# Medicube Triple Collagen Serum 4.0 for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other serums fit it better.

## Why this fit

- This serum offers moderate hydration and plumping benefits for your combination skin, with niacinamide helping to regulate oil production and multiple forms of collagen and sodium hyaluronate providing humectant action and barrier support.
- While it is safe for your combination skin and free from harsh ingredients, its primary focus on hydration and elasticity does not directly address your main concerns of acne, blemishes, and breakouts.
- The product is safe for your combination skin as it lacks prohibited or harsh ingredients, minimizing the risk of irritation.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/oily-acne-prone-skin): Average

## Key ingredients

Collagen Extract, Sodium Hyaluronate, Niacinamide, Adenosine, Glycerin

## What the research says

- Treatment with a combination of niacinamide and hyaluronic acid improved skin aging signs and demonstrated a senomorphic effect by decreasing SASP and autocrine signaling genes in women. ([Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Both oral and topical collagen supplements help delay the skin aging process by improving moisture, elasticity, and hydration, with no differences arising between the two types of collagen. ([Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/))
- The use of cosmetic products containing collagen or its peptides improves the general condition of the skin, reduces wrinkle depth, improves hydration and density, reduces transepithelial water loss, and delays the aging process, while oral bioactive collagen peptides also reduce nail breakage. ([Current Issues in Molecular Biology, 2024](https://pubmed.ncbi.nlm.nih.gov/38534748/))
- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of 0.1% hyaluronic acid formulations of different molecular weights led to significant improvements in skin hydration and elasticity, with low-molecular-weight formulations also significantly reducing wrinkle depth in seventy-six female subjects compared to a vehicle control. ([Journal of Drugs in Dermatology, 2011](https://pubmed.ncbi.nlm.nih.gov/22052267/))
- Topical application of hyaluronic acid in conjunction with free gingival graft significantly reduced donor site postoperative pain until day 7 compared to normal saline, with no significant differences in graft dimensions or patient satisfaction. ([Clinical Oral Investigations, 2022](https://pubmed.ncbi.nlm.nih.gov/34623507/))
- Treatment with a hyaluronic acid-containing mouth rinse or topical gel led to significant lesion reduction, pain relief, and normalization of lesion color in adult patients with minor recurrent aphthous stomatitis, with the gel formulation showing an earlier healing onset at 3 days. ([BMC Oral Health, 2019](https://pubmed.ncbi.nlm.nih.gov/31311529/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- The emollient V0034CR significantly reduced TEWL compared to vehicle and vehicle plus glycerol, and significantly increased corneometry scores compared to vehicle and vehicle plus petrolatum in healthy volunteers with dry skin, demonstrating combined barrier function improvement from petrolatum and hydration improvement from glycerol. ([Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/31532576/))
- Ten days of treatment with a cream containing 20% glycerin significantly increased skin hydration measured by corneometer values in 17 healthy volunteers compared to a placebo cream, but showed no influence on transepidermal water loss or skin sensitivity to an irritating surfactant. ([International Journal of Cosmetic Science, 2001](https://pubmed.ncbi.nlm.nih.gov/18498456/))

## Why other serums fit acne-prone skin better

- Topical nicotinamide plus an antibacterial adhesive agent and zinc-pyrrolidone carboxylic acid combined with adapalene significantly reduced noninflammatory acne lesions by the second week of therapy compared to placebo with adapalene in patients with moderate acne vulgaris. ([The Journal of Clinical and Aesthetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32983333/))
- A cream combining propolis, tea tree oil, and Aloe vera reduced erythema scars, acne severity index, and total lesion count better than erythromycin cream in sixty patients with mild to moderate acne vulgaris compared to placebo. ([Clinical Pharmacology, 2018](https://pubmed.ncbi.nlm.nih.gov/30588129/))
- Niacinamide and ferulic acid incorporated in a stable multiple emulsion successfully reduced melanin, sebum, and skin erythema while improving skin elasticity and hydration in human skin compared to a placebo. ([BioMed Research International, 2022](https://pubmed.ncbi.nlm.nih.gov/35342760/))

## What reviewers say

Users consistently praise this serum for delivering a "glass skin" finish and deep hydration, making it a favorite for those with dry, dull, or mature skin. While the plumping and glow-boosting effects are widely celebrated, some users with oily or sensitive skin find the formula slightly sticky or the fragrance too strong.

- Liked: Glass skin glow (mostly mentioned)
- Liked: Deep hydration (often mentioned)
- Liked: Makeup compatibility (sometimes noted)
- Liked: Silky texture (sometimes noted)
- Disliked: Added fragrance (sometimes noted)
- Disliked: Sticky or heavy (sometimes noted)
- Disliked: Packaging issues (rarely noted)
- Disliked: Price vs. quantity (rarely noted)

## How to apply

- Use your serum as part of your PM routine and start 3x/week before working up to daily use.
- Apply this treatment after cleansing and toner, and before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the product on clean, dry skin to help manage your breakouts safely.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Triple Collagen Serum work for acne-prone skin?

This serum works for acne-prone skin with an average fit, offering moderate hydration and oil control while lacking ingredients that directly target breakouts. Acne-prone skin needs products with ingredients like niacinamide, propolis, and zinc PCA that provide excellent benefits for acne and breakouts without causing irritation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Dermatology Practical & Conceptual, 2022](https://pubmed.ncbi.nlm.nih.gov/35223163/)

### Which ingredients make this serum a good fit for acne-prone skin?

Niacinamide helps regulate oil production for acne-prone skin, while multiple forms of collagen and sodium hyaluronate provide moisture and support the skin barrier. Because acne-prone skin needs more direct blemish care, products of this type work best when they include targeted ingredients like propolis or zinc PCA along with a safe, irritation-free formulation.
Sources: [Scientific Reports, 2024](https://pubmed.ncbi.nlm.nih.gov/39009698/), [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Collagen Extract do for acne-prone skin?

Collagen Extract is unlikely to clog pores and may help soothe redness and keep acne-prone skin calm. Because this type of product is a poor fit for oily skin, acne-prone skin needs lightweight formulas with soothing ingredients and gentle acne-fighting extracts to stay clear and smooth.
Sources: [Nutrients, 2022](https://pubmed.ncbi.nlm.nih.gov/36501011/)

### What does Hyaluronic Acid do for acne-prone skin?

Hyaluronic acid helps acne-prone skin by soothing irritation, calming redness, and keeping the skin balanced without clogging pores. When combined with targeted ingredients like zinc oxide, it may also help reduce breakouts.
Sources: [Biomedicines, 2025](https://pubmed.ncbi.nlm.nih.gov/41007718/), [Drug Delivery, 2017](https://pubmed.ncbi.nlm.nih.gov/28155509/)

### Where does this serum go in a skincare routine for acne-prone skin?

This treatment serum goes in the evening routine after cleansing and before moisturizing, though acne-prone skin needs products that specifically target breakouts and blemishes.

### Can I use this serum with retinol, and in what order?

You can use this serum with retinol, applying the treatment serum after your cleansing steps and before your moisturizer. It is unlikely to cause irritation since it lacks harsh ingredients, though acne-prone skin needs targeted active ingredients like retinoids or benzoyl peroxide to directly address breakouts.
Sources: [American Family Physician, 2012](https://pubmed.ncbi.nlm.nih.gov/23062156/)

### How often should I use this serum?

You can use this serum in the evening as part of your routine, or twice a day if your skin tolerates it well. It is safe for your skin and unlikely to cause irritation, but an acne-prone skin needs a product that directly targets blemishes and breakouts with clarifying or exfoliating ingredients.

### Can this serum clog pores, cause breakouts or purging for acne-prone skin?

This serum is unlikely to cause purging since it lacks exfoliating acids, but it may feel a bit heavy or sticky on acne-prone skin. It is safe to use as it lacks harsh ingredients, though a product for this skin works best when it also includes ingredients that directly target breakouts and blemishes.

### Is this serum fragrance-free and alcohol-free?

It contains fragrance (linalool, limonene, geraniol, citronellol, citral, and benzyl alcohol) and drying alcohol (alcohol denat).

## Alternatives for acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/acne-prone-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Niacinamide 15% Firming Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-niacinamide-15-firming-serum/for/acne-prone-skin) — Superior fit — €35.29 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/acne-prone-skin) — Superior fit — €169.99 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- Moisturizer: [Some By Mi Yuja Niacin Brightening Moisture Gel Cream](https://lovi.care/skincare/de/p/some-by-mi/yuja-niacin-brightening-moisture-gel-cream/for/acne-prone-skin) — Superior fit — €13.67 at Amazon

## Where to buy

- Lookfantastic: €21.16 (https://www.lookfantastic.de/p/medicube-triple-collagen-serum-4.0-55ml/16858546/)
- Notino: €27.50 (https://www.notino.de/medicube/triple-collagen-serum-festigendes-serum-mit-kollagen/p-16304405/)
Prices checked 13 Oct – 17 Oct 2026.

## Ingredients

Water, Glycerin, Butylene Glycol, Cetyl Ethylhexanoate, Niacinamide, Glycereth-26, Alcohol Denat, 2-Hexanediol, Cyclopentasiloxane, Cyclohexasiloxane, Trehalose, Dimethicone, Carbomer, Cetearyl Olivate, Tromethamine, Sorbitan Olivate, Ethylhexylglycerin, Collagen Extract, Adenosine, Disodium Edta, Benzyl Benzoate, Linalool, Limonene, Geraniol, Atelocollagen, Desamido Collagen, Citronellol, Hydrolyzed Collagen, Sodium Hyaluronate, Water-Soluble Collagen, Hydroxycitronellal, Sodium Hyaluronate Crosspolymer, Hydrolyzed Sodium Hyaluronate, Hydrolyzed Hyaluronic Acid, Collagen, Collagen Amino Acids, Sodium Acetylated Hyaluronate, Procollagen, Hydroxypropyltrimonium Hyaluronate, Citral, Benzyl Alcohol
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
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- Netherlands: https://lovi.care/skincare/nl/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
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- Canada: https://lovi.care/skincare/ca/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/triple-collagen-serum-4-0/for/acne-prone-skin