# Medicube Super Cica Ampoule for oily acne-prone skin

**Lovi Fit: High fit for oily acne-prone skin.**
Oily Skin Fit: Superior · Effectiveness: High · Safety: Excellent.

Page: https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with oily acne-prone skin: shine, breakouts, blemishes, and enlarged pores. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for oily acne-prone skin; a few serums fit it even better.

## Why this fit

- Excellent suitability for your oily skin as Centella Asiatica Extract and Madecassoside work synergistically to soothe inflammation and strengthen your skin barrier, addressing your acne and blemishes effectively.
- Licorice Root Extract further aids in seboregulation, helping to manage oiliness and maintain a balanced complexion.
- The formulation is safe for your skin, with no reported irritation risks and a focus on calming ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/dry-skin): Superior
- [Combination skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/sensitive-skin): High
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/acne-prone-skin): Superior
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/dry-sensitive-skin): Superior
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin): High (this page)

## Key ingredients

Centella Asiatica Extract, Madecassoside, Asiatic Acid, Madecassic Acid, Extract Tree

## What the research says

- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- Asiatic acid-loaded solid lipid microparticles stabilized with poloxamer-188 reduced porphyrin intensity, enhanced skin barriers, and improved skin hydration and brightness in fifteen participants with mild-to-moderate acne. ([International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38460769/))
- Licochalcone A activated Nrf2 signaling, elevated cytoprotective enzymes, increased the reduced-to-oxidized glutathione ratio, and decreased reactive oxygen species in human fibroblasts and neutrophils, while a LicA-rich licorice extract lowered UVA-induced oxidative processes in vivo. ([Experimental Dermatology, 2015](https://pubmed.ncbi.nlm.nih.gov/25381913/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))

## What reviewers say

This ampoule is highly effective for users with acne-prone and sensitive skin, frequently noted for its rapid soothing of redness and calming of active breakouts, acting as a significant aid for compromised skin barriers. A notable portion of users express dissatisfaction with its sticky or tacky finish, which can be problematic for morning routines and makeup application.

- Liked: Soothing & calming (mostly mentioned)
- Liked: Acne & blemish care (often mentioned)
- Disliked: Small quantity/price (often mentioned)
- Disliked: Sticky texture (often mentioned)
- Liked: Hydration & glow (sometimes noted)
- Disliked: Packaging/dropper issues (sometimes noted)

## How to apply

- Could be used as part of your PM routine. Start 3 times a week and build up to daily use if your skin tolerates it well.
- Apply your serum after cleansing and toning, but before putting on your moisturizer.
- Gently press 2 to 3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on clean, dry skin to help manage your blemishes safely.
- Do a patch test before your first use and avoid the delicate eye area.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Super Cica Ampoule a great fit for oily acne-prone skin?

Medicube Super Cica Ampoule is a great fit because centella asiatica extract and madecassoside work together to calm redness and strengthen your skin barrier, which helps manage breakouts. Licorice root extract also helps balance oil levels to keep your skin clear and comfortable. The formula is gentle on oily skin and is unlikely to cause irritation.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Which ingredients make this serum a good fit for oily acne-prone skin?

Centella Asiatica Extract and Madecassoside make this serum a great fit because they help soothe inflammation and calm breakouts while strengthening your skin barrier. Licorice Root Extract also aids in managing excess oil to keep your complexion balanced.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38460769/)

### What does Centella Asiatica Extract do for oily acne-prone skin?

Centella Asiatica Extract helps calm red spots and supports skin healing in oily, acne-prone skin. It may also help balance moisture and reduce breakouts by soothing irritated areas.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/)

### What does Madecassoside do for oily acne-prone skin?

Madecassoside helps calm oily, acne-prone skin by reducing redness and soothing irritation while supporting barrier repair. It may help decrease acne blemishes and moisture loss in human skin.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### Where does this serum go in a skincare routine for oily acne-prone skin?

This serum goes in the evening routine after cleansing and before moisturizing, making it simple and safe for your skin. Using it at night helps calm inflammation and manage oiliness without extra sun exposure risks.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the retinol first and following it with this ampoule to help soothe your skin and keep it calm. This product has a safe formula with no reported irritation risks for oily acne-prone skin.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38460769/)

### How often should I use it?

Use this treatment in your evening routine for simplicity and extra safety around sun exposure. It is a great fit for oily acne-prone skin, helping to soothe inflammation and manage oiliness without irritation risks.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38460769/)

### Can this serum clog pores, cause breakouts or purging for oily acne-prone skin?

This serum is a great fit for oily acne-prone skin because it contains soothing ingredients like Centella Asiatica Extract and Madecassoside that calm inflammation and manage oiliness without causing breakouts. It has a very safe profile with no reported irritation risks, making it unlikely to clog your pores or cause purging.
Sources: [Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/), [International Journal of Pharmaceutics, 2024](https://pubmed.ncbi.nlm.nih.gov/38460769/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for oily acne-prone skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/oily-acne-prone-skin) — Superior fit — €9.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/oily-acne-prone-skin) — Superior fit — €29.76 at Amazon
- [NEOGEN DERMALOGY REAL VITA C SERUM](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vita-c-serum/for/oily-acne-prone-skin) — High fit — €36.50 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/oily-acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [Paula's Choice Pore-Reducing Toner](https://lovi.care/skincare/de/p/paula-s-choice/skin-balancing-pore-reducing-toner/for/oily-acne-prone-skin) — Superior fit — €36.00 at Amazon
- Moisturizer: [innisfree Green Tea Seed Hyaluronic Acid Hydrating Serum](https://lovi.care/skincare/de/p/innisfree/green-tea-seed-hyaluronic-acid-hydrating-serum/for/oily-acne-prone-skin) — Superior fit — €37.64 at Amazon

## Where to buy

No store in Germany has a checked price for this product, so the page shows none.

## Ingredients

Centella Asiatica Extract, Water, Glycerin, Butylene Glycol, Methylpropanediol, Glycereth-26, 1,2-Hexanediol, Betaine, Licorice Root Extract, Carbomer, Tromethamine, Glycereth-25 Pca Isostearate, Ethylhexylglycerin, Dipotassium Glycyrrhizate, Allantoin, Glyceryl Acrylate Acrylic Acid Copolymer, Dipropylene Glycol, Panthenol, Gardenia Extract, Adenosine, Propanediol, Polyglyceryl-10 Oleate, Centella Asiatica Root Extract, Centella Asiatica Leaf Extract, Nelumbo Nucifera Extract, Pentylene Glycol, Tree Leaf Water, Madecassoside, Biosaccharide Gum-1, Extract Tree, Asiatic Acid, Madecassic Acid, Asiaticoside, Ectoin
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/super-cica-ampoule/for/oily-acne-prone-skin