

This serum is unlikely to clog pores or cause breakouts for sensitive skin, as it lacks harsh ingredients and carries a very safe profile. However, because it does not target redness and irritation, a product of this type for sensitive skin needs soothing ingredients like Centella asiatica or aloe to calm redness while hydrating.
Sources: [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (linalool, limonene, geraniol, citronellol, citral, and benzyl alcohol) and drying alcohol (alcohol denat).

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Lookfantastic: €21.16 (https://www.lookfantastic.de/p/medicube-triple-collagen-serum-4.0-55ml/16858546/)
- Notino: €27.50 (https://www.notino.de/medicube/triple-collagen-serum-festigendes-serum-mit-kollagen/p-16304405/)
Prices checked 13 Oct – 17 Oct 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 2-Hexanediol, Cyclopentasiloxane, Cyclohexasiloxane, Trehalose, Dimethicone, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Benzyl Benzoate, Linalool, Limonene, Geraniol, Atelocollagen, Desamido Collagen, Citronellol, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Hydroxycitronellal, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Hydroxypropyltrimonium Hyaluronate, Citral, Benzyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin