# Medicube One Day Exosome Shot 2000 for sensitive skin

**Lovi Fit: High fit for sensitive skin.**
Normal Skin Fit: Superior · Effectiveness: High · Safety: High.

Page: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [Medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Serums and treatments](https://lovi.care/skincare/de/best/serums)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

A great choice for sensitive skin; a few serums fit it even better.

## Why this fit

- Offers excellent skin treatment for your normal skin, as Lactobacillus Extracellular Vesicles and Niacinamide support barrier repair and regulate melanogenesis, while also providing moderate benefits for redness and irritation by soothing and calming the skin.
- The presence of Betaine Salicylate further enhances skin regeneration through chemical exfoliation, contributing to overall skin health.
- The formulation is safe for your sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/oily-skin): High
- [Dry skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/dry-skin): High
- [Combination skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/combination-skin): High
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin): High (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/acne-prone-skin): High
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/dark-spots): High
- [Mature skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/mature-skin): High
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/dry-sensitive-skin): High
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/oily-acne-prone-skin): High

## Key ingredients

Lactobacillus Extracellular Vesicles, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Adenosine

## What the research says

- Topical post-laser application of human adipocyte-derived mesenchymal stem cell media combined with niacinamide significantly improved wrinkle index, melanin index, patient satisfaction, and investigator esthetic improvement scores compared to vehicle cream in patients with aging skin. ([Journal of Cosmetic Dermatology, 2021](https://pubmed.ncbi.nlm.nih.gov/33103316/))
- Topical nicotinamide prevented solar-simulated UV-induced immunosuppression in healthy volunteers, and men experienced immunosuppression at solar-simulated UV doses three times lower than those required for women. ([The Journal of Investigative Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/17882270/))
- Topical 5% niacinamide applied twice daily for 12 weeks reduced fine lines and wrinkles, hyperpigmented spots, red blotchiness, and skin sallowness, and improved skin elasticity compared to vehicle control in 50 female white subjects with facial photoaging. ([Dermatologic Surgery, 2005](https://pubmed.ncbi.nlm.nih.gov/16029679/))
- Electrospun poly (vinyl butyral-co-vinyl alcohol-co-vinyl acetate) patches loaded with evening primrose oil applied to the forearm of volunteers for 6 hours increased skin moisture, with pore size, shape, and fiber diameter influencing oil transport. ([Biomaterials Advances, 2022](https://pubmed.ncbi.nlm.nih.gov/35929319/))
- A topical preparation containing urea, sunflower oil, evening primrose oil, wheat germ oil, and sodium pyruvate led to clinical improvement after a month in diverse hyperkeratotic skin conditions except pityriasis lichenoides. ([Medicina Cutanea Ibero-latino-americana, 1986](https://pubmed.ncbi.nlm.nih.gov/3528709/))
- Oenothera biennis cell culture aqueous extract promoted matrix collagen contraction, actin polymerization, and essential extracellular matrix protein production by increasing MYLK gene expression in in vitro, cell, and ex vivo skin aging models. ([Metabolites, 2021](https://pubmed.ncbi.nlm.nih.gov/34436468/))
- Topical application of Bifidobacterium-fermented soy milk extract significantly restored elasticity and viscoelasticity, increased hyaluronic acid content, and improved hydration and thickness in mouse skin, and lessened the decrease in skin elasticity in human skin compared to baseline. ([Journal of Cosmetic Science, 2004](https://pubmed.ncbi.nlm.nih.gov/15608997/))
- Genistein and daidzein inhibited UVB-induced hydrogen peroxide production in keratinocytes acting as free radical scavengers with negligible skin disruption, whereas glycitein showed no protective activity. ([International Journal of Pharmaceutics, 2008](https://pubmed.ncbi.nlm.nih.gov/18761396/))
- A water-in-oil microemulsion vehicle significantly enhanced the intradermal delivery of genistein, daidzein, and biochanin A in excised guinea pig and Yucatan micropig skin, with genistein exhibiting the most marked increase in skin accumulation and effectively preventing UV irradiation-induced erythema formation. ([Chemical & Pharmaceutical Bulletin, 2010](https://pubmed.ncbi.nlm.nih.gov/20190449/))
- Topical adenosine treatment significantly increased the anagen hair growth rate and thick hair rate compared to placebo in Japanese women with female pattern hair loss over 12 months. ([The Journal of Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/19239555/))
- Topical application of a disodium adenosine monophosphate-based formulation reduced wrinkles and hyperpigmentation while improving hydration, barrier function, skin lifting, and epidermal turnover in female participants. ([International Journal of Molecular Sciences, 2026](https://pubmed.ncbi.nlm.nih.gov/42278371/))
- Adenosine and cordycepin stimulate the Wnt/beta-catenin signaling pathway through adenosine receptor and PKA activation, promoting cell proliferation, migration, and growth factor secretion in cultured dermal fibroblasts. ([International Journal of Molecular Sciences, 2021](https://pubmed.ncbi.nlm.nih.gov/34070360/))

## What reviewers say

This ampoule is highly praised for its ability to refine skin texture and minimize pores, leading to smoother skin and a glow. While a tingling sensation from spicules is frequently noted and can be uncomfortable for some, most users experience visible improvements in smoothness and reduced blackheads within weeks. Some users with sensitive skin may experience irritation or dryness.

- Liked: Smoother skin texture (mostly mentioned)
- Disliked: Prickly/tingling sensation (mostly mentioned)
- Liked: Pore tightening (often mentioned)
- Liked: Blackhead reduction (sometimes noted)
- Liked: Fast results (sometimes noted)
- Disliked: Can be drying (rarely noted)
- Disliked: Skin irritation/breakouts (rarely noted)

## How to apply

- Use your serum in the PM routine, starting 3 times a week before building up to daily use if your skin is happy.
- Apply the serum after cleansing and toning, but before putting on your moisturizer for the best results.
- Gently press 2-3 drops of the serum into your skin and wait a minute ⏱ for it to soak in.
- Since your skin is sensitive and easily irritated, apply the serum on completely dry skin to help keep it calm.
- Always do a patch test before your first use and avoid getting the serum too close to your eyes .
- Video: https://storage.pora.ai/c879dda8655a61c19d3d8c9ebad6b06d.mp4

## Questions and answers

### What makes Medicube Exosome Shot 2000 a great fit for sensitive skin?

Medicube One Day Exosome Shot 2000 is a great fit because it supports barrier repair and gently soothes redness and irritation while avoiding harsh ingredients that could upset your skin. Niacinamide and Lactobacillus Extracellular Vesicles help calm the skin, and ingredients like betaine salicylate gently encourage cell turnover for a smooth, healthy feel.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### Which ingredients make this treatment a good fit for sensitive skin?

Lactobacillus Extracellular Vesicles and niacinamide make this treatment a great fit because they support barrier repair and soothe sensitive skin without harsh ingredients. Niacinamide also helps even out skin tone by reducing dark spots.
Sources: [The British Journal of Dermatology, 2002](https://pubmed.ncbi.nlm.nih.gov/12100180/)

### What do Lactobacillus Extracellular Vesicles do for sensitive skin?

Lactobacillus extracellular vesicles help calm sensitive skin by strengthening the skin barrier and easing redness and irritation. They support moisture retention and help shield skin from everyday stress.
Sources: [Frontiers in Immunology, 2026](https://pubmed.ncbi.nlm.nih.gov/42643438/), [International Journal of Biological Macromolecules, 2025](https://pubmed.ncbi.nlm.nih.gov/41175997/)

### What does Niacinamide do for sensitive skin?

Niacinamide helps calm sensitive skin by strengthening the skin barrier and reducing redness and irritation. It is very well tolerated and may improve overall comfort and resilience with regular use.
Sources: [Cutis, 2005](https://pubmed.ncbi.nlm.nih.gov/16209160/), [Journal of Cosmetic Dermatology, 2004](https://pubmed.ncbi.nlm.nih.gov/17147561/)

### Where does this treatment go in a skincare routine for sensitive skin?

This treatment goes in your evening routine, applied after your soothing toner and before your moisturizer. Putting treatments at night helps keep things simple and adds extra safety around sun exposure.

### Can I use it with retinol, and in what order?

You can use this treatment with retinol by applying the treatment first in your evening routine, but use them on alternate nights if your sensitive skin feels dry or easily irritated. A gentle approach helps you avoid redness while still giving you smooth skin.

### How often should I use this treatment?

This treatment fits sensitive skin very well and is used in the evening, starting once a week to see how your skin reacts. If your skin feels comfortable and looks good, you may carefully use it more often.

### Can it clog pores, cause breakouts or purging for sensitive skin?

Medicube One Day Exosome Shot 2000 is unlikely to cause breakouts or clog pores on sensitive skin since it is formulated without harsh or prohibited ingredients, though users frequently report a prickly or tingling sensation. It helps calm the skin and supports barrier repair, keeping irritation low.

### Is this treatment fragrance-free and alcohol-free?

Yes, it has no fragrance and no drying alcohol.

## Alternatives for sensitive skin

- [Paula's Choice RESIST Super Antioxidant Concentrate Serum](https://lovi.care/skincare/de/p/paula-s-choice/resist-super-antioxidant-concentrate-serum/for/sensitive-skin) — Superior fit — €57.00 at Amazon
- [SkinCeuticals C E Ferulic](https://lovi.care/skincare/de/p/skinceuticals/c-e-ferulic/for/sensitive-skin) — High fit — €169.99 at Amazon
- [Neogen Dermalogy Real Vitamin C Serum](https://lovi.care/skincare/de/p/neogen-dermalogy/real-vitamin-c-serum/for/sensitive-skin) — High fit — €29.76 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Soothing Toner: [SKIN1004 Centella Asiatica Toning Toner](https://lovi.care/skincare/de/p/skin1004/centella-asiatica-toning-toner/for/sensitive-skin) — Superior fit — €19.89 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon

## Where to buy

- Amazon.de: €16.00 (https://www.amazon.de/dp/B0FNRSCSBG?tag=lovi-care-web-product05-21&linkCode=osi&th=1&psc=1)
- Lookfantastic: €19.84 (https://www.lookfantastic.de/p/medicube-one-day-exosome-shot-pore-ampoule-2000-30ml/16858542/)
- Notino: €27.50 (https://www.notino.de/medicube/one-day-exosome-shot-2000-intensives-regenerierendes-serum-fuer-klare-und-glatte-haut/p-16313459/)
Prices checked 10 Oct – 6 Nov 2026.

## Ingredients

Water, Dipropylene Glycol, Glycerin, 1,2-Hexanediol, Lactobacillus Extracellular Vesicles, Butylene Glycol, Niacinamide, Oenothera Biennis Flower Extract, Pueraria Lobata Root Extract, Pinus Palustris Leaf Extract, Ulmus Davidiana Root Extract, Ethylhexyl Palmitate, Sodium Polyacrylate, Hydrogenated Polydecene, Caprylyl Capryl Glucoside, C12-14 Alketh-12, Hydrolyzed Sponge, Calcium Silicate, Sodium Silicate, Campsis Grandiflora Flower Extract, Ethylhexylglycerin, Adenosine, Disodium Edta, Panthenol, Betaine Salicylate, Citric Acid, Gluconolactone
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/one-day-exosome-shot-2000/for/sensitive-skin