# Medicube One Day Exosome Shot 7500 for dry skin

**Lovi Fit: Average fit for dry skin.**
Dry Skin Fit: Average · Effectiveness: Average · Safety: Low Risk.

Page: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/dry-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with dry skin: flakiness, tightness, dehydration, fine lines, and wrinkles. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for dry skin; other serums fit it better.

## Why this fit

- Offers excellent skin rejuvenation for your dry skin due to Lactobacillus Extracellular Vesicles and Niacinamide, which promote skin repair and improve skin tone.
- Glycerin and Panthenol provide hydration supportive for dry or flaky skin, though the formula lacks sufficient emollients for optimal dry skin hydration.
- The product is generally safe for your dry skin, with minor irritation risks from Betaine Salicylate and Citric Acid.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/dry-skin): Average (this page)
- [Combination skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/sensitive-skin): Average
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/dark-spots): Average
- [Mature skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/mature-skin): Average
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/oily-acne-prone-skin): Average

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Adenosine, Betaine Salicylate, Oenothera Biennis Flower Extract

## What the research says

- Niacinamide significantly decreased hyperpigmentation and increased skin lightness compared with vehicle alone after 4 weeks of use in women by inhibiting melanosome transfer. ([The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/))
- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical dexpanthenol acts as a moisturizer, improves stratum corneum hydration, accelerates wound healing and epidermal regeneration, reduces erythema, and improves symptoms of skin irritation compared to vehicle or no pretreatment. ([American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- A new topical panthenol-containing emollient significantly improved transepidermal water loss reduction, stratum corneum hydration, and intercellular lipid lamellae length compared with control in healthy subjects without negatively impacting bacterial viability. ([The Journal of Dermatological Treatment, 2017](https://pubmed.ncbi.nlm.nih.gov/27425824/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Topical 2% niacinamide significantly decreased sebum excretion rate in Japanese individuals and casual sebum levels in Caucasian individuals compared to placebo or baseline. ([Journal of Cosmetic and Laser Therapy, 2006](https://pubmed.ncbi.nlm.nih.gov/16766489/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))

## Why other serums fit dry skin better

- Treatment with cross-linked hyaluronic acid-based microneedle patches combined with acetyl hexapeptide-8 or epidermal growth factor significantly improved wrinkles and skin hydration compared to the patch alone in Korean females over 29 days. ([Annals of Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/33911590/))
- Treatment with 14% ferulic acid and 12% l-ascorbic acid significantly reduced pigmentation and erythema while improving hydration and elasticity in 20 women with photoaged skin, with neither acid proving definitively more effective overall though ascorbic acid showed slightly greater skin lightening. ([Dermatologic Therapy, 2022](https://pubmed.ncbi.nlm.nih.gov/34877760/))

## What reviewers say

Users frequently report a "glass skin" effect with noticeable improvements in skin texture and pore size after overnight use, though the application involves a distinct prickly sensation due to the spicules. While highly effective for smoothing and tightening, it is polarizing due to the "needle-like" pain and potential for irritation on sensitive skin.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Painful application (mostly mentioned)
- Liked: Fast/overnight results (often mentioned)
- Liked: Visible pore reduction (often mentioned)
- Liked: Enhanced product absorption (sometimes noted)
- Disliked: Not for sensitive skin (sometimes noted)
- Disliked: Skin irritation (sometimes noted)
- Disliked: High price point (rarely noted)

## How to apply

- Apply this serum PM, starting 3×/week and working up to daily use as your skin adjusts.
- Place the serum after cleansing and toner, but right before your moisturizer.
- Gently press 2-3 drops of the serum into your skin and let it absorb for a minute.
- Apply the serum on slightly damp skin to help lock in extra moisture.
- Avoid the eye area and do a patch test before your first use.
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### How well does Medicube Exosome Shot 7500 work for dry skin?

This treatment works for your dry skin, though other products fit it better because the formula lacks sufficient rich softening ingredients for optimal dry skin hydration. It helps repair skin and improve tone with niacinamide, while glycerin and panthenol provide hydration, though it may cause minor irritation due to betaine salicylate and citric acid. A dry skin routine needs soothing ingredients, ceramides, and peptides that provide deep hydration and support the skin barrier without irritation.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this serum a good fit for dry skin?

Lactobacillus extracellular vesicles and niacinamide make this treatment a good fit by promoting skin repair and improving tone, while glycerin and panthenol help provide hydration. However, dry skin needs a product of this type to include rich hydrating ingredients, soothing emollients, and barrier-supporting components like ceramides, peptides, or propolis to prevent irritation and ensure optimal moisture.
Sources: [American Journal of Clinical Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12113650/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What do Lactobacillus Extracellular Vesicles do for dry skin?

Lactobacillus extracellular vesicles help dry skin by restoring and strengthening the skin barrier while calming irritation. This approach helps keep skin soft and smooth while protecting against environmental stress.
Sources: [World Journal of Microbiology & Biotechnology, 2026](https://pubmed.ncbi.nlm.nih.gov/42804019/), [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/)

### What does Niacinamide do for dry skin?

Niacinamide helps dry skin by strengthening the skin barrier, increasing hydration, and reducing water loss. It supports ceramide production and helps keep the surface smooth and calm. This ingredient tends to be very well tolerated and is unlikely to irritate dry skin.
Sources: [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/), [Journal of Cosmetic Dermatology, 2026](https://pubmed.ncbi.nlm.nih.gov/42108609/)

### Where does this serum go in a skincare routine for dry skin?

This treatment goes in the evening routine after cleansing, followed by a moisturizer to lock in hydration. A product of this type needs rich moisturizing ingredients and soothing elements to deeply comfort and hydrate dry skin.

### Can I use this serum with retinol, and in what order?

You can use this treatment alongside retinol by applying the treatment first and following with your retinol on separate nights or with caution, as it carries a risk of minor irritation from exfoliating ingredients. To work best for dry skin, this type of product needs rich moisturizing oils and butters to lock in hydration and prevent flakiness.

### How often should I use this serum?

You can use this treatment once a week in the evening to start, since it is an exfoliating step, and then slowly use it more often if your dry skin tolerates it well. This product needs richer, softening ingredients to lock in moisture and keep dry or flaky skin comfortable.

### Can this serum clog pores, cause breakouts or purging for dry skin?

This treatment is unlikely to clog pores or cause breakouts for dry skin, though mild irritation may happen due to exfoliating ingredients. To keep dry skin comfortable, products of this type need rich moisturizing ingredients that lock in hydration.

### Is this serum fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for dry skin

- [Beauty of Joseon Propolis + Niacinamide Glow Serum](https://lovi.care/skincare/de/p/beauty-of-joseon/propolis-niacinamide-glow-serum/for/dry-skin) — Superior fit — €9.99 at Amazon
- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/dry-skin) — Superior fit — €57.00 at Amazon
- [ma:nyo Bifida Biome Complex Ampoule](https://lovi.care/skincare/de/p/ma-nyo/bifida-biome-complex-ampoule/for/dry-skin) — Superior fit — €18.50 at Amazon

## Pairs well with

- Cleanser: [La Roche-Posay Hydrating Gentle Cleanser](https://lovi.care/skincare/de/p/la-roche-posay/toleriane-hydrating-gentle-cleanser/for/dry-skin) — Superior fit — €19.75 at Amazon
- Hydrating Toner: [Dear, Klairs Supple Preparation Unscented Toner](https://lovi.care/skincare/de/p/dear-klairs/supple-preparation-unscented-toner/for/dry-skin) — Superior fit — €12.59 at Amazon
- Moisturizer: [d'Alba First Spray Serum](https://lovi.care/skincare/de/p/d-alba/first-spray-serum/for/dry-skin) — Superior fit — €16.99 at Amazon

## Where to buy

- Amazon.de: €15.98 (https://www.amazon.de/dp/B0DQCLFJCB?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €21.56 (https://www.lookfantastic.de/p/medicube-one-day-exosome-shot-pore-ampoule-7500-30ml/16858544/)
- Notino: €33.50 (https://www.notino.de/medicube/one-day-exosome-shot-pore-ampoule-7500-intensives-revitalisierendes-serum-gegen-die-unvollkommenheiten-der-haut/p-16313460/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-7500/for/dry-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-7500/for/dry-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-7500/for/dry-skin