# Medicube PDRN Pink Peptide Ampoule for acne-prone skin

**Lovi Fit: Average fit for acne-prone skin.**
Combination Skin Fit: High · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Moisturizers and moisturizing serums](https://lovi.care/skincare/de/best/moisturizers)

This fit is calculated for the concerns frequently associated with acne-prone skin: breakouts, blackheads, and post-acne marks. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for acne-prone skin; other moisturizers fit it better.

## Why this fit

- Offers moderate benefits for your acne and blemishes, as Niacinamide and Hyaluronic Acid hydrate and soothe the skin, while also being highly suitable for combination skin due to niacinamide's seboregulation and hyaluronic acid's humectant action.
- The Peptide Complex and Hyaluronic Acid provide excellent moisturizing and treatment, improving skin elasticity and hydration.
- The safety profile is excellent, with no risks of irritation for your acne-prone skin due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin): Average (this page)
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/oily-acne-prone-skin): Average

## Key ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone

## What the research says

- Topical palmitoyl pentapeptide (pal-KTTKS) provided significant improvement versus placebo control in the reduction of wrinkles and fine lines in Caucasian female subjects. ([International Journal of Cosmetic Science, 2005](https://pubmed.ncbi.nlm.nih.gov/18492182/))
- Topical hyaluronic acid filler serum combined with Botulinum toxin type A lengthened the duration of the toxin's effect in reducing wrinkles compared to Botulinum toxin type A alone. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/))
- Topical copper tripeptide complex on CO2 laser-resurfaced skin caused no significant reduction in erythema or objective improvement in wrinkles compared to controls, but significantly increased patient satisfaction regarding overall skin quality. ([Archives of Facial Plastic Surgery, 2006](https://pubmed.ncbi.nlm.nih.gov/16847171/))
- Topical application of Low-Peony PDRN enhanced barrier recovery and improved periorbital skin elasticity in human subjects. ([International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/))
- Polydeoxyribonucleotide promotes skin regeneration by increasing ERK phosphorylation, collagen accumulation, and cell proliferation and migration in fibroblasts while inhibiting ERK phosphorylation and inflammatory cytokine expression in keratinocytes. ([Molecular Medicine Reports, 2023](https://pubmed.ncbi.nlm.nih.gov/37350391/))
- A topical mixture of polydeoxyribonucleotide, vitamin C, and niacinamide delivered via a microneedling therapy system decreased skin pigmentation and increased skin elasticity by attenuating melanogenesis and the destruction of collagen and elastin fibers in a UV-B-radiated animal model. ([Molecules, 2022](https://pubmed.ncbi.nlm.nih.gov/35209068/))
- Topical application of TAC/Collagen postbiotics gel improved skin moisture score and inflammation index, and reduced porphyrins and brown spots in 20 volunteers with acne vulgaris. ([Journal of Cosmetic Dermatology, 2022](https://pubmed.ncbi.nlm.nih.gov/35818134/))
- Topical collagen tripeptide application improved skin wrinkles, elasticity, and density while reducing advanced glycated end products in 22 Asian women over 4 weeks. ([International Journal of Molecular Sciences, 2022](https://pubmed.ncbi.nlm.nih.gov/35163025/))
- Marine collagen extracted from Greenland halibut skin showed a non-cytotoxic effect on fibroblast cells and provided a slight skin hydration effect when incorporated into cosmetic hydrogel formulations at dosages of 0.1, 0.25, and 0.5% in 23 healthy volunteers. ([Marine Drugs, 2023](https://pubmed.ncbi.nlm.nih.gov/36827098/))
- Topical application of CoQ10 improves mitochondrial function in aging skin in vivo, combating cellular signs of aging caused by an age-dependent shift to a functionally anaerobic energy metabolism. ([BioFactors, 2008](https://pubmed.ncbi.nlm.nih.gov/19096122/))
- Encapsulating coenzyme Q10 in lipid nanoparticles for topical use improves skin compatibility, protects against degradation, increases skin penetration, and provides controlled release to counteract aging effects. ([Colloids and Surfaces. B, Biointerfaces, 2023](https://pubmed.ncbi.nlm.nih.gov/37574615/))
- Review of topical administration of carotenoids and coenzyme Q10 loaded in lipid nanoparticles highlights their improved bioavailability, chemical stability, skin absorption, and photoprotective effects. ([Antioxidants, 2021](https://pubmed.ncbi.nlm.nih.gov/34206935/))

## What reviewers say

Based on a very large amount of data, users consistently report that this ampoule delivers a "glass skin" effect, providing deep hydration and a noticeable plumping effect that benefits dry and aging skin. While it is widely praised for smoothing texture and soothing sensitive skin, results regarding blemish fading are mixed and take longer to appear.

- Disliked: Deep hydration (mostly mentioned)
- Disliked: Radiant glow (mostly mentioned)
- Disliked: Fast absorption (often mentioned)
- Liked: Noticeable fragrance (sometimes noted)
- Liked: Small volume (sometimes noted)
- Disliked: Soothing and gentle (sometimes noted)
- Liked: Minor breakouts (rarely noted)
- Liked: Slight stickiness (rarely noted)

## How to apply

- Use your moisturizer twice a day in your AM and PM routines. Apply it daily to help keep breakouts under control.
- Apply after your cleanser and toner, and make sure to use your SPF right after in the morning.
- Gently spread a small amount of moisturizer over your face using soft motions. Let it absorb into the skin for a minute before getting dressed or applying makeup.
- Apply on slightly damp skin to help lock in extra moisture. This keeps your combination skin balanced without feeling heavy.
- Avoid the eye area and do a patch test before your first use. Stop using if you feel any irritation.
- Video: https://storage.pora.ai/2f72f5d69f07beeafc30237f829efbff.mp4

## Questions and answers

### How well does medicube PDRN Pink Peptide Ampoule work for acne-prone skin?

This product works fairly well for acne-prone skin, offering moderate benefits for breakouts while keeping irritation unlikely. It hydrates and calms the skin using niacinamide and hyaluronic acid, though acne-prone skin often needs a product with specialized ingredients that balance oil and support skin repair without feeling heavy.

### Which ingredients make this serum a good fit for acne-prone skin?

Niacinamide and hyaluronic acid make this serum a good fit for acne-prone skin by helping hydrate and calm the skin while balancing oil. A product of this type needs effective hydrating ingredients, skin-repairing elements, and soothing botanical extracts to give acne-prone skin optimal moisture without extra oiliness.
Sources: [Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/36200921/)

### What does Salmon Pdrn do for acne-prone skin?

Salmon PDRN helps calm irritated acne-prone skin and supports faster recovery from blemishes. Because this product is a poor fit for acne-prone skin, a product of this type for this skin needs soothing ingredients and lightweight hydrators that calm redness without clogging pores.
Sources: [Pharmaceutics, 2025](https://pubmed.ncbi.nlm.nih.gov/40871045/), [International Journal of Molecular Sciences, 2025](https://pubmed.ncbi.nlm.nih.gov/41516097/)

### What does Salmon Collagen do for acne-prone skin?

Salmon collagen helps support overall skin health, but it does not directly target acne. A product for acne-prone skin needs soothing and balancing ingredients that keep pores clear and calm inflammation.

### Where does it go in a skincare routine for acne-prone skin?

This treatment goes in the evening routine after cleansing and before your moisturizer. It is unlikely to cause irritation for your acne-prone skin, though acne-prone skin generally needs lightweight hydrators and ingredients that help balance oil.

### Can I use this serum with retinol, and in what order?

You can use this moisturizing treatment with retinol by applying the serum first to hydrate and soothe the skin, followed by your retinol product. Using a barrier-enhancing moisturizer or treatment helps lower the likelihood of dryness and irritation when starting or continuing retinol use.
Sources: [Cutis, 2006](https://pubmed.ncbi.nlm.nih.gov/17121065/)

### How often should I use it?

You can use this treatment in the evening as part of your routine for acne-prone skin, applying it after cleansing and toning and before moisturizing. Daily application of a moisturizing treatment helps improve skin moisture and barrier function.
Sources: [Health Science Reports, 2021](https://pubmed.ncbi.nlm.nih.gov/34141902/), [Journal of Cosmetic Dermatology, 2020](https://pubmed.ncbi.nlm.nih.gov/32141711/)

### Can it clog pores, cause breakouts or purging for acne-prone skin?

This product is unlikely to clog pores or cause breakouts for acne-prone skin because it avoids harsh ingredients and features a very safe formula. To truly thrive, acne-prone skin needs soothing and balancing ingredients like niacinamide and hydrating agents that calm blemishes without heavy oils.

### Can I use this serum around the eyes or on my body?

You can use this moisturizing treatment safely around your eyes or on your body, as it has a very safe formula with no harsh ingredients that may cause irritation. To fit acne-prone skin best, products of this type need soothing ingredients like niacinamide and lightweight hydrators that keep pores clear while calming breakouts.
Sources: [Surgical and Radiologic Anatomy, 2002](https://pubmed.ncbi.nlm.nih.gov/12375070/)

### Is it fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for acne-prone skin

- [MEDI-PEEL Peptide 9 Volume White Cica All-in-one Essence](https://lovi.care/skincare/de/p/medi-peel/peptide-9-volume-white-cica-all-in-one-essence/for/acne-prone-skin) — High fit — €29.98 at Amazon
- [COSRX Hydrium Triple Hyaluronic Moisture Ampoule](https://lovi.care/skincare/de/p/cosrx/hydrium-triple-hyaluronic-moisture-ampoule/for/acne-prone-skin) — High fit — €17.99 at Amazon
- [MISSHA Super Aqua Ultra Hyalron Ampoule](https://lovi.care/skincare/de/p/missha/super-aqua-ultra-hyalron-ampoule/for/acne-prone-skin) — Average fit — €22.75 at Amazon

## Pairs well with

- Cleanser: [CeraVe Foaming Facial Cleanser](https://lovi.care/skincare/de/p/cerave/foaming-facial-cleanser/for/acne-prone-skin) — Superior fit — €11.75 at Amazon
- Hydrating Toner: [SOME BY MI Snail Truecica Miracle Repair Toner](https://lovi.care/skincare/de/p/some-by-mi/snail-truecica-miracle-repair-toner/for/acne-prone-skin) — Superior fit — €16.59 at Amazon
- SPF: [innisfree Daily UV Defense Mineral Sunscreen](https://lovi.care/skincare/de/p/innisfree/daily-uv-defense-mineral-sunscreen/for/acne-prone-skin) — Superior fit — €65.41 at Amazon

## Where to buy

- Amazon.de: €16.60 (https://www.amazon.de/dp/B0DBF65JYY?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Notino: €18.90 (https://www.notino.de/medicube/pdrn-pink-peptide-serum-festigendes-hautserum-mit-peptiden/p-16329864/)
- Lookfantastic: €21.60 (https://www.lookfantastic.de/p/medicube-pdrn-pink-peptide-serum-30ml/17692818/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Salmon Pdrn, Salmon Collagen Complex, Ubiquinone, Ocimum Tenuiflorum, Hyaluronic Acid, Niacinamide, Curcuma Longa Root Extract, Adenosine, Ocimum Sanctum Leaf Extract, Peptide Complex, Rose Pdrn Extract Rosa Damascena Sodium Dna Extract
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Germany: https://lovi.care/skincare/de/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Italy: https://lovi.care/skincare/it/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Spain: https://lovi.care/skincare/es/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Australia: https://lovi.care/skincare/au/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/pdrn-pink-peptide-ampoule/for/acne-prone-skin