# medicube Exosome Cica Calming Toner for sensitive skin

**Lovi Fit: Average fit for sensitive skin.**
Normal Skin Fit: High · Effectiveness: Average · Safety: High.

Page: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/sensitive-skin

The Lovi Fit is the same in every country; only the stores and prices differ, and the ones here are for Germany.

Brand: [medicube](https://lovi.care/skincare/de/brands/medicube)
Category: [Toners](https://lovi.care/skincare/de/best/toners)

This fit is calculated for the concerns frequently associated with sensitive skin: redness, stinging, and reactions to new products. For scores based on a full skin profile (12D face scan, goals, preferences), use the Lovi app.

Works for sensitive skin; other toners fit it better.

## Why this fit

- Offers moderate soothing benefits for your redness and irritation, as Centella Asiatica Extract and Heart Leaf Extract provide mild calming effects suitable for normal skin. Glycerin further supports hydration, enhancing the overall comfort for your skin type.
- The formulation is safe for your sensitive skin, as it lacks harsh ingredients that could cause irritation.
- This product is generally safe for your sensitive skin, with no risks of irritation due to the absence of prohibited or harsh ingredients.

## Fit by skin type

- [Oily skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/oily-skin): Average
- [Dry skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/dry-skin): Average
- [Combination skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/combination-skin): Average
- [Sensitive skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/sensitive-skin): Average (this page)
- [Acne-prone skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/acne-prone-skin): Average
- [Skin with dark spots](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/dark-spots): Low
- [Mature skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/mature-skin): Low
- [Dry sensitive skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/dry-sensitive-skin): Average
- [Oily acne-prone skin](https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/oily-acne-prone-skin): High

## Key ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract

## What the research says

- Cosmetic formulations containing 5% Centella asiatica extract showed the best efficacy in improving skin moisture and decreasing transepidermal water loss, while also exhibiting antiinflammatory properties in 25 volunteers compared to baseline measurements. ([Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/))
- A single application of a moisturizing fluid containing hyaluronic acid 1%, glycerin 5%, and Centella asiatica stem cells extract significantly increased skin hydration by 29% and reduced transepidermal water loss at 24 hours compared to baseline and an untreated control site in twenty healthy women. ([Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/))
- Co-delivery of paeonol and madecassoside via nanoemulsions improved transdermal delivery, promoted barrier repair proteins, inhibited inflammatory cytokine secretion in cellular and 3D models, and reduced transepidermal water loss and acne in human facial skin compared to free components. ([Molecules, 2023](https://pubmed.ncbi.nlm.nih.gov/37446936/))
- A hyperoside-enriched fraction of Houttuynia cordata Thunb. inhibited UVB-induced oxidative stress, inflammation, and collagen degradation in human dermal fibroblasts by regulating the MAPK signaling pathway. ([Plants, 2021](https://pubmed.ncbi.nlm.nih.gov/34961096/))
- Topical application of 0.05% w/w ECa 233 gel reduced erythema index by 0.03 U and improved early crusting and general wound appearance compared to placebo in thirty individuals undergoing facial laser resurfacing. ([Journal of Alternative and Complementary Medicine, 2020](https://pubmed.ncbi.nlm.nih.gov/32310680/))
- Moisturizer containing 5% panthenol, madecassoside, and copper-zinc-manganese decreased adverse reactions and downtime after ablative fractional carbon dioxide laser resurfacing with comparable efficacy to 0.02% triamcinolone acetonide cream in 20 subjects. ([Journal of Cosmetic Dermatology, 2019](https://pubmed.ncbi.nlm.nih.gov/30945430/))
- Topical treatment with 5% vitamin C and 0.1% madecassoside significantly improved clinical scores for wrinkles, suppleness, firmness, roughness, and skin hydration, along with functional and structural remodeling of the elastic fiber network in 20 female volunteers with photoaged skin after 6 months compared to baseline. ([Experimental Dermatology, 2008](https://pubmed.ncbi.nlm.nih.gov/18503551/))
- Adjuvant application of human adipose tissue stem cell-derived exosomes gel following fractional CO2 laser significantly improved the reduction of acne scars (32.5% vs 19.9%, p < 0.01) and reduced erythema and downtime in 25 patients compared to the control gel. ([Acta Dermato-venereologica, 2020](https://pubmed.ncbi.nlm.nih.gov/33073298/))
- Topical mesenchymal stem cell-derived exosomes reduced Ocular Surface Disease Index scores, increased tear secretion, lowered fluorescein scores, prolonged tear-film break-up time, increased Epidermal Growth Factor and thrombospondin-1, and decreased interleukin-6 and Matrix metalloproteinase-9 in patients with Sjögren's syndrome-related dry eye compared to phosphate buffered saline control. ([BMC Ophthalmology, 2025](https://pubmed.ncbi.nlm.nih.gov/40394561/))
- Topical human platelet extract exosome serum improved skin health scores and reduced redness, wrinkles, and melanin production while enhancing luminosity and color evenness at 6 weeks. ([Aesthetic Surgery Journal, 2022](https://pubmed.ncbi.nlm.nih.gov/35689936/))
- Quercetin phospholipids 1% cream significantly reduced UV-, histamine-, and chemical-induced skin erythema (-10.05%) and mean wheal diameter in 30 healthy human volunteers, showing comparable efficacy to 1% dexchlorpheniramine cream. ([Clinical, Cosmetic and Investigational Dermatology, 2016](https://pubmed.ncbi.nlm.nih.gov/27013898/))
- Quercetin-loaded niosomes formulated with Span60-RH40 at a 9:11 mass ratio improved quercetin solubility, photostability, sustained release, and transdermal penetration, yielding a skin retention 2.95 times higher than quercetin solution. ([Molecules, 2019](https://pubmed.ncbi.nlm.nih.gov/31238562/))
- Optimized rutin-loaded glycerosomes formulated into a nanosunscreen gel demonstrated sustained drug release, greater skin permeation, good antioxidant activity, and better epidermal retention compared to the dermis, indicating high safety, stability, and sun protection factor values for topical administration. ([Gels, 2023](https://pubmed.ncbi.nlm.nih.gov/37754433/))

## What reviewers say

This toner is highly praised for its lightweight, watery texture that absorbs quickly without stickiness, making it suitable for oily and acne-prone skin. It is very effective at reducing redness and soothing irritation, with many users reporting improved skin balance. Some users noted concerns about the scent, price, and potential for fungal acne, though these were less common observations.

- Liked: Calms redness (mostly mentioned)
- Liked: Lightweight absorption (mostly mentioned)
- Liked: Deeply hydrating (often mentioned)
- Liked: Improves acne (sometimes noted)
- Disliked: Not fungal acne safe (rarely noted)
- Disliked: Price point (rarely noted)
- Disliked: Scent preferences (rarely noted)
- Disliked: Unclear long-term benefits (rarely noted)

## How to apply

- Could be used as part of your AM or PM routine. Start using this soothing toner 3×/week, and move to daily use if your skin likes it.
- Apply this soothing toner after your cleanser, and before your moisturizer or SPF.
- Gently press 2-3 drops of the soothing toner into your skin with your hands. Let it absorb for a minute before moving on.
- Since your skin is sensitive, apply this soothing toner on completely dry skin to make it feel extra comfortable.
- Be sure to avoid the eye area and do a quick patch test before your very first use.
- Video: https://storage.pora.ai/25abe7eb181ba53153fd15de2058c2a9.mp4

## Questions and answers

### How well does medicube Exosome Cica Calming Toner work for sensitive skin?

This toner works for sensitive skin, though other products fit it better because they offer stronger soothing and more effective barrier support. A soothing toner for sensitive skin needs effective calming ingredients to address redness and irritation, along with rich hydration and barrier support.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Which ingredients make this toner a good fit for sensitive skin?

Centella Asiatica Extract, Heart Leaf Extract, and glycerin make this toner a good fit for sensitive skin by offering moderate calming benefits and supporting hydration. To work best for sensitive skin, a product of this type needs powerful soothing ingredients and barrier support to address redness and irritation without any risk of irritation.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### What does Centella Asiatica Extract do for sensitive skin?

Centella asiatica extract helps calm sensitive skin and keeps it comfortable by easing irritation and supporting moisture retention. Using this ingredient helps soothe redness and supports a healthy skin barrier with a very low likelihood of irritation.
Sources: [Journal of Cosmetic Dermatology, 2025](https://pubmed.ncbi.nlm.nih.gov/40682399/), [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/)

### What do Exosomes do for sensitive skin?

Exosomes help calm sensitive skin by reducing redness and irritation while supporting the skin's natural barrier. This type of product works best when it also includes soothing ingredients like ceramides and gentle hydrators to keep dry or easily irritated skin comfortable and protected.
Sources: [Cells, 2020](https://pubmed.ncbi.nlm.nih.gov/32164386/), [International Journal of Biological Sciences, 2024](https://pubmed.ncbi.nlm.nih.gov/38481799/)

### Where does this toner go in a skincare routine for sensitive skin?

This soothing toner goes after cleansing in both your morning and evening skincare routines. Sensitive skin needs a gentle toner packed with calming plant extracts and hydrating ingredients to help ease redness and keep the skin comfortable.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can I use this toner with retinol, and in what order?

You can use this toner with retinol by applying the toner first to damp skin and following with your retinol once it absorbs. This product is safe for sensitive skin because it lacks harsh ingredients, though a product for this skin needs richer soothing extracts and barrier-supporting ingredients to give you the best fit.

### How often should I use this toner?

You can use this toner twice a day in your morning and evening routines. It helps calm redness and irritation while keeping your skin comfortable, though this type of skin needs stronger soothing and barrier-repairing ingredients for a better fit.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

### Can this toner clog pores, cause breakouts or purging for sensitive skin?

This toner is unlikely to clog pores or cause breakouts on sensitive skin, as it lacks harsh ingredients and includes calming plant extracts that help keep skin comfortable. To fully care for sensitive skin, a product of this type needs soothing ingredients like Centella Asiatica and hydrating components like glycerin to calm redness and support moisture without heavy oils.
Sources: [Indian Journal of Pharmaceutical Sciences, 2016](https://pubmed.ncbi.nlm.nih.gov/27168678/), [Clinical, Cosmetic and Investigational Dermatology, 2017](https://pubmed.ncbi.nlm.nih.gov/28860834/)

## Alternatives for sensitive skin

- [Dr.G R.E.D Blemish Clear Soothing Toner](https://lovi.care/skincare/de/p/dr-g/r-e-d-blemish-clear-soothing-toner/for/sensitive-skin) — High fit — €21.29 at Amazon
- [iUnik Tea Tree Relief Toner](https://lovi.care/skincare/de/p/iunik/tea-tree-relief-toner/for/sensitive-skin) — High fit — €19.59 at Amazon
- [La Roche-Posay Soothing Lotion Sensitive Skin Toner](https://lovi.care/skincare/de/p/la-roche-posay/soothing-lotion-sensitive-skin/for/sensitive-skin) — High fit — €20.95 at Amazon

## Pairs well with

- Cleanser: [Fresh Soy Face Cleanser](https://lovi.care/skincare/de/p/fresh/soy-face-cleanser/for/sensitive-skin) — Superior fit — €39.99 at Amazon
- Moisturizer with Sun Protection: [Torriden DIVE-IN Mild Sunscreen](https://lovi.care/skincare/de/p/torriden/dive-in-mild-sunscreen/for/sensitive-skin) — Superior fit — €18.00 at Amazon
- Pre-Cleanser: [MISSHA Ultra Hyalon Cleansing Cream](https://lovi.care/skincare/de/p/missha/ultra-hyalon-cleansing-cream/for/sensitive-skin) — Superior fit — €10.97 at Amazon

## Where to buy

- Notino: €20.90 (https://www.notino.de/medicube/exosome-cica-toner-erfrischendes-gesichtstonikum-zur-beruhigung-der-haut/p-16359264/)
Prices checked 10 Oct 2026.

## Ingredients

Centella Asiatica Extract, Exosome, Heart Leaf Extract, Extract Tree, Glycerin, Butylene Glycol, Water
## About the Lovi Fit

Lovi: Unbiased, science-based skincare AI trained on real user outcomes.

Lovi calculates every fit score from the full ingredient list with brand-independent rules its dermatologists and cosmetic chemists build and review, and personalizes every pick with AI trained on the real results of millions of users. Lovi trains its fit score models on a proprietary dataset built from more than 10,000 expert-labeled products and more than 100,000 simulated examples, following an internally consistent methodology presented at Cosmoprof, AMWC, and Skin of Color Update. Levels from best to worst: Superior, High, Average, Low, Caution, Warning.

Behind this fit score: Nadia Kapleva, MS (Co-founder, Medical Director); Alexey Shagraev, PhD (Co-founder, CEO and CTO); Dr. Sofía Perea Pérez, MD, MSc (Medical Board); Aishani Shah, MD (Medical Board); Asya Zubkova, MS (Medical Board); Hanna Kurets, MD (Medical Board, Medical Advisor); Elina Nazarenko, MD (Medical Board); Victoria Derkova, MS (Medical Board).

Page built Nov 8, 2026.

More from Lovi: https://lovi.care/skincare/llms.txt

## This page in other countries

- United States: https://lovi.care/skincare/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- United Kingdom: https://lovi.care/skincare/uk/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Ireland: https://lovi.care/skincare/ie/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Germany: https://lovi.care/skincare/de/p/medicube/exosome-cica-calming-toner/for/sensitive-skin (this page)
- France: https://lovi.care/skincare/fr/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Italy: https://lovi.care/skincare/it/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Netherlands: https://lovi.care/skincare/nl/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Spain: https://lovi.care/skincare/es/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Canada: https://lovi.care/skincare/ca/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Australia: https://lovi.care/skincare/au/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Singapore: https://lovi.care/skincare/sg/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- Saudi Arabia: https://lovi.care/skincare/sa/p/medicube/exosome-cica-calming-toner/for/sensitive-skin
- United Arab Emirates: https://lovi.care/skincare/ae/p/medicube/exosome-cica-calming-toner/for/sensitive-skin